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Tardive dyskinesia

MedGen UID:
151939
•Concept ID:
C0686347
•
Disease or Syndrome
Synonyms: Dyskinesia, Tardive; Dyskinesias, Tardive; Dystonia, Tardive; Dystonias, Tardive; Tardive Dyskinesia; Tardive Dyskinesias; Tardive Dystonia; Tardive Dystonias
 
HPO: HP:0040141
Monarch Initiative: MONDO:0010096
OMIM®: 272620

Definition

Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is estimated to occur in 20 to 30% of chronic schizophrenics on long-term treatment (Thelma et al., 2008). [from OMIM]

Clinical features

From HPO
Akathisia
MedGen UID:
97881
•Concept ID:
C0392156
•
Sign or Symptom
A state of motor restlessness, usually in the lower extremities, that is often but not always accompanied by a subjective sense of inner restlessness, an urge to move, and anxiety or dysphoria.
See: Feature record | Search on this feature
Tardive dyskinesia
MedGen UID:
151939
•Concept ID:
C0686347
•
Disease or Syndrome
Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is estimated to occur in 20 to 30% of chronic schizophrenics on long-term treatment (Thelma et al., 2008).
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTardive dyskinesia

Conditions with this feature

Tardive dyskinesia
MedGen UID:
151939
•Concept ID:
C0686347
•
Disease or Syndrome
Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is estimated to occur in 20 to 30% of chronic schizophrenics on long-term treatment (Thelma et al., 2008).
See: Condition Record
Tardive dyskinesia

Professional guidelines

PubMed

Pharmacotherapies for Treatment-Resistant Depression: How Antipsychotics Fit in the Rapidly Evolving Therapeutic Landscape.
Jha MK, Mathew SJ
Am J Psychiatry 2023 Mar 1;180(3):190-199. doi: 10.1176/appi.ajp.20230025. PMID: 36855876
Current Management of Tics and Tourette Syndrome: Behavioral, Pharmacologic, and Surgical Treatments.
Billnitzer A, Jankovic J
Neurotherapeutics 2020 Oct;17(4):1681-1693. doi: 10.1007/s13311-020-00914-6. PMID: 32856174Free PMC Article
Treatment of Tardive Dyskinesia.
Bashir HH, Jankovic J
Neurol Clin 2020 May;38(2):379-396. Epub 2020 Feb 28 doi: 10.1016/j.ncl.2020.01.004. PMID: 32279716

Recent clinical studies

Etiology

Treatment Strategies for Tardive Dyskinesia.
Kremens DE
J Clin Psychiatry 2019 Dec 24;81(1) doi: 10.4088/JCP.NU18041BR4C. PMID: 31880872
Earlier Diagnosis of Tardive Dyskinesia.
Kremens DE
J Clin Psychiatry 2019 Dec 10;81(1) doi: 10.4088/JCP.NU18041BR1C. PMID: 31846242
Valbenazine for Tardive Dyskinesia.
Freudenreich O, Remington G
Clin Schizophr Relat Psychoses 2017 Summer;11(2):113-119. doi: 10.3371/CSRP.OFGR.071717. PMID: 28742396
Tardive dyskinesia.
Tarsy D, Baldessarini RJ
Annu Rev Med 1984;35:605-23. doi: 10.1146/annurev.me.35.020184.003133. PMID: 6144288
Tardive dyskinesia.
Br Med J (Clin Res Ed) 1981 Apr 18;282(6272):1257-8. PMID: 6112037Free PMC Article

Diagnosis

Atypical antipsychotics: Managing adverse effects.
Kameg B, Champion C
Perspect Psychiatr Care 2022 Apr;58(2):691-695. Epub 2021 May 5 doi: 10.1111/ppc.12837. PMID: 33955013
Assessing Patients for Tardive Dyskinesia.
Kane JM
J Clin Psychiatry 2017 Nov/Dec;78(9):e1428. doi: 10.4088/JCP.tv17016tx2c. PMID: 29345876
Facial dyskinesias.
Kaufman DM
Psychosomatics 1989 Summer;30(3):263-9. doi: 10.1016/S0033-3182(89)72270-2. PMID: 2669010
Tardive dyskinesia.
Tarsy D, Baldessarini RJ
Annu Rev Med 1984;35:605-23. doi: 10.1146/annurev.me.35.020184.003133. PMID: 6144288
Tardive dyskinesia.
Maxwell S, Massengill R Jr, Nashold B
J Speech Hear Disord 1970 Feb;35(1):33-6. doi: 10.1044/jshd.3501.33. PMID: 5438827

Therapy

Earlier Diagnosis of Tardive Dyskinesia.
Kremens DE
J Clin Psychiatry 2019 Dec 10;81(1) doi: 10.4088/JCP.NU18041BR1C. PMID: 31846242
Comparing Treatments for Tardive Dyskinesia.
Citrome LL
J Clin Psychiatry 2017 Nov/Dec;78(9):e1429. doi: 10.4088/JCP.tv17016tx3c. PMID: 29345877
Assessing Patients for Tardive Dyskinesia.
Kane JM
J Clin Psychiatry 2017 Nov/Dec;78(9):e1428. doi: 10.4088/JCP.tv17016tx2c. PMID: 29345876
Valbenazine for Tardive Dyskinesia.
Freudenreich O, Remington G
Clin Schizophr Relat Psychoses 2017 Summer;11(2):113-119. doi: 10.3371/CSRP.OFGR.071717. PMID: 28742396
Valbenazine: First Global Approval.
Kim ES
Drugs 2017 Jul;77(10):1123-1129. doi: 10.1007/s40265-017-0770-9. PMID: 28578484

Prognosis

Current treatment of tardive dyskinesia.
Margolius A, Fernandez HH
Parkinsonism Relat Disord 2019 Feb;59:155-160. Epub 2018 Dec 19 doi: 10.1016/j.parkreldis.2018.12.022. PMID: 30591350
Pharmacogenetics and schizophrenia.
Foster A, Miller DD, Buckley PF
Psychiatr Clin North Am 2007 Sep;30(3):417-35. doi: 10.1016/j.psc.2007.04.004. PMID: 17720030
Intermittent medication--an alternative?
Gaebel W
Acta Psychiatr Scand Suppl 1994;382:33-8. doi: 10.1111/j.1600-0447.1994.tb05863.x. PMID: 7916527
Tardive dyskinesia.
Jeste DV, Caligiuri MP
Schizophr Bull 1993;19(2):303-15. doi: 10.1093/schbul/19.2.303. PMID: 8100643
Tardive dyskinesia.
Gerlach J, Casey DE
Acta Psychiatr Scand 1988 Apr;77(4):369-78. doi: 10.1111/j.1600-0447.1988.tb05138.x. PMID: 2898870

Clinical prediction guides

Pharmacotherapy for the treatment of tardive dyskinesia in schizophrenia patients.
Witter DP, Holbert RC, Suryadevara U
Expert Opin Pharmacother 2017 Jul;18(10):965-972. Epub 2017 May 8 doi: 10.1080/14656566.2017.1323874. PMID: 28443349
Deep brain stimulation for intractable tardive dystonia: Literature overview.
Sobstyl M, Ząbek M
Neurol Neurochir Pol 2016;50(2):114-22. Epub 2016 Jan 16 doi: 10.1016/j.pjnns.2016.01.004. PMID: 26969568
Role of deep brain stimulation in the treatment of secondary dystonia-dyskinesia syndromes.
Saleh C, Gonzalez V, Coubes P
Handb Clin Neurol 2013;116:189-208. doi: 10.1016/B978-0-444-53497-2.00015-2. PMID: 24112894
Levetiracetam in tardive dyskinesia.
Meco G, Fabrizio E, Epifanio A, Morgante F, Valente M, Vanacore N, Di Rosa AE, Morgante L
Clin Neuropharmacol 2006 Sep-Oct;29(5):265-8. doi: 10.1097/01.WNF.0000228807.49044.7D. PMID: 16960471
Tardive dyskinesia: are first signs reversible?
Quitkin F, Rifkin A, Gochfeld L, Klein DF
Am J Psychiatry 1977 Jan;134(1):84-7. doi: 10.1176/ajp.134.1.84. PMID: 12666

Recent systematic reviews

Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.
Ali T, Sisay M, Tariku M, Mekuria AN, Desalew A
PLoS One 2021;16(9):e0257129. Epub 2021 Sep 10 doi: 10.1371/journal.pone.0257129. PMID: 34506552Free PMC Article
Cholinergic Medication for Antipsychotic-Induced Tardive Dyskinesia.
Christie J
Issues Ment Health Nurs 2019 Dec;40(12):1049-1050. Epub 2019 Sep 5 doi: 10.1080/01612840.2019.1635668. PMID: 31487207
Treatment Recommendations for Tardive Dyskinesia.
Ricciardi L, Pringsheim T, Barnes TRE, Martino D, Gardner D, Remington G, Addington D, Morgante F, Poole N, Carson A, Edwards M
Can J Psychiatry 2019 Jun;64(6):388-399. Epub 2019 Feb 21 doi: 10.1177/0706743719828968. PMID: 30791698Free PMC Article
Atypical antipsychotics and glucose dysregulation: a systematic review.
Jin H, Meyer JM, Jeste DV
Schizophr Res 2004 Dec 1;71(2-3):195-212. doi: 10.1016/j.schres.2004.03.024. PMID: 15474892
Anticholinergic medication for neuroleptic-induced tardive dyskinesia.
Soares KV, McGrath JJ
Cochrane Database Syst Rev 2000;(2):CD000204. doi: 10.1002/14651858.CD000204. PMID: 10796321

Supplemental Content

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