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Tardive dyskinesia

MedGen UID:
151939
Concept ID:
C0686347
Disease or Syndrome
Synonyms: Dyskinesia, Tardive; Dyskinesias, Tardive; Dystonia, Tardive; Dystonias, Tardive; Tardive Dyskinesia; Tardive Dyskinesias; Tardive Dystonia; Tardive Dystonias
 
HPO: HP:0040141
Monarch Initiative: MONDO:0010096
OMIM®: 272620

Definition

Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is estimated to occur in 20 to 30% of chronic schizophrenics on long-term treatment (Thelma et al., 2008). [from OMIM]

Clinical features

From HPO
Akathisia
MedGen UID:
97881
Concept ID:
C0392156
Sign or Symptom
A state of motor restlessness, usually in the lower extremities, that is often but not always accompanied by a subjective sense of inner restlessness, an urge to move, and anxiety or dysphoria.
Tardive dyskinesia
MedGen UID:
151939
Concept ID:
C0686347
Disease or Syndrome
Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is estimated to occur in 20 to 30% of chronic schizophrenics on long-term treatment (Thelma et al., 2008).

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTardive dyskinesia

Conditions with this feature

Tardive dyskinesia
MedGen UID:
151939
Concept ID:
C0686347
Disease or Syndrome
Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is estimated to occur in 20 to 30% of chronic schizophrenics on long-term treatment (Thelma et al., 2008).

Professional guidelines

PubMed

Billnitzer A, Jankovic J
Neurotherapeutics 2020 Oct;17(4):1681-1693. doi: 10.1007/s13311-020-00914-6. PMID: 32856174Free PMC Article
Bashir HH, Jankovic J
Neurol Clin 2020 May;38(2):379-396. Epub 2020 Feb 28 doi: 10.1016/j.ncl.2020.01.004. PMID: 32279716
Ricciardi L, Pringsheim T, Barnes TRE, Martino D, Gardner D, Remington G, Addington D, Morgante F, Poole N, Carson A, Edwards M
Can J Psychiatry 2019 Jun;64(6):388-399. Epub 2019 Feb 21 doi: 10.1177/0706743719828968. PMID: 30791698Free PMC Article

Recent clinical studies

Etiology

Cangemi DJ, Lacy BE
Curr Opin Gastroenterol 2021 Nov 1;37(6):596-601. doi: 10.1097/MOG.0000000000000782. PMID: 34560721
Sienaert P, van Harten P, Rhebergen D
Handb Clin Neurol 2019;165:415-428. doi: 10.1016/B978-0-444-64012-3.00025-3. PMID: 31727227
Ricciardi L, Pringsheim T, Barnes TRE, Martino D, Gardner D, Remington G, Addington D, Morgante F, Poole N, Carson A, Edwards M
Can J Psychiatry 2019 Jun;64(6):388-399. Epub 2019 Feb 21 doi: 10.1177/0706743719828968. PMID: 30791698Free PMC Article
Savitt D, Jankovic J
J Neurol Sci 2018 Jun 15;389:35-42. Epub 2018 Feb 5 doi: 10.1016/j.jns.2018.02.005. PMID: 29506749
Carbon M, Hsieh CH, Kane JM, Correll CU
J Clin Psychiatry 2017 Mar;78(3):e264-e278. doi: 10.4088/JCP.16r10832. PMID: 28146614

Diagnosis

Hauser RA, Meyer JM, Factor SA, Comella CL, Tanner CM, Xavier RM, Caroff SN, Lundt L
CNS Spectr 2022 Apr;27(2):208-217. Epub 2020 Nov 20 doi: 10.1017/S109285292000200X. PMID: 33213556Free PMC Article
Cangemi DJ, Lacy BE
Curr Opin Gastroenterol 2021 Nov 1;37(6):596-601. doi: 10.1097/MOG.0000000000000782. PMID: 34560721
Friedman JH
Continuum (Minneap Minn) 2019 Aug;25(4):1081-1098. doi: 10.1212/CON.0000000000000754. PMID: 31356294
Savitt D, Jankovic J
J Neurol Sci 2018 Jun 15;389:35-42. Epub 2018 Feb 5 doi: 10.1016/j.jns.2018.02.005. PMID: 29506749
Chouinard G, Samaha AN, Chouinard VA, Peretti CS, Kanahara N, Takase M, Iyo M
Psychother Psychosom 2017;86(4):189-219. Epub 2017 Jun 24 doi: 10.1159/000477313. PMID: 28647739

Therapy

Billnitzer A, Jankovic J
Neurotherapeutics 2020 Oct;17(4):1681-1693. doi: 10.1007/s13311-020-00914-6. PMID: 32856174Free PMC Article
Friedman JH
Continuum (Minneap Minn) 2019 Aug;25(4):1081-1098. doi: 10.1212/CON.0000000000000754. PMID: 31356294
Freudenreich O, Remington G
Clin Schizophr Relat Psychoses 2017 Summer;11(2):113-119. doi: 10.3371/CSRP.OFGR.071717. PMID: 28742396
Hauser RA, Factor SA, Marder SR, Knesevich MA, Ramirez PM, Jimenez R, Burke J, Liang GS, O'Brien CF
Am J Psychiatry 2017 May 1;174(5):476-484. Epub 2017 Mar 21 doi: 10.1176/appi.ajp.2017.16091037. PMID: 28320223
Carbon M, Hsieh CH, Kane JM, Correll CU
J Clin Psychiatry 2017 Mar;78(3):e264-e278. doi: 10.4088/JCP.16r10832. PMID: 28146614

Prognosis

Al-Saffar A, Lennernäs H, Hellström PM
Neurogastroenterol Motil 2019 Nov;31(11):e13617. Epub 2019 May 2 doi: 10.1111/nmo.13617. PMID: 31050085
Margolius A, Fernandez HH
Parkinsonism Relat Disord 2019 Feb;59:155-160. Epub 2018 Dec 19 doi: 10.1016/j.parkreldis.2018.12.022. PMID: 30591350
Frei K
Parkinsonism Relat Disord 2019 Feb;59:151-154. Epub 2018 Nov 15 doi: 10.1016/j.parkreldis.2018.11.017. PMID: 30522959
Savitt D, Jankovic J
J Neurol Sci 2018 Jun 15;389:35-42. Epub 2018 Feb 5 doi: 10.1016/j.jns.2018.02.005. PMID: 29506749
Casey DE
West J Med 1990 Nov;153(5):535-41. PMID: 1979705Free PMC Article

Clinical prediction guides

Ali T, Sisay M, Tariku M, Mekuria AN, Desalew A
PLoS One 2021;16(9):e0257129. Epub 2021 Sep 10 doi: 10.1371/journal.pone.0257129. PMID: 34506552Free PMC Article
Frei K
Parkinsonism Relat Disord 2019 Feb;59:151-154. Epub 2018 Nov 15 doi: 10.1016/j.parkreldis.2018.11.017. PMID: 30522959
Solmi M, Pigato G, Kane JM, Correll CU
Drug Des Devel Ther 2018;12:1215-1238. Epub 2018 May 14 doi: 10.2147/DDDT.S133205. PMID: 29795977Free PMC Article
Baizabal-Carvallo JF, Jankovic J
J Neurol 2017 Jul;264(7):1482-1487. Epub 2017 Jun 26 doi: 10.1007/s00415-017-8551-7. PMID: 28653211
Hauser RA, Factor SA, Marder SR, Knesevich MA, Ramirez PM, Jimenez R, Burke J, Liang GS, O'Brien CF
Am J Psychiatry 2017 May 1;174(5):476-484. Epub 2017 Mar 21 doi: 10.1176/appi.ajp.2017.16091037. PMID: 28320223

Recent systematic reviews

Ali T, Sisay M, Tariku M, Mekuria AN, Desalew A
PLoS One 2021;16(9):e0257129. Epub 2021 Sep 10 doi: 10.1371/journal.pone.0257129. PMID: 34506552Free PMC Article
Artukoglu BB, Li F, Szejko N, Bloch MH
J Clin Psychiatry 2020 May 26;81(4) doi: 10.4088/JCP.19r12798. PMID: 32459404
Ricciardi L, Pringsheim T, Barnes TRE, Martino D, Gardner D, Remington G, Addington D, Morgante F, Poole N, Carson A, Edwards M
Can J Psychiatry 2019 Jun;64(6):388-399. Epub 2019 Feb 21 doi: 10.1177/0706743719828968. PMID: 30791698Free PMC Article
Solmi M, Pigato G, Kane JM, Correll CU
Drug Des Devel Ther 2018;12:1215-1238. Epub 2018 May 14 doi: 10.2147/DDDT.S133205. PMID: 29795977Free PMC Article
Bergman H, Bhoopathi PS, Soares-Weiser K
Cochrane Database Syst Rev 2018 Jan 20;1(1):CD000205. doi: 10.1002/14651858.CD000205.pub3. PMID: 29352477Free PMC Article

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