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Benign neoplasm of adrenal medulla

MedGen UID:
151941
•Concept ID:
C0686512
•
Neoplastic Process
Synonyms: adrenal medulla benign neoplasm; Benign Adrenal Medulla Neoplasm; benign adrenal medulla neoplasm; Benign Adrenal Medulla Tumor; benign adrenal medulla tumor; benign adrenal medulla tumour; Benign Neoplasm of Adrenal Medulla; benign neoplasm of adrenal medulla; Benign Neoplasm of the Adrenal Medulla; benign neoplasm of the adrenal medulla; Benign tumor of adrenal medulla; Benign Tumor of Adrenal Medulla; benign tumor of adrenal medulla; Benign Tumor of the Adrenal Medulla; benign tumor of the adrenal medulla; benign tumour of adrenal medulla; benign tumour of the adrenal medulla
SNOMED CT: Benign tumor of adrenal medulla (91968002); Benign neoplasm of adrenal medulla (91968002)
 
Monarch Initiative: MONDO:0021468

Definition

A neoplasm that arises from the adrenal medulla and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Diagnosis and Management of Pheochromocytomas and Paragangliomas: A Guide for the Clinician.
Sharma S, Fishbein L
Endocr Pract 2023 Dec;29(12):999-1006. Epub 2023 Aug 15 doi: 10.1016/j.eprac.2023.07.027. PMID: 37586639
Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Pheochromocytoma: presentation, diagnosis and treatment.
Reisch N, Peczkowska M, Januszewicz A, Neumann HP
J Hypertens 2006 Dec;24(12):2331-9. doi: 10.1097/01.hjh.0000251887.01885.54. PMID: 17082709

Recent clinical studies

Therapy

Pheochromocytoma. Preoperative approach.
Araujo-Castro M
Med Clin (Barc) 2024 Sep 27;163(6):294-300. Epub 2024 Jun 6 doi: 10.1016/j.medcli.2024.03.025. PMID: 38849272
The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma.
Peng S, Zhang J, Tan X, Huang Y, Xu J, Silk N, Zhang D, Liu Q, Jiang J
Front Endocrinol (Lausanne) 2020;11:586857. Epub 2020 Nov 24 doi: 10.3389/fendo.2020.586857. PMID: 33329393Free PMC Article
E-Cigarettes and Cancer Risk.
Mravec B, Tibensky M, Horvathova L, Babal P
Cancer Prev Res (Phila) 2020 Feb;13(2):137-144. Epub 2019 Oct 16 doi: 10.1158/1940-6207.CAPR-19-0346. PMID: 31619443
Robot-assisted adrenalectomy: indications and drawbacks.
Nomine-Criqui C, Germain A, Ayav A, Bresler L, Brunaud L
Updates Surg 2017 Jun;69(2):127-133. Epub 2017 May 12 doi: 10.1007/s13304-017-0448-6. PMID: 28497219
Pheochromocytoma.
Eigelberger MS, Duh QY
Curr Treat Options Oncol 2001 Aug;2(4):321-9. doi: 10.1007/s11864-001-0025-5. PMID: 12057112

Prognosis

Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Biological and Genetic Features of Neuroblastoma and Their Clinical Importance.
Aygun N
Curr Pediatr Rev 2018;14(2):73-90. doi: 10.2174/1573396314666180129101627. PMID: 29380702
Pheochromocytomas and Hypertension.
Pappachan JM, Tun NN, Arunagirinathan G, Sodi R, Hanna FWF
Curr Hypertens Rep 2018 Jan 22;20(1):3. doi: 10.1007/s11906-018-0804-z. PMID: 29356966
Neuroblastoma.
Castleberry RP
Eur J Cancer 1997 Aug;33(9):1430-7; discussion 1437-8. doi: 10.1016/s0959-8049(97)00308-0. PMID: 9337686

Clinical prediction guides

Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Origin and initiation mechanisms of neuroblastoma.
Tsubota S, Kadomatsu K
Cell Tissue Res 2018 May;372(2):211-221. Epub 2018 Feb 14 doi: 10.1007/s00441-018-2796-z. PMID: 29445860
Biological and Genetic Features of Neuroblastoma and Their Clinical Importance.
Aygun N
Curr Pediatr Rev 2018;14(2):73-90. doi: 10.2174/1573396314666180129101627. PMID: 29380702
Neuroblastoma.
Castleberry RP
Eur J Cancer 1997 Aug;33(9):1430-7; discussion 1437-8. doi: 10.1016/s0959-8049(97)00308-0. PMID: 9337686

Recent systematic reviews

Adrenal Medullary Hyperplasia: A Systematic Review and Meta-analysis.
Ganni R, Torpy DJ, Falhammar H, Louise Rushworth R
J Clin Endocrinol Metab 2023 Aug 18;108(9):e885-e892. doi: 10.1210/clinem/dgad121. PMID: 36896586Free PMC Article

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