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Benign neoplasm of adrenal gland

MedGen UID:
56330
•Concept ID:
C0154040
•
Neoplastic Process
Synonyms: adrenal gland benign neoplasm; Benign Adrenal Gland Neoplasm; benign adrenal gland neoplasm; Benign Adrenal Gland Tumor; benign adrenal gland tumor; benign adrenal gland tumour; Benign Adrenal Neoplasm; benign adrenal neoplasm; Benign Adrenal Tumor; benign adrenal tumor; benign adrenal tumour; Benign Neoplasm of Adrenal Gland; benign neoplasm of adrenal gland; Benign Neoplasm of the Adrenal Gland; benign neoplasm of the adrenal gland; Benign tumor of adrenal gland; Benign Tumor of Adrenal Gland; benign tumor of adrenal gland; Benign Tumor of the Adrenal Gland; benign tumor of the adrenal gland; benign tumour of adrenal gland; benign tumour of the adrenal gland
SNOMED CT: Benign tumor of adrenal gland (91967007); Benign neoplasm of adrenal gland (91967007)
 
Monarch Initiative: MONDO:0021511

Definition

A neoplasm that arises from the adrenal gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
Personalized Management of Pheochromocytoma and Paraganglioma.
Nölting S, Bechmann N, Taieb D, Beuschlein F, Fassnacht M, Kroiss M, Eisenhofer G, Grossman A, Pacak K
Endocr Rev 2022 Mar 9;43(2):199-239. doi: 10.1210/endrev/bnab019. PMID: 34147030Free PMC Article
Management of Neuroblastoma in Pediatric Patients.
Croteau N, Nuchtern J, LaQuaglia MP
Surg Oncol Clin N Am 2021 Apr;30(2):291-304. Epub 2021 Feb 10 doi: 10.1016/j.soc.2020.11.010. PMID: 33706901

Recent clinical studies

Etiology

Surgical approaches to the adrenal gland.
Sada A, McKenzie TJ
Curr Opin Endocrinol Diabetes Obes 2023 Jun 1;30(3):161-166. Epub 2023 Apr 14 doi: 10.1097/MED.0000000000000810. PMID: 37057653
Mixed corticomedullary tumor of the adrenal gland.
Kimura N, Motoyama T, Saito J, Nishikawa T
Front Endocrinol (Lausanne) 2022;13:1026918. Epub 2022 Sep 16 doi: 10.3389/fendo.2022.1026918. PMID: 36187098Free PMC Article
Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma.
Jansky S, Sharma AK, Körber V, Quintero A, Toprak UH, Wecht EM, Gartlgruber M, Greco A, Chomsky E, Grünewald TGP, Henrich KO, Tanay A, Herrmann C, Höfer T, Westermann F
Nat Genet 2021 May;53(5):683-693. Epub 2021 Mar 25 doi: 10.1038/s41588-021-00806-1. PMID: 33767450
The Treatment of Cushing's Disease.
Pivonello R, De Leo M, Cozzolino A, Colao A
Endocr Rev 2015 Aug;36(4):385-486. Epub 2015 Jun 11 doi: 10.1210/er.2013-1048. PMID: 26067718Free PMC Article
Adrenal autotransplantation.
Srougi M, Gittes RF
Urol Surv 1978 Apr;28(2):41-8. PMID: 209598

Diagnosis

Incidental Adrenal Nodules.
Glazer DI, Corwin MT, Mayo-Smith WW
Radiol Clin North Am 2021 Jul;59(4):591-601. doi: 10.1016/j.rcl.2021.03.008. PMID: 34053607
Adrenal Incidentaloma.
Kebebew E
N Engl J Med 2021 Apr 22;384(16):1542-1551. doi: 10.1056/NEJMcp2031112. PMID: 33882207
Adrenal Incidentaloma.
Sherlock M, Scarsbrook A, Abbas A, Fraser S, Limumpornpetch P, Dineen R, Stewart PM
Endocr Rev 2020 Dec 1;41(6):775-820. doi: 10.1210/endrev/bnaa008. PMID: 32266384Free PMC Article
Adrenal Imaging.
Mendiratta-Lala M, Avram A, Turcu AF, Dunnick NR
Endocrinol Metab Clin North Am 2017 Sep;46(3):741-759. Epub 2017 Jun 12 doi: 10.1016/j.ecl.2017.04.009. PMID: 28760236
Adrenal autotransplantation.
Srougi M, Gittes RF
Urol Surv 1978 Apr;28(2):41-8. PMID: 209598

Therapy

Targeted Therapies in Pheochromocytoma and Paraganglioma.
Wang K, Crona J, Beuschlein F, Grossman AB, Pacak K, Nölting S
J Clin Endocrinol Metab 2022 Nov 23;107(11):2963-2972. doi: 10.1210/clinem/dgac471. PMID: 35973976Free PMC Article
Adrenal biopsy: performance and use.
Zhang CD, Delivanis DA, Eiken PW, Atwell TD, Bancos I
Minerva Endocrinol 2019 Sep;44(3):288-300. Epub 2019 Feb 6 doi: 10.23736/S0391-1977.19.02969-9. PMID: 30732427
The role of microRNAs in the pathophysiology of adrenal tumors.
Hassan N, Zhao JT, Sidhu SB
Mol Cell Endocrinol 2017 Nov 15;456:36-43. Epub 2016 Dec 20 doi: 10.1016/j.mce.2016.12.011. PMID: 28007658
Adrenal vein sampling.
Kahn SL, Angle JF
Tech Vasc Interv Radiol 2010 Jun;13(2):110-25. doi: 10.1053/j.tvir.2010.02.006. PMID: 20540920
Adrenal autotransplantation.
Srougi M, Gittes RF
Urol Surv 1978 Apr;28(2):41-8. PMID: 209598

Prognosis

Mixed corticomedullary tumor of the adrenal gland.
Kimura N, Motoyama T, Saito J, Nishikawa T
Front Endocrinol (Lausanne) 2022;13:1026918. Epub 2022 Sep 16 doi: 10.3389/fendo.2022.1026918. PMID: 36187098Free PMC Article
Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma.
Jansky S, Sharma AK, Körber V, Quintero A, Toprak UH, Wecht EM, Gartlgruber M, Greco A, Chomsky E, Grünewald TGP, Henrich KO, Tanay A, Herrmann C, Höfer T, Westermann F
Nat Genet 2021 May;53(5):683-693. Epub 2021 Mar 25 doi: 10.1038/s41588-021-00806-1. PMID: 33767450
Imaging of Adrenal-Related Endocrine Disorders.
Yalniz C, Morani AC, Waguespack SG, Elsayes KM
Radiol Clin North Am 2020 Nov;58(6):1099-1113. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.010. PMID: 33040851
Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma.
Kimura N, Takayanagi R, Takizawa N, Itagaki E, Katabami T, Kakoi N, Rakugi H, Ikeda Y, Tanabe A, Nigawara T, Ito S, Kimura I, Naruse M; Phaeochromocytoma Study Group in Japan
Endocr Relat Cancer 2014 Jun;21(3):405-14. Epub 2014 May 6 doi: 10.1530/ERC-13-0494. PMID: 24521857
Adrenal vein sampling.
Kahn SL, Angle JF
Tech Vasc Interv Radiol 2010 Jun;13(2):110-25. doi: 10.1053/j.tvir.2010.02.006. PMID: 20540920

Clinical prediction guides

Surgical and non-surgical management of thoracic and cervical paraganglioma.
Araujo-Castro M, Redondo López S, Pascual-Corrales E, Polo López R, Alonso-Gordoa T, Molina-Cerrillo J, Moreno Mata N, Caballero Silva U, Barberá Durbán R
Ann Endocrinol (Paris) 2023 Aug;84(4):466-471. Epub 2022 Nov 2 doi: 10.1016/j.ando.2022.10.013. PMID: 36334803
Adrenal myelolipoma: a comprehensive review.
Decmann Á, Perge P, Tóth M, Igaz P
Endocrine 2018 Jan;59(1):7-15. Epub 2017 Nov 21 doi: 10.1007/s12020-017-1473-4. PMID: 29164520
Update on CT and MRI of Adrenal Nodules.
Schieda N, Siegelman ES
AJR Am J Roentgenol 2017 Jun;208(6):1206-1217. Epub 2017 Feb 22 doi: 10.2214/AJR.16.17758. PMID: 28225653
DHEA and mortality: what is the nature of the association?
Ohlsson C, Vandenput L, Tivesten A
J Steroid Biochem Mol Biol 2015 Jan;145:248-53. Epub 2014 Apr 2 doi: 10.1016/j.jsbmb.2014.03.006. PMID: 24704256
Adrenal vein sampling.
Kahn SL, Angle JF
Tech Vasc Interv Radiol 2010 Jun;13(2):110-25. doi: 10.1053/j.tvir.2010.02.006. PMID: 20540920

Recent systematic reviews

Comorbidities in mild autonomous cortisol secretion and the effect of treatment: systematic review and meta-analysis.
Pelsma ICM, Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Oct 17;189(4):S88-S101. doi: 10.1093/ejendo/lvad134. PMID: 37801655
Adrenal Medullary Hyperplasia: A Systematic Review and Meta-analysis.
Ganni R, Torpy DJ, Falhammar H, Louise Rushworth R
J Clin Endocrinol Metab 2023 Aug 18;108(9):e885-e892. doi: 10.1210/clinem/dgad121. PMID: 36896586Free PMC Article
Prevalence of Functioning Adrenal Incidentalomas: A Systematic Review and Meta-analysis.
Sconfienza E, Tetti M, Forestiero V, Veglio F, Mulatero P, Monticone S
J Clin Endocrinol Metab 2023 Jun 16;108(7):1813-1823. doi: 10.1210/clinem/dgad044. PMID: 36718682
ROHHAD(NET) Syndrome: Systematic Review of the Clinical Timeline and Recommendations for Diagnosis and Prognosis.
Harvengt J, Gernay C, Mastouri M, Farhat N, Lebrethon MC, Seghaye MC, Bours V
J Clin Endocrinol Metab 2020 Jul 1;105(7) doi: 10.1210/clinem/dgaa247. PMID: 32407531
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM
JAMA Oncol 2018 Feb 1;4(2):173-182. doi: 10.1001/jamaoncol.2017.3064. PMID: 28973656Free PMC Article

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