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Vascular malformation of the nervous system

MedGen UID:
156014
Concept ID:
C0752155
Anatomical Abnormality
Synonym: Central Nervous System Vascular Malformations
SNOMED CT: Vascular malformation of the nervous system (253193002)

Definition

A congenital abnormality of the arteries and veins that is located in the brain or spina cord, and which may increase the risk of bleeding, possibly resulting in impaired mental or physical function. [from NCI]

Professional guidelines

PubMed

Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Flemming KD
Curr Cardiol Rep 2017 Oct 18;19(12):122. doi: 10.1007/s11886-017-0931-1. PMID: 29046973
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

Recent clinical studies

Etiology

Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Ghali MGZ
Neurosurg Rev 2021 Feb;44(1):77-96. Epub 2019 Dec 7 doi: 10.1007/s10143-019-01209-x. PMID: 31811518
Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Goyal P, Mangla R, Gupta S, Malhotra A, Almast J, Sapire J, Kolar B
J Neuroimaging 2019 Mar;29(2):165-181. Epub 2018 Oct 31 doi: 10.1111/jon.12575. PMID: 30378722
Clark AJ, Wang DD, Lawton MT
Handb Clin Neurol 2017;143:303-308. doi: 10.1016/B978-0-444-63640-9.00030-8. PMID: 28552154

Diagnosis

Requejo F, Teplisky D, Dutra MLG, Mouratian DM, Kikano R, Nguyen TN, Abdalkader M
Semin Neurol 2023 Jun;43(3):408-418. Epub 2023 Aug 3 doi: 10.1055/s-0043-1771511. PMID: 37536373
Alexander MD, Darflinger R, Cooke DL, Halbach VV
Handb Clin Neurol 2021;176:179-198. doi: 10.1016/B978-0-444-64034-5.00004-3. PMID: 33272395
Ghali MGZ
Neurosurg Rev 2021 Feb;44(1):77-96. Epub 2019 Dec 7 doi: 10.1007/s10143-019-01209-x. PMID: 31811518
Rinaldo L, Lanzino G, Flemming KD, Krings T, Brinjikji W
Acta Neurochir (Wien) 2020 May;162(5):1115-1125. Epub 2020 Jan 11 doi: 10.1007/s00701-020-04213-z. PMID: 31925540
Clark AJ, Wang DD, Lawton MT
Handb Clin Neurol 2017;143:303-308. doi: 10.1016/B978-0-444-63640-9.00030-8. PMID: 28552154

Therapy

Lanfranconi S, Scola E, Meessen JMTA, Pallini R, Bertani GA, Al-Shahi Salman R, Dejana E, Latini R; Treat_CCM Investigators
Lancet Neurol 2023 Jan;22(1):35-44. Epub 2022 Nov 17 doi: 10.1016/S1474-4422(22)00409-4. PMID: 36403580
Vollherbst DF, Chapot R, Bendszus M, Möhlenbruch MA
Clin Neuroradiol 2022 Mar;32(1):25-38. Epub 2021 Jul 29 doi: 10.1007/s00062-021-01066-6. PMID: 34324005Free PMC Article
Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Rudy RF, Du R
Handb Clin Neurol 2017;143:309-316. doi: 10.1016/B978-0-444-63640-9.00031-X. PMID: 28552155
Wang QT, Tuhrim S
Curr Atheroscler Rep 2012 Aug;14(4):314-21. doi: 10.1007/s11883-012-0253-0. PMID: 22562528

Prognosis

Ghali MGZ
Neurosurg Rev 2021 Feb;44(1):77-96. Epub 2019 Dec 7 doi: 10.1007/s10143-019-01209-x. PMID: 31811518
Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Goyal P, Mangla R, Gupta S, Malhotra A, Almast J, Sapire J, Kolar B
J Neuroimaging 2019 Mar;29(2):165-181. Epub 2018 Oct 31 doi: 10.1111/jon.12575. PMID: 30378722
Goldstein HE, Solomon RA
Handb Clin Neurol 2017;143:241-247. doi: 10.1016/B978-0-444-63640-9.00023-0. PMID: 28552146
Barreau X, Marnat G, Gariel F, Dousset V
Diagn Interv Imaging 2014 Dec;95(12):1175-86. Epub 2014 Nov 24 doi: 10.1016/j.diii.2014.10.004. PMID: 25465120

Clinical prediction guides

Yates JF, Troester MM, Ingram DG
Curr Neurol Neurosci Rep 2018 May 23;18(7):38. doi: 10.1007/s11910-018-0850-6. PMID: 29789951
Atwal GS, Sarris CE, Spetzler RF
Handb Clin Neurol 2017;143:291-295. doi: 10.1016/B978-0-444-63640-9.00028-X. PMID: 28552152
Flores BC, Klinger DR, White JA, Batjer HH
Neurosurg Rev 2017 Jan;40(1):15-28. Epub 2016 Apr 13 doi: 10.1007/s10143-016-0713-z. PMID: 27075861
Chang W, Huang M, Chien A
Neuroradiol J 2015 Feb;28(1):19-27. doi: 10.15274/NRJ-2014-10115. PMID: 25924168Free PMC Article
San Millán Ruíz D, Gailloud P
Childs Nerv Syst 2010 Oct;26(10):1395-406. Epub 2010 Aug 12 doi: 10.1007/s00381-010-1253-4. PMID: 20703485

Recent systematic reviews

Guo X, Gao L, Shi Z, Liu D, Wang Y, Sun Z, Chen Y, Chen W, Yang Y
World Neurosurg 2018 Jul;115:e592-e598. Epub 2018 Apr 24 doi: 10.1016/j.wneu.2018.04.106. PMID: 29702312
Hughes JD, Bond KM, Mekary RA, Dewan MC, Rattani A, Baticulon R, Kato Y, Azevedo-Filho H, Morcos JJ, Park KB
World Neurosurg 2018 Jul;115:430-447.e7. Epub 2018 Apr 9 doi: 10.1016/j.wneu.2018.03.220. PMID: 29649643
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article
Yu J, Guo Y, Xu B, Xu K
Int J Med Sci 2016;13(10):790-799. Epub 2016 Oct 17 doi: 10.7150/ijms.16489. PMID: 27766029Free PMC Article
Gross BA, Batjer HH, Awad IA, Bendok BR
Neurosurgery 2009 May;64(5):E805-18; discussion E818. doi: 10.1227/01.NEU.0000343668.44288.18. PMID: 19404127

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