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Vascular malformation of the nervous system

MedGen UID:
156014
Concept ID:
C0752155
Anatomical Abnormality
Synonyms: Central Nervous System Vascular Anomalies; Central Nervous System Vascular Malformations; CNS Vascular Malformation; CNS Vascular Malformations; Malformation, CNS Vascular; Malformations, CNS Vascular; Vascular Anomalies, Central Nervous System; Vascular Malformation, CNS; Vascular Malformations, Central Nervous System; Vascular Malformations, CNS
SNOMED CT: Vascular malformation of the nervous system (253193002)

Definition

A congenital abnormality of the arteries and veins that is located in the brain or spina cord, and which may increase the risk of bleeding, possibly resulting in impaired mental or physical function. [from NCI]

Professional guidelines

PubMed

Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Rotter A, Samorano LP, Rivitti-Machado MC, Oliveira ZNP, Gontijo B
An Bras Dermatol 2018 Jun;93(3):405-411. doi: 10.1590/abd1806-4841.20187693. PMID: 29924216Free PMC Article
Hofmann E, Behr R, Neumann-Haefelin T, Schwager K
Dtsch Arztebl Int 2013 Jun;110(26):451-8. Epub 2013 Jun 28 doi: 10.3238/arztebl.2013.0451. PMID: 23885280Free PMC Article

Recent clinical studies

Etiology

Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Ghali MGZ
Neurosurg Rev 2021 Feb;44(1):77-96. Epub 2019 Dec 7 doi: 10.1007/s10143-019-01209-x. PMID: 31811518
Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Clark AJ, Wang DD, Lawton MT
Handb Clin Neurol 2017;143:303-308. doi: 10.1016/B978-0-444-63640-9.00030-8. PMID: 28552154
Mooney MA, Zabramski JM
Handb Clin Neurol 2017;143:279-282. doi: 10.1016/B978-0-444-63640-9.00026-6. PMID: 28552150

Diagnosis

Requejo F, Teplisky D, Dutra MLG, Mouratian DM, Kikano R, Nguyen TN, Abdalkader M
Semin Neurol 2023 Jun;43(3):408-418. Epub 2023 Aug 3 doi: 10.1055/s-0043-1771511. PMID: 37536373
Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Alexander MD, Darflinger R, Cooke DL, Halbach VV
Handb Clin Neurol 2021;176:179-198. doi: 10.1016/B978-0-444-64034-5.00004-3. PMID: 33272395
Elhammady MS, Ambekar S, Heros RC
Handb Clin Neurol 2017;143:99-105. doi: 10.1016/B978-0-444-63640-9.00009-6. PMID: 28552162
Clark AJ, Wang DD, Lawton MT
Handb Clin Neurol 2017;143:303-308. doi: 10.1016/B978-0-444-63640-9.00030-8. PMID: 28552154

Therapy

Lanfranconi S, Scola E, Meessen JMTA, Pallini R, Bertani GA, Al-Shahi Salman R, Dejana E, Latini R; Treat_CCM Investigators
Lancet Neurol 2023 Jan;22(1):35-44. Epub 2022 Nov 17 doi: 10.1016/S1474-4422(22)00409-4. PMID: 36403580
Vollherbst DF, Chapot R, Bendszus M, Möhlenbruch MA
Clin Neuroradiol 2022 Mar;32(1):25-38. Epub 2021 Jul 29 doi: 10.1007/s00062-021-01066-6. PMID: 34324005Free PMC Article
Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Rudy RF, Du R
Handb Clin Neurol 2017;143:309-316. doi: 10.1016/B978-0-444-63640-9.00031-X. PMID: 28552155
Wang QT, Tuhrim S
Curr Atheroscler Rep 2012 Aug;14(4):314-21. doi: 10.1007/s11883-012-0253-0. PMID: 22562528

Prognosis

Idiculla PS, Gurala D, Philipose J, Rajdev K, Patibandla P
Eur Neurol 2020;83(4):360-368. Epub 2020 Jul 30 doi: 10.1159/000508748. PMID: 32731220
Flemming KD, Lanzino G
Mayo Clin Proc 2020 Sep;95(9):2005-2020. Epub 2020 Jun 27 doi: 10.1016/j.mayocp.2019.11.005. PMID: 32605781
Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Elhammady MS, Ambekar S, Heros RC
Handb Clin Neurol 2017;143:99-105. doi: 10.1016/B978-0-444-63640-9.00009-6. PMID: 28552162
Barreau X, Marnat G, Gariel F, Dousset V
Diagn Interv Imaging 2014 Dec;95(12):1175-86. Epub 2014 Nov 24 doi: 10.1016/j.diii.2014.10.004. PMID: 25465120

Clinical prediction guides

Liu P, Liu Y, Shi Y, An Q, Zhu W, Liu Y, Li P, Tian Y
World Neurosurg 2022 Oct;166:e770-e780. Epub 2022 Aug 3 doi: 10.1016/j.wneu.2022.07.094. PMID: 35933096
Grossberg JA, Howard BM, Saindane AM
Neurosurg Focus 2019 Dec 1;47(6):E3. doi: 10.3171/2019.9.FOCUS19627. PMID: 31786556
Yates JF, Troester MM, Ingram DG
Curr Neurol Neurosci Rep 2018 May 23;18(7):38. doi: 10.1007/s11910-018-0850-6. PMID: 29789951
Atwal GS, Sarris CE, Spetzler RF
Handb Clin Neurol 2017;143:291-295. doi: 10.1016/B978-0-444-63640-9.00028-X. PMID: 28552152
Chang W, Huang M, Chien A
Neuroradiol J 2015 Feb;28(1):19-27. doi: 10.15274/NRJ-2014-10115. PMID: 25924168Free PMC Article

Recent systematic reviews

Che Yusof R, Norhayati MN, Mohd Azman Y
Int J Environ Res Public Health 2022 Oct 13;19(20) doi: 10.3390/ijerph192013183. PMID: 36293763Free PMC Article
El-Abtah ME, Petitt JC, Kashkoush A, Achey R, Bain MD, Moore NZ
World Neurosurg 2022 Aug;164:257-269. Epub 2022 May 18 doi: 10.1016/j.wneu.2022.05.051. PMID: 35597540
Brosnan C, Amoo M, Javadpour M
Neurosurg Rev 2022 Jun;45(3):2051-2063. Epub 2022 Mar 9 doi: 10.1007/s10143-022-01766-8. PMID: 35260972Free PMC Article
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article
Gross BA, Batjer HH, Awad IA, Bendok BR
Neurosurgery 2009 May;64(5):E805-18; discussion E818. doi: 10.1227/01.NEU.0000343668.44288.18. PMID: 19404127

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