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Vascular malformation of the nervous system

MedGen UID:
156014
•Concept ID:
C0752155
•
Anatomical Abnormality
Synonym: Central Nervous System Vascular Malformations
SNOMED CT: Vascular malformation of the nervous system (253193002)

Definition

A congenital abnormality of the arteries and veins that is located in the brain or spina cord, and which may increase the risk of bleeding, possibly resulting in impaired mental or physical function. [from NCI]

Professional guidelines

PubMed

Intracranial dural arteriovenous fistula: a comprehensive review of the history, management, and future prospective.
Alkhaibary A, Alnefaie N, Alharbi A, Alammar H, Arishy AM, Alshaya W, Khairy S
Acta Neurol Belg 2023 Apr;123(2):359-366. Epub 2022 Nov 14 doi: 10.1007/s13760-022-02133-6. PMID: 36374476
Updates in the management of cranial dural arteriovenous fistula.
Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

Recent clinical studies

Etiology

Pediatric Cerebral Cavernous Malformations.
Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Sphenoid dural arteriovenous fistulas.
Ghali MGZ
Neurosurg Rev 2021 Feb;44(1):77-96. Epub 2019 Dec 7 doi: 10.1007/s10143-019-01209-x. PMID: 31811518
Updates in the management of cranial dural arteriovenous fistula.
Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Pediatric Congenital Cerebrovascular Anomalies.
Goyal P, Mangla R, Gupta S, Malhotra A, Almast J, Sapire J, Kolar B
J Neuroimaging 2019 Mar;29(2):165-181. Epub 2018 Oct 31 doi: 10.1111/jon.12575. PMID: 30378722
Spinal cavernous malformations.
Clark AJ, Wang DD, Lawton MT
Handb Clin Neurol 2017;143:303-308. doi: 10.1016/B978-0-444-63640-9.00030-8. PMID: 28552154

Diagnosis

Pediatric Interventional Neuroradiology.
Requejo F, Teplisky D, Dutra MLG, Mouratian DM, Kikano R, Nguyen TN, Abdalkader M
Semin Neurol 2023 Jun;43(3):408-418. Epub 2023 Aug 3 doi: 10.1055/s-0043-1771511. PMID: 37536373
Intracranial dural arteriovenous fistula: a comprehensive review of the history, management, and future prospective.
Alkhaibary A, Alnefaie N, Alharbi A, Alammar H, Arishy AM, Alshaya W, Khairy S
Acta Neurol Belg 2023 Apr;123(2):359-366. Epub 2022 Nov 14 doi: 10.1007/s13760-022-02133-6. PMID: 36374476
Cerebral arteriovenous fistulae.
Alexander MD, Darflinger R, Cooke DL, Halbach VV
Handb Clin Neurol 2021;176:179-198. doi: 10.1016/B978-0-444-64034-5.00004-3. PMID: 33272395
Spinal cavernous malformations.
Clark AJ, Wang DD, Lawton MT
Handb Clin Neurol 2017;143:303-308. doi: 10.1016/B978-0-444-63640-9.00030-8. PMID: 28552154
Cavernous malformations.
Ryan D
J Neurosci Nurs 2010 Oct;42(5):294-9. doi: 10.1097/jnn.0b013e3181ecaf95. PMID: 20968226

Therapy

Circulating biomarkers in familial cerebral cavernous malformation.
Lazzaroni F, Meessen JMTA, Sun Y, Lanfranconi S, Scola E, D'Alessandris QG, Tassi L, Carriero MR, Castori M, Marino S, Blanda A, Nicolis EB, Novelli D, Calabrese R, Agnelli NM, Bottazzi B, Leone R, Mazzola S, Besana S, Catozzi C, Nezi L, Lampugnani MG, Malinverno M, Grdseloff N, Rödel CJ, Rezai Jahromi B, Bolli N, Passamonti F, Magnusson PU, Abdelilah-Seyfried S, Dejana E, Latini R
EBioMedicine 2024 Jan;99:104914. Epub 2023 Dec 18 doi: 10.1016/j.ebiom.2023.104914. PMID: 38113759Free PMC Article
Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial.
Lanfranconi S, Scola E, Meessen JMTA, Pallini R, Bertani GA, Al-Shahi Salman R, Dejana E, Latini R; Treat_CCM Investigators
Lancet Neurol 2023 Jan;22(1):35-44. Epub 2022 Nov 17 doi: 10.1016/S1474-4422(22)00409-4. PMID: 36403580
Glue, Onyx, Squid or PHIL? Liquid Embolic Agents for the Embolization of Cerebral Arteriovenous Malformations and Dural Arteriovenous Fistulas.
Vollherbst DF, Chapot R, Bendszus M, Möhlenbruch MA
Clin Neuroradiol 2022 Mar;32(1):25-38. Epub 2021 Jul 29 doi: 10.1007/s00062-021-01066-6. PMID: 34324005Free PMC Article
Updates in the management of cranial dural arteriovenous fistula.
Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Pharmacotherapy for cavernous malformations.
Rudy RF, Du R
Handb Clin Neurol 2017;143:309-316. doi: 10.1016/B978-0-444-63640-9.00031-X. PMID: 28552155

Prognosis

Intracranial dural arteriovenous fistula: a comprehensive review of the history, management, and future prospective.
Alkhaibary A, Alnefaie N, Alharbi A, Alammar H, Arishy AM, Alshaya W, Khairy S
Acta Neurol Belg 2023 Apr;123(2):359-366. Epub 2022 Nov 14 doi: 10.1007/s13760-022-02133-6. PMID: 36374476
Updates in the management of cranial dural arteriovenous fistula.
Baharvahdat H, Ooi YC, Kim WJ, Mowla A, Coon AL, Colby GP
Stroke Vasc Neurol 2020;5(1):50-58. Epub 2019 Nov 21 doi: 10.1136/svn-2019-000269. PMID: 32411408Free PMC Article
Pediatric Congenital Cerebrovascular Anomalies.
Goyal P, Mangla R, Gupta S, Malhotra A, Almast J, Sapire J, Kolar B
J Neuroimaging 2019 Mar;29(2):165-181. Epub 2018 Oct 31 doi: 10.1111/jon.12575. PMID: 30378722
Epidemiology of cavernous malformations.
Goldstein HE, Solomon RA
Handb Clin Neurol 2017;143:241-247. doi: 10.1016/B978-0-444-63640-9.00023-0. PMID: 28552146
Intracranial arteriovenous malformations.
Barreau X, Marnat G, Gariel F, Dousset V
Diagn Interv Imaging 2014 Dec;95(12):1175-86. Epub 2014 Nov 24 doi: 10.1016/j.diii.2014.10.004. PMID: 25465120

Clinical prediction guides

Dural Arteriovenous Fistula.
El Naamani K, Tjoumakaris SI, Gooch MR, Jabbour P
Neurosurg Clin N Am 2024 Jul;35(3):331-342. Epub 2024 Mar 19 doi: 10.1016/j.nec.2024.02.005. PMID: 38782526
Intracranial dural arteriovenous fistula: a comprehensive review of the history, management, and future prospective.
Alkhaibary A, Alnefaie N, Alharbi A, Alammar H, Arishy AM, Alshaya W, Khairy S
Acta Neurol Belg 2023 Apr;123(2):359-366. Epub 2022 Nov 14 doi: 10.1007/s13760-022-02133-6. PMID: 36374476
Sleep in Children with Congenital Malformations of the Central Nervous System.
Yates JF, Troester MM, Ingram DG
Curr Neurol Neurosci Rep 2018 May 23;18(7):38. doi: 10.1007/s11910-018-0850-6. PMID: 29789951
Brainstem and cerebellar cavernous malformations.
Atwal GS, Sarris CE, Spetzler RF
Handb Clin Neurol 2017;143:291-295. doi: 10.1016/B978-0-444-63640-9.00028-X. PMID: 28552152
Emerging techniques for evaluation of the hemodynamics of intracranial vascular pathology.
Chang W, Huang M, Chien A
Neuroradiol J 2015 Feb;28(1):19-27. doi: 10.15274/NRJ-2014-10115. PMID: 25924168Free PMC Article

Recent systematic reviews

Arteriovenous Malformation Hemorrhage in Pregnancy: A Systematic Review and Meta-Analysis.
Che Yusof R, Norhayati MN, Mohd Azman Y
Int J Environ Res Public Health 2022 Oct 13;19(20) doi: 10.3390/ijerph192013183. PMID: 36293763Free PMC Article
Endovascular Management of Arteriovenous Malformation-Associated Intracranial Aneurysms: A Systematic Literature Review.
El-Abtah ME, Petitt JC, Kashkoush A, Achey R, Bain MD, Moore NZ
World Neurosurg 2022 Aug;164:257-269. Epub 2022 May 18 doi: 10.1016/j.wneu.2022.05.051. PMID: 35597540
Preoperative embolisation of brain arteriovenous malformations: a systematic review and meta-analysis.
Brosnan C, Amoo M, Javadpour M
Neurosurg Rev 2022 Jun;45(3):2051-2063. Epub 2022 Mar 9 doi: 10.1007/s10143-022-01766-8. PMID: 35260972Free PMC Article
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article
Brainstem cavernous malformations.
Gross BA, Batjer HH, Awad IA, Bendok BR
Neurosurgery 2009 May;64(5):E805-18; discussion E818. doi: 10.1227/01.NEU.0000343668.44288.18. PMID: 19404127

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