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Hypertryptophanemia

MedGen UID:
1618729
•Concept ID:
C4521096
•
Finding
Synonym: HYPERTRYPTOPHANEMIA
 
HPO: HP:0500134
OMIM®: 191070

Definition

An increased amount of tryptophan in the blood. [from HPO]

Conditions with this feature

Familial hypertryptophanemia
MedGen UID:
419177
•Concept ID:
C2931837
•
Disease or Syndrome
Congenital hypertryptophanemia, which is accompanied by hyperserotonemia, does not appear to have significant clinical consequences (Ferreira et al., 2017).
See: Condition Record
Familial hypertryptophanemia

Professional guidelines

PubMed

The emerging role of novel antihyperglycemic agents in the treatment of heart failure and diabetes: A focus on cardiorenal outcomes.
McHugh KR, DeVore AD, Mentz RJ, Edmonston D, Green JB, Hernandez AF
Clin Cardiol 2018 Sep;41(9):1259-1267. Epub 2018 Sep 21 doi: 10.1002/clc.23054. PMID: 30125365Free PMC Article

Recent clinical studies

Etiology

Initiation of Brain Extract Fibrillation and Effective Cellular Internalization of Tryptophan Fibrils Unveils Its Neurotoxicity Risk.
Prajapati KP, Ansari M, Mittal S, Anand BG, Kar K
ACS Chem Neurosci 2023 Dec 20;14(24):4274-4281. Epub 2023 Nov 14 doi: 10.1021/acschemneuro.3c00367. PMID: 37962955
Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study.
Pradhan AD, Paynter NP, Everett BM, Glynn RJ, Amarenco P, Elam M, Ginsberg H, Hiatt WR, Ishibashi S, Koenig W, Nordestgaard BG, Fruchart JC, Libby P, Ridker PM
Am Heart J 2018 Dec;206:80-93. Epub 2018 Sep 29 doi: 10.1016/j.ahj.2018.09.011. PMID: 30342298
Prevalence of Positive Troponin and Echocardiogram Findings and Association With Mortality in Acute Ischemic Stroke.
Wrigley P, Khoury J, Eckerle B, Alwell K, Moomaw CJ, Woo D, Flaherty ML, De Los Rios la Rosa F, Mackey J, Adeoye O, Martini S, Ferioli S, Kissela BM, Kleindorfer DO
Stroke 2017 May;48(5):1226-1232. Epub 2017 Apr 5 doi: 10.1161/STROKEAHA.116.014561. PMID: 28381647Free PMC Article
Is triglyceride therapy worth the effort?
Miller M
Cleve Clin J Med 2015 Mar;82(3):162-6. doi: 10.3949/ccjm.82a.13157. PMID: 25932741

Diagnosis

Hypertryptasemia and Mast Cell-Related Disorders in Severe Osteoporotic Patients.
Carosi G, Guabello G, Longhi M, Grifoni F, Passeri E, Corbetta S
Mediators Inflamm 2020;2020:5785378. Epub 2020 Oct 20 doi: 10.1155/2020/5785378. PMID: 33144848Free PMC Article

Therapy

Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study.
Pradhan AD, Paynter NP, Everett BM, Glynn RJ, Amarenco P, Elam M, Ginsberg H, Hiatt WR, Ishibashi S, Koenig W, Nordestgaard BG, Fruchart JC, Libby P, Ridker PM
Am Heart J 2018 Dec;206:80-93. Epub 2018 Sep 29 doi: 10.1016/j.ahj.2018.09.011. PMID: 30342298
The emerging role of novel antihyperglycemic agents in the treatment of heart failure and diabetes: A focus on cardiorenal outcomes.
McHugh KR, DeVore AD, Mentz RJ, Edmonston D, Green JB, Hernandez AF
Clin Cardiol 2018 Sep;41(9):1259-1267. Epub 2018 Sep 21 doi: 10.1002/clc.23054. PMID: 30125365Free PMC Article
Is triglyceride therapy worth the effort?
Miller M
Cleve Clin J Med 2015 Mar;82(3):162-6. doi: 10.3949/ccjm.82a.13157. PMID: 25932741

Prognosis

Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study.
Pradhan AD, Paynter NP, Everett BM, Glynn RJ, Amarenco P, Elam M, Ginsberg H, Hiatt WR, Ishibashi S, Koenig W, Nordestgaard BG, Fruchart JC, Libby P, Ridker PM
Am Heart J 2018 Dec;206:80-93. Epub 2018 Sep 29 doi: 10.1016/j.ahj.2018.09.011. PMID: 30342298
The emerging role of novel antihyperglycemic agents in the treatment of heart failure and diabetes: A focus on cardiorenal outcomes.
McHugh KR, DeVore AD, Mentz RJ, Edmonston D, Green JB, Hernandez AF
Clin Cardiol 2018 Sep;41(9):1259-1267. Epub 2018 Sep 21 doi: 10.1002/clc.23054. PMID: 30125365Free PMC Article
Prevalence of Positive Troponin and Echocardiogram Findings and Association With Mortality in Acute Ischemic Stroke.
Wrigley P, Khoury J, Eckerle B, Alwell K, Moomaw CJ, Woo D, Flaherty ML, De Los Rios la Rosa F, Mackey J, Adeoye O, Martini S, Ferioli S, Kissela BM, Kleindorfer DO
Stroke 2017 May;48(5):1226-1232. Epub 2017 Apr 5 doi: 10.1161/STROKEAHA.116.014561. PMID: 28381647Free PMC Article

Clinical prediction guides

Tryptophan self-assembly yields cytotoxic nanofibers containing amyloid-mimicking and cross-seeding competent conformers.
Prajapati KP, Anand BG, Ansari M, Tiku AB, Kar K
Nanoscale 2022 Nov 10;14(43):16270-16285. doi: 10.1039/d2nr03544h. PMID: 36300424
Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study.
Pradhan AD, Paynter NP, Everett BM, Glynn RJ, Amarenco P, Elam M, Ginsberg H, Hiatt WR, Ishibashi S, Koenig W, Nordestgaard BG, Fruchart JC, Libby P, Ridker PM
Am Heart J 2018 Dec;206:80-93. Epub 2018 Sep 29 doi: 10.1016/j.ahj.2018.09.011. PMID: 30342298

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