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Abnormal circulating tryptophan concentration

MedGen UID:
870874
•Concept ID:
C4025335
•
Finding
Synonym: Abnormality of tryptophan metabolism
 
HPO: HP:0004365

Definition

Any deviation from the normal concentration of tryptophan in the blood circulation. [from HPO]

Conditions with this feature

Tryptophan malabsorption syndrome
MedGen UID:
75685
•Concept ID:
C0268478
•
Disease or Syndrome
Blue Diaper syndrome is a hereditary metabolic disorder characterised by hypercalcaemia with nephrocalcinosis and indicanuria.
See: Condition Record
Tryptophan malabsorption syndrome

Professional guidelines

PubMed

Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.
Christensen MH, Pedersen EK, Nordbø Y, Varhaug JE, Midttun Ø, Ueland PM, Nygård OK, Mellgren G, Lien EA
J Intern Med 2012 Dec;272(6):583-91. Epub 2012 Aug 5 doi: 10.1111/j.1365-2796.2012.02570.x. PMID: 22757621

Recent clinical studies

Etiology

Tryptophan breakdown is increased in euthymic overweight individuals with bipolar disorder: a preliminary report.
Reininghaus EZ, McIntyre RS, Reininghaus B, Geisler S, Bengesser SA, Lackner N, Hecht K, Birner A, Kattnig F, Unterweger R, Kapfhammer HP, Zelzer S, Fuchs D, Mangge H
Bipolar Disord 2014 Jun;16(4):432-40. Epub 2013 Dec 12 doi: 10.1111/bdi.12166. PMID: 24330408
Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.
Christensen MH, Pedersen EK, Nordbø Y, Varhaug JE, Midttun Ø, Ueland PM, Nygård OK, Mellgren G, Lien EA
J Intern Med 2012 Dec;272(6):583-91. Epub 2012 Aug 5 doi: 10.1111/j.1365-2796.2012.02570.x. PMID: 22757621
The influence of nutrition on IGF-1 in tube-fed profoundly retarded adults.
Glick NR, Fischer MH, Adkins WN Jr
J Am Coll Nutr 2001 Feb;20(1):81-6. doi: 10.1080/07315724.2001.10719018. PMID: 11293472

Therapy

The influence of nutrition on IGF-1 in tube-fed profoundly retarded adults.
Glick NR, Fischer MH, Adkins WN Jr
J Am Coll Nutr 2001 Feb;20(1):81-6. doi: 10.1080/07315724.2001.10719018. PMID: 11293472
Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation.
Castell LM, Poortmans JR, Leclercq R, Brasseur M, Duchateau J, Newsholme EA
Eur J Appl Physiol Occup Physiol 1997;75(1):47-53. doi: 10.1007/s004210050125. PMID: 9007457
A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation.
Deakin JF, Pennell I, Upadhyaya AJ, Lofthouse R
Psychopharmacology (Berl) 1990;101(1):85-92. doi: 10.1007/BF02253723. PMID: 2343077

Prognosis

Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma.
Mohapatra SR, Sadik A, Tykocinski LO, Dietze J, Poschet G, Heiland I, Opitz CA
Front Immunol 2019;10:2762. Epub 2019 Dec 4 doi: 10.3389/fimmu.2019.02762. PMID: 31866995Free PMC Article
Tryptophan breakdown is increased in euthymic overweight individuals with bipolar disorder: a preliminary report.
Reininghaus EZ, McIntyre RS, Reininghaus B, Geisler S, Bengesser SA, Lackner N, Hecht K, Birner A, Kattnig F, Unterweger R, Kapfhammer HP, Zelzer S, Fuchs D, Mangge H
Bipolar Disord 2014 Jun;16(4):432-40. Epub 2013 Dec 12 doi: 10.1111/bdi.12166. PMID: 24330408
Activated immune system in patients with Huntington's disease.
Leblhuber F, Walli J, Jellinger K, Tilz GP, Widner B, Laccone F, Fuchs D
Clin Chem Lab Med 1998 Oct;36(10):747-50. doi: 10.1515/CCLM.1998.132. PMID: 9853799
Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation.
Castell LM, Poortmans JR, Leclercq R, Brasseur M, Duchateau J, Newsholme EA
Eur J Appl Physiol Occup Physiol 1997;75(1):47-53. doi: 10.1007/s004210050125. PMID: 9007457
A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation.
Deakin JF, Pennell I, Upadhyaya AJ, Lofthouse R
Psychopharmacology (Berl) 1990;101(1):85-92. doi: 10.1007/BF02253723. PMID: 2343077

Clinical prediction guides

Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma.
Mohapatra SR, Sadik A, Tykocinski LO, Dietze J, Poschet G, Heiland I, Opitz CA
Front Immunol 2019;10:2762. Epub 2019 Dec 4 doi: 10.3389/fimmu.2019.02762. PMID: 31866995Free PMC Article
Tryptophan breakdown is increased in euthymic overweight individuals with bipolar disorder: a preliminary report.
Reininghaus EZ, McIntyre RS, Reininghaus B, Geisler S, Bengesser SA, Lackner N, Hecht K, Birner A, Kattnig F, Unterweger R, Kapfhammer HP, Zelzer S, Fuchs D, Mangge H
Bipolar Disord 2014 Jun;16(4):432-40. Epub 2013 Dec 12 doi: 10.1111/bdi.12166. PMID: 24330408
Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.
Christensen MH, Pedersen EK, Nordbø Y, Varhaug JE, Midttun Ø, Ueland PM, Nygård OK, Mellgren G, Lien EA
J Intern Med 2012 Dec;272(6):583-91. Epub 2012 Aug 5 doi: 10.1111/j.1365-2796.2012.02570.x. PMID: 22757621
A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation.
Deakin JF, Pennell I, Upadhyaya AJ, Lofthouse R
Psychopharmacology (Berl) 1990;101(1):85-92. doi: 10.1007/BF02253723. PMID: 2343077

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