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Decreased VLDL cholesterol concentration

MedGen UID:
1625610
•Concept ID:
C4531249
•
Finding
Synonym: Decreased circulating very-low-density lipoprotein levels
 
HPO: HP:0031243

Definition

A reduction in the amount of very-low-density lipoprotein cholesterol in the blood. [from HPO]

Professional guidelines

PubMed

Contribution of ApoCIII to Diabetic Dyslipidemia and Treatment With Volanesorsen.
Zhang J, Rocha NA, McCullough PA
Rev Cardiovasc Med 2018 Mar 30;19(1):13-19. doi: 10.31083/j.rcm.2018.01.890. PMID: 31032598
The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia.
Backes J, Anzalone D, Hilleman D, Catini J
Lipids Health Dis 2016 Jul 22;15(1):118. doi: 10.1186/s12944-016-0286-4. PMID: 27444154Free PMC Article
Treatment of diabetic dyslipidemia.
Garg A
Am J Cardiol 1998 Feb 26;81(4A):47B-51B. doi: 10.1016/s0002-9149(98)00038-1. PMID: 9526814

Recent clinical studies

Etiology

The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia.
Backes J, Anzalone D, Hilleman D, Catini J
Lipids Health Dis 2016 Jul 22;15(1):118. doi: 10.1186/s12944-016-0286-4. PMID: 27444154Free PMC Article
Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism.
Hooper AJ, van Bockxmeer FM, Burnett JR
Crit Rev Clin Lab Sci 2005;42(5-6):515-45. doi: 10.1080/10408360500295113. PMID: 16390683
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and hepatic apolipoprotein B secretion.
Huff MW, Burnett JR
Curr Opin Lipidol 1997 Jun;8(3):138-45. doi: 10.1097/00041433-199706000-00003. PMID: 9211061
Growth hormone and lipids.
Keller U, Miles JM
Horm Res 1991;36 Suppl 1:36-40. doi: 10.1159/000182186. PMID: 1806482
Importance of apolipoproteins in lipid metabolism.
Cham BE
Chem Biol Interact 1978 Mar;20(3):263-77. doi: 10.1016/0009-2797(78)90105-9. PMID: 207449

Diagnosis

Probiotic supplementation and the effects on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
Ahmadi S, Jamilian M, Karamali M, Tajabadi-Ebrahimi M, Jafari P, Taghizadeh M, Memarzadeh MR, Asemi Z
Hum Fertil (Camb) 2017 Dec;20(4):254-261. Epub 2017 Feb 1 doi: 10.1080/14647273.2017.1283446. PMID: 28142296
Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Jamilian M, Asemi Z
Ann Nutr Metab 2015;67(1):42-8. doi: 10.1159/000438465. PMID: 26279073
Coulometric detection in high-performance liquid chromatographic analysis of cholesteryl ester hydroperoxides.
Arai H, Terao J, Abdalla DS, Suzuki T, Takama K
Free Radic Biol Med 1996;20(3):365-71. doi: 10.1016/0891-5849(96)02062-x. PMID: 8720907
Low high density lipoprotein-2 concentrations in obese male subjects.
Bertière MC, Fumeron F, Rigaud D, Malon D, Apfelbaum M, Girard-Globa A
Atherosclerosis 1988 Sep;73(1):57-61. doi: 10.1016/0021-9150(88)90163-3. PMID: 3178932
The biochemical, clinical, and genetic features of type III hyperlipoproteinemia.
Morganroth J, Levy RI, Fredrickson DS
Ann Intern Med 1975 Feb;82(2):158-74. doi: 10.7326/0003-4819-82-2-158. PMID: 163608

Therapy

Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Jamilian M, Asemi Z
Ann Nutr Metab 2015;67(1):42-8. doi: 10.1159/000438465. PMID: 26279073
Effect of different forms of dietary hydrogenated fats on LDL particle size.
Mauger JF, Lichtenstein AH, Ausman LM, Jalbert SM, Jauhiainen M, Ehnholm C, Lamarche B
Am J Clin Nutr 2003 Sep;78(3):370-5. doi: 10.1093/ajcn/78.3.370. PMID: 12936917
Pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid.
Carlson LA, Hamsten A, Asplund A
J Intern Med 1989 Oct;226(4):271-6. doi: 10.1111/j.1365-2796.1989.tb01393.x. PMID: 2530298
Lovastatin therapy in receptor-negative homozygous familial hypercholesterolemia: lack of effect on low-density lipoprotein concentrations or turnover.
Uauy R, Vega GL, Grundy SM, Bilheimer DM
J Pediatr 1988 Aug;113(2):387-92. doi: 10.1016/s0022-3476(88)80289-0. PMID: 3397806
Reduction of high density lipoprotein cholesterol and apoliproprotein A-I concentrations by a lipid-lowering diet.
Vessby B, Boberg J, Gustafsson IB, Karlström B, Lithell H, Ostlund-Linqvist AM
Atherosclerosis 1980 Jan;35(1):21-7. doi: 10.1016/0021-9150(80)90024-6. PMID: 6768372

Prognosis

Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy.
Julve J, Rossell J, Correig E, Rojo-Lopez MI, Amigó N, Hernández M, Traveset A, Carbonell M, Alonso N, Mauricio D, Castelblanco E
Nutrients 2022 Sep 22;14(19) doi: 10.3390/nu14193932. PMID: 36235586Free PMC Article
Evolocumab Effects on Lipoproteins, Measured by High-Performance Liquid Chromatography.
Masuda D, Kiyosue A, Hirayama A, Shimauchi J, López JAG, Miyawaki K, Yamashita S
J Atheroscler Thromb 2020 Nov 1;27(11):1183-1207. Epub 2020 May 20 doi: 10.5551/jat.54353. PMID: 32435010Free PMC Article
VLDL Triglyceride Kinetics in Lean, Overweight, and Obese Men and Women.
Mittendorfer B, Yoshino M, Patterson BW, Klein S
J Clin Endocrinol Metab 2016 Nov;101(11):4151-4160. Epub 2016 Sep 2 doi: 10.1210/jc.2016-1500. PMID: 27588438Free PMC Article
Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography.
Dobiásová M, Frohlich J, Sedová M, Cheung MC, Brown BG
J Lipid Res 2011 Mar;52(3):566-71. Epub 2011 Jan 11 doi: 10.1194/jlr.P011668. PMID: 21224290Free PMC Article
Physical activity, diet, and health: independent and interactive effects.
Wood PD
Med Sci Sports Exerc 1994 Jul;26(7):838-43. PMID: 7934756

Clinical prediction guides

Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Jamilian M, Asemi Z
Ann Nutr Metab 2015;67(1):42-8. doi: 10.1159/000438465. PMID: 26279073
Effect of different forms of dietary hydrogenated fats on LDL particle size.
Mauger JF, Lichtenstein AH, Ausman LM, Jalbert SM, Jauhiainen M, Ehnholm C, Lamarche B
Am J Clin Nutr 2003 Sep;78(3):370-5. doi: 10.1093/ajcn/78.3.370. PMID: 12936917
Phospholipid transfer protein.
van Tol A
Curr Opin Lipidol 2002 Apr;13(2):135-9. doi: 10.1097/00041433-200204000-00004. PMID: 11891415
Plasma homocyst(e)ine levels and graded risk for myocardial infarction: findings in two populations at contrasting risk for coronary heart disease.
Malinow MR, Ducimetiere P, Luc G, Evans AE, Arveiler D, Cambien F, Upson BM
Atherosclerosis 1996 Sep 27;126(1):27-34. doi: 10.1016/0021-9150(96)05890-x. PMID: 8879431
Ultracentrifugal study of metabolic effects of probucol: plasma lipoproteins in patients with proven coronary artery disease.
Opplt JJ, Bahler RC
Artery 1982;10(2):108-30. PMID: 7092579

Recent systematic reviews

The effects of chromium supplementation on lipidprofile in humans: A systematic review and meta-analysis ofrandomized controlled trials.
Tarrahi MJ, Tarrahi MA, Rafiee M, Mansourian M
Pharmacol Res 2021 Feb;164:105308. Epub 2020 Nov 14 doi: 10.1016/j.phrs.2020.105308. PMID: 33197598
Effects of α-linolenic acid intake on blood lipid profiles：a systematic review and meta-analysis of randomized controlled trials.
Yue H, Qiu B, Jia M, Liu W, Guo XF, Li N, Xu ZX, Du FL, Xu T, Li D
Crit Rev Food Sci Nutr 2021;61(17):2894-2910. Epub 2020 Jul 9 doi: 10.1080/10408398.2020.1790496. PMID: 32643951
The Effects of L-Carnitine Supplementation on Serum Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Fathizadeh H, Milajerdi A, Reiner Ž, Kolahdooz F, Chamani M, Amirani E, Asemi Z
Curr Pharm Des 2019;25(30):3266-3281. doi: 10.2174/1381612825666190830154336. PMID: 31470778
Rice Bran Oil Decreases Total and LDL Cholesterol in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.
Jolfaie NR, Rouhani MH, Surkan PJ, Siassi F, Azadbakht L
Horm Metab Res 2016 Jul;48(7):417-26. Epub 2016 Jun 16 doi: 10.1055/s-0042-105748. PMID: 27311126
Effect of alpha linolenic acid on cardiovascular risk markers: a systematic review.
Wendland E, Farmer A, Glasziou P, Neil A
Heart 2006 Feb;92(2):166-9. Epub 2005 May 12 doi: 10.1136/hrt.2004.053538. PMID: 15890766Free PMC Article

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