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Abnormal VLDL cholesterol concentration

MedGen UID:
1633574
•Concept ID:
C4703601
•
Finding
HPO: HP:0031889

Definition

Any deviation from the normal concentration of very-low-density lipoprotein cholesterol in the blood. [from HPO]

Professional guidelines

PubMed

Impact of Chronic Hepatitis C Virus Genotype 1b Infection on Triglyceride Concentration in Serum Lipoprotein Fractions.
Nagano T, Seki N, Tomita Y, Sugita T, Aida Y, Itagaki M, Sutoh S, Abe H, Tsubota A, Aizawa Y
Int J Mol Sci 2015 Aug 31;16(9):20576-94. doi: 10.3390/ijms160920576. PMID: 26334270Free PMC Article
Fenofibrate: treatment of hyperlipidemia and beyond.
Rosenson RS
Expert Rev Cardiovasc Ther 2008 Nov;6(10):1319-30. doi: 10.1586/14779072.6.10.1319. PMID: 19018684
Lipid abnormalities in the nephrotic syndrome: causes, consequences, and treatment.
Wheeler DC, Bernard DB
Am J Kidney Dis 1994 Mar;23(3):331-46. doi: 10.1016/s0272-6386(12)80994-2. PMID: 8128933

Recent clinical studies

Etiology

Nuclear Magnetic Resonance-Based Metabolomics and Risk of CKD.
Geng TT, Chen JX, Lu Q, Wang PL, Xia PF, Zhu K, Li Y, Guo KQ, Yang K, Liao YF, Zhou YF, Liu G, Pan A
Am J Kidney Dis 2024 Jan;83(1):9-17. Epub 2023 Sep 9 doi: 10.1053/j.ajkd.2023.05.014. PMID: 37678743
Growth, body composition, and cardiovascular and nutritional risk of 5- to 10-y-old children consuming vegetarian, vegan, or omnivore diets.
Desmond MA, Sobiecki JG, Jaworski M, Płudowski P, Antoniewicz J, Shirley MK, Eaton S, Książyk J, Cortina-Borja M, De Stavola B, Fewtrell M, Wells JCK
Am J Clin Nutr 2021 Jun 1;113(6):1565-1577. doi: 10.1093/ajcn/nqaa445. PMID: 33740036Free PMC Article
Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Does statin monotherapy address the multiple lipid abnormalities in type 2 diabetes?
Shepherd J
Atheroscler Suppl 2005 Sep;6(3):15-9. doi: 10.1016/j.atherosclerosissup.2005.06.004. PMID: 16046280
Growth hormone and lipids.
Keller U, Miles JM
Horm Res 1991;36 Suppl 1:36-40. doi: 10.1159/000182186. PMID: 1806482

Diagnosis

Lipoprotein profiles of fat distribution and its association with insulin sensitivity.
Wei D, Marrachelli VG, Melgarejo JD, Liao CT, Janssens S, Verhamme P, Vanassche T, Van Aelst L, Monleon D, Redón J, Zhang ZY
Front Endocrinol (Lausanne) 2022;13:978745. Epub 2022 Oct 25 doi: 10.3389/fendo.2022.978745. PMID: 36387872Free PMC Article
Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis.
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article
Growth, body composition, and cardiovascular and nutritional risk of 5- to 10-y-old children consuming vegetarian, vegan, or omnivore diets.
Desmond MA, Sobiecki JG, Jaworski M, Płudowski P, Antoniewicz J, Shirley MK, Eaton S, Książyk J, Cortina-Borja M, De Stavola B, Fewtrell M, Wells JCK
Am J Clin Nutr 2021 Jun 1;113(6):1565-1577. doi: 10.1093/ajcn/nqaa445. PMID: 33740036Free PMC Article
Comparative serum apolipoprotein studies in ischaemic heart disease and control subjects.
Onitiri AC, Jover E
Clin Chim Acta 1980 Nov 20;108(1):25-30. doi: 10.1016/0009-8981(80)90288-0. PMID: 7470245
The biochemical, clinical, and genetic features of type III hyperlipoproteinemia.
Morganroth J, Levy RI, Fredrickson DS
Ann Intern Med 1975 Feb;82(2):158-74. doi: 10.7326/0003-4819-82-2-158. PMID: 163608

Therapy

Lipoprotein profiles of fat distribution and its association with insulin sensitivity.
Wei D, Marrachelli VG, Melgarejo JD, Liao CT, Janssens S, Verhamme P, Vanassche T, Van Aelst L, Monleon D, Redón J, Zhang ZY
Front Endocrinol (Lausanne) 2022;13:978745. Epub 2022 Oct 25 doi: 10.3389/fendo.2022.978745. PMID: 36387872Free PMC Article
Mediterranean diet in healthy lifestyle and prevention of stroke.
Demarin V, Lisak M, Morović S
Acta Clin Croat 2011 Mar;50(1):67-77. PMID: 22034786
Fenofibrate: treatment of hyperlipidemia and beyond.
Rosenson RS
Expert Rev Cardiovasc Ther 2008 Nov;6(10):1319-30. doi: 10.1586/14779072.6.10.1319. PMID: 19018684
Dyslipidemias in patients with diabetes mellitus: classification and risks and benefits of therapy.
Oki JC
Pharmacotherapy 1995 May-Jun;15(3):317-37. PMID: 7667166
HDL from type III dysbetalipoproteinaemic patients show decreased capacity to inhibit VLDL uptake in rat liver endothelial cells.
Gustafson S, Vessby B, Ostlund-Lindqvist AM, Ehnholm C
Atherosclerosis 1986 Nov;62(2):145-9. doi: 10.1016/0021-9150(86)90060-2. PMID: 3801082

Prognosis

Longitudinal trends in lipid profile in indian children and youth with type-1 diabetes: a 5-year follow up from a single centre.
Oza C, Khadilkar A, Mondkar SA, Gondhalekar K, Khadilkar V
Endocrine 2023 Feb;79(2):313-322. Epub 2022 Nov 22 doi: 10.1007/s12020-022-03259-6. PMID: 36414859
Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis.
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article
Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Reducing lipids for CV protection in CKD patients-current evidence.
Wanner C, Ritz E
Kidney Int Suppl 2008 Dec;(111):S24-8. doi: 10.1038/ki.2008.520. PMID: 19034322
Lipoprotein metabolism in liver disease.
Sabesin SM, Bertram PD, Freeman MR
Adv Intern Med 1980;25:117-46. PMID: 6987838

Clinical prediction guides

Nuclear Magnetic Resonance-Based Metabolomics and Risk of CKD.
Geng TT, Chen JX, Lu Q, Wang PL, Xia PF, Zhu K, Li Y, Guo KQ, Yang K, Liao YF, Zhou YF, Liu G, Pan A
Am J Kidney Dis 2024 Jan;83(1):9-17. Epub 2023 Sep 9 doi: 10.1053/j.ajkd.2023.05.014. PMID: 37678743
Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Lipoprotein metabolism and CKD: overview.
Barter P
Clin Exp Nephrol 2014 Apr;18(2):243-6. Epub 2013 Sep 20 doi: 10.1007/s10157-013-0866-9. PMID: 24052157
Fenofibrate: treatment of hyperlipidemia and beyond.
Rosenson RS
Expert Rev Cardiovasc Ther 2008 Nov;6(10):1319-30. doi: 10.1586/14779072.6.10.1319. PMID: 19018684
Hyperlipidaemia of diabetes.
Gibbons GF
Clin Sci (Lond) 1986 Nov;71(5):477-86. doi: 10.1042/cs0710477. PMID: 3533393

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