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Refractory Central Nervous System Lymphoma

MedGen UID:
1626037
•Concept ID:
C4527329
•
Neoplastic Process
Synonym: Refractory Primary Central Nervous System Lymphoma

Definition

Central nervous system lymphoma that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Central Nervous System Prophylaxis and Treatment in Acute Leukemias.
Wu SY, Short NJ, Nasr L, Dabaja BS, Fang PQ
Curr Treat Options Oncol 2022 Dec;23(12):1829-1844. Epub 2022 Dec 13 doi: 10.1007/s11864-022-01032-5. PMID: 36510037Free PMC Article
Treatment Options for Recurrent Primary CNS Lymphoma.
Kaulen LD, Baehring JM
Curr Treat Options Oncol 2022 Nov;23(11):1548-1565. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01016-5. PMID: 36205806
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616

Recent clinical studies

Etiology

Preclinical and clinical evaluation of Buparlisib (BKM120) in recurrent/refractory Central Nervous System Lymphoma.
Grommes C, Pentsova E, Schaff LR, Nolan CP, Kaley T, Reiner AS, Panageas KS, Mellinghoff IK
Leuk Lymphoma 2023 Sep;64(9):1545-1553. Epub 2023 Jun 15 doi: 10.1080/10428194.2023.2223734. PMID: 37317993Free PMC Article
The outcome of ibrutinib-based regimens in relapsed/refractory central nervous system lymphoma and the potential impact of genomic variants.
Wang S, Zhu Y, Qian X, Ding T, Yuan Y, Li Y, Wu H, Chen T
Adv Clin Exp Med 2023 Aug;32(8):855-863. doi: 10.17219/acem/159288. PMID: 36881367
Efficacy and safety of ibrutinib in diffuse large B-cell lymphoma: A single-arm meta-analysis.
Hou K, Yu Z, Jia Y, Fang H, Shao S, Huang L, Feng Y
Crit Rev Oncol Hematol 2020 Aug;152:103010. Epub 2020 May 28 doi: 10.1016/j.critrevonc.2020.103010. PMID: 32540781
Retrospective study of pemetrexed as salvage therapy for central nervous system lymphoma.
Zhang JP, Lee EQ, Nayak L, Doherty L, Kesari S, Muzikansky A, Norden AD, Chen H, Wen PY, Drappatz J
J Neurooncol 2013 Oct;115(1):71-7. Epub 2013 Jul 5 doi: 10.1007/s11060-013-1196-1. PMID: 23828279

Diagnosis

Successful treatment with reduced-intensity stem cell transplantation in a case of relapsed refractory central nervous system lymphoma.
Aoyama Y, Yamamura R, Shima E, Nakamae H, Makita K, Kho G, Ohta K, Yamane T, Takubo T, Hino M
Ann Hematol 2003 Jun;82(6):371-3. Epub 2003 Apr 29 doi: 10.1007/s00277-003-0651-z. PMID: 12719887

Therapy

Preclinical and clinical evaluation of Buparlisib (BKM120) in recurrent/refractory Central Nervous System Lymphoma.
Grommes C, Pentsova E, Schaff LR, Nolan CP, Kaley T, Reiner AS, Panageas KS, Mellinghoff IK
Leuk Lymphoma 2023 Sep;64(9):1545-1553. Epub 2023 Jun 15 doi: 10.1080/10428194.2023.2223734. PMID: 37317993Free PMC Article
Efficacy and safety of ibrutinib in diffuse large B-cell lymphoma: A single-arm meta-analysis.
Hou K, Yu Z, Jia Y, Fang H, Shao S, Huang L, Feng Y
Crit Rev Oncol Hematol 2020 Aug;152:103010. Epub 2020 May 28 doi: 10.1016/j.critrevonc.2020.103010. PMID: 32540781
Retrospective study of pemetrexed as salvage therapy for central nervous system lymphoma.
Zhang JP, Lee EQ, Nayak L, Doherty L, Kesari S, Muzikansky A, Norden AD, Chen H, Wen PY, Drappatz J
J Neurooncol 2013 Oct;115(1):71-7. Epub 2013 Jul 5 doi: 10.1007/s11060-013-1196-1. PMID: 23828279

Prognosis

Retrospective study of pemetrexed as salvage therapy for central nervous system lymphoma.
Zhang JP, Lee EQ, Nayak L, Doherty L, Kesari S, Muzikansky A, Norden AD, Chen H, Wen PY, Drappatz J
J Neurooncol 2013 Oct;115(1):71-7. Epub 2013 Jul 5 doi: 10.1007/s11060-013-1196-1. PMID: 23828279

Clinical prediction guides

Successful treatment with reduced-intensity stem cell transplantation in a case of relapsed refractory central nervous system lymphoma.
Aoyama Y, Yamamura R, Shima E, Nakamae H, Makita K, Kho G, Ohta K, Yamane T, Takubo T, Hino M
Ann Hematol 2003 Jun;82(6):371-3. Epub 2003 Apr 29 doi: 10.1007/s00277-003-0651-z. PMID: 12719887

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