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Central nervous system hematopoietic neoplasm

MedGen UID:
234101
•Concept ID:
C1332882
•
Neoplastic Process
Synonyms: central nervous system haematopoietic and lymphoid system neoplasm; central nervous system haematopoietic neoplasms; central nervous system haematopoietic tumour; central nervous system hematologic cancer; central nervous system hematopoietic and lymphoid system neoplasm; Central Nervous System Hematopoietic Neoplasm; central nervous system hematopoietic neoplasm; Central Nervous System Hematopoietic Neoplasms; central nervous system hematopoietic neoplasms; Central Nervous System Hematopoietic Tumor; central nervous system hematopoietic tumor; CNS haematopoietic neoplasm; CNS haematopoietic tumour; CNS Hematopoietic Neoplasm; CNS hematopoietic neoplasm; CNS Hematopoietic Tumor; CNS hematopoietic tumor; haematopoietic and lymphoid system neoplasm of central nervous system; haematopoietic neoplasm of central nervous system; haematopoietic neoplasm of CNS; haematopoietic neoplasm of the central nervous system; haematopoietic neoplasm of the CNS; haematopoietic tumour of central nervous system; haematopoietic tumour of the central nervous system; hematopoietic and lymphoid system neoplasm of central nervous system; Hematopoietic Neoplasm of Central Nervous System; hematopoietic neoplasm of central nervous system; Hematopoietic Neoplasm of CNS; hematopoietic neoplasm of CNS; Hematopoietic Neoplasm of the Central Nervous System; hematopoietic neoplasm of the central nervous system; Hematopoietic Neoplasm of the CNS; hematopoietic neoplasm of the CNS; Hematopoietic Tumor of Central Nervous System; hematopoietic tumor of central nervous system; Hematopoietic Tumor of the Central Nervous System; hematopoietic tumor of the central nervous system; Lymphomas and Hemopoietic Neoplasms of CNS; lymphomas and hemopoietic neoplasms of CNS; Lymphomas and Hemopoietic Neoplasms of the CNS; lymphomas and hemopoietic neoplasms of the CNS
 
Monarch Initiative: MONDO:0003641

Definition

A neoplasm of hematopoietic origin that affects the brain, meninges, or spinal cord. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral nervous system hematopoietic neoplasm

Professional guidelines

PubMed

Inpatient recognition and management of HLH.
Zoref-Lorenz A, Ellis M, Jordan MB
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):259-266. doi: 10.1182/hematology.2023000509. PMID: 38066887Free PMC Article
Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490

Recent clinical studies

Etiology

Molecular Alterations in Pediatric Solid Tumors.
Slack JC, Church AJ
Clin Lab Med 2024 Jun;44(2):277-304. doi: 10.1016/j.cll.2023.08.012. PMID: 38821645
Molecular Alterations in Pediatric Solid Tumors.
Slack JC, Church AJ
Surg Pathol Clin 2021 Sep;14(3):473-492. Epub 2021 Jul 8 doi: 10.1016/j.path.2021.05.010. PMID: 34373097
T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies.
Vadillo E, Dorantes-Acosta E, Pelayo R, Schnoor M
Blood Rev 2018 Jan;32(1):36-51. Epub 2017 Aug 15 doi: 10.1016/j.blre.2017.08.006. PMID: 28830639
Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.
Abrey LE, Batchelor TT, Ferreri AJ, Gospodarowicz M, Pulczynski EJ, Zucca E, Smith JR, Korfel A, Soussain C, DeAngelis LM, Neuwelt EA, O'Neill BP, Thiel E, Shenkier T, Graus F, van den Bent M, Seymour JF, Poortmans P, Armitage JO, Cavalli F; International Primary CNS Lymphoma Collaborative Group
J Clin Oncol 2005 Aug 1;23(22):5034-43. Epub 2005 Jun 13 doi: 10.1200/JCO.2005.13.524. PMID: 15955902
The hyper-CVAD regimen in adult acute lymphocytic leukemia.
Garcia-Manero G, Kantarjian HM
Hematol Oncol Clin North Am 2000 Dec;14(6):1381-96, x-xi. doi: 10.1016/s0889-8588(05)70192-1. PMID: 11147229

Diagnosis

Molecular Alterations in Pediatric Solid Tumors.
Slack JC, Church AJ
Clin Lab Med 2024 Jun;44(2):277-304. doi: 10.1016/j.cll.2023.08.012. PMID: 38821645
Inpatient recognition and management of HLH.
Zoref-Lorenz A, Ellis M, Jordan MB
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):259-266. doi: 10.1182/hematology.2023000509. PMID: 38066887Free PMC Article
Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
Molecular Alterations in Pediatric Solid Tumors.
Slack JC, Church AJ
Surg Pathol Clin 2021 Sep;14(3):473-492. Epub 2021 Jul 8 doi: 10.1016/j.path.2021.05.010. PMID: 34373097
Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.
Abrey LE, Batchelor TT, Ferreri AJ, Gospodarowicz M, Pulczynski EJ, Zucca E, Smith JR, Korfel A, Soussain C, DeAngelis LM, Neuwelt EA, O'Neill BP, Thiel E, Shenkier T, Graus F, van den Bent M, Seymour JF, Poortmans P, Armitage JO, Cavalli F; International Primary CNS Lymphoma Collaborative Group
J Clin Oncol 2005 Aug 1;23(22):5034-43. Epub 2005 Jun 13 doi: 10.1200/JCO.2005.13.524. PMID: 15955902

Therapy

The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Checkpoint inhibition in meningiomas.
Bi WL, Wu WW, Santagata S, Reardon DA, Dunn IF
Immunotherapy 2016 Jun;8(6):721-31. doi: 10.2217/imt-2016-0017. PMID: 27197540
Clinical management of HIV-associated hematologic malignancies.
Wang CC, Kaplan LD
Expert Rev Hematol 2016;9(4):361-76. Epub 2016 Mar 18 doi: 10.1586/17474086.2016.1130615. PMID: 26652941
Intrathecal chemotherapy.
Kerr JZ, Berg S, Blaney SM
Crit Rev Oncol Hematol 2001 Mar;37(3):227-36. doi: 10.1016/s1040-8428(00)00115-3. PMID: 11248578
The hyper-CVAD regimen in adult acute lymphocytic leukemia.
Garcia-Manero G, Kantarjian HM
Hematol Oncol Clin North Am 2000 Dec;14(6):1381-96, x-xi. doi: 10.1016/s0889-8588(05)70192-1. PMID: 11147229

Prognosis

Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
Molecular Alterations in Pediatric Solid Tumors.
Slack JC, Church AJ
Surg Pathol Clin 2021 Sep;14(3):473-492. Epub 2021 Jul 8 doi: 10.1016/j.path.2021.05.010. PMID: 34373097
Leptomeningeal metastasis from solid tumors.
Thakkar JP, Kumthekar P, Dixit KS, Stupp R, Lukas RV
J Neurol Sci 2020 Apr 15;411:116706. Epub 2020 Jan 23 doi: 10.1016/j.jns.2020.116706. PMID: 32007755
T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies.
Vadillo E, Dorantes-Acosta E, Pelayo R, Schnoor M
Blood Rev 2018 Jan;32(1):36-51. Epub 2017 Aug 15 doi: 10.1016/j.blre.2017.08.006. PMID: 28830639
Checkpoint inhibition in meningiomas.
Bi WL, Wu WW, Santagata S, Reardon DA, Dunn IF
Immunotherapy 2016 Jun;8(6):721-31. doi: 10.2217/imt-2016-0017. PMID: 27197540

Clinical prediction guides

Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors.
Lin FY, Stuckert A, Tat C, White M, Ruggieri L, Zhang H, Mehta B, Lapteva N, Mei Z, Major A, Thakkar S, Shum T, Parikh K, Wu MF, Lindsay HB, Scherer L, Shekar M, Baxter P, Wang T, Grilley B, Moeller K, Hicks J, Roy A, Anastas J, Malbari F, Aldave G, Chintagumpala M, Blaney S, Parsons DW, Brenner MK, Heslop HE, Rooney CM, Omer B
J Clin Oncol 2024 Aug 10;42(23):2769-2779. Epub 2024 May 21 doi: 10.1200/JCO.23.02019. PMID: 38771986Free PMC Article
Langerhans cell histiocytosis: promises and caveats of targeted therapies in high-risk and CNS disease.
Abla O
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):386-395. doi: 10.1182/hematology.2023000439. PMID: 38066856Free PMC Article
Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant.
Scordo M, Wang TP, Ahn KW, Chen Y, Ahmed S, Awan FT, Beitinjaneh A, Chen A, Chow VA, Dholaria B, Epperla N, Farooq U, Ghosh N, Grover N, Hamad N, Hildebrandt GC, Holmberg L, Hong S, Inwards DJ, Jimenez-Jimenez A, Karmali R, Kenkre VP, Khimani F, Klyuchnikov E, Krem MM, Munshi PN, Nieto Y, Prestidge T, Ramakrishnan Geethakumari P, Rezvani AR, Riedell PA, Seo S, Shah NN, Solh M, Yared JA, Kharfan-Dabaja MA, Herrera A, Hamadani M, Sauter CS
JAMA Oncol 2021 Jul 1;7(7):993-1003. doi: 10.1001/jamaoncol.2021.1074. PMID: 33956047Free PMC Article
Checkpoint inhibition in meningiomas.
Bi WL, Wu WW, Santagata S, Reardon DA, Dunn IF
Immunotherapy 2016 Jun;8(6):721-31. doi: 10.2217/imt-2016-0017. PMID: 27197540
Practical pituitary pathology: what does the pathologist need to know?
Asa SL
Arch Pathol Lab Med 2008 Aug;132(8):1231-40. doi: 10.5858/2008-132-1231-PPPWDT. PMID: 18684022

Recent systematic reviews

Bruton's Tyrosine Kinase Inhibitors in Refractory or Relapsing Primary Central Nervous System Lymphoma: A Meta-analysis and Systematic Review.
Guo HP, Dang XL, Kang L, Liu C, Liu XW
World Neurosurg 2024 Aug;188:161-169. Epub 2024 Apr 17 doi: 10.1016/j.wneu.2024.04.066. PMID: 38641241
Autologous hematopoietic cell transplantation versus whole-brain radiotherapy consolidation in primary central nervous system lymphoma: A systematic review and meta-analysis.
Epperla N, Reljic T, Chowdhury SM, Ferreri AJM, Kumar A, Hamadani M
Hematol Oncol 2023 Feb;41(1):88-96. Epub 2022 Oct 6 doi: 10.1002/hon.3083. PMID: 36192141
Literature review on cancer risk in children born after fertility treatment suggests increased risk of haematological cancers.
Reigstad MM, Oldereid NB, Omland AK, Storeng R
Acta Paediatr 2017 May;106(5):698-709. Epub 2017 Mar 3 doi: 10.1111/apa.13755. PMID: 28128867
Effectiveness and safety of thiotepa as conditioning treatment prior to stem cell transplant in patients with central nervous system lymphoma.
Kokolo MB, Fergusson D, O'Neill J, Tay J, Tinmouth AT, Stewart D, Bredeson C
Leuk Lymphoma 2014 Dec;55(12):2712-20. Epub 2014 Mar 26 doi: 10.3109/10428194.2014.889825. PMID: 24491026
Management of recurrent medulloblastoma in adult patients: a systematic review and recommendations.
Kostaras X, Easaw JC
J Neurooncol 2013 Oct;115(1):1-8. Epub 2013 Jul 23 doi: 10.1007/s11060-013-1206-3. PMID: 23877361

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