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Extrahepatic bile duct signet ring cell carcinoma

MedGen UID:
163667
•Concept ID:
C0861859
•
Neoplastic Process
Synonyms: Bile Duct Signet Ring Cell Carcinoma; bile duct signet ring cell carcinoma; bile duct signet Ring cell carcinoma; Extrahepatic Bile Duct Signet Ring Cell Carcinoma; extrahepatic bile duct signet ring cell carcinoma; extrahepatic bile duct signet Ring cell carcinoma; Extrahepatic Bile Duct Signet-Ring Cell Carcinoma; Signet Ring Cell Bile Duct Carcinoma; signet Ring cell bile duct carcinoma; Signet Ring Cell Carcinoma of Bile Duct; signet Ring cell carcinoma of bile duct; Signet Ring Cell Carcinoma of the Bile Duct; signet Ring cell carcinoma of the bile duct
 
Monarch Initiative: MONDO:0002664

Definition

An adenocarcinoma that arises from the extrahepatic bile ducts. It is characterized by the presence of signet ring malignant epithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic bile duct signet ring cell carcinoma

Recent clinical studies

Etiology

Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Signet-ring cell carcinoma of the ampulla of Vater: report of a case.
Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y
Surg Today 2007;37(12):1110-4. Epub 2007 Nov 26 doi: 10.1007/s00595-007-3534-4. PMID: 18030577
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813
Signet-ring cell carcinoma of the ampulla of Vater.
Li L, Chen QH, Sullivan JD, Breuer FU
Ann Clin Lab Sci 2004 Autumn;34(4):471-5. PMID: 15648791
Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up.
Zhou H, Schaefer N, Wolff M, Fischer HP
Am J Surg Pathol 2004 Jul;28(7):875-82. doi: 10.1097/00000478-200407000-00005. PMID: 15223956

Diagnosis

Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States.
Kinslow CJ, May MS, Kozak M, Pollom EL, Chang DT
HPB (Oxford) 2020 Dec;22(12):1759-1765. Epub 2020 Apr 18 doi: 10.1016/j.hpb.2020.03.024. PMID: 32317226
Signet-ring cell carcinoma of the ampulla of Vater: a case diagnosed via repeated biopsies.
Ikeda C, Makino N, Matsuda A, Kakizaki Y, Ishizawa T, Kobayashi T, Sugahara S, Nishiduka M, Tsunoda M, Haga J, Tsunoda R, Ueno Y
Clin J Gastroenterol 2020 Aug;13(4):607-614. Epub 2020 Jan 24 doi: 10.1007/s12328-020-01097-5. PMID: 31981088Free PMC Article
Rapidly Progressing Primary Extrahepatic Bile Duct Signet-Ring Cell Carcinoma in a Caucasian Woman.
Welsh JL, Jaber O, Ivanovic M, Johlin FC, El Abiad RG, Clamon GH, Smith MC, Chan CHF
J Gastrointest Cancer 2018 Mar;49(1):63-66. doi: 10.1007/s12029-016-9843-3. PMID: 27270710
Signet-ring cell carcinoma coexisting with adenocarcinoma arising in a choledochal cyst: report of a case.
Hua R, Zhang JF, Liu W, Huo YM, Sun YW
Surg Today 2015 Aug;45(8):1049-52. Epub 2014 Oct 29 doi: 10.1007/s00595-014-1049-3. PMID: 25352010

Therapy

Feasibility study of postoperative adjuvant chemotherapy with S-1 in patients with biliary tract cancer.
Nakachi K, Konishi M, Ikeda M, Shimada K, Okusaka T, Saiura A, Ishii H, Sugiyama M, Furuse J, Sakamoto H, Shimamura T, Ohta T
Int J Clin Oncol 2018 Oct;23(5):894-899. Epub 2018 Apr 28 doi: 10.1007/s10147-018-1283-6. PMID: 29705976
Poorly differentiated adenocarcinoma with signet-ring cells of the Vater's ampulla, without jaundice but with disseminated carcinomatosis.
Nabeshima S, Kishihara Y, Nabeshima A, Yamaga S, Kinjo M, Kashiwagi S, Hayashi J
Fukuoka Igaku Zasshi 2003 Jul;94(7):235-40. PMID: 14509231

Prognosis

Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States.
Kinslow CJ, May MS, Kozak M, Pollom EL, Chang DT
HPB (Oxford) 2020 Dec;22(12):1759-1765. Epub 2020 Apr 18 doi: 10.1016/j.hpb.2020.03.024. PMID: 32317226
Poorly Cohesive (Signet Ring Cell) Carcinoma of the Ampulla of Vater.
Tuncel D, Basturk O, Bradley KT, Kim GE, Xue Y, Reid MD, Balci S, Erbarut I, Adsay V
Int J Surg Pathol 2020 May;28(3):236-244. Epub 2019 Oct 15 doi: 10.1177/1066896919880968. PMID: 31612756
Rapidly Progressing Primary Extrahepatic Bile Duct Signet-Ring Cell Carcinoma in a Caucasian Woman.
Welsh JL, Jaber O, Ivanovic M, Johlin FC, El Abiad RG, Clamon GH, Smith MC, Chan CHF
J Gastrointest Cancer 2018 Mar;49(1):63-66. doi: 10.1007/s12029-016-9843-3. PMID: 27270710
Signet-ring cell carcinoma coexisting with adenocarcinoma arising in a choledochal cyst: report of a case.
Hua R, Zhang JF, Liu W, Huo YM, Sun YW
Surg Today 2015 Aug;45(8):1049-52. Epub 2014 Oct 29 doi: 10.1007/s00595-014-1049-3. PMID: 25352010

Clinical prediction guides

Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Feasibility study of postoperative adjuvant chemotherapy with S-1 in patients with biliary tract cancer.
Nakachi K, Konishi M, Ikeda M, Shimada K, Okusaka T, Saiura A, Ishii H, Sugiyama M, Furuse J, Sakamoto H, Shimamura T, Ohta T
Int J Clin Oncol 2018 Oct;23(5):894-899. Epub 2018 Apr 28 doi: 10.1007/s10147-018-1283-6. PMID: 29705976
Inhibin-expressing clear cell neuroendocrine tumor of the ampulla: an unusual presentation of von Hippel-Lindau disease.
Gucer H, Szentgyorgyi E, Ezzat S, Asa SL, Mete O
Virchows Arch 2013 Oct;463(4):593-7. Epub 2013 Aug 4 doi: 10.1007/s00428-013-1465-6. PMID: 23913169
Signet-ring cell carcinoma of the ampulla of Vater: report of a case.
Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y
Surg Today 2007;37(12):1110-4. Epub 2007 Nov 26 doi: 10.1007/s00595-007-3534-4. PMID: 18030577
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM
Am J Surg Pathol 2005 Mar;29(3):359-67. doi: 10.1097/01.pas.0000149708.12335.6a. PMID: 15725805

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