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Recurrent Malignant Bladder Neoplasm

MedGen UID:
163669
•Concept ID:
C0862326
•
Neoplastic Process

Definition

The reemergence of a malignant bladder neoplasm after a period of remission. [from NCI]

Professional guidelines

PubMed

Advances in diagnosis and treatment of bladder cancer.
Lopez-Beltran A, Cookson MS, Guercio BJ, Cheng L
BMJ 2024 Feb 12;384:e076743. doi: 10.1136/bmj-2023-076743. PMID: 38346808
Bladder Cancer: Diagnosis and Treatment.
DeGeorge KC, Holt HR, Hodges SC
Am Fam Physician 2017 Oct 15;96(8):507-514. PMID: 29094888
Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline.
Chang SS, Boorjian SA, Chou R, Clark PE, Daneshmand S, Konety BR, Pruthi R, Quale DZ, Ritch CR, Seigne JD, Skinner EC, Smith ND, McKiernan JM
J Urol 2016 Oct;196(4):1021-9. Epub 2016 Jun 16 doi: 10.1016/j.juro.2016.06.049. PMID: 27317986

Recent clinical studies

Etiology

Young population bladder neoplasms.
Çivi Çetin K, Öner S, Erdoğan B, Simşek G, Sezer M
Eur Rev Med Pharmacol Sci 2023 Nov;27(21):10454-10461. doi: 10.26355/eurrev_202311_34320. PMID: 37975369
BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer.
Rouanne M, Adam J, Radulescu C, Letourneur D, Bredel D, Mouraud S, Goubet AG, Leduc M, Chen N, Tan TZ, Signolle N, Bigorgne A, Dussiot M, Tselikas L, Susini S, Danlos FX, Schneider AK, Chabanon R, Vacher S, Bièche I, Lebret T, Allory Y, Soria JC, Arpaia N, Kroemer G, Kepp O, Thiery JP, Zitvogel L, Marabelle A
J Clin Invest 2022 Jun 15;132(12) doi: 10.1172/JCI145666. PMID: 35503263Free PMC Article
ctDNA guiding adjuvant immunotherapy in urothelial carcinoma.
Powles T, Assaf ZJ, Davarpanah N, Banchereau R, Szabados BE, Yuen KC, Grivas P, Hussain M, Oudard S, Gschwend JE, Albers P, Castellano D, Nishiyama H, Daneshmand S, Sharma S, Zimmermann BG, Sethi H, Aleshin A, Perdicchio M, Zhang J, Shames DS, Degaonkar V, Shen X, Carter C, Bais C, Bellmunt J, Mariathasan S
Nature 2021 Jul;595(7867):432-437. Epub 2021 Jun 16 doi: 10.1038/s41586-021-03642-9. PMID: 34135506
Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer.
Chen X, Zhang J, Ruan W, Huang M, Wang C, Wang H, Jiang Z, Wang S, Liu Z, Liu C, Tan W, Yang J, Chen J, Chen Z, Li X, Zhang X, Xu P, Chen L, Xie R, Zhou Q, Xu S, Irwin DL, Fan JB, Huang J, Lin T
J Clin Invest 2020 Dec 1;130(12):6278-6289. doi: 10.1172/JCI139597. PMID: 32817589Free PMC Article
Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma.
Christensen E, Birkenkamp-Demtröder K, Sethi H, Shchegrova S, Salari R, Nordentoft I, Wu HT, Knudsen M, Lamy P, Lindskrog SV, Taber A, Balcioglu M, Vang S, Assaf Z, Sharma S, Tin AS, Srinivasan R, Hafez D, Reinert T, Navarro S, Olson A, Ram R, Dashner S, Rabinowitz M, Billings P, Sigurjonsson S, Andersen CL, Swenerton R, Aleshin A, Zimmermann B, Agerbæk M, Lin CJ, Jensen JB, Dyrskjøt L
J Clin Oncol 2019 Jun 20;37(18):1547-1557. Epub 2019 May 6 doi: 10.1200/JCO.18.02052. PMID: 31059311

Diagnosis

NAT10 Drives Cisplatin Chemoresistance by Enhancing ac4C-Associated DNA Repair in Bladder Cancer.
Xie R, Cheng L, Huang M, Huang L, Chen Z, Zhang Q, Li H, Lu J, Wang H, Zhou Q, Huang J, Chen X, Lin T
Cancer Res 2023 May 15;83(10):1666-1683. doi: 10.1158/0008-5472.CAN-22-2233. PMID: 36939377
ctDNA guiding adjuvant immunotherapy in urothelial carcinoma.
Powles T, Assaf ZJ, Davarpanah N, Banchereau R, Szabados BE, Yuen KC, Grivas P, Hussain M, Oudard S, Gschwend JE, Albers P, Castellano D, Nishiyama H, Daneshmand S, Sharma S, Zimmermann BG, Sethi H, Aleshin A, Perdicchio M, Zhang J, Shames DS, Degaonkar V, Shen X, Carter C, Bais C, Bellmunt J, Mariathasan S
Nature 2021 Jul;595(7867):432-437. Epub 2021 Jun 16 doi: 10.1038/s41586-021-03642-9. PMID: 34135506
Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer.
Chen X, Zhang J, Ruan W, Huang M, Wang C, Wang H, Jiang Z, Wang S, Liu Z, Liu C, Tan W, Yang J, Chen J, Chen Z, Li X, Zhang X, Xu P, Chen L, Xie R, Zhou Q, Xu S, Irwin DL, Fan JB, Huang J, Lin T
J Clin Invest 2020 Dec 1;130(12):6278-6289. doi: 10.1172/JCI139597. PMID: 32817589Free PMC Article
Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma.
Christensen E, Birkenkamp-Demtröder K, Sethi H, Shchegrova S, Salari R, Nordentoft I, Wu HT, Knudsen M, Lamy P, Lindskrog SV, Taber A, Balcioglu M, Vang S, Assaf Z, Sharma S, Tin AS, Srinivasan R, Hafez D, Reinert T, Navarro S, Olson A, Ram R, Dashner S, Rabinowitz M, Billings P, Sigurjonsson S, Andersen CL, Swenerton R, Aleshin A, Zimmermann B, Agerbæk M, Lin CJ, Jensen JB, Dyrskjøt L
J Clin Oncol 2019 Jun 20;37(18):1547-1557. Epub 2019 May 6 doi: 10.1200/JCO.18.02052. PMID: 31059311
Bladder cancer.
de Braud F, Maffezzini M, Vitale V, Bruzzi P, Gatta G, Hendry WF, Sternberg CN
Crit Rev Oncol Hematol 2002 Jan;41(1):89-106. doi: 10.1016/s1040-8428(01)00128-7. PMID: 11796234

Therapy

Intermediate-risk Non-muscle-invasive Bladder Cancer: Updated Consensus Definition and Management Recommendations from the International Bladder Cancer Group.
Tan WS, Steinberg G, Witjes JA, Li R, Shariat SF, Roupret M, Babjuk M, Bivalacqua TJ, Psutka SP, Williams SB, Cookson MS, Palou J, Kamat AM
Eur Urol Oncol 2022 Oct;5(5):505-516. Epub 2022 Jun 17 doi: 10.1016/j.euo.2022.05.005. PMID: 35718695
Adjuvant Chemotherapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis of Individual Participant Data from Randomised Controlled Trials.
Advanced Bladder Cancer (ABC) Meta-analysis Collaborators Group
Eur Urol 2022 Jan;81(1):50-61. Epub 2021 Nov 19 doi: 10.1016/j.eururo.2021.09.028. PMID: 34802798Free PMC Article
ctDNA guiding adjuvant immunotherapy in urothelial carcinoma.
Powles T, Assaf ZJ, Davarpanah N, Banchereau R, Szabados BE, Yuen KC, Grivas P, Hussain M, Oudard S, Gschwend JE, Albers P, Castellano D, Nishiyama H, Daneshmand S, Sharma S, Zimmermann BG, Sethi H, Aleshin A, Perdicchio M, Zhang J, Shames DS, Degaonkar V, Shen X, Carter C, Bais C, Bellmunt J, Mariathasan S
Nature 2021 Jul;595(7867):432-437. Epub 2021 Jun 16 doi: 10.1038/s41586-021-03642-9. PMID: 34135506
Perioperative pembrolizumab therapy in muscle-invasive bladder cancer: Phase III KEYNOTE-866 and KEYNOTE-905/EV-303.
Galsky MD, Hoimes CJ, Necchi A, Shore N, Witjes JA, Steinberg G, Bedke J, Nishiyama H, Fang X, Kataria R, Sbar E, Jia X, Siefker-Radtke A
Future Oncol 2021 Aug;17(24):3137-3150. Epub 2021 May 19 doi: 10.2217/fon-2021-0273. PMID: 34008425
Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer.
Chen X, Zhang J, Ruan W, Huang M, Wang C, Wang H, Jiang Z, Wang S, Liu Z, Liu C, Tan W, Yang J, Chen J, Chen Z, Li X, Zhang X, Xu P, Chen L, Xie R, Zhou Q, Xu S, Irwin DL, Fan JB, Huang J, Lin T
J Clin Invest 2020 Dec 1;130(12):6278-6289. doi: 10.1172/JCI139597. PMID: 32817589Free PMC Article

Prognosis

Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Bladder lipoma: Moroccan case report.
Jendouzi O, Boukhlifi Y, Houadfi OE, Essaoudi MA, Alami M, Ameur A
Pan Afr Med J 2020;37:380. Epub 2020 Dec 29 doi: 10.11604/pamj.2020.37.380.25672. PMID: 33796193Free PMC Article
Spotlight on gender-specific disparities in bladder cancer.
Mancini M, Righetto M, Baggio G
Urologia 2020 Aug;87(3):103-114. Epub 2019 Dec 23 doi: 10.1177/0391560319887327. PMID: 31868559
Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients.
Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, Skinner E, Bochner B, Thangathurai D, Mikhail M, Raghavan D, Skinner DG
J Clin Oncol 2001 Feb 1;19(3):666-75. doi: 10.1200/JCO.2001.19.3.666. PMID: 11157016
Extra-adrenal pheochromocytoma.
Whalen RK, Althausen AF, Daniels GH
J Urol 1992 Jan;147(1):1-10. doi: 10.1016/s0022-5347(17)37119-7. PMID: 1729490

Clinical prediction guides

A HER2-targeted Antibody-Drug Conjugate, RC48-ADC, Exerted Promising Antitumor Efficacy and Safety with Intravesical Instillation in Preclinical Models of Bladder Cancer.
Hong X, Chen X, Wang H, Xu Q, Xiao K, Zhang Y, Chi Z, Liu Y, Liu G, Li H, Fang J, Lin T, Zhang Y
Adv Sci (Weinh) 2023 Nov;10(32):e2302377. Epub 2023 Oct 12 doi: 10.1002/advs.202302377. PMID: 37824205Free PMC Article
BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer.
Rouanne M, Adam J, Radulescu C, Letourneur D, Bredel D, Mouraud S, Goubet AG, Leduc M, Chen N, Tan TZ, Signolle N, Bigorgne A, Dussiot M, Tselikas L, Susini S, Danlos FX, Schneider AK, Chabanon R, Vacher S, Bièche I, Lebret T, Allory Y, Soria JC, Arpaia N, Kroemer G, Kepp O, Thiery JP, Zitvogel L, Marabelle A
J Clin Invest 2022 Jun 15;132(12) doi: 10.1172/JCI145666. PMID: 35503263Free PMC Article
ctDNA guiding adjuvant immunotherapy in urothelial carcinoma.
Powles T, Assaf ZJ, Davarpanah N, Banchereau R, Szabados BE, Yuen KC, Grivas P, Hussain M, Oudard S, Gschwend JE, Albers P, Castellano D, Nishiyama H, Daneshmand S, Sharma S, Zimmermann BG, Sethi H, Aleshin A, Perdicchio M, Zhang J, Shames DS, Degaonkar V, Shen X, Carter C, Bais C, Bellmunt J, Mariathasan S
Nature 2021 Jul;595(7867):432-437. Epub 2021 Jun 16 doi: 10.1038/s41586-021-03642-9. PMID: 34135506
Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer.
Chen X, Zhang J, Ruan W, Huang M, Wang C, Wang H, Jiang Z, Wang S, Liu Z, Liu C, Tan W, Yang J, Chen J, Chen Z, Li X, Zhang X, Xu P, Chen L, Xie R, Zhou Q, Xu S, Irwin DL, Fan JB, Huang J, Lin T
J Clin Invest 2020 Dec 1;130(12):6278-6289. doi: 10.1172/JCI139597. PMID: 32817589Free PMC Article
Identification of Differential Tumor Subtypes of T1 Bladder Cancer.
Robertson AG, Groeneveld CS, Jordan B, Lin X, McLaughlin KA, Das A, Fall LA, Fantini D, Taxter TJ, Mogil LS, Lindskrog SV, Dyrskjøt L, McConkey DJ, Svatek RS, de Reyniès A, Castro MAA, Meeks JJ
Eur Urol 2020 Oct;78(4):533-537. Epub 2020 Jul 17 doi: 10.1016/j.eururo.2020.06.048. PMID: 32684305

Recent systematic reviews

Adjuvant Chemotherapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis of Individual Participant Data from Randomised Controlled Trials.
Advanced Bladder Cancer (ABC) Meta-analysis Collaborators Group
Eur Urol 2022 Jan;81(1):50-61. Epub 2021 Nov 19 doi: 10.1016/j.eururo.2021.09.028. PMID: 34802798Free PMC Article
Diagnostic Accuracy of Novel Urinary Biomarker Tests in Non-muscle-invasive Bladder Cancer: A Systematic Review and Network Meta-analysis.
Laukhtina E, Shim SR, Mori K, D'Andrea D, Soria F, Rajwa P, Mostafaei H, Compérat E, Cimadamore A, Moschini M, Teoh JY, Enikeev D, Xylinas E, Lotan Y, Palou J, Gontero P, Babjuk M, Witjes JA, Kamat AM, Roupret M, Shariat SF, Pradere B; European Association of Urology–Young Academic Urologists (EAU-YAU): Urothelial Carcinoma Working Group
Eur Urol Oncol 2021 Dec;4(6):927-942. Epub 2021 Nov 6 doi: 10.1016/j.euo.2021.10.003. PMID: 34753702
Intravesical gemcitabine for non-muscle invasive bladder cancer.
Han MA, Maisch P, Jung JH, Hwang JE, Narayan V, Cleves A, Hwang EC, Dahm P
Cochrane Database Syst Rev 2021 Jun 14;6(6):CD009294. doi: 10.1002/14651858.CD009294.pub3. PMID: 34125951Free PMC Article
Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline.
Chang SS, Boorjian SA, Chou R, Clark PE, Daneshmand S, Konety BR, Pruthi R, Quale DZ, Ritch CR, Seigne JD, Skinner EC, Smith ND, McKiernan JM
J Urol 2016 Oct;196(4):1021-9. Epub 2016 Jun 16 doi: 10.1016/j.juro.2016.06.049. PMID: 27317986
Systematic Review and Individual Patient Data Meta-analysis of Randomized Trials Comparing a Single Immediate Instillation of Chemotherapy After Transurethral Resection with Transurethral Resection Alone in Patients with Stage pTa-pT1 Urothelial Carcinoma of the Bladder: Which Patients Benefit from the Instillation?
Sylvester RJ, Oosterlinck W, Holmang S, Sydes MR, Birtle A, Gudjonsson S, De Nunzio C, Okamura K, Kaasinen E, Solsona E, Ali-El-Dein B, Tatar CA, Inman BA, N'Dow J, Oddens JR, Babjuk M
Eur Urol 2016 Feb;69(2):231-44. Epub 2015 Jun 16 doi: 10.1016/j.eururo.2015.05.050. PMID: 26091833

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