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Metastatic Skin Squamous Cell Carcinoma

MedGen UID:
1639831
Concept ID:
C4087141
Neoplastic Process
Synonym: Metastatic Cutaneous Squamous Cell Carcinoma

Definition

Squamous cell carcinoma of the skin which has spread to other anatomic sites. [from NCI]

Professional guidelines

PubMed

Jones OT, Matin RN, van der Schaar M, Prathivadi Bhayankaram K, Ranmuthu CKI, Islam MS, Behiyat D, Boscott R, Calanzani N, Emery J, Williams HC, Walter FM
Lancet Digit Health 2022 Jun;4(6):e466-e476. doi: 10.1016/S2589-7500(22)00023-1. PMID: 35623799
Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, Bataille V, Bastholt L, Dreno B, Concetta Fargnoli M, Forsea AM, Frenard C, Harwood CA, Hauschild A, Hoeller C, Kandolf-Sekulovic L, Kaufmann R, Kelleners-Smeets NWJ, Malvehy J, Del Marmol V, Middleton MR, Moreno-Ramirez D, Pellecani G, Peris K, Saiag P, van den Beuken-van Everdingen MHJ, Vieira R, Zalaudek I, Eggermont AMM, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2020 Mar;128:83-102. Epub 2020 Feb 26 doi: 10.1016/j.ejca.2020.01.008. PMID: 32113942
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406

Recent clinical studies

Etiology

de Jong E, Lammerts MUPA, Genders RE, Bouwes Bavinck JN
J Eur Acad Dermatol Venereol 2022 Jan;36 Suppl 1(Suppl 1):6-10. doi: 10.1111/jdv.17728. PMID: 34855246Free PMC Article
Corchado-Cobos R, García-Sancha N, González-Sarmiento R, Pérez-Losada J, Cañueto J
Int J Mol Sci 2020 Apr 22;21(8) doi: 10.3390/ijms21082956. PMID: 32331425Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979
Que SKT, Zwald FO, Schmults CD
J Am Acad Dermatol 2018 Feb;78(2):237-247. doi: 10.1016/j.jaad.2017.08.059. PMID: 29332704
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187

Diagnosis

de Jong E, Lammerts MUPA, Genders RE, Bouwes Bavinck JN
J Eur Acad Dermatol Venereol 2022 Jan;36 Suppl 1(Suppl 1):6-10. doi: 10.1111/jdv.17728. PMID: 34855246Free PMC Article
Schmults CD, Blitzblau R, Aasi SZ, Alam M, Andersen JS, Baumann BC, Bordeaux J, Chen PL, Chin R, Contreras CM, DiMaio D, Donigan JM, Farma JM, Ghosh K, Grekin RC, Harms K, Ho AL, Holder A, Lukens JN, Medina T, Nehal KS, Nghiem P, Park S, Patel T, Puzanov I, Scott J, Sekulic A, Shaha AR, Srivastava D, Stebbins W, Thomas V, Xu YG, McCullough B, Dwyer MA, Nguyen MQ
J Natl Compr Canc Netw 2021 Dec;19(12):1382-1394. doi: 10.6004/jnccn.2021.0059. PMID: 34902824
Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, Bataille V, Bastholt L, Dreno B, Concetta Fargnoli M, Forsea AM, Frenard C, Harwood CA, Hauschild A, Hoeller C, Kandolf-Sekulovic L, Kaufmann R, Kelleners-Smeets NWJ, Malvehy J, Del Marmol V, Middleton MR, Moreno-Ramirez D, Pellecani G, Peris K, Saiag P, van den Beuken-van Everdingen MHJ, Vieira R, Zalaudek I, Eggermont AMM, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2020 Mar;128:83-102. Epub 2020 Feb 26 doi: 10.1016/j.ejca.2020.01.008. PMID: 32113942
Que SKT, Zwald FO, Schmults CD
J Am Acad Dermatol 2018 Feb;78(2):237-247. doi: 10.1016/j.jaad.2017.08.059. PMID: 29332704
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187

Therapy

Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Kaufman HL, Seebach F, Lowy I, Yoo SY, Mathias M, Fenech K, Han H, Fury MG, Rischin D
N Engl J Med 2022 Oct 27;387(17):1557-1568. Epub 2022 Sep 12 doi: 10.1056/NEJMoa2209813. PMID: 36094839Free PMC Article
Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, Bataille V, Bastholt L, Dreno B, Concetta Fargnoli M, Forsea AM, Frenard C, Harwood CA, Hauschild A, Hoeller C, Kandolf-Sekulovic L, Kaufmann R, Kelleners-Smeets NWJ, Malvehy J, Del Marmol V, Middleton MR, Moreno-Ramirez D, Pellecani G, Peris K, Saiag P, van den Beuken-van Everdingen MHJ, Vieira R, Zalaudek I, Eggermont AMM, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2020 Mar;128:83-102. Epub 2020 Feb 26 doi: 10.1016/j.ejca.2020.01.008. PMID: 32113942
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979
Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, Peyrade F, Benasso M, Vynnychenko I, De Raucourt D, Bokemeyer C, Schueler A, Amellal N, Hitt R
N Engl J Med 2008 Sep 11;359(11):1116-27. doi: 10.1056/NEJMoa0802656. PMID: 18784101

Prognosis

Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Rischin D, Migden MR, Lim AM, Schmults CD, Khushalani NI, Hughes BGM, Schadendorf D, Dunn LA, Hernandez-Aya L, Chang ALS, Modi B, Hauschild A, Ulrich C, Eigentler T, Stein B, Pavlick AC, Geiger JL, Gutzmer R, Alam M, Okoye E, Mathias M, Jankovic V, Stankevich E, Booth J, Li S, Lowy I, Fury MG, Guminski A
J Immunother Cancer 2020 Jun;8(1) doi: 10.1136/jitc-2020-000775. PMID: 32554615Free PMC Article
Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, Bataille V, Bastholt L, Dreno B, Fargnoli MC, Forsea AM, Frenard C, Harwood CΑ, Hauschild A, Hoeller C, Kandolf-Sekulovic L, Kaufmann R, Kelleners-Smeets NW, Malvehy J, Del Marmol V, Middleton MR, Moreno-Ramirez D, Pellecani G, Peris K, Saiag P, van den Beuken-van Everdingen MHJ, Vieira R, Zalaudek I, Eggermont AMM, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2020 Mar;128:60-82. Epub 2020 Feb 26 doi: 10.1016/j.ejca.2020.01.007. PMID: 32113941
Que SKT, Zwald FO, Schmults CD
J Am Acad Dermatol 2018 Feb;78(2):237-247. doi: 10.1016/j.jaad.2017.08.059. PMID: 29332704
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187

Clinical prediction guides

Allen NC, Martin AJ, Snaidr VA, Eggins R, Chong AH, Fernandéz-Peñas P, Gin D, Sidhu S, Paddon VL, Banney LA, Lim A, Upjohn E, Schaider H, Ganhewa AD, Nguyen J, McKenzie CA, Prakash S, McLean C, Lochhead A, Ibbetson J, Dettrick A, Landgren A, Allnutt KJ, Allison C, Davenport RB, Mumford BP, Wong B, Stagg B, Tedman A, Gribbin H, Edwards HA, De Rosa N, Stewart T, Doolan BJ, Kok Y, Simpson K, Low ZM, Kovitwanichkanont T, Scolyer RA, Dhillon HM, Vardy JL, Chadban SJ, Bowen DG, Chen AC, Damian DL
N Engl J Med 2023 Mar 2;388(9):804-812. doi: 10.1056/NEJMoa2203086. PMID: 36856616
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Kaufman HL, Seebach F, Lowy I, Yoo SY, Mathias M, Fenech K, Han H, Fury MG, Rischin D
N Engl J Med 2022 Oct 27;387(17):1557-1568. Epub 2022 Sep 12 doi: 10.1056/NEJMoa2209813. PMID: 36094839Free PMC Article
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187

Recent systematic reviews

Jones OT, Matin RN, van der Schaar M, Prathivadi Bhayankaram K, Ranmuthu CKI, Islam MS, Behiyat D, Boscott R, Calanzani N, Emery J, Williams HC, Walter FM
Lancet Digit Health 2022 Jun;4(6):e466-e476. doi: 10.1016/S2589-7500(22)00023-1. PMID: 35623799
Mainville L, Smilga AS, Fortin PR
J Cutan Med Surg 2022 May-Jun;26(3):297-308. Epub 2022 Feb 8 doi: 10.1177/12034754221078201. PMID: 35134311Free PMC Article
Corrigan RA, Barlow G, Hartley C, McNally M
Surgeon 2022 Dec;20(6):e322-e337. Epub 2021 Dec 28 doi: 10.1016/j.surge.2021.12.003. PMID: 34969605
Naik PP
Dermatol Ther 2021 Nov;34(6):e15184. Epub 2021 Nov 8 doi: 10.1111/dth.15184. PMID: 34716727
Green AC, McBride P
BMJ Clin Evid 2014 Aug 18;2014 PMID: 25137222Free PMC Article

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