U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal chylomicron concentration

MedGen UID:
1642949
•Concept ID:
C4703599
•
Finding
HPO: HP:0031887

Definition

Any deviation from the normal circulating concentration of chylomicrons. [from HPO]

Professional guidelines

PubMed

Apolipoprotein profiling as a personalized approach to the diagnosis and treatment of dyslipidaemia.
Renee Ruhaak L, van der Laarse A, Cobbaert CM
Ann Clin Biochem 2019 May;56(3):338-356. Epub 2019 Mar 19 doi: 10.1177/0004563219827620. PMID: 30889974Free PMC Article
Recommendations for severe hypertriglyceridemia treatment, are there new strategies?
Filippatos TD, Elisaf MS
Curr Vasc Pharmacol 2014;12(4):598-616. doi: 10.2174/15701611113119990133. PMID: 23627980
Lipoprotein modifications during dietary treatment in patients with primary type V hyperlipoproteinaemia.
Manzato E, Marin R, Gasparotto A, Baggio G, Martini S, Gabelli C, Crepaldi G
Eur J Clin Invest 1986 Apr;16(2):149-56. doi: 10.1111/j.1365-2362.1986.tb01322.x. PMID: 3089810

Recent clinical studies

Etiology

Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Isolation of remnant particles by immunoseparation: a new approach for investigation of postprandial lipoprotein metabolism in normolipidemic subjects.
Schreuder PC, Twickler TB, Wang T, Nakajima K, Erkelens DW, Dallinga-Thie GM
Atherosclerosis 2001 Jul;157(1):145-50. doi: 10.1016/s0021-9150(00)00666-3. PMID: 11427214
Fasting remnant lipoprotein cholesterol and triglyceride concentrations are elevated in nondiabetic, insulin-resistant, female volunteers.
Abbasi F, McLaughlin T, Lamendola C, Yeni-Komshian H, Tanaka A, Wang T, Nakajima K, Reaven GM
J Clin Endocrinol Metab 1999 Nov;84(11):3903-6. doi: 10.1210/jcem.84.11.6136. PMID: 10566626
Mechanisms of hepatic chylomicron remnant clearance.
Willnow TE
Diabet Med 1997 Aug;14 Suppl 3:S75-80. doi: 10.1002/(sici)1096-9136(199708)14:3+<s75::aid-dia449>3.3.co;2-0. PMID: 9272618
The relative importance of the factors involved in the absorption of vitamin E in children.
Muller DP, Harries JT, Lloyd JK
Gut 1974 Dec;15(12):966-71. doi: 10.1136/gut.15.12.966. PMID: 4448411Free PMC Article

Diagnosis

A case report of pseudo-hypertriglyceridemia.
Hajar S, Boumraya S, Tali A
Ann Biol Clin (Paris) 2021 Oct 1;79(5):453-455. doi: 10.1684/abc.2021.1674. PMID: 34726160
Apolipoprotein profiling as a personalized approach to the diagnosis and treatment of dyslipidaemia.
Renee Ruhaak L, van der Laarse A, Cobbaert CM
Ann Clin Biochem 2019 May;56(3):338-356. Epub 2019 Mar 19 doi: 10.1177/0004563219827620. PMID: 30889974Free PMC Article
Contribution of triglyceride-rich lipoproteins to plasma free fatty acids.
Miles JM, Nelson RH
Horm Metab Res 2007 Oct;39(10):726-9. doi: 10.1055/s-2007-990273. PMID: 17952834
Comparison of triglyceride concentration with lipemic index in disorders of triglyceride and glycerol metabolism.
De Haene H, Taes Y, Christophe A, Delanghe J
Clin Chem Lab Med 2006;44(2):220-2. doi: 10.1515/CCLM.2006.040. PMID: 16475911
Fasting remnant lipoprotein cholesterol and triglyceride concentrations are elevated in nondiabetic, insulin-resistant, female volunteers.
Abbasi F, McLaughlin T, Lamendola C, Yeni-Komshian H, Tanaka A, Wang T, Nakajima K, Reaven GM
J Clin Endocrinol Metab 1999 Nov;84(11):3903-6. doi: 10.1210/jcem.84.11.6136. PMID: 10566626

Therapy

Impact of Chronic Hepatitis C Virus Genotype 1b Infection on Triglyceride Concentration in Serum Lipoprotein Fractions.
Nagano T, Seki N, Tomita Y, Sugita T, Aida Y, Itagaki M, Sutoh S, Abe H, Tsubota A, Aizawa Y
Int J Mol Sci 2015 Aug 31;16(9):20576-94. doi: 10.3390/ijms160920576. PMID: 26334270Free PMC Article
Abnormal postprandial apolipoprotein B-48 and triglyceride responses in normolipidemic women with greater than 70% stenotic coronary artery disease: a case-control study.
Meyer E, Westerveld HT, de Ruyter-Meijstek FC, van Greevenbroek MM, Rienks R, van Rijn HJ, Erkelens DW, de Bruin TW
Atherosclerosis 1996 Aug 2;124(2):221-35. doi: 10.1016/0021-9150(96)05832-7. PMID: 8830935
HDL from type III dysbetalipoproteinaemic patients show decreased capacity to inhibit VLDL uptake in rat liver endothelial cells.
Gustafson S, Vessby B, Ostlund-Lindqvist AM, Ehnholm C
Atherosclerosis 1986 Nov;62(2):145-9. doi: 10.1016/0021-9150(86)90060-2. PMID: 3801082
High density lipoprotein changes during treatment of diabetic ketoacidosis.
Joven J, Rubiés-Prat J, de la Figuera M, Valdés M, Villabona CM, Chacón P, Masdeu S
Diabete Metab 1985 Apr;11(2):102-5. PMID: 3924672
The relative importance of the factors involved in the absorption of vitamin E in children.
Muller DP, Harries JT, Lloyd JK
Gut 1974 Dec;15(12):966-71. doi: 10.1136/gut.15.12.966. PMID: 4448411Free PMC Article

Prognosis

Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Lipoprotein particle concentrations in children and adults following Kawasaki disease.
Lin J, Jain S, Sun X, Liu V, Sato YZ, Jimenez-Fernandez S, Newfield RS, Pourfarzib R, Tremoulet AH, Gordon JB, Daniels LB, Burns JC
J Pediatr 2014 Oct;165(4):727-31. Epub 2014 Jul 16 doi: 10.1016/j.jpeds.2014.06.017. PMID: 25039043Free PMC Article
Reducing lipids for CV protection in CKD patients-current evidence.
Wanner C, Ritz E
Kidney Int Suppl 2008 Dec;(111):S24-8. doi: 10.1038/ki.2008.520. PMID: 19034322
Beta-VLDL accumulation in familial dysbetalipoproteinemia is associated with increased exchange or diffusion of chylomicron lipids to apo B-100 containing triglyceride-rich lipoproteins.
Demacker PN, Bredie SJ, Vogelaar JM, Hectors MP, van Heijst P, Stuyt PM, Stalenhoef AF
Atherosclerosis 1998 Jun;138(2):301-12. doi: 10.1016/s0021-9150(98)00035-5. PMID: 9690913
Lipoprotein metabolism in liver disease.
Sabesin SM, Bertram PD, Freeman MR
Adv Intern Med 1980;25:117-46. PMID: 6987838

Clinical prediction guides

Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Lipoprotein metabolism and CKD: overview.
Barter P
Clin Exp Nephrol 2014 Apr;18(2):243-6. Epub 2013 Sep 20 doi: 10.1007/s10157-013-0866-9. PMID: 24052157
Beta-VLDL accumulation in familial dysbetalipoproteinemia is associated with increased exchange or diffusion of chylomicron lipids to apo B-100 containing triglyceride-rich lipoproteins.
Demacker PN, Bredie SJ, Vogelaar JM, Hectors MP, van Heijst P, Stuyt PM, Stalenhoef AF
Atherosclerosis 1998 Jun;138(2):301-12. doi: 10.1016/s0021-9150(98)00035-5. PMID: 9690913
An investigation of the abnormal metabolic status of synovial fluid from patients with rheumatoid arthritis by high field proton nuclear magnetic resonance spectroscopy.
Naughton D, Whelan M, Smith EC, Williams R, Blake DR, Grootveld M
FEBS Lett 1993 Feb 8;317(1-2):135-8. doi: 10.1016/0014-5793(93)81508-w. PMID: 8381364
Tocopherol content of adipose tissue from vitamin E-deficient humans.
Kayden HJ
Ciba Found Symp 1983;101:70-91. doi: 10.1002/9780470720820.ch6. PMID: 6360590

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...