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Abnormal chylomicron concentration

MedGen UID:
1642949
•Concept ID:
C4703599
•
Finding
HPO: HP:0031887

Definition

Any deviation from the normal circulating concentration of chylomicrons. [from HPO]

Professional guidelines

PubMed

Apolipoprotein profiling as a personalized approach to the diagnosis and treatment of dyslipidaemia.
Renee Ruhaak L, van der Laarse A, Cobbaert CM
Ann Clin Biochem 2019 May;56(3):338-356. Epub 2019 Mar 19 doi: 10.1177/0004563219827620. PMID: 30889974Free PMC Article
Recommendations for severe hypertriglyceridemia treatment, are there new strategies?
Filippatos TD, Elisaf MS
Curr Vasc Pharmacol 2014;12(4):598-616. doi: 10.2174/15701611113119990133. PMID: 23627980
Lipoprotein modifications during dietary treatment in patients with primary type V hyperlipoproteinaemia.
Manzato E, Marin R, Gasparotto A, Baggio G, Martini S, Gabelli C, Crepaldi G
Eur J Clin Invest 1986 Apr;16(2):149-56. doi: 10.1111/j.1365-2362.1986.tb01322.x. PMID: 3089810

Recent clinical studies

Etiology

Apolipoprotein profiling as a personalized approach to the diagnosis and treatment of dyslipidaemia.
Renee Ruhaak L, van der Laarse A, Cobbaert CM
Ann Clin Biochem 2019 May;56(3):338-356. Epub 2019 Mar 19 doi: 10.1177/0004563219827620. PMID: 30889974Free PMC Article
Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Recommendations for severe hypertriglyceridemia treatment, are there new strategies?
Filippatos TD, Elisaf MS
Curr Vasc Pharmacol 2014;12(4):598-616. doi: 10.2174/15701611113119990133. PMID: 23627980
Mechanisms of hepatic chylomicron remnant clearance.
Willnow TE
Diabet Med 1997 Aug;14 Suppl 3:S75-80. doi: 10.1002/(sici)1096-9136(199708)14:3+<s75::aid-dia449>3.3.co;2-0. PMID: 9272618
Recent progress in understanding apolipoprotein B.
Young SG
Circulation 1990 Nov;82(5):1574-94. doi: 10.1161/01.cir.82.5.1574. PMID: 1977530

Diagnosis

A case report of pseudo-hypertriglyceridemia.
Hajar S, Boumraya S, Tali A
Ann Biol Clin (Paris) 2021 Oct 1;79(5):453-455. doi: 10.1684/abc.2021.1674. PMID: 34726160
Apolipoprotein profiling as a personalized approach to the diagnosis and treatment of dyslipidaemia.
Renee Ruhaak L, van der Laarse A, Cobbaert CM
Ann Clin Biochem 2019 May;56(3):338-356. Epub 2019 Mar 19 doi: 10.1177/0004563219827620. PMID: 30889974Free PMC Article
Long-Term Efficacy and Safety of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor-α Modulator (SPPARMα), in Dyslipidemic Patients with Renal Impairment.
Yokote K, Yamashita S, Arai H, Araki E, Suganami H, Ishibashi S, Of The K-Study Group OB
Int J Mol Sci 2019 Feb 6;20(3) doi: 10.3390/ijms20030706. PMID: 30736366Free PMC Article
The effect of antidiabetic drugs on genes regulating lipid metabolism.
Tomkin GH
Curr Opin Lipidol 2009 Feb;20(1):10-6. doi: 10.1097/MOL.0b013e32831ac56c. PMID: 19106706
Lipoprotein metabolism in liver disease.
Sabesin SM, Bertram PD, Freeman MR
Adv Intern Med 1980;25:117-46. PMID: 6987838

Therapy

Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study.
Berge RK, Ramsvik MS, Bohov P, Svardal A, Nordrehaug JE, Rostrup E, Bruheim I, Bjørndal B
Lipids Health Dis 2015 Dec 15;14:163. doi: 10.1186/s12944-015-0162-7. PMID: 26666303Free PMC Article
Recommendations for severe hypertriglyceridemia treatment, are there new strategies?
Filippatos TD, Elisaf MS
Curr Vasc Pharmacol 2014;12(4):598-616. doi: 10.2174/15701611113119990133. PMID: 23627980
Reducing lipids for CV protection in CKD patients-current evidence.
Wanner C, Ritz E
Kidney Int Suppl 2008 Dec;(111):S24-8. doi: 10.1038/ki.2008.520. PMID: 19034322
Metabolism and function of myo-inositol and inositol phospholipids.
Holub BJ
Annu Rev Nutr 1986;6:563-97. doi: 10.1146/annurev.nu.06.070186.003023. PMID: 2425833
Chylomicronaemia in multiple myeloma.
Aviram M, Carter A, Brook JG, Tatarsky I
Scand J Haematol 1985 May;34(5):436-41. doi: 10.1111/j.1600-0609.1985.tb00774.x. PMID: 4012223

Prognosis

Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Lipoprotein particle concentrations in children and adults following Kawasaki disease.
Lin J, Jain S, Sun X, Liu V, Sato YZ, Jimenez-Fernandez S, Newfield RS, Pourfarzib R, Tremoulet AH, Gordon JB, Daniels LB, Burns JC
J Pediatr 2014 Oct;165(4):727-31. Epub 2014 Jul 16 doi: 10.1016/j.jpeds.2014.06.017. PMID: 25039043Free PMC Article
Reducing lipids for CV protection in CKD patients-current evidence.
Wanner C, Ritz E
Kidney Int Suppl 2008 Dec;(111):S24-8. doi: 10.1038/ki.2008.520. PMID: 19034322
Atherosclerotic risk factors in cardiovascular disease.
LaRosa JC
J Reprod Med 1986 Sep;31(9 Suppl):906-12. PMID: 3772910
Lipoprotein metabolism in liver disease.
Sabesin SM, Bertram PD, Freeman MR
Adv Intern Med 1980;25:117-46. PMID: 6987838

Clinical prediction guides

Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Lipoprotein metabolism and CKD: overview.
Barter P
Clin Exp Nephrol 2014 Apr;18(2):243-6. Epub 2013 Sep 20 doi: 10.1007/s10157-013-0866-9. PMID: 24052157
Reducing lipids for CV protection in CKD patients-current evidence.
Wanner C, Ritz E
Kidney Int Suppl 2008 Dec;(111):S24-8. doi: 10.1038/ki.2008.520. PMID: 19034322
Dietary fatty acids and chylomicron synthesis and secretion.
Williams CM, Bateman PA, Jackson KG, Yaqoob P
Biochem Soc Trans 2004 Feb;32(Pt 1):55-8. doi: 10.1042/bst0320055. PMID: 14748712
Chylomicronaemia in multiple myeloma.
Aviram M, Carter A, Brook JG, Tatarsky I
Scand J Haematol 1985 May;34(5):436-41. doi: 10.1111/j.1600-0609.1985.tb00774.x. PMID: 4012223

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