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Refractory WHO Grade 3 Glioma

MedGen UID:
1659708
Concept ID:
C4727432
Neoplastic Process
Synonym: Refractory WHO Grade III Glioma

Definition

A WHO grade 3 glioma that is resistant to treatment. [from NCI]

Recent clinical studies

Etiology

Xue B, Hou Z, Deng Z, Sun S, Zhang C, Pan Y, Zhang Y, Li Z, Xie J
Cancer Med 2024 Jun;13(11):e7377. doi: 10.1002/cam4.7377. PMID: 38850123Free PMC Article
Zhang D, Li H, Jia W
Neurol Sci 2023 May;44(5):1755-1764. Epub 2023 Jan 6 doi: 10.1007/s10072-022-06557-z. PMID: 36604383Free PMC Article
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Reiss SN, Yerram P, Modelevsky L, Grommes C
J Immunother Cancer 2017 Dec 19;5(1):99. doi: 10.1186/s40425-017-0302-x. PMID: 29254497Free PMC Article
Gounder MM, Nayak L, Sahebjam S, Muzikansky A, Sanchez AJ, Desideri S, Ye X, Ivy SP, Nabors LB, Prados M, Grossman S, DeAngelis LM, Wen PY
J Clin Oncol 2015 Oct 1;33(28):3186-92. Epub 2015 Aug 17 doi: 10.1200/JCO.2015.61.1525. PMID: 26282642Free PMC Article

Diagnosis

Evans L, Walker R, MacDiarmid J, Brahmbhatt H, Anazodo A, McCowage G, Gifford AJ, Kavallaris M, Trahair T, Ziegler DS
Target Oncol 2024 May;19(3):333-342. Epub 2024 Mar 28 doi: 10.1007/s11523-024-01051-2. PMID: 38546944Free PMC Article
Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Zhang D, Li H, Jia W
Neurol Sci 2023 May;44(5):1755-1764. Epub 2023 Jan 6 doi: 10.1007/s10072-022-06557-z. PMID: 36604383Free PMC Article
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Aykut-Bingol C, Bronen RA, Kim JH, Spencer DD, Spencer SS
Ann Neurol 1998 Jul;44(1):60-9. doi: 10.1002/ana.410440112. PMID: 9667593

Therapy

Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Myers RM, Taraseviciute A, Steinberg SM, Lamble AJ, Sheppard J, Yates B, Kovach AE, Wood B, Borowitz MJ, Stetler-Stevenson M, Yuan CM, Pillai V, Foley T, Chung P, Chen L, Lee DW, Annesley C, DiNofia A, Grupp SA, John S, Bhojwani D, Brown PA, Laetsch TW, Gore L, Gardner RA, Rheingold SR, Pulsipher MA, Shah NN
J Clin Oncol 2022 Mar 20;40(9):932-944. Epub 2021 Nov 12 doi: 10.1200/JCO.21.01405. PMID: 34767461Free PMC Article
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Reiss SN, Yerram P, Modelevsky L, Grommes C
J Immunother Cancer 2017 Dec 19;5(1):99. doi: 10.1186/s40425-017-0302-x. PMID: 29254497Free PMC Article
Grimm SA, Chamberlain MC
CNS Oncol 2015;4(5):333-9. Epub 2015 Oct 28 doi: 10.2217/cns.15.27. PMID: 26509217Free PMC Article

Prognosis

Xue B, Hou Z, Deng Z, Sun S, Zhang C, Pan Y, Zhang Y, Li Z, Xie J
Cancer Med 2024 Jun;13(11):e7377. doi: 10.1002/cam4.7377. PMID: 38850123Free PMC Article
Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Zhang D, Li H, Jia W
Neurol Sci 2023 May;44(5):1755-1764. Epub 2023 Jan 6 doi: 10.1007/s10072-022-06557-z. PMID: 36604383Free PMC Article
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Kong DS, Lee JI, Kim JH, Kim ST, Kim WS, Suh YL, Dong SM, Nam DH
Neuro Oncol 2010 Mar;12(3):289-96. Epub 2010 Jan 11 doi: 10.1093/neuonc/nop030. PMID: 20167817Free PMC Article

Clinical prediction guides

Xue B, Hou Z, Deng Z, Sun S, Zhang C, Pan Y, Zhang Y, Li Z, Xie J
Cancer Med 2024 Jun;13(11):e7377. doi: 10.1002/cam4.7377. PMID: 38850123Free PMC Article
Zhang D, Li H, Jia W
Neurol Sci 2023 May;44(5):1755-1764. Epub 2023 Jan 6 doi: 10.1007/s10072-022-06557-z. PMID: 36604383Free PMC Article
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Gounder MM, Nayak L, Sahebjam S, Muzikansky A, Sanchez AJ, Desideri S, Ye X, Ivy SP, Nabors LB, Prados M, Grossman S, DeAngelis LM, Wen PY
J Clin Oncol 2015 Oct 1;33(28):3186-92. Epub 2015 Aug 17 doi: 10.1200/JCO.2015.61.1525. PMID: 26282642Free PMC Article
Aykut-Bingol C, Bronen RA, Kim JH, Spencer DD, Spencer SS
Ann Neurol 1998 Jul;44(1):60-9. doi: 10.1002/ana.410440112. PMID: 9667593

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