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Refractory WHO Grade 3 Glioma

MedGen UID:
1659708
•Concept ID:
C4727432
•
Neoplastic Process
Synonym: Refractory WHO Grade III Glioma

Definition

A WHO grade 3 glioma that is resistant to treatment. [from NCI]

Recent clinical studies

Etiology

A multi-center prospective study of re-irradiation with bevacizumab and temozolomide in patients with bevacizumab refractory recurrent high-grade gliomas.
Dixit KS, Sachdev S, Amidei C, Kumthekar P, Kruser TJ, Gondi V, Grimm S, Lukas RV, Nicholas MK, Chmura SJ, Fought AJ, Mehta M, Raizer JJ
J Neurooncol 2021 Dec;155(3):297-306. Epub 2021 Oct 24 doi: 10.1007/s11060-021-03875-8. PMID: 34689306
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
High-level Sp1 is Associated with Proliferation, Invasion, and Poor Prognosis in Astrocytoma.
Chen YT, Tsai HP, Wu CC, Chen CY, Chai CY, Kwan AL
Pathol Oncol Res 2019 Jul;25(3):1003-1013. Epub 2018 Jun 9 doi: 10.1007/s12253-018-0422-8. PMID: 29948615
Trametinib for progressive pediatric low-grade gliomas.
Kondyli M, Larouche V, Saint-Martin C, Ellezam B, Pouliot L, Sinnett D, Legault G, Crevier L, Weil A, Farmer JP, Jabado N, Perreault S
J Neurooncol 2018 Nov;140(2):435-444. Epub 2018 Aug 10 doi: 10.1007/s11060-018-2971-9. PMID: 30097824
Retrospective study of nivolumab for patients with recurrent high grade gliomas.
Mantica M, Pritchard A, Lieberman F, Drappatz J
J Neurooncol 2018 Sep;139(3):625-631. Epub 2018 May 19 doi: 10.1007/s11060-018-2907-4. PMID: 29779086

Diagnosis

Exploration of the prognostic value of the resection of adult brainstem high-grade glioma based on competing risk model, propensity score matching, and conditional survival rate.
Zhang D, Li H, Jia W
Neurol Sci 2023 May;44(5):1755-1764. Epub 2023 Jan 6 doi: 10.1007/s10072-022-06557-z. PMID: 36604383Free PMC Article
Outcomes of salvage fractionated re-irradiation combined with bevacizumab for recurrent high-grade gliomas that progressed after bevacizumab treatment*.
Yonezawa H, Ohno M, Igaki H, Miyakita Y, Takahashi M, Tamura Y, Shima S, Matsushita Y, Ichimura K, Narita Y
Jpn J Clin Oncol 2021 Jul 1;51(7):1028-1035. doi: 10.1093/jjco/hyab063. PMID: 33959771
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Trametinib for progressive pediatric low-grade gliomas.
Kondyli M, Larouche V, Saint-Martin C, Ellezam B, Pouliot L, Sinnett D, Legault G, Crevier L, Weil A, Farmer JP, Jabado N, Perreault S
J Neurooncol 2018 Nov;140(2):435-444. Epub 2018 Aug 10 doi: 10.1007/s11060-018-2971-9. PMID: 30097824
High expression of cystine-glutamate antiporter xCT (SLC7A11) is an independent biomarker for epileptic seizures at diagnosis in glioma.
Sørensen MF, Heimisdóttir SB, Sørensen MD, Mellegaard CS, Wohlleben H, Kristensen BW, Beier CP
J Neurooncol 2018 May;138(1):49-53. Epub 2018 Feb 5 doi: 10.1007/s11060-018-2785-9. PMID: 29404978

Therapy

Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL.
Myers RM, Taraseviciute A, Steinberg SM, Lamble AJ, Sheppard J, Yates B, Kovach AE, Wood B, Borowitz MJ, Stetler-Stevenson M, Yuan CM, Pillai V, Foley T, Chung P, Chen L, Lee DW, Annesley C, DiNofia A, Grupp SA, John S, Bhojwani D, Brown PA, Laetsch TW, Gore L, Gardner RA, Rheingold SR, Pulsipher MA, Shah NN
J Clin Oncol 2022 Mar 20;40(9):932-944. Epub 2021 Nov 12 doi: 10.1200/JCO.21.01405. PMID: 34767461Free PMC Article
Intraarterial delivery of bevacizumab and cetuximab utilizing blood-brain barrier disruption in children with high-grade glioma and diffuse intrinsic pontine glioma: results of a phase I trial.
McCrea HJ, Ivanidze J, O'Connor A, Hersh EH, Boockvar JA, Gobin YP, Knopman J, Greenfield JP
J Neurosurg Pediatr 2021 Aug 6;28(4):371-379. doi: 10.3171/2021.3.PEDS20738. PMID: 34359048
Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation-Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study.
Hargrave DR, Bouffet E, Tabori U, Broniscer A, Cohen KJ, Hansford JR, Geoerger B, Hingorani P, Dunkel IJ, Russo MW, Tseng L, Dasgupta K, Gasal E, Whitlock JA, Kieran MW
Clin Cancer Res 2019 Dec 15;25(24):7303-7311. doi: 10.1158/1078-0432.CCR-19-2177. PMID: 31811016
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Bevacizumab and other novel therapies for recurrent oligodendroglial tumors.
Grimm SA, Chamberlain MC
CNS Oncol 2015;4(5):333-9. Epub 2015 Oct 28 doi: 10.2217/cns.15.27. PMID: 26509217Free PMC Article

Prognosis

Exploration of the prognostic value of the resection of adult brainstem high-grade glioma based on competing risk model, propensity score matching, and conditional survival rate.
Zhang D, Li H, Jia W
Neurol Sci 2023 May;44(5):1755-1764. Epub 2023 Jan 6 doi: 10.1007/s10072-022-06557-z. PMID: 36604383Free PMC Article
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
High-level Sp1 is Associated with Proliferation, Invasion, and Poor Prognosis in Astrocytoma.
Chen YT, Tsai HP, Wu CC, Chen CY, Chai CY, Kwan AL
Pathol Oncol Res 2019 Jul;25(3):1003-1013. Epub 2018 Jun 9 doi: 10.1007/s12253-018-0422-8. PMID: 29948615
Angiocentric glioma transformed into anaplastic ependymoma: Review of the evidence for malignant potential.
McCracken JA, Gonzales MF, Phal PM, Drummond KJ
J Clin Neurosci 2016 Dec;34:47-52. Epub 2016 Oct 11 doi: 10.1016/j.jocn.2016.08.012. PMID: 27742374
Phase I study of non-pegylated liposomal doxorubicin in children with recurrent/refractory high-grade glioma.
Chastagner P, Devictor B, Geoerger B, Aerts I, Leblond P, Frappaz D, Gentet JC, Bracard S, André N
Cancer Chemother Pharmacol 2015 Aug;76(2):425-32. Epub 2015 Jun 27 doi: 10.1007/s00280-015-2781-0. PMID: 26115930

Clinical prediction guides

Exploration of the prognostic value of the resection of adult brainstem high-grade glioma based on competing risk model, propensity score matching, and conditional survival rate.
Zhang D, Li H, Jia W
Neurol Sci 2023 May;44(5):1755-1764. Epub 2023 Jan 6 doi: 10.1007/s10072-022-06557-z. PMID: 36604383Free PMC Article
A multi-center prospective study of re-irradiation with bevacizumab and temozolomide in patients with bevacizumab refractory recurrent high-grade gliomas.
Dixit KS, Sachdev S, Amidei C, Kumthekar P, Kruser TJ, Gondi V, Grimm S, Lukas RV, Nicholas MK, Chmura SJ, Fought AJ, Mehta M, Raizer JJ
J Neurooncol 2021 Dec;155(3):297-306. Epub 2021 Oct 24 doi: 10.1007/s11060-021-03875-8. PMID: 34689306
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Trametinib for progressive pediatric low-grade gliomas.
Kondyli M, Larouche V, Saint-Martin C, Ellezam B, Pouliot L, Sinnett D, Legault G, Crevier L, Weil A, Farmer JP, Jabado N, Perreault S
J Neurooncol 2018 Nov;140(2):435-444. Epub 2018 Aug 10 doi: 10.1007/s11060-018-2971-9. PMID: 30097824
Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma.
Geoerger B, Kieran MW, Grupp S, Perek D, Clancy J, Krygowski M, Ananthakrishnan R, Boni JP, Berkenblit A, Spunt SL
Eur J Cancer 2012 Jan;48(2):253-62. Epub 2011 Oct 25 doi: 10.1016/j.ejca.2011.09.021. PMID: 22033322Free PMC Article

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