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Resectable Undifferentiated Pleomorphic Sarcoma

MedGen UID:
1660314
•Concept ID:
C4725870
•
Neoplastic Process

Definition

Undifferentiated pleomorphic sarcoma that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Undifferentiated Pleomorphic Sarcoma

Professional guidelines

PubMed

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
The Management of Head and Neck Sarcoma.
Han S, Yin X, Xu W, Wang Y, Han W
J Craniofac Surg 2020 Mar/Apr;31(2):e189-e192. doi: 10.1097/SCS.0000000000006162. PMID: 31934973
Management of the "Other" retroperitoneal sarcomas.
Rutkowski PL, Mullen JT
J Surg Oncol 2018 Jan;117(1):79-86. Epub 2017 Nov 11 doi: 10.1002/jso.24893. PMID: 29127695

Recent clinical studies

Etiology

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Clinical characteristics of undifferentiated pleomorphic sarcoma of bone and the impact of adjuvant chemotherapy on the affected patients: a population-based cohort study.
Kobayashi H, Zhang L, Hirai T, Tsuda Y, Ikegami M, Tanaka S
Jpn J Clin Oncol 2022 May 31;52(6):589-598. doi: 10.1093/jjco/hyac017. PMID: 35184191
The Management of Head and Neck Sarcoma.
Han S, Yin X, Xu W, Wang Y, Han W
J Craniofac Surg 2020 Mar/Apr;31(2):e189-e192. doi: 10.1097/SCS.0000000000006162. PMID: 31934973
Subclassification of pleomorphic sarcomas: How and why should we care?
Hornick JL
Ann Diagn Pathol 2018 Dec;37:118-124. Epub 2018 Oct 11 doi: 10.1016/j.anndiagpath.2018.10.006. PMID: 30340082
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Diagnosis

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Subclassification of pleomorphic sarcomas: How and why should we care?
Hornick JL
Ann Diagn Pathol 2018 Dec;37:118-124. Epub 2018 Oct 11 doi: 10.1016/j.anndiagpath.2018.10.006. PMID: 30340082
Malignant bone tumors.
Weber K, Damron TA, Frassica FJ, Sim FH
Instr Course Lect 2008;57:673-88. PMID: 18399615
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171
Liposarcoma.
Springfield D
Clin Orthop Relat Res 1993 Apr;(289):50-7. PMID: 8472432

Therapy

Soft tissue sarcomas of the buttock: A systematic review and meta-analysis.
Sacco R, Lalevée M, Pellegrino P, Ferro A, Yasmine B, André G, Matthieu G, Hamza A, Piana R, Dujardin F
Surg Oncol 2022 Dec;45:101883. Epub 2022 Nov 7 doi: 10.1016/j.suronc.2022.101883. PMID: 36371906
The histone deacetylase inhibitor LBH589 inhibits undifferentiated pleomorphic sarcoma growth via downregulation of FOS-like antigen 1.
Saitoh Y, Bureta C, Sasaki H, Nagano S, Maeda S, Furukawa T, Taniguchi N, Setoguchi T
Mol Carcinog 2019 Feb;58(2):234-246. Epub 2018 Nov 2 doi: 10.1002/mc.22922. PMID: 30303565
Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.
Keung EZ, Lazar AJ, Torres KE, Wang WL, Cormier JN, Ashleigh Guadagnolo B, Bishop AJ, Lin H, Hunt KK, Bird J, Lewis VO, Patel SR, Wargo JA, Somaiah N, Roland CL
BMC Cancer 2018 Sep 24;18(1):913. doi: 10.1186/s12885-018-4829-0. PMID: 30249211Free PMC Article
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171
Liposarcoma.
Springfield D
Clin Orthop Relat Res 1993 Apr;(289):50-7. PMID: 8472432

Prognosis

Clinical characteristics of undifferentiated pleomorphic sarcoma of bone and the impact of adjuvant chemotherapy on the affected patients: a population-based cohort study.
Kobayashi H, Zhang L, Hirai T, Tsuda Y, Ikegami M, Tanaka S
Jpn J Clin Oncol 2022 May 31;52(6):589-598. doi: 10.1093/jjco/hyac017. PMID: 35184191
The Management of Head and Neck Sarcoma.
Han S, Yin X, Xu W, Wang Y, Han W
J Craniofac Surg 2020 Mar/Apr;31(2):e189-e192. doi: 10.1097/SCS.0000000000006162. PMID: 31934973
Malignant bone tumors.
Weber K, Damron TA, Frassica FJ, Sim FH
Instr Course Lect 2008;57:673-88. PMID: 18399615
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171
Liposarcoma.
Springfield D
Clin Orthop Relat Res 1993 Apr;(289):50-7. PMID: 8472432

Clinical prediction guides

Soft tissue sarcomas of the buttock: A systematic review and meta-analysis.
Sacco R, Lalevée M, Pellegrino P, Ferro A, Yasmine B, André G, Matthieu G, Hamza A, Piana R, Dujardin F
Surg Oncol 2022 Dec;45:101883. Epub 2022 Nov 7 doi: 10.1016/j.suronc.2022.101883. PMID: 36371906
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Clinical characteristics of undifferentiated pleomorphic sarcoma of bone and the impact of adjuvant chemotherapy on the affected patients: a population-based cohort study.
Kobayashi H, Zhang L, Hirai T, Tsuda Y, Ikegami M, Tanaka S
Jpn J Clin Oncol 2022 May 31;52(6):589-598. doi: 10.1093/jjco/hyac017. PMID: 35184191
The Management of Head and Neck Sarcoma.
Han S, Yin X, Xu W, Wang Y, Han W
J Craniofac Surg 2020 Mar/Apr;31(2):e189-e192. doi: 10.1097/SCS.0000000000006162. PMID: 31934973
Adult urological sarcoma.
Russo P, Brady MS, Conlon K, Hajdu SI, Fair WR, Herr HW, Brennan MF
J Urol 1992 Apr;147(4):1032-6; discussion 1036-7. doi: 10.1016/s0022-5347(17)37456-6. PMID: 1552580

Recent systematic reviews

Surgical Management of Invasive Atypical Fibroxanthomas/Undifferentiated Pleomorphic Sarcomas of the Scalp: A Systematic Review Comparing Outer Table Resection to Full-Thickness Craniectomy.
Granger PM, Mathew D, Leach G, Holcombe T
J Craniofac Surg 2023 Jan-Feb 01;34(1):e8-e10. Epub 2022 Sep 22 doi: 10.1097/SCS.0000000000008832. PMID: 36136912
Functional Muscle Transfer after Oncologic Extremity Resection.
Hassan AM, Tesfaye EA, Rashiwala A, Roubaud MJ, Mericli AF
J Reconstr Microsurg 2023 Mar;39(3):195-208. Epub 2022 Jun 29 doi: 10.1055/a-1887-7530. PMID: 35768008
Soft tissue sarcomas of the buttock: A systematic review and meta-analysis.
Sacco R, Lalevée M, Pellegrino P, Ferro A, Yasmine B, André G, Matthieu G, Hamza A, Piana R, Dujardin F
Surg Oncol 2022 Dec;45:101883. Epub 2022 Nov 7 doi: 10.1016/j.suronc.2022.101883. PMID: 36371906
Reconstruction of upper limb soft-tissue defects after sarcoma resection with free flaps: A systematic review.
Lucattelli E, Lusetti IL, Cipriani F, Innocenti A, De Santis G, Innocenti M
J Plast Reconstr Aesthet Surg 2021 Apr;74(4):755-767. Epub 2020 Nov 8 doi: 10.1016/j.bjps.2020.10.065. PMID: 33277214
Isolated Limb Perfusion and Infusion for Extremity Soft Tissue Sarcoma: A Contemporary Systematic Review and Meta-Analysis.
Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC
Ann Surg Oncol 2017 Dec;24(13):3803-3810. Epub 2017 Oct 11 doi: 10.1245/s10434-017-6109-7. PMID: 29022281

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