U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Pancreatic Neuroendocrine Tumor

MedGen UID:
1662841
•Concept ID:
C2609093
•
Neoplastic Process
Synonym: Metastatic Pancreatic Islet Cell Tumor

Definition

A neuroendocrine tumor that arises from the islet cells of the pancreas and has spread to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Pancreatic Neuroendocrine Tumor

Professional guidelines

PubMed

The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Management of Metastatic and/or Unresectable Pheochromocytoma and Paraganglioma.
Fishbein L, Del Rivero J, Else T, Howe JR, Asa SL, Cohen DL, Dahia PLM, Fraker DL, Goodman KA, Hope TA, Kunz PL, Perez K, Perrier ND, Pryma DA, Ryder M, Sasson AR, Soulen MC, Jimenez C
Pancreas 2021 Apr 1;50(4):469-493. doi: 10.1097/MPA.0000000000001792. PMID: 33939658
Novel Treatment Options for Neuroendocrine Tumors.
Kulke MH
J Natl Compr Canc Netw 2017 May;15(5S):737-739. doi: 10.6004/jnccn.2017.0088. PMID: 28515259
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Recent clinical studies

Etiology

Opsoclonus-myoclonus syndrome associated with pancreatic neuroendocrine tumor: a case report.
Reinecke R, Reiländer A, Seiler A, Koch C, Voss M
BMC Neurol 2022 Dec 30;22(1):507. doi: 10.1186/s12883-022-03012-6. PMID: 36581905Free PMC Article
Nomograms predict survival outcomes for distant metastatic pancreatic neuroendocrine tumor: A population based STROBE compliant study.
Li G, Tian ML, Bing YT, Wang HY, Yuan CH, Xiu DR
Medicine (Baltimore) 2020 Mar;99(13):e19593. doi: 10.1097/MD.0000000000019593. PMID: 32221079Free PMC Article
The impact of surgery for metastatic pancreatic neuroendocrine tumor: a contemporary evaluation matching for chromogranin a level.
Concors SJ, Sinnamon AJ, Ecker BL, Metz DC, Vollmer CM, Fraker DL, Roses RE
HPB (Oxford) 2020 Jan;22(1):83-90. Epub 2019 Jun 22 doi: 10.1016/j.hpb.2019.05.011. PMID: 31239188
Primary site surgery for elderly patients with distant metastatic pancreatic neuroendocrine tumor: to do or not to do?
Zhang J, Peng CS, Tian YH
Clin Interv Aging 2019;14:1419-1432. Epub 2019 Aug 6 doi: 10.2147/CIA.S209428. PMID: 31496669Free PMC Article
Management of the primary tumor in patients with metastatic pancreatic neuroendocrine tumor: a contemporary single-institution review.
Bruzoni M, Parikh P, Celis R, Are C, Ly QP, Meza JL, Sasson AR
Am J Surg 2009 Mar;197(3):376-81. doi: 10.1016/j.amjsurg.2008.11.005. PMID: 19245918

Diagnosis

Opsoclonus-myoclonus syndrome associated with pancreatic neuroendocrine tumor: a case report.
Reinecke R, Reiländer A, Seiler A, Koch C, Voss M
BMC Neurol 2022 Dec 30;22(1):507. doi: 10.1186/s12883-022-03012-6. PMID: 36581905Free PMC Article
Belzutifan in a Patient With VHL-Associated Metastatic Pancreatic Neuroendocrine Tumor.
Pelle E, Al-Toubah T, Morse B, Strosberg J
J Natl Compr Canc Netw 2022 Dec;20(12):1285-1287. doi: 10.6004/jnccn.2022.7047. PMID: 36509068
Nomograms predict survival outcomes for distant metastatic pancreatic neuroendocrine tumor: A population based STROBE compliant study.
Li G, Tian ML, Bing YT, Wang HY, Yuan CH, Xiu DR
Medicine (Baltimore) 2020 Mar;99(13):e19593. doi: 10.1097/MD.0000000000019593. PMID: 32221079Free PMC Article
The impact of surgery for metastatic pancreatic neuroendocrine tumor: a contemporary evaluation matching for chromogranin a level.
Concors SJ, Sinnamon AJ, Ecker BL, Metz DC, Vollmer CM, Fraker DL, Roses RE
HPB (Oxford) 2020 Jan;22(1):83-90. Epub 2019 Jun 22 doi: 10.1016/j.hpb.2019.05.011. PMID: 31239188
Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1.
Milanesi A, Yu R, Geller SA, Burton D, Deftos LJ, Wolin EM
Pancreas 2011 May;40(4):634-7. doi: 10.1097/MPA.0b013e318214f65e. PMID: 21483254

Therapy

Meningioma Presenting with Spontaneous Venous Intraparenchymal Hemorrhage.
Giantini-Larsen A, Abou-Mrad Z, Moss NS
World Neurosurg 2023 Mar;171:8-9. Epub 2022 Dec 8 doi: 10.1016/j.wneu.2022.12.007. PMID: 36503122Free PMC Article
Usefulness of an immunohistochemical score in advanced pancreatic neuroendocrine tumors treated with CAPTEM or everolimus.
Viúdez A, Crespo G, Gómez Dorronsoro ML, Arozarena I, Marín-Méndez JJ, Custodio A, Benavent M, Goñi S, García-Paredes B, Hernando J, Durantez M, Alonso V, Riesco MDC, López C, Jiménez-Fonseca P, San Vicente BL, González-Borja I, Sevilla I, Hernández-Garcia I, Carmona-Bayonas A, Capdevila J, Pérez-Sanz J, García-Carbonero R, Pérez-Ricarte L, Llanos M, Vera R, De Jesús Acosta A
Pancreatology 2021 Jan;21(1):215-223. Epub 2020 Dec 19 doi: 10.1016/j.pan.2020.12.009. PMID: 33358592
Nomograms predict survival outcomes for distant metastatic pancreatic neuroendocrine tumor: A population based STROBE compliant study.
Li G, Tian ML, Bing YT, Wang HY, Yuan CH, Xiu DR
Medicine (Baltimore) 2020 Mar;99(13):e19593. doi: 10.1097/MD.0000000000019593. PMID: 32221079Free PMC Article
Primary site surgery for elderly patients with distant metastatic pancreatic neuroendocrine tumor: to do or not to do?
Zhang J, Peng CS, Tian YH
Clin Interv Aging 2019;14:1419-1432. Epub 2019 Aug 6 doi: 10.2147/CIA.S209428. PMID: 31496669Free PMC Article
Metastatic pancreatic neuroendocrine tumor presenting as a pituitary space occupying lesion: a case report.
Gur C, Lalazar G, Salmon A, Dubiner V, Gross DJ
Pituitary 2008;11(3):293-7. doi: 10.1007/s11102-007-0053-7. PMID: 17638085

Prognosis

Severe hypercalcemia due to metastatic pancreatic neuroendocrine tumor: a case report.
Behdadnia A, Jeddi M
J Med Case Rep 2023 Sep 6;17(1):400. doi: 10.1186/s13256-023-04042-5. PMID: 37670372Free PMC Article
Nomograms predict survival outcomes for distant metastatic pancreatic neuroendocrine tumor: A population based STROBE compliant study.
Li G, Tian ML, Bing YT, Wang HY, Yuan CH, Xiu DR
Medicine (Baltimore) 2020 Mar;99(13):e19593. doi: 10.1097/MD.0000000000019593. PMID: 32221079Free PMC Article
The impact of surgery for metastatic pancreatic neuroendocrine tumor: a contemporary evaluation matching for chromogranin a level.
Concors SJ, Sinnamon AJ, Ecker BL, Metz DC, Vollmer CM, Fraker DL, Roses RE
HPB (Oxford) 2020 Jan;22(1):83-90. Epub 2019 Jun 22 doi: 10.1016/j.hpb.2019.05.011. PMID: 31239188
Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition.
Allen A, Qin ACR, Raj N, Wang J, Uddin S, Yao Z, Tang L, Meyers PA, Taylor BS, Berger MF, Yaeger R, Reidy-Lagunes D, Pratilas CA
PLoS One 2019;14(6):e0217399. Epub 2019 Jun 3 doi: 10.1371/journal.pone.0217399. PMID: 31158244Free PMC Article
Pancreaticoduodenectomy and metastasectomy for metastatic pancreatic neuroendocrine tumors.
Chawla A, Williams RT, Sich N, Clancy T, Wang J, Ashley S, Pezzi C, Swanson R
J Surg Oncol 2018 Nov;118(6):983-990. Epub 2018 Sep 13 doi: 10.1002/jso.25219. PMID: 30212595

Clinical prediction guides

Usefulness of an immunohistochemical score in advanced pancreatic neuroendocrine tumors treated with CAPTEM or everolimus.
Viúdez A, Crespo G, Gómez Dorronsoro ML, Arozarena I, Marín-Méndez JJ, Custodio A, Benavent M, Goñi S, García-Paredes B, Hernando J, Durantez M, Alonso V, Riesco MDC, López C, Jiménez-Fonseca P, San Vicente BL, González-Borja I, Sevilla I, Hernández-Garcia I, Carmona-Bayonas A, Capdevila J, Pérez-Sanz J, García-Carbonero R, Pérez-Ricarte L, Llanos M, Vera R, De Jesús Acosta A
Pancreatology 2021 Jan;21(1):215-223. Epub 2020 Dec 19 doi: 10.1016/j.pan.2020.12.009. PMID: 33358592
Nomograms predict survival outcomes for distant metastatic pancreatic neuroendocrine tumor: A population based STROBE compliant study.
Li G, Tian ML, Bing YT, Wang HY, Yuan CH, Xiu DR
Medicine (Baltimore) 2020 Mar;99(13):e19593. doi: 10.1097/MD.0000000000019593. PMID: 32221079Free PMC Article
The impact of surgery for metastatic pancreatic neuroendocrine tumor: a contemporary evaluation matching for chromogranin a level.
Concors SJ, Sinnamon AJ, Ecker BL, Metz DC, Vollmer CM, Fraker DL, Roses RE
HPB (Oxford) 2020 Jan;22(1):83-90. Epub 2019 Jun 22 doi: 10.1016/j.hpb.2019.05.011. PMID: 31239188
Primary site surgery for elderly patients with distant metastatic pancreatic neuroendocrine tumor: to do or not to do?
Zhang J, Peng CS, Tian YH
Clin Interv Aging 2019;14:1419-1432. Epub 2019 Aug 6 doi: 10.2147/CIA.S209428. PMID: 31496669Free PMC Article
Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition.
Allen A, Qin ACR, Raj N, Wang J, Uddin S, Yao Z, Tang L, Meyers PA, Taylor BS, Berger MF, Yaeger R, Reidy-Lagunes D, Pratilas CA
PLoS One 2019;14(6):e0217399. Epub 2019 Jun 3 doi: 10.1371/journal.pone.0217399. PMID: 31158244Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...