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Metastatic Cervical Squamous Cell Carcinoma

MedGen UID:
1665005
•Concept ID:
C4727218
•
Neoplastic Process

Definition

Cervical squamous cell carcinoma that has spread to another anatomic site. [from NCI]

Professional guidelines

PubMed

Delays in definitive cervical cancer treatment: An analysis of disparities and overall survival impact.
Ramey SJ, Asher D, Kwon D, Ahmed AA, Wolfson AH, Yechieli R, Portelance L
Gynecol Oncol 2018 Apr;149(1):53-62. doi: 10.1016/j.ygyno.2017.12.010. PMID: 29605051
Squamous cell carcinoma from an unknown head and neck primary site: a "selective treatment" approach.
Patel RS, Clark J, Wyten R, Gao K, O'Brien CJ
Arch Otolaryngol Head Neck Surg 2007 Dec;133(12):1282-7. doi: 10.1001/archotol.133.12.1282. PMID: 18086973
Outcome of treatment for advanced cervical metastatic squamous cell carcinoma.
Clark J, Li W, Smith G, Shannon K, Clifford A, McNeil E, Gao K, Jackson M, Mo Tin M, O'Brien C
Head Neck 2005 Feb;27(2):87-94. doi: 10.1002/hed.20129. PMID: 15627246

Recent clinical studies

Etiology

Survival outcomes in head and neck squamous cell carcinoma of unknown primary: A national cohort study.
Hardman JC, Constable J, Dobbs S, Hogan C, Hulse K, Khosla S, Milinis K, Tudor-Green B, Williamson A, Paleri V; INTEGRATE (The UK ENT Trainee Research Network)
Clin Otolaryngol 2024 Sep;49(5):604-620. Epub 2024 May 20 doi: 10.1111/coa.14167. PMID: 38766691
Effect of hypoxia-inducible factor-1 alpha expression on survival in patients with metastatic cervical squamous cell carcinoma treated with first-line chemotherapy and bevacizumab.
Yildirim HC, Anik H, Ozdemir DA, Ismayilov R, Akyildiz A, Cayiroz K, Ceyhan F, Kavruk O, Guven DC, Ates O, Usubutun A, Arik Z
Biomol Biomed 2024 Mar 5;24(4):998-1003. doi: 10.17305/bb.2024.10255. PMID: 38447002Free PMC Article
Prognostic models for predicting overall and cancer-specific survival of patients with initially diagnosed metastatic cervical squamous cell carcinoma: A study based on SEER database.
Ding R, Su Z, Chen M, Chen L
Medicine (Baltimore) 2023 Jul 14;102(28):e34313. doi: 10.1097/MD.0000000000034313. PMID: 37443499Free PMC Article
Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancer.
Zhang Y, Li N, Yuan G, Yao H, Zhang D, Li N, Zhang G, Sun Y, Wang W, Zeng J, Xu N, Liu M, Wu L
BMC Med 2022 Feb 8;20(1):55. doi: 10.1186/s12916-022-02248-w. PMID: 35130902Free PMC Article
Squamous cell carcinoma from an unknown head and neck primary site: a "selective treatment" approach.
Patel RS, Clark J, Wyten R, Gao K, O'Brien CJ
Arch Otolaryngol Head Neck Surg 2007 Dec;133(12):1282-7. doi: 10.1001/archotol.133.12.1282. PMID: 18086973

Diagnosis

Survival outcomes in head and neck squamous cell carcinoma of unknown primary: A national cohort study.
Hardman JC, Constable J, Dobbs S, Hogan C, Hulse K, Khosla S, Milinis K, Tudor-Green B, Williamson A, Paleri V; INTEGRATE (The UK ENT Trainee Research Network)
Clin Otolaryngol 2024 Sep;49(5):604-620. Epub 2024 May 20 doi: 10.1111/coa.14167. PMID: 38766691
Prognostic models for predicting overall and cancer-specific survival of patients with initially diagnosed metastatic cervical squamous cell carcinoma: A study based on SEER database.
Ding R, Su Z, Chen M, Chen L
Medicine (Baltimore) 2023 Jul 14;102(28):e34313. doi: 10.1097/MD.0000000000034313. PMID: 37443499Free PMC Article
PD-L1 expression and immune stromal features in HPV-independent cervical adenocarcinoma.
Song F, Jia M, Yu S, Cao L, Sun PL, Gao H
Histopathology 2021 Nov;79(5):861-871. Epub 2021 Sep 3 doi: 10.1111/his.14435. PMID: 34156708
Transoral Robotic Surgery and the Unknown Primary.
Ofo E, Spiers H, Kim D, Duvvuri U
ORL J Otorhinolaryngol Relat Spec 2018;80(3-4):148-155. Epub 2018 Nov 12 doi: 10.1159/000490596. PMID: 30419564
Metastatic ovarian squamous cell carcinoma.
Samaila MO, Adesiyun AG, Oluwole OP
Singapore Med J 2008 May;49(5):e139-41. PMID: 18465040

Therapy

Effect of hypoxia-inducible factor-1 alpha expression on survival in patients with metastatic cervical squamous cell carcinoma treated with first-line chemotherapy and bevacizumab.
Yildirim HC, Anik H, Ozdemir DA, Ismayilov R, Akyildiz A, Cayiroz K, Ceyhan F, Kavruk O, Guven DC, Ates O, Usubutun A, Arik Z
Biomol Biomed 2024 Mar 5;24(4):998-1003. doi: 10.17305/bb.2024.10255. PMID: 38447002Free PMC Article
Prognostic models for predicting overall and cancer-specific survival of patients with initially diagnosed metastatic cervical squamous cell carcinoma: A study based on SEER database.
Ding R, Su Z, Chen M, Chen L
Medicine (Baltimore) 2023 Jul 14;102(28):e34313. doi: 10.1097/MD.0000000000034313. PMID: 37443499Free PMC Article
A multicenter phase 2 trial of camrelizumab plus famitinib for women with recurrent or metastatic cervical squamous cell carcinoma.
Xia L, Zhou Q, Gao Y, Hu W, Lou G, Sun H, Zhu J, Shu J, Zhou X, Sun R, Wu X
Nat Commun 2022 Dec 8;13(1):7581. doi: 10.1038/s41467-022-35133-4. PMID: 36481736Free PMC Article
Pembrolizumab-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis in a Patient With Metastatic Cervical Squamous Cell Carcinoma: A Case Report.
Robinson S, Saleh J, Curry J, Mudaliar K
Am J Dermatopathol 2020 Apr;42(4):292-296. doi: 10.1097/DAD.0000000000001527. PMID: 31567395
Retinoids, cisplatin and interferon-alpha in recurrent or metastatic cervical squamous cell carcinoma: clinical results of 2 phase II trials.
Braud AC, Gonzague L, Bertucci F, Genre D, Camerlo J, Gravis G, Goncalves A, Moutardier V, Viret F, Maraninchi D, Viens P
Eur Cytokine Netw 2002 Jan-Mar;13(1):115-20. PMID: 11956030

Prognosis

Survival outcomes in head and neck squamous cell carcinoma of unknown primary: A national cohort study.
Hardman JC, Constable J, Dobbs S, Hogan C, Hulse K, Khosla S, Milinis K, Tudor-Green B, Williamson A, Paleri V; INTEGRATE (The UK ENT Trainee Research Network)
Clin Otolaryngol 2024 Sep;49(5):604-620. Epub 2024 May 20 doi: 10.1111/coa.14167. PMID: 38766691
Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancer.
Zhang Y, Li N, Yuan G, Yao H, Zhang D, Li N, Zhang G, Sun Y, Wang W, Zeng J, Xu N, Liu M, Wu L
BMC Med 2022 Feb 8;20(1):55. doi: 10.1186/s12916-022-02248-w. PMID: 35130902Free PMC Article
PD-L1 expression and immune stromal features in HPV-independent cervical adenocarcinoma.
Song F, Jia M, Yu S, Cao L, Sun PL, Gao H
Histopathology 2021 Nov;79(5):861-871. Epub 2021 Sep 3 doi: 10.1111/his.14435. PMID: 34156708
The role of human papilloma virus and p16 in occult primary of the head and neck: a comprehensive review of the literature.
Fotopoulos G, Pavlidis N
Oral Oncol 2015 Feb;51(2):119-23. Epub 2014 Nov 18 doi: 10.1016/j.oraloncology.2014.10.018. PMID: 25467774
Squamous cell carcinoma from an unknown head and neck primary site: a "selective treatment" approach.
Patel RS, Clark J, Wyten R, Gao K, O'Brien CJ
Arch Otolaryngol Head Neck Surg 2007 Dec;133(12):1282-7. doi: 10.1001/archotol.133.12.1282. PMID: 18086973

Clinical prediction guides

Survival outcomes in head and neck squamous cell carcinoma of unknown primary: A national cohort study.
Hardman JC, Constable J, Dobbs S, Hogan C, Hulse K, Khosla S, Milinis K, Tudor-Green B, Williamson A, Paleri V; INTEGRATE (The UK ENT Trainee Research Network)
Clin Otolaryngol 2024 Sep;49(5):604-620. Epub 2024 May 20 doi: 10.1111/coa.14167. PMID: 38766691
Prognostic models for predicting overall and cancer-specific survival of patients with initially diagnosed metastatic cervical squamous cell carcinoma: A study based on SEER database.
Ding R, Su Z, Chen M, Chen L
Medicine (Baltimore) 2023 Jul 14;102(28):e34313. doi: 10.1097/MD.0000000000034313. PMID: 37443499Free PMC Article
A multicenter phase 2 trial of camrelizumab plus famitinib for women with recurrent or metastatic cervical squamous cell carcinoma.
Xia L, Zhou Q, Gao Y, Hu W, Lou G, Sun H, Zhu J, Shu J, Zhou X, Sun R, Wu X
Nat Commun 2022 Dec 8;13(1):7581. doi: 10.1038/s41467-022-35133-4. PMID: 36481736Free PMC Article
PD-L1 expression and immune stromal features in HPV-independent cervical adenocarcinoma.
Song F, Jia M, Yu S, Cao L, Sun PL, Gao H
Histopathology 2021 Nov;79(5):861-871. Epub 2021 Sep 3 doi: 10.1111/his.14435. PMID: 34156708
Retinoids, cisplatin and interferon-alpha in recurrent or metastatic cervical squamous cell carcinoma: clinical results of 2 phase II trials.
Braud AC, Gonzague L, Bertucci F, Genre D, Camerlo J, Gravis G, Goncalves A, Moutardier V, Viret F, Maraninchi D, Viens P
Eur Cytokine Netw 2002 Jan-Mar;13(1):115-20. PMID: 11956030

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