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Advanced Sarcoma of the Extremity

MedGen UID:
1670157
•Concept ID:
C4744309
•
Neoplastic Process
Synonym: Advanced Extremity Sarcoma

Definition

A sarcoma of the soft tissues or bones of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Sarcoma of the Extremity

Professional guidelines

PubMed

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine.
Gamboa AC, Gronchi A, Cardona K
CA Cancer J Clin 2020 May;70(3):200-229. Epub 2020 Apr 10 doi: 10.3322/caac.21605. PMID: 32275330
TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility.
van Horssen R, Ten Hagen TL, Eggermont AM
Oncologist 2006 Apr;11(4):397-408. doi: 10.1634/theoncologist.11-4-397. PMID: 16614236

Recent clinical studies

Etiology

Trimodality Treatment of Extremity Soft Tissue Sarcoma: Where Do We Go Now?
Oberoi S, Choy E, Chen YL, Scharschmidt T, Weiss AR
Curr Treat Options Oncol 2023 Apr;24(4):300-326. Epub 2023 Mar 6 doi: 10.1007/s11864-023-01059-2. PMID: 36877374
Management of Synovial Sarcoma and Myxoid Liposarcoma.
Hindi N, Haas RL
Surg Oncol Clin N Am 2022 Jul;31(3):547-558. doi: 10.1016/j.soc.2022.03.012. PMID: 35715149
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial.
Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D
Lancet Oncol 2020 Aug;21(8):1110-1122. Epub 2020 Jul 20 doi: 10.1016/S1470-2045(20)30325-9. PMID: 32702309Free PMC Article
Radiotherapy in soft-tissue sarcoma of the extremities.
Correa R, Gómez-Millán J, Lobato M, Fernández A, Ordoñez R, Castro C, Lupiañez Y, Medina JA
Clin Transl Oncol 2018 Sep;20(9):1127-1135. Epub 2018 Feb 23 doi: 10.1007/s12094-018-1848-x. PMID: 29476322

Diagnosis

Management of Synovial Sarcoma and Myxoid Liposarcoma.
Hindi N, Haas RL
Surg Oncol Clin N Am 2022 Jul;31(3):547-558. doi: 10.1016/j.soc.2022.03.012. PMID: 35715149
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Evaluation and Management of Intra-Articular Tumors of the Knee.
Auran RL, Martin JR, Duran MD, de Comas AM, Jacofsky DJ
J Knee Surg 2022 May;35(6):597-606. Epub 2022 Feb 21 doi: 10.1055/s-0042-1743223. PMID: 35189664
Soft-tissue sarcoma.
Gilbert NF, Cannon CP, Lin PP, Lewis VO
J Am Acad Orthop Surg 2009 Jan;17(1):40-7. doi: 10.5435/00124635-200901000-00006. PMID: 19136426
Osteosarcoma.
Jaffe N
Pediatr Rev 1991 May;12(11):333-43. PMID: 2062744

Therapy

Trimodality Treatment of Extremity Soft Tissue Sarcoma: Where Do We Go Now?
Oberoi S, Choy E, Chen YL, Scharschmidt T, Weiss AR
Curr Treat Options Oncol 2023 Apr;24(4):300-326. Epub 2023 Mar 6 doi: 10.1007/s11864-023-01059-2. PMID: 36877374
Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial.
Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D
Lancet Oncol 2020 Aug;21(8):1110-1122. Epub 2020 Jul 20 doi: 10.1016/S1470-2045(20)30325-9. PMID: 32702309Free PMC Article
Radiotherapy in soft-tissue sarcoma of the extremities.
Correa R, Gómez-Millán J, Lobato M, Fernández A, Ordoñez R, Castro C, Lupiañez Y, Medina JA
Clin Transl Oncol 2018 Sep;20(9):1127-1135. Epub 2018 Feb 23 doi: 10.1007/s12094-018-1848-x. PMID: 29476322
TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility.
van Horssen R, Ten Hagen TL, Eggermont AM
Oncologist 2006 Apr;11(4):397-408. doi: 10.1634/theoncologist.11-4-397. PMID: 16614236
Osteosarcoma.
Jaffe N
Pediatr Rev 1991 May;12(11):333-43. PMID: 2062744

Prognosis

A review of retroperitoneal liposarcoma genomics.
Tyler R, Wanigasooriya K, Taniere P, Almond M, Ford S, Desai A, Beggs A
Cancer Treat Rev 2020 Jun;86:102013. Epub 2020 Mar 28 doi: 10.1016/j.ctrv.2020.102013. PMID: 32278233
Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine.
Gamboa AC, Gronchi A, Cardona K
CA Cancer J Clin 2020 May;70(3):200-229. Epub 2020 Apr 10 doi: 10.3322/caac.21605. PMID: 32275330
Diagnosis and Management of Rhabdomyosarcoma in Children and Adolescents: ICMR Consensus Document.
Panda SP, Chinnaswamy G, Vora T, Prasad M, Bansal D, Kapoor G, Radhakrishnan V, Agarwala S, Laskar S, Arora B, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 May;84(5):393-402. Epub 2017 Apr 5 doi: 10.1007/s12098-017-2315-3. PMID: 28378141
Soft-tissue sarcoma.
Gilbert NF, Cannon CP, Lin PP, Lewis VO
J Am Acad Orthop Surg 2009 Jan;17(1):40-7. doi: 10.5435/00124635-200901000-00006. PMID: 19136426
Osteosarcoma.
Jaffe N
Pediatr Rev 1991 May;12(11):333-43. PMID: 2062744

Clinical prediction guides

A League of Its Own? Established and Emerging Therapies in Undifferentiated Pleomorphic Sarcoma.
Graves L, Jeck WR, Grilley-Olson JE
Curr Treat Options Oncol 2023 Mar;24(3):212-228. Epub 2023 Feb 2 doi: 10.1007/s11864-023-01054-7. PMID: 36729198
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial.
Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D
Lancet Oncol 2020 Aug;21(8):1110-1122. Epub 2020 Jul 20 doi: 10.1016/S1470-2045(20)30325-9. PMID: 32702309Free PMC Article
Leiomyosarcoma: Prognostic outline of a rare head and neck malignancy.
Saluja TS, Iyer J, Singh SK
Oral Oncol 2019 Aug;95:100-105. Epub 2019 Jun 13 doi: 10.1016/j.oraloncology.2019.06.010. PMID: 31345375
Isolated Limb Perfusion and Infusion for Extremity Soft Tissue Sarcoma: A Contemporary Systematic Review and Meta-Analysis.
Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC
Ann Surg Oncol 2017 Dec;24(13):3803-3810. Epub 2017 Oct 11 doi: 10.1245/s10434-017-6109-7. PMID: 29022281

Recent systematic reviews

Limb salvage surgery reconstructive techniques following long-bone lower limb oncological resection: a systematic review and meta-analysis.
Hovav O, Kolonko S, Zahir SF, Velli G, Chouhan P, Wagels M
ANZ J Surg 2023 Nov;93(11):2609-2620. Epub 2023 Feb 23 doi: 10.1111/ans.18335. PMID: 36821561
Isolated Limb Perfusion and Infusion for Extremity Soft Tissue Sarcoma: A Contemporary Systematic Review and Meta-Analysis.
Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC
Ann Surg Oncol 2017 Dec;24(13):3803-3810. Epub 2017 Oct 11 doi: 10.1245/s10434-017-6109-7. PMID: 29022281
Pediatric lower extremity sarcoma reconstruction: A review of limb salvage procedures and outcomes.
Piper M, Irwin C, Sbitany H
J Plast Reconstr Aesthet Surg 2016 Jan;69(1):91-6. Epub 2015 Sep 5 doi: 10.1016/j.bjps.2015.08.035. PMID: 26601876
Outcomes of isolated limb perfusion in the treatment of extremity soft tissue sarcoma: a systematic review.
Bhangu A, Broom L, Nepogodiev D, Gourevitch D, Desai A
Eur J Surg Oncol 2013 Apr;39(4):311-9. Epub 2013 Jan 23 doi: 10.1016/j.ejso.2012.12.018. PMID: 23351681
Hyperthermic isolated limb perfusion for extremity soft tissue sarcomas: systematic review of clinical efficacy and quality assessment of reported trials.
Trabulsi NH, Patakfalvi L, Nassif MO, Turcotte RE, Nichols A, Meguerditchian AN
J Surg Oncol 2012 Dec;106(8):921-8. Epub 2012 Jul 17 doi: 10.1002/jso.23200. PMID: 22806575

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