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Advanced Sarcoma of the Extremity

MedGen UID:
1670157
•Concept ID:
C4744309
•
Neoplastic Process
Synonym: Advanced Extremity Sarcoma

Definition

A sarcoma of the soft tissues or bones of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Sarcoma of the Extremity

Professional guidelines

PubMed

Advances in treatment of alveolar soft part sarcoma: an updated review.
Fujiwara T, Kunisada T, Nakata E, Nishida K, Yanai H, Nakamura T, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Nov 5;53(11):1009-1018. doi: 10.1093/jjco/hyad102. PMID: 37626447Free PMC Article
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine.
Gamboa AC, Gronchi A, Cardona K
CA Cancer J Clin 2020 May;70(3):200-229. Epub 2020 Apr 10 doi: 10.3322/caac.21605. PMID: 32275330

Recent clinical studies

Etiology

The history of resection prosthesis.
Crimì A, Joyce DM, Binitie O, Ruggieri P, Letson GD
Int Orthop 2023 Mar;47(3):873-883. Epub 2023 Jan 18 doi: 10.1007/s00264-023-05698-w. PMID: 36651984
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial.
Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D
Lancet Oncol 2020 Aug;21(8):1110-1122. Epub 2020 Jul 20 doi: 10.1016/S1470-2045(20)30325-9. PMID: 32702309Free PMC Article
Radiotherapy in soft-tissue sarcoma of the extremities.
Correa R, Gómez-Millán J, Lobato M, Fernández A, Ordoñez R, Castro C, Lupiañez Y, Medina JA
Clin Transl Oncol 2018 Sep;20(9):1127-1135. Epub 2018 Feb 23 doi: 10.1007/s12094-018-1848-x. PMID: 29476322
Advances in chemotherapy for patients with extremity soft tissue sarcoma.
Eilber FC, Tap WD, Nelson SD, Eckardt JJ, Eilber FR
Orthop Clin North Am 2006 Jan;37(1):15-22. doi: 10.1016/j.ocl.2005.07.001. PMID: 16311108

Diagnosis

Advances in treatment of alveolar soft part sarcoma: an updated review.
Fujiwara T, Kunisada T, Nakata E, Nishida K, Yanai H, Nakamura T, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Nov 5;53(11):1009-1018. doi: 10.1093/jjco/hyad102. PMID: 37626447Free PMC Article
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Dermoscopy of dermatofibrosarcoma protuberans on black skin.
Piccolo V, Russo T, Staibano S, Coppola N, Russo D, Alessio L, Argenziano G
J Am Acad Dermatol 2016 Jun;74(6):e119-20. doi: 10.1016/j.jaad.2015.12.015. PMID: 27185450
Soft-tissue sarcoma.
Gilbert NF, Cannon CP, Lin PP, Lewis VO
J Am Acad Orthop Surg 2009 Jan;17(1):40-7. doi: 10.5435/00124635-200901000-00006. PMID: 19136426
Osteosarcoma.
Jaffe N
Pediatr Rev 1991 May;12(11):333-43. PMID: 2062744

Therapy

A randomized, non-comparative phase 2 study of neoadjuvant immune-checkpoint blockade in retroperitoneal dedifferentiated liposarcoma and extremity/truncal undifferentiated pleomorphic sarcoma.
Roland CL, Nassif Haddad EF, Keung EZ, Wang WL, Lazar AJ, Lin H, Chelvanambi M, Parra ER, Wani K, Guadagnolo BA, Bishop AJ, Burton EM, Hunt KK, Torres KE, Feig BW, Scally CP, Lewis VO, Bird JE, Ratan R, Araujo D, Zarzour MA, Patel S, Benjamin R, Conley AP, Livingston JA, Ravi V, Tawbi HA, Lin PP, Moon BS, Satcher RL, Mujtaba B, Witt RG, Traweek RS, Cope B, Lazcano R, Wu CC, Zhou X, Mohammad MM, Chu RA, Zhang J, Damania A, Sahasrabhojane P, Tate T, Callahan K, Nguyen S, Ingram D, Morey R, Crosby S, Mathew G, Duncan S, Lima CF, Blay JY, Fridman WH, Shaw K, Wistuba I, Futreal A, Ajami N, Wargo JA, Somaiah N
Nat Cancer 2024 Apr;5(4):625-641. Epub 2024 Feb 13 doi: 10.1038/s43018-024-00726-z. PMID: 38351182
Radiation therapy: neoadjuvant, adjuvant, or not at all.
Delaney TF
Surg Oncol Clin N Am 2012 Apr;21(2):215-41. doi: 10.1016/j.soc.2011.12.005. PMID: 22365516
Advances in chemotherapy for patients with extremity soft tissue sarcoma.
Eilber FC, Tap WD, Nelson SD, Eckardt JJ, Eilber FR
Orthop Clin North Am 2006 Jan;37(1):15-22. doi: 10.1016/j.ocl.2005.07.001. PMID: 16311108
Osteosarcoma.
Jaffe N
Pediatr Rev 1991 May;12(11):333-43. PMID: 2062744
Perfusion therapy for skin cancer.
Golomb FM
J Dermatol Surg 1975 Dec;1(4):39-48. doi: 10.1111/j.1524-4725.1975.tb00118.x. PMID: 1083398

Prognosis

A review of retroperitoneal liposarcoma genomics.
Tyler R, Wanigasooriya K, Taniere P, Almond M, Ford S, Desai A, Beggs A
Cancer Treat Rev 2020 Jun;86:102013. Epub 2020 Mar 28 doi: 10.1016/j.ctrv.2020.102013. PMID: 32278233
Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine.
Gamboa AC, Gronchi A, Cardona K
CA Cancer J Clin 2020 May;70(3):200-229. Epub 2020 Apr 10 doi: 10.3322/caac.21605. PMID: 32275330
Soft-tissue sarcoma.
Gilbert NF, Cannon CP, Lin PP, Lewis VO
J Am Acad Orthop Surg 2009 Jan;17(1):40-7. doi: 10.5435/00124635-200901000-00006. PMID: 19136426
Advances in chemotherapy for patients with extremity soft tissue sarcoma.
Eilber FC, Tap WD, Nelson SD, Eckardt JJ, Eilber FR
Orthop Clin North Am 2006 Jan;37(1):15-22. doi: 10.1016/j.ocl.2005.07.001. PMID: 16311108
Osteosarcoma.
Jaffe N
Pediatr Rev 1991 May;12(11):333-43. PMID: 2062744

Clinical prediction guides

Progress in histology specific treatments in soft tissue sarcoma.
Radaelli S, Merlini A, Khan M, Gronchi A
Expert Rev Anticancer Ther 2024 Sep;24(9):845-868. Epub 2024 Aug 5 doi: 10.1080/14737140.2024.2384584. PMID: 39099398
A League of Its Own? Established and Emerging Therapies in Undifferentiated Pleomorphic Sarcoma.
Graves L, Jeck WR, Grilley-Olson JE
Curr Treat Options Oncol 2023 Mar;24(3):212-228. Epub 2023 Feb 2 doi: 10.1007/s11864-023-01054-7. PMID: 36729198
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial.
Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D
Lancet Oncol 2020 Aug;21(8):1110-1122. Epub 2020 Jul 20 doi: 10.1016/S1470-2045(20)30325-9. PMID: 32702309Free PMC Article
Leiomyosarcoma: Prognostic outline of a rare head and neck malignancy.
Saluja TS, Iyer J, Singh SK
Oral Oncol 2019 Aug;95:100-105. Epub 2019 Jun 13 doi: 10.1016/j.oraloncology.2019.06.010. PMID: 31345375

Recent systematic reviews

Molecular characteristics and systemic treatment options of liposarcoma: A systematic review.
Zhou XP, Xing JP, Sun LB, Tian SQ, Luo R, Liu WH, Song XY, Gao SH
Biomed Pharmacother 2024 Sep;178:117204. Epub 2024 Jul 26 doi: 10.1016/j.biopha.2024.117204. PMID: 39067161
Limb salvage surgery reconstructive techniques following long-bone lower limb oncological resection: a systematic review and meta-analysis.
Hovav O, Kolonko S, Zahir SF, Velli G, Chouhan P, Wagels M
ANZ J Surg 2023 Nov;93(11):2609-2620. Epub 2023 Feb 23 doi: 10.1111/ans.18335. PMID: 36821561
Isolated Limb Perfusion and Infusion for Extremity Soft Tissue Sarcoma: A Contemporary Systematic Review and Meta-Analysis.
Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC
Ann Surg Oncol 2017 Dec;24(13):3803-3810. Epub 2017 Oct 11 doi: 10.1245/s10434-017-6109-7. PMID: 29022281
Pediatric lower extremity sarcoma reconstruction: A review of limb salvage procedures and outcomes.
Piper M, Irwin C, Sbitany H
J Plast Reconstr Aesthet Surg 2016 Jan;69(1):91-6. Epub 2015 Sep 5 doi: 10.1016/j.bjps.2015.08.035. PMID: 26601876
Outcomes of isolated limb perfusion in the treatment of extremity soft tissue sarcoma: a systematic review.
Bhangu A, Broom L, Nepogodiev D, Gourevitch D, Desai A
Eur J Surg Oncol 2013 Apr;39(4):311-9. Epub 2013 Jan 23 doi: 10.1016/j.ejso.2012.12.018. PMID: 23351681

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