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Low Grade Anal Intraepithelial Neoplasia

MedGen UID:
1675577
•Concept ID:
C4763712
•
Neoplastic Process
Synonym: Anal Intraepithelial Neoplasia 1

Definition

Anal canal or perianal skin intraepithelial neoplasia with mild dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Anal Intraepithelial Neoplasia

Professional guidelines

PubMed

Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Raman spectroscopy for screening and diagnosis of cervical cancer.
Lyng FM, Traynor D, Ramos IR, Bonnier F, Byrne HJ
Anal Bioanal Chem 2015 Nov;407(27):8279-89. Epub 2015 Aug 16 doi: 10.1007/s00216-015-8946-1. PMID: 26277185
Controversies in the management of anal high-grade squamous intraepithelial lesions.
Pineda CE, Welton ML
Minerva Chir 2008 Oct;63(5):389-99. PMID: 18923350

Recent clinical studies

Etiology

Cytology-based Screening for Anal Intraepithelial Neoplasia in Immunocompetent Brazilian Women with a History of High-Grade Cervical Intraepithelial Neoplasia or Cancer.
Brum VOR, Tricoti ASO, Pannain GD, Drumond DG, Leite ICG
Rev Bras Ginecol Obstet 2022 Jul;44(7):678-685. Epub 2022 Aug 8 doi: 10.1055/s-0042-1743163. PMID: 35940173Free PMC Article
DNA Methylation Analysis to predict Regression of high-grade anal Intraepithelial Neoplasia in HIV+ men (MARINE): a cohort study protocol.
Dias Gonçalves Lima F, van der Zee RP, Dick S, van Noesel CJM, Berkhof J, Schim van der Loeff MF, Prins JM, Steenbergen RDM, de Vries HJC
BMJ Open 2022 Aug 3;12(8):e060301. doi: 10.1136/bmjopen-2021-060301. PMID: 35922105Free PMC Article
Low- and high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men who have sex with men.
Siegenbeek van Heukelom ML, Richel O, de Vries HJ, van de Sandt MM, Beck S, van den Munckhof HA, Pirog EC, de Koning MN, Prins JM, Quint KD
Br J Dermatol 2016 Oct;175(4):735-43. Epub 2016 Jul 6 doi: 10.1111/bjd.14567. PMID: 26994411
Clinical effectiveness and cost-effectiveness of quadrivalent human papillomavirus vaccination in HIV-negative men who have sex with men to prevent recurrent high-grade anal intraepithelial neoplasia.
Deshmukh AA, Chiao EY, Das P, Cantor SB
Vaccine 2014 Dec 5;32(51):6941-6947. Epub 2014 Nov 1 doi: 10.1016/j.vaccine.2014.10.052. PMID: 25444820Free PMC Article
Anal intraepithelial neoplasia in a multisite study of HIV-infected and high-risk HIV-uninfected women.
Hessol NA, Holly EA, Efird JT, Minkoff H, Schowalter K, Darragh TM, Burk RD, Strickler HD, Greenblatt RM, Palefsky JM
AIDS 2009 Jan 2;23(1):59-70. doi: 10.1097/QAD.0b013e32831cc101. PMID: 19050387Free PMC Article

Diagnosis

Cytology-based Screening for Anal Intraepithelial Neoplasia in Immunocompetent Brazilian Women with a History of High-Grade Cervical Intraepithelial Neoplasia or Cancer.
Brum VOR, Tricoti ASO, Pannain GD, Drumond DG, Leite ICG
Rev Bras Ginecol Obstet 2022 Jul;44(7):678-685. Epub 2022 Aug 8 doi: 10.1055/s-0042-1743163. PMID: 35940173Free PMC Article
DNA Methylation Analysis to predict Regression of high-grade anal Intraepithelial Neoplasia in HIV+ men (MARINE): a cohort study protocol.
Dias Gonçalves Lima F, van der Zee RP, Dick S, van Noesel CJM, Berkhof J, Schim van der Loeff MF, Prins JM, Steenbergen RDM, de Vries HJC
BMJ Open 2022 Aug 3;12(8):e060301. doi: 10.1136/bmjopen-2021-060301. PMID: 35922105Free PMC Article
Utility of Stathmin-1 as a Novel Marker in Evaluating Anal Intraepithelial Neoplasia (AIN).
Hissong E, Cimic A, Leeman A, Pirog EC
Appl Immunohistochem Mol Morphol 2019 Feb;27(2):134-139. doi: 10.1097/PAI.0000000000000547. PMID: 28777150
Clinical effectiveness and cost-effectiveness of quadrivalent human papillomavirus vaccination in HIV-negative men who have sex with men to prevent recurrent high-grade anal intraepithelial neoplasia.
Deshmukh AA, Chiao EY, Das P, Cantor SB
Vaccine 2014 Dec 5;32(51):6941-6947. Epub 2014 Nov 1 doi: 10.1016/j.vaccine.2014.10.052. PMID: 25444820Free PMC Article
Anal intraepithelial neoplasia and other neoplastic precursor lesions of the anal canal and perianal region.
Shepherd NA
Gastroenterol Clin North Am 2007 Dec;36(4):969-87, ix. doi: 10.1016/j.gtc.2007.08.001. PMID: 17996800

Therapy

DNA Methylation Analysis to predict Regression of high-grade anal Intraepithelial Neoplasia in HIV+ men (MARINE): a cohort study protocol.
Dias Gonçalves Lima F, van der Zee RP, Dick S, van Noesel CJM, Berkhof J, Schim van der Loeff MF, Prins JM, Steenbergen RDM, de Vries HJC
BMJ Open 2022 Aug 3;12(8):e060301. doi: 10.1136/bmjopen-2021-060301. PMID: 35922105Free PMC Article
Low- and high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men who have sex with men.
Siegenbeek van Heukelom ML, Richel O, de Vries HJ, van de Sandt MM, Beck S, van den Munckhof HA, Pirog EC, de Koning MN, Prins JM, Quint KD
Br J Dermatol 2016 Oct;175(4):735-43. Epub 2016 Jul 6 doi: 10.1111/bjd.14567. PMID: 26994411
Clinical effectiveness and cost-effectiveness of quadrivalent human papillomavirus vaccination in HIV-negative men who have sex with men to prevent recurrent high-grade anal intraepithelial neoplasia.
Deshmukh AA, Chiao EY, Das P, Cantor SB
Vaccine 2014 Dec 5;32(51):6941-6947. Epub 2014 Nov 1 doi: 10.1016/j.vaccine.2014.10.052. PMID: 25444820Free PMC Article

Prognosis

DNA Methylation Analysis to predict Regression of high-grade anal Intraepithelial Neoplasia in HIV+ men (MARINE): a cohort study protocol.
Dias Gonçalves Lima F, van der Zee RP, Dick S, van Noesel CJM, Berkhof J, Schim van der Loeff MF, Prins JM, Steenbergen RDM, de Vries HJC
BMJ Open 2022 Aug 3;12(8):e060301. doi: 10.1136/bmjopen-2021-060301. PMID: 35922105Free PMC Article
Utility of Stathmin-1 as a Novel Marker in Evaluating Anal Intraepithelial Neoplasia (AIN).
Hissong E, Cimic A, Leeman A, Pirog EC
Appl Immunohistochem Mol Morphol 2019 Feb;27(2):134-139. doi: 10.1097/PAI.0000000000000547. PMID: 28777150
Incidence of Anal Dysplasia in a Population of High-Risk Women: Observations at a Cervical Pathology Unit.
Oliver-Pérez MLR, Bravo Violeta V, Legorburu Alonso B, Betancor Pérez D, Bebia Conesa V, Jiménez López JS
J Low Genit Tract Dis 2017 Oct;21(4):329-335. doi: 10.1097/LGT.0000000000000328. PMID: 28953128
Cost-effectiveness of screening high-risk HIV-positive men who have sex with men (MSM) and HIV-positive women for anal cancer.
Czoski-Murray C, Karnon J, Jones R, Smith K, Kinghorn G
Health Technol Assess 2010 Nov;14(53):iii-iv, ix-x, 1-101. doi: 10.3310/hta14530. PMID: 21083999
Expression of Ki-67 can assist in predicting recurrences of low-grade anal intraepithelial neoplasia in AIDS.
Calore EE, Nadal SR, Manzione CR, Cavaliere MJ, de Almeida LV, Villa LL
Dis Colon Rectum 2001 Apr;44(4):534-7. doi: 10.1007/BF02234325. PMID: 11330580

Clinical prediction guides

DNA Methylation Analysis to predict Regression of high-grade anal Intraepithelial Neoplasia in HIV+ men (MARINE): a cohort study protocol.
Dias Gonçalves Lima F, van der Zee RP, Dick S, van Noesel CJM, Berkhof J, Schim van der Loeff MF, Prins JM, Steenbergen RDM, de Vries HJC
BMJ Open 2022 Aug 3;12(8):e060301. doi: 10.1136/bmjopen-2021-060301. PMID: 35922105Free PMC Article
Utility of Stathmin-1 as a Novel Marker in Evaluating Anal Intraepithelial Neoplasia (AIN).
Hissong E, Cimic A, Leeman A, Pirog EC
Appl Immunohistochem Mol Morphol 2019 Feb;27(2):134-139. doi: 10.1097/PAI.0000000000000547. PMID: 28777150
Incidence of Anal Dysplasia in a Population of High-Risk Women: Observations at a Cervical Pathology Unit.
Oliver-Pérez MLR, Bravo Violeta V, Legorburu Alonso B, Betancor Pérez D, Bebia Conesa V, Jiménez López JS
J Low Genit Tract Dis 2017 Oct;21(4):329-335. doi: 10.1097/LGT.0000000000000328. PMID: 28953128
Anal study in immunocompetent women with human papillomavirus related lower genital tract pathology.
Donaire C, Reillo M, Martínez-Escoriza JC, López-Fernández JA
Eur J Obstet Gynecol Reprod Biol 2017 Apr;211:15-20. Epub 2017 Jan 19 doi: 10.1016/j.ejogrb.2017.01.023. PMID: 28161543
Expression of Ki-67 can assist in predicting recurrences of low-grade anal intraepithelial neoplasia in AIDS.
Calore EE, Nadal SR, Manzione CR, Cavaliere MJ, de Almeida LV, Villa LL
Dis Colon Rectum 2001 Apr;44(4):534-7. doi: 10.1007/BF02234325. PMID: 11330580

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