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Metastatic Salivary Gland Carcinoma

MedGen UID:
1676948
•Concept ID:
C4764238
•
Neoplastic Process

Definition

A salivary gland carcinoma that has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Treatment Efficacy of PD-1 Inhibitor Therapy in Patients With Recurrent and/or Metastatic Salivary Gland Carcinoma.
Hashimoto K, Yasumatsu R, Kuga R, Hongo T, Yamamoto H, Matsuo M, Wakasaki T, Jiromaru R, Manako T, Toh S, Masuda M, Yamauchi M, Kuratomi Y, Uryu H, Nakashima T, Tamae A, Tanaka R, Taura M, Takeuchi T, Yoshida T, Nakagawa T
Anticancer Res 2022 Feb;42(2):981-989. doi: 10.21873/anticanres.15558. PMID: 35093898

Recent clinical studies

Etiology

A comparison of two chemotherapy regimens in advanced, recurrent, or metastatic salivary gland carcinoma.
Ameri A, Sourati A, Behzadi B, Lesan M, Taghizadeh-Hesary F
Indian J Cancer 2023 Jul-Sep;60(3):418-426. doi: 10.4103/ijc.IJC_1226_20. PMID: 36861690
Treatment Efficacy of PD-1 Inhibitor Therapy in Patients With Recurrent and/or Metastatic Salivary Gland Carcinoma.
Hashimoto K, Yasumatsu R, Kuga R, Hongo T, Yamamoto H, Matsuo M, Wakasaki T, Jiromaru R, Manako T, Toh S, Masuda M, Yamauchi M, Kuratomi Y, Uryu H, Nakashima T, Tamae A, Tanaka R, Taura M, Takeuchi T, Yoshida T, Nakagawa T
Anticancer Res 2022 Feb;42(2):981-989. doi: 10.21873/anticanres.15558. PMID: 35093898
Metastatic salivary gland carcinoma: A role for stereotactic body radiation therapy? A study of AIRO-Head and Neck working group.
Franzese C, Ingargiola R, Tomatis S, Iacovelli NA, Beltramo G, Franco P, Bonomo P, Zanetti IB, Argenone A, Cante D, Romanello DA, Musio D, De Felice F, Furlan C, Scorsetti M, Orlandi E
Oral Dis 2022 Mar;28(2):345-351. Epub 2020 Dec 25 doi: 10.1111/odi.13755. PMID: 33320410
Multicentre, retrospective study of the efficacy and safety of nivolumab for recurrent and metastatic salivary gland carcinoma.
Niwa K, Kawakita D, Nagao T, Takahashi H, Saotome T, Okazaki M, Yamazaki K, Okamoto I, Hirai H, Saigusa N, Fushimi C, Masubuchi T, Miura K, Okazaki SI, Matsui H, Okada T, Iwaki S, Matsuki T, Hanyu K, Tsukahara K, Oridate N, Tada Y
Sci Rep 2020 Oct 12;10(1):16988. doi: 10.1038/s41598-020-73965-6. PMID: 33046752Free PMC Article
Combination chemotherapy of carboplatin and paclitaxel for advanced/metastatic salivary gland carcinoma patients: differences in responses by different pathological diagnoses.
Nakano K, Sato Y, Sasaki T, Shimbashi W, Fukushima H, Yonekawa H, Mitani H, Kawabata K, Takahashi S
Acta Otolaryngol 2016 Sep;136(9):948-51. Epub 2016 Apr 20 doi: 10.3109/00016489.2016.1170876. PMID: 27094013

Diagnosis

Efficacy of Cetuximab Combined with Paclitaxel in Patients with Recurrent Salivary Gland Carcinoma: A Retrospective Observational Study.
Sato R, Yuasa R, Kumai T, Wakisaka R, Komatsuda H, Kono M, Yamaki H, Ishida Y, Wada T, Takahara M, Katada A
ORL J Otorhinolaryngol Relat Spec 2024;86(1):41-49. Epub 2023 Dec 13 doi: 10.1159/000534516. PMID: 38091970
Combination chemotherapy of carboplatin and paclitaxel for advanced/metastatic salivary gland carcinoma patients: differences in responses by different pathological diagnoses.
Nakano K, Sato Y, Sasaki T, Shimbashi W, Fukushima H, Yonekawa H, Mitani H, Kawabata K, Takahashi S
Acta Otolaryngol 2016 Sep;136(9):948-51. Epub 2016 Apr 20 doi: 10.3109/00016489.2016.1170876. PMID: 27094013

Therapy

Apalutamide and Goserelin for Androgen Receptor-Positive Salivary Gland Carcinoma: A Phase II Nonrandomized Clinical Trial, YATAGARASU.
Honma Y, Monden N, Yamazaki K, Kano S, Satake H, Kadowaki S, Utsumi Y, Nakatogawa T, Takano R, Fujii K, Koroki Y, Aoyama J, Ouchi S, Ogawa T, McCarthy S, Brookman-May SD, Mundle S, Li J, Thaper D, Nagao T, Tada Y
Clin Cancer Res 2024 Aug 15;30(16):3416-3427. doi: 10.1158/1078-0432.CCR-24-0455. PMID: 38940667
A comparison of two chemotherapy regimens in advanced, recurrent, or metastatic salivary gland carcinoma.
Ameri A, Sourati A, Behzadi B, Lesan M, Taghizadeh-Hesary F
Indian J Cancer 2023 Jul-Sep;60(3):418-426. doi: 10.4103/ijc.IJC_1226_20. PMID: 36861690
Treatment Efficacy of PD-1 Inhibitor Therapy in Patients With Recurrent and/or Metastatic Salivary Gland Carcinoma.
Hashimoto K, Yasumatsu R, Kuga R, Hongo T, Yamamoto H, Matsuo M, Wakasaki T, Jiromaru R, Manako T, Toh S, Masuda M, Yamauchi M, Kuratomi Y, Uryu H, Nakashima T, Tamae A, Tanaka R, Taura M, Takeuchi T, Yoshida T, Nakagawa T
Anticancer Res 2022 Feb;42(2):981-989. doi: 10.21873/anticanres.15558. PMID: 35093898
Metastatic salivary gland carcinoma: A role for stereotactic body radiation therapy? A study of AIRO-Head and Neck working group.
Franzese C, Ingargiola R, Tomatis S, Iacovelli NA, Beltramo G, Franco P, Bonomo P, Zanetti IB, Argenone A, Cante D, Romanello DA, Musio D, De Felice F, Furlan C, Scorsetti M, Orlandi E
Oral Dis 2022 Mar;28(2):345-351. Epub 2020 Dec 25 doi: 10.1111/odi.13755. PMID: 33320410
Multicentre, retrospective study of the efficacy and safety of nivolumab for recurrent and metastatic salivary gland carcinoma.
Niwa K, Kawakita D, Nagao T, Takahashi H, Saotome T, Okazaki M, Yamazaki K, Okamoto I, Hirai H, Saigusa N, Fushimi C, Masubuchi T, Miura K, Okazaki SI, Matsui H, Okada T, Iwaki S, Matsuki T, Hanyu K, Tsukahara K, Oridate N, Tada Y
Sci Rep 2020 Oct 12;10(1):16988. doi: 10.1038/s41598-020-73965-6. PMID: 33046752Free PMC Article

Prognosis

PD-L1 expression as a predictive biomarker in patients with recurrent or metastatic salivary gland carcinoma treated with pembrolizumab.
Matsuki T, Kawakita D, Takahashi H, Okada T, Sakai A, Ueki Y, Tsuge H, Hanyu K, Momiyama K, Shodo R, Yamauchi M, Asako Y, Hirai H, Nagao T, Tada Y
Sci Rep 2024 Aug 27;14(1):19794. doi: 10.1038/s41598-024-70779-8. PMID: 39187586Free PMC Article
Multicentre, retrospective study of the efficacy and safety of nivolumab for recurrent and metastatic salivary gland carcinoma.
Niwa K, Kawakita D, Nagao T, Takahashi H, Saotome T, Okazaki M, Yamazaki K, Okamoto I, Hirai H, Saigusa N, Fushimi C, Masubuchi T, Miura K, Okazaki SI, Matsui H, Okada T, Iwaki S, Matsuki T, Hanyu K, Tsukahara K, Oridate N, Tada Y
Sci Rep 2020 Oct 12;10(1):16988. doi: 10.1038/s41598-020-73965-6. PMID: 33046752Free PMC Article
High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma.
Hsieh CE, Hung CY, Lin CY, Chen JS, Chang KP, Aithala SP, Lee LY, Tsang NM, Lu CH, Chen MF, Cheng YF, Yeh KY, Wang CH, Chou WC
Head Neck 2019 Jun;41(6):1572-1582. Epub 2019 Jan 16 doi: 10.1002/hed.25603. PMID: 30652371
Metastatic HER-2-positive salivary gland carcinoma treated with trastuzumab and a taxane: a series of six patients.
De Block K, Vander Poorten V, Dormaar T, Nuyts S, Hauben E, Floris G, Deroose CM, Schöffski P, Clement PM
Acta Clin Belg 2016 Dec;71(6):383-388. Epub 2016 May 30 doi: 10.1080/17843286.2016.1173940. PMID: 27285571
Combination chemotherapy of carboplatin and paclitaxel for advanced/metastatic salivary gland carcinoma patients: differences in responses by different pathological diagnoses.
Nakano K, Sato Y, Sasaki T, Shimbashi W, Fukushima H, Yonekawa H, Mitani H, Kawabata K, Takahashi S
Acta Otolaryngol 2016 Sep;136(9):948-51. Epub 2016 Apr 20 doi: 10.3109/00016489.2016.1170876. PMID: 27094013

Clinical prediction guides

Apalutamide and Goserelin for Androgen Receptor-Positive Salivary Gland Carcinoma: A Phase II Nonrandomized Clinical Trial, YATAGARASU.
Honma Y, Monden N, Yamazaki K, Kano S, Satake H, Kadowaki S, Utsumi Y, Nakatogawa T, Takano R, Fujii K, Koroki Y, Aoyama J, Ouchi S, Ogawa T, McCarthy S, Brookman-May SD, Mundle S, Li J, Thaper D, Nagao T, Tada Y
Clin Cancer Res 2024 Aug 15;30(16):3416-3427. doi: 10.1158/1078-0432.CCR-24-0455. PMID: 38940667
Metastatic salivary gland carcinoma: A role for stereotactic body radiation therapy? A study of AIRO-Head and Neck working group.
Franzese C, Ingargiola R, Tomatis S, Iacovelli NA, Beltramo G, Franco P, Bonomo P, Zanetti IB, Argenone A, Cante D, Romanello DA, Musio D, De Felice F, Furlan C, Scorsetti M, Orlandi E
Oral Dis 2022 Mar;28(2):345-351. Epub 2020 Dec 25 doi: 10.1111/odi.13755. PMID: 33320410
Multicentre, retrospective study of the efficacy and safety of nivolumab for recurrent and metastatic salivary gland carcinoma.
Niwa K, Kawakita D, Nagao T, Takahashi H, Saotome T, Okazaki M, Yamazaki K, Okamoto I, Hirai H, Saigusa N, Fushimi C, Masubuchi T, Miura K, Okazaki SI, Matsui H, Okada T, Iwaki S, Matsuki T, Hanyu K, Tsukahara K, Oridate N, Tada Y
Sci Rep 2020 Oct 12;10(1):16988. doi: 10.1038/s41598-020-73965-6. PMID: 33046752Free PMC Article
High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma.
Hsieh CE, Hung CY, Lin CY, Chen JS, Chang KP, Aithala SP, Lee LY, Tsang NM, Lu CH, Chen MF, Cheng YF, Yeh KY, Wang CH, Chou WC
Head Neck 2019 Jun;41(6):1572-1582. Epub 2019 Jan 16 doi: 10.1002/hed.25603. PMID: 30652371
Combination chemotherapy of carboplatin and paclitaxel for advanced/metastatic salivary gland carcinoma patients: differences in responses by different pathological diagnoses.
Nakano K, Sato Y, Sasaki T, Shimbashi W, Fukushima H, Yonekawa H, Mitani H, Kawabata K, Takahashi S
Acta Otolaryngol 2016 Sep;136(9):948-51. Epub 2016 Apr 20 doi: 10.3109/00016489.2016.1170876. PMID: 27094013

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