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Metastatic Kidney Medullary Carcinoma

MedGen UID:
1677812
•Concept ID:
C4763832
•
Neoplastic Process

Definition

Kidney medullary carcinoma that has spread to another anatomical site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Kidney Medullary Carcinoma

Professional guidelines

PubMed

"Collecting duct carcinoma of the kidney: diagnosis and implications for management".
Cabanillas G, Montoya-Cerrillo D, Kryvenko ON, Pal SK, Arias-Stella JA 3rd
Urol Oncol 2022 Dec;40(12):525-536. Epub 2021 Jun 8 doi: 10.1016/j.urolonc.2021.04.041. PMID: 34116936
The Differential Diagnosis of Medullary-Based Renal Masses.
Baniak N, Tsai H, Hirsch MS
Arch Pathol Lab Med 2021 Sep 1;145(9):1148-1170. doi: 10.5858/arpa.2020-0464-RA. PMID: 33406251
Cabozantinib for the treatment of kidney cancer.
Abdelaziz A, Vaishampayan U
Expert Rev Anticancer Ther 2017 Jul;17(7):577-584. doi: 10.1080/14737140.2017.1344553. PMID: 28633552Free PMC Article

Recent clinical studies

Etiology

A Phase 2 Trial of Talazoparib and Avelumab in Genomically Defined Metastatic Kidney Cancer.
Kotecha RR, Doshi SD, Knezevic A, Chaim J, Chen Y, Jacobi R, Zucker M, Reznik E, McHugh D, Shah NJ, Feld E, Aggen DH, Rafelson W, Xiao H, Carlo MI, Feldman DR, Lee CH, Motzer RJ, Voss MH
Eur Urol Oncol 2024 Aug;7(4):804-811. Epub 2023 Nov 7 doi: 10.1016/j.euo.2023.10.017. PMID: 37945488Free PMC Article
Advanced nccRCC: what therapeutic options in 2022?
Bigot C, Boudier P, Ladoire S, Barthélémy P
Bull Cancer 2022 May;109(2S):2S39-2S46. doi: 10.1016/S0007-4551(22)00237-5. PMID: 35760469
Safety and efficacy of nivolumab plus ipilimumab in patients with advanced non-clear cell renal cell carcinoma: results from the phase 3b/4 CheckMate 920 trial.
Tykodi SS, Gordan LN, Alter RS, Arrowsmith E, Harrison MR, Percent I, Singal R, Van Veldhuizen P, George DJ, Hutson T, Zhang J, Zoco J, Johansen JL, Rezazadeh Kalebasty A
J Immunother Cancer 2022 Feb;10(2) doi: 10.1136/jitc-2021-003844. PMID: 35210307Free PMC Article
Renal Medullary Carcinoma: Establishing Standards in Practice.
Beckermann KE, Sharma D, Chaturvedi S, Msaouel P, Abboud MR, Allory Y, Bourdeaut F, Calderaro J, de Cubas AA, Derebail VK, Hong AL, Naik RP, Malouf GG, Mullen EA, Reuter VE, Roberts CWM, Walker CL, Wood CG, DeBaun MR, Van Poppel H, Tannir NM, Rathmell WK
J Oncol Pract 2017 Jul;13(7):414-421. doi: 10.1200/JOP.2017.020909. PMID: 28697319Free PMC Article
Cabozantinib for the treatment of kidney cancer.
Abdelaziz A, Vaishampayan U
Expert Rev Anticancer Ther 2017 Jul;17(7):577-584. doi: 10.1080/14737140.2017.1344553. PMID: 28633552Free PMC Article

Diagnosis

Renal Medullary Carcinoma: A Surveillance, Epidemiology, and End Results (SEER) Analysis.
Haupt T, Akinyemi O, Raju RA, Wadley AE, Nnorom S, Aponte V, Thelus J, Tonkin JB, Coleman PW, Metwalli AR
J Surg Res 2023 Dec;292:1-6. Epub 2023 Aug 9 doi: 10.1016/j.jss.2023.06.019. PMID: 37567029
Peptide Receptor Radionuclide Therapy in Thyroid Cancer.
Gubbi S, Koch CA, Klubo-Gwiezdzinska J
Front Endocrinol (Lausanne) 2022;13:896287. Epub 2022 May 30 doi: 10.3389/fendo.2022.896287. PMID: 35712243Free PMC Article
"Collecting duct carcinoma of the kidney: diagnosis and implications for management".
Cabanillas G, Montoya-Cerrillo D, Kryvenko ON, Pal SK, Arias-Stella JA 3rd
Urol Oncol 2022 Dec;40(12):525-536. Epub 2021 Jun 8 doi: 10.1016/j.urolonc.2021.04.041. PMID: 34116936
The Differential Diagnosis of Medullary-Based Renal Masses.
Baniak N, Tsai H, Hirsch MS
Arch Pathol Lab Med 2021 Sep 1;145(9):1148-1170. doi: 10.5858/arpa.2020-0464-RA. PMID: 33406251
Renal Medullary Carcinoma: Establishing Standards in Practice.
Beckermann KE, Sharma D, Chaturvedi S, Msaouel P, Abboud MR, Allory Y, Bourdeaut F, Calderaro J, de Cubas AA, Derebail VK, Hong AL, Naik RP, Malouf GG, Mullen EA, Reuter VE, Roberts CWM, Walker CL, Wood CG, DeBaun MR, Van Poppel H, Tannir NM, Rathmell WK
J Oncol Pract 2017 Jul;13(7):414-421. doi: 10.1200/JOP.2017.020909. PMID: 28697319Free PMC Article

Therapy

A Phase 2 Trial of Talazoparib and Avelumab in Genomically Defined Metastatic Kidney Cancer.
Kotecha RR, Doshi SD, Knezevic A, Chaim J, Chen Y, Jacobi R, Zucker M, Reznik E, McHugh D, Shah NJ, Feld E, Aggen DH, Rafelson W, Xiao H, Carlo MI, Feldman DR, Lee CH, Motzer RJ, Voss MH
Eur Urol Oncol 2024 Aug;7(4):804-811. Epub 2023 Nov 7 doi: 10.1016/j.euo.2023.10.017. PMID: 37945488Free PMC Article
Peptide Receptor Radionuclide Therapy in Thyroid Cancer.
Gubbi S, Koch CA, Klubo-Gwiezdzinska J
Front Endocrinol (Lausanne) 2022;13:896287. Epub 2022 May 30 doi: 10.3389/fendo.2022.896287. PMID: 35712243Free PMC Article
Safety and efficacy of nivolumab plus ipilimumab in patients with advanced non-clear cell renal cell carcinoma: results from the phase 3b/4 CheckMate 920 trial.
Tykodi SS, Gordan LN, Alter RS, Arrowsmith E, Harrison MR, Percent I, Singal R, Van Veldhuizen P, George DJ, Hutson T, Zhang J, Zoco J, Johansen JL, Rezazadeh Kalebasty A
J Immunother Cancer 2022 Feb;10(2) doi: 10.1136/jitc-2021-003844. PMID: 35210307Free PMC Article
Cabozantinib for the treatment of kidney cancer.
Abdelaziz A, Vaishampayan U
Expert Rev Anticancer Ther 2017 Jul;17(7):577-584. doi: 10.1080/14737140.2017.1344553. PMID: 28633552Free PMC Article
Clinical Pharmacokinetics and Pharmacodynamics of Cabozantinib.
Lacy SA, Miles DR, Nguyen LT
Clin Pharmacokinet 2017 May;56(5):477-491. doi: 10.1007/s40262-016-0461-9. PMID: 27734291

Prognosis

Renal Medullary Carcinoma: A Surveillance, Epidemiology, and End Results (SEER) Analysis.
Haupt T, Akinyemi O, Raju RA, Wadley AE, Nnorom S, Aponte V, Thelus J, Tonkin JB, Coleman PW, Metwalli AR
J Surg Res 2023 Dec;292:1-6. Epub 2023 Aug 9 doi: 10.1016/j.jss.2023.06.019. PMID: 37567029
"Collecting duct carcinoma of the kidney: diagnosis and implications for management".
Cabanillas G, Montoya-Cerrillo D, Kryvenko ON, Pal SK, Arias-Stella JA 3rd
Urol Oncol 2022 Dec;40(12):525-536. Epub 2021 Jun 8 doi: 10.1016/j.urolonc.2021.04.041. PMID: 34116936
The Differential Diagnosis of Medullary-Based Renal Masses.
Baniak N, Tsai H, Hirsch MS
Arch Pathol Lab Med 2021 Sep 1;145(9):1148-1170. doi: 10.5858/arpa.2020-0464-RA. PMID: 33406251
Cabozantinib for the treatment of kidney cancer.
Abdelaziz A, Vaishampayan U
Expert Rev Anticancer Ther 2017 Jul;17(7):577-584. doi: 10.1080/14737140.2017.1344553. PMID: 28633552Free PMC Article
Clinical Pharmacokinetics and Pharmacodynamics of Cabozantinib.
Lacy SA, Miles DR, Nguyen LT
Clin Pharmacokinet 2017 May;56(5):477-491. doi: 10.1007/s40262-016-0461-9. PMID: 27734291

Clinical prediction guides

Renal Medullary Carcinoma: A Surveillance, Epidemiology, and End Results (SEER) Analysis.
Haupt T, Akinyemi O, Raju RA, Wadley AE, Nnorom S, Aponte V, Thelus J, Tonkin JB, Coleman PW, Metwalli AR
J Surg Res 2023 Dec;292:1-6. Epub 2023 Aug 9 doi: 10.1016/j.jss.2023.06.019. PMID: 37567029
The Differential Diagnosis of Medullary-Based Renal Masses.
Baniak N, Tsai H, Hirsch MS
Arch Pathol Lab Med 2021 Sep 1;145(9):1148-1170. doi: 10.5858/arpa.2020-0464-RA. PMID: 33406251
Renal cell carcinoma, unclassified with medullary phenotype: poorly differentiated adenocarcinomas overlapping with renal medullary carcinoma.
Sirohi D, Smith SC, Ohe C, Colombo P, Divatia M, Dragoescu E, Rao P, Hirsch MS, Chen YB, Mehra R, Amin MB
Hum Pathol 2017 Sep;67:134-145. Epub 2017 Jul 15 doi: 10.1016/j.humpath.2017.07.006. PMID: 28716439
Clinical Pharmacokinetics and Pharmacodynamics of Cabozantinib.
Lacy SA, Miles DR, Nguyen LT
Clin Pharmacokinet 2017 May;56(5):477-491. doi: 10.1007/s40262-016-0461-9. PMID: 27734291
Multiple endocrine neoplasia syndromes, children, Hirschsprung's disease and RET.
Moore SW, Zaahl MG
Pediatr Surg Int 2008 May;24(5):521-30. Epub 2008 Mar 26 doi: 10.1007/s00383-008-2137-5. PMID: 18365214

Recent systematic reviews

Renal medullary carcinoma and sickle cell trait: A systematic review.
Alvarez O, Rodriguez MM, Jordan L, Sarnaik S
Pediatr Blood Cancer 2015 Oct;62(10):1694-9. Epub 2015 Jun 5 doi: 10.1002/pbc.25592. PMID: 26053587

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