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Renal carcinoma

MedGen UID:
235133
•Concept ID:
C1378703
•
Neoplastic Process
Synonym: Kidney Carcinoma
 
Monarch Initiative: MONDO:0005206

Definition

A carcinoma arising from the epithelium of the renal parenchyma or the renal pelvis. The majority are renal cell carcinomas. Kidney carcinomas usually affect middle aged and elderly adults. Hematuria, abdominal pain, and a palpable mass are common symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Renal carcinoma

Professional guidelines

PubMed

Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies.
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
The Differential Diagnosis of Medullary-Based Renal Masses.
Baniak N, Tsai H, Hirsch MS
Arch Pathol Lab Med 2021 Sep 1;145(9):1148-1170. doi: 10.5858/arpa.2020-0464-RA. PMID: 33406251
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530

Recent clinical studies

Etiology

Combined use of pembrolizumab and lenvatinib: A review.
Eisinger C, Muluneh B
J Oncol Pharm Pract 2023 Sep;29(6):1461-1466. Epub 2023 May 25 doi: 10.1177/10781552231178461. PMID: 37231712Free PMC Article
Translocation carcinomas of the kidney.
Argani P
Genes Chromosomes Cancer 2022 May;61(5):219-227. Epub 2021 Nov 3 doi: 10.1002/gcc.23007. PMID: 34704642
Distal nephron neoplasms.
Fleming S
Semin Diagn Pathol 2015 Mar;32(2):114-23. Epub 2015 Mar 9 doi: 10.1053/j.semdp.2015.02.004. PMID: 25804446
Birt-Hogg-Dubé syndrome.
Lencastre A, Ponte P, Apetato M, Nunes L, Lestre S
An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):203-5. doi: 10.1590/abd1806-4841.20132199. PMID: 24346920Free PMC Article
Renal cell carcinoma.
Savage PD
Curr Opin Oncol 1994 May;6(3):301-7. doi: 10.1097/00001622-199405000-00013. PMID: 8080860

Diagnosis

Radiomics and Artificial Intelligence: Renal Cell Carcinoma.
Raman AG, Fisher D, Yap F, Oberai A, Duddalwar VA
Urol Clin North Am 2024 Feb;51(1):35-45. Epub 2023 Jul 28 doi: 10.1016/j.ucl.2023.06.007. PMID: 37945101
Facial Papules and Renal Carcinoma: A Quiz.
Capurro N, Riva S, Molle MF, Cozzani E, Guadagno A, Parodi A
Acta Derm Venereol 2022 Nov 29;102:adv00824. doi: 10.2340/actadv.v102.4575. PMID: 36317861Free PMC Article
Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma.
Li M, Liu G, Jin X, Guo H, Setrerrahmane S, Xu X, Li T, Lin Y, Xu H
Mol Cancer 2022 Sep 19;21(1):181. doi: 10.1186/s12943-022-01654-1. PMID: 36117171Free PMC Article
Primary Renal Leiomyosarcoma.
Ding Y, Quan C
J Coll Physicians Surg Pak 2021 Jun;31(6):725-727. doi: 10.29271/jcpsp.2021.06.725. PMID: 34102790
Distal nephron neoplasms.
Fleming S
Semin Diagn Pathol 2015 Mar;32(2):114-23. Epub 2015 Mar 9 doi: 10.1053/j.semdp.2015.02.004. PMID: 25804446

Therapy

Combined use of pembrolizumab and lenvatinib: A review.
Eisinger C, Muluneh B
J Oncol Pharm Pract 2023 Sep;29(6):1461-1466. Epub 2023 May 25 doi: 10.1177/10781552231178461. PMID: 37231712Free PMC Article
Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma.
Li M, Liu G, Jin X, Guo H, Setrerrahmane S, Xu X, Li T, Lin Y, Xu H
Mol Cancer 2022 Sep 19;21(1):181. doi: 10.1186/s12943-022-01654-1. PMID: 36117171Free PMC Article
Pembrolizumab for the treatment of colorectal cancer.
Coupez D, Hulo P, Touchefeu Y, Bossard C, Bennouna J
Expert Opin Biol Ther 2020 Mar;20(3):219-226. Epub 2020 Feb 3 doi: 10.1080/14712598.2020.1718095. PMID: 31952453
Renal cell carcinoma.
Rathmell WK, Godley PA, Rini BI
Curr Opin Oncol 2005 May;17(3):261-7. doi: 10.1097/01.cco.0000155007.51495.d6. PMID: 15818172
Fever.
Dinarello CA, Bunn PA Jr
Semin Oncol 1997 Jun;24(3):288-98. PMID: 9208885

Prognosis

Radiomics and Artificial Intelligence: Renal Cell Carcinoma.
Raman AG, Fisher D, Yap F, Oberai A, Duddalwar VA
Urol Clin North Am 2024 Feb;51(1):35-45. Epub 2023 Jul 28 doi: 10.1016/j.ucl.2023.06.007. PMID: 37945101
Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma.
Li M, Liu G, Jin X, Guo H, Setrerrahmane S, Xu X, Li T, Lin Y, Xu H
Mol Cancer 2022 Sep 19;21(1):181. doi: 10.1186/s12943-022-01654-1. PMID: 36117171Free PMC Article
Acute kidney injury in cancer patients.
César BN, Durão Júnior MS
Rev Assoc Med Bras (1992) 2020 Jan 13;66Suppl 1(Suppl 1):s25-s30. doi: 10.1590/1806-9282.66.S1.25. PMID: 31939532
Pathology, therapy and prognosis of papillary renal carcinoma.
Fernandes DS, Lopes JM
Future Oncol 2015;11(1):121-32. doi: 10.2217/fon.14.133. PMID: 25572787
Renal cell carcinoma.
Savage PD
Curr Opin Oncol 1994 May;6(3):301-7. doi: 10.1097/00001622-199405000-00013. PMID: 8080860

Clinical prediction guides

Radiomics and Artificial Intelligence: Renal Cell Carcinoma.
Raman AG, Fisher D, Yap F, Oberai A, Duddalwar VA
Urol Clin North Am 2024 Feb;51(1):35-45. Epub 2023 Jul 28 doi: 10.1016/j.ucl.2023.06.007. PMID: 37945101
Immune checkpoint inhibitors in non-conventional histologies of renal-cell carcinoma.
Bersanelli M, Rebuzzi SE, Roviello G, Catalano M, Brunelli M, Rizzo M
Hum Vaccin Immunother 2023 Dec 31;19(1):2171672. Epub 2023 Feb 9 doi: 10.1080/21645515.2023.2171672. PMID: 36758960Free PMC Article
Birt-Hogg-Dubé syndrome.
Lencastre A, Ponte P, Apetato M, Nunes L, Lestre S
An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):203-5. doi: 10.1590/abd1806-4841.20132199. PMID: 24346920Free PMC Article
Renal cell carcinoma.
Rathmell WK, Godley PA, Rini BI
Curr Opin Oncol 2005 May;17(3):261-7. doi: 10.1097/01.cco.0000155007.51495.d6. PMID: 15818172
von Hippel-Lindau disease.
Singh AD, Shields CL, Shields JA
Surv Ophthalmol 2001 Sep-Oct;46(2):117-42. doi: 10.1016/s0039-6257(01)00245-4. PMID: 11578646

Recent systematic reviews

Perioperative and oncologic outcomes of transperitoneal versus retroperitoneal laparoscopic radical nephrectomy for large-volume renal carcinoma (> 7 cm): a systematic review and pooled analysis of comparative outcomes.
Wang L, Li KP, Liu Y, Yin S, Zhu PY
World J Surg Oncol 2023 Mar 9;21(1):86. doi: 10.1186/s12957-023-02967-1. PMID: 36894912Free PMC Article
Renal functional and cardiovascular outcomes of partial nephrectomy versus radical nephrectomy for renal tumors: a systematic review and meta-analysis.
Ochoa-Arvizo M, García-Campa M, Santos-Santillana KM, Klatte T, García-Chairez LR, González-Colmenero AD, Pallares-Méndez R, Cervantes-Miranda DE, Plata-Huerta HH, Rodriguez-Gutierrez R, Gutiérrez-González A
Urol Oncol 2023 Mar;41(3):113-124. Epub 2023 Jan 14 doi: 10.1016/j.urolonc.2022.11.024. PMID: 36642639
New first-line immunotherapy-based combinations for metastatic renal cell carcinoma: A systematic review and network meta-analysis.
Lombardi P, Filetti M, Falcone R, Di Bidino R, Iacovelli R, Ciccarese C, Bria E, Tortora G, Scambia G, Daniele G
Cancer Treat Rev 2022 May;106:102377. Epub 2022 Mar 16 doi: 10.1016/j.ctrv.2022.102377. PMID: 35313232
SFRP1 Promoter Methylation and Renal Carcinoma Risk: A Systematic Review and Meta-Analysis.
Mo S, Su Z, Heng B, Chen W, Shi L, Du X, Lai C
J Nippon Med Sch 2018;85(2):78-86. doi: 10.1272/jnms.2018_85-13. PMID: 29731501
Systematic review of renal carcinoma prognostic factors.
Lorente D, Trilla E, Meseguer A, Planas J, Placer J, Celma A, Salvador C, Regis L, Morote J
Actas Urol Esp 2017 May;41(4):215-225. Epub 2016 Sep 20 doi: 10.1016/j.acuro.2016.08.003. PMID: 27659130

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