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Abnormal circulating purine concentration

MedGen UID:
1684703
•Concept ID:
C5139037
•
Finding
Synonym: Abnormality of purine metabolism
 
HPO: HP:0004352

Definition

Any deviation from the normal concentration of a purine in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Associations of Serum Uric Acid Levels With Macrovascular and Renal Microvascular Dysfunction Among Individuals From Sub-Saharan Africa.
Hayfron-Benjamin CF, van den Born BJ, Amoah AGB, Maitland-van der Zee AH, Meeks KAC, Beune EJAJ, Klipstein-Grobusch K, Agyemang C
JAMA Netw Open 2021 Oct 1;4(10):e2128985. doi: 10.1001/jamanetworkopen.2021.28985. PMID: 34648008Free PMC Article
Circulating cyclic adenosine monophosphate concentrations in milrinone treated paediatric patients after congenital heart surgery.
Gist KM, Korst A, Nakano SJ, Stauffer BL, Karimpour-Fard A, Zhou W, Campbell K, Wempe MF, Sucharov CC, Miyamoto SD
Cardiol Young 2021 Sep;31(9):1393-1400. Epub 2021 Feb 3 doi: 10.1017/S1047951121000251. PMID: 33533327Free PMC Article
Eryptosis in lead-exposed workers.
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Importance of platelet aggregation in patients with end-stage renal disease.
Martinović Z, Basić-Jukić N, Pavlović DB, Kes P
Acta Clin Croat 2013 Dec;52(4):472-7. PMID: 24696998
Homocysteine, coagulation, platelet function, and thrombosis.
Coppola A, Davi G, De Stefano V, Mancini FP, Cerbone AM, Di Minno G
Semin Thromb Hemost 2000;26(3):243-54. doi: 10.1055/s-2000-8469. PMID: 11011842

Diagnosis

Fanconi syndrome induced by the long-term use of tenofovir disoproxil fumarate: a case report and literature review.
Li J, Zang X, Heng H, Liu X, Geng H, Liang J
J Int Med Res 2023 Aug;51(8):3000605231195469. doi: 10.1177/03000605231195469. PMID: 37666224Free PMC Article
Associations of Serum Uric Acid Levels With Macrovascular and Renal Microvascular Dysfunction Among Individuals From Sub-Saharan Africa.
Hayfron-Benjamin CF, van den Born BJ, Amoah AGB, Maitland-van der Zee AH, Meeks KAC, Beune EJAJ, Klipstein-Grobusch K, Agyemang C
JAMA Netw Open 2021 Oct 1;4(10):e2128985. doi: 10.1001/jamanetworkopen.2021.28985. PMID: 34648008Free PMC Article
Eryptosis in lead-exposed workers.
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Endothelial dysfunction in salt-sensitive essential hypertension.
Bragulat E, de la Sierra A, Antonio MT, Coca A
Hypertension 2001 Feb;37(2 Pt 2):444-8. doi: 10.1161/01.hyp.37.2.444. PMID: 11230316
Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
Prentki M, Corkey BE
Diabetes 1996 Mar;45(3):273-83. doi: 10.2337/diab.45.3.273. PMID: 8593930

Therapy

Circulating cyclic adenosine monophosphate concentrations in milrinone treated paediatric patients after congenital heart surgery.
Gist KM, Korst A, Nakano SJ, Stauffer BL, Karimpour-Fard A, Zhou W, Campbell K, Wempe MF, Sucharov CC, Miyamoto SD
Cardiol Young 2021 Sep;31(9):1393-1400. Epub 2021 Feb 3 doi: 10.1017/S1047951121000251. PMID: 33533327Free PMC Article
Eryptosis in lead-exposed workers.
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Importance of platelet aggregation in patients with end-stage renal disease.
Martinović Z, Basić-Jukić N, Pavlović DB, Kes P
Acta Clin Croat 2013 Dec;52(4):472-7. PMID: 24696998
The effects of sildenafil on human sperm function in healthy volunteers.
Purvis K, Muirhead GJ, Harness JA
Br J Clin Pharmacol 2002;53 Suppl 1(Suppl 1):53S-60S. doi: 10.1046/j.0306-5251.2001.00033.x. PMID: 11879260Free PMC Article
Homocysteine, coagulation, platelet function, and thrombosis.
Coppola A, Davi G, De Stefano V, Mancini FP, Cerbone AM, Di Minno G
Semin Thromb Hemost 2000;26(3):243-54. doi: 10.1055/s-2000-8469. PMID: 11011842

Prognosis

The value of Doppler assessment of the uteroplacental circulation in predicting preeclampsia or intrauterine growth retardation.
Jacobson SL, Imhof R, Manning N, Mannion V, Little D, Rey E, Redman C
Am J Obstet Gynecol 1990 Jan;162(1):110-4. doi: 10.1016/0002-9378(90)90832-r. PMID: 2405672
Renal function and urate metabolism in late survivors with cyanotic congenital heart disease.
Ross EA, Perloff JK, Danovitch GM, Child JS, Canobbio MM
Circulation 1986 Mar;73(3):396-400. doi: 10.1161/01.cir.73.3.396. PMID: 3948350
In vivo platelet activation with in vitro hyperaggregability to arachidonic acid in renal allograft recipients.
Frampton G, Parbtani A, Marchesi D, Duffus P, Livio M, Remuzzi G, Cameron JS
Kidney Int 1983 Mar;23(3):506-13. doi: 10.1038/ki.1983.48. PMID: 6405075
Urate metabolism and renal calcium stone disease.
Fellström B
Scand J Urol Nephrol Suppl 1981;62:1-59. PMID: 6960474

Clinical prediction guides

Circulating cyclic adenosine monophosphate concentrations in milrinone treated paediatric patients after congenital heart surgery.
Gist KM, Korst A, Nakano SJ, Stauffer BL, Karimpour-Fard A, Zhou W, Campbell K, Wempe MF, Sucharov CC, Miyamoto SD
Cardiol Young 2021 Sep;31(9):1393-1400. Epub 2021 Feb 3 doi: 10.1017/S1047951121000251. PMID: 33533327Free PMC Article
Coronary microvascular dysfunction is associated with poor glycemic control amongst female diabetics with chest pain and non-obstructive coronary artery disease.
Sara JD, Taher R, Kolluri N, Vella A, Lerman LO, Lerman A
Cardiovasc Diabetol 2019 Feb 28;18(1):22. doi: 10.1186/s12933-019-0833-1. PMID: 30819191Free PMC Article
Contractile properties and Ca2+ release activity of the sarcoplasmic reticulum in dilated cardiomyopathy.
D'Agnolo A, Luciani GB, Mazzucco A, Gallucci V, Salviati G
Circulation 1992 Feb;85(2):518-25. doi: 10.1161/01.cir.85.2.518. PMID: 1735148
Renal function and urate metabolism in late survivors with cyanotic congenital heart disease.
Ross EA, Perloff JK, Danovitch GM, Child JS, Canobbio MM
Circulation 1986 Mar;73(3):396-400. doi: 10.1161/01.cir.73.3.396. PMID: 3948350
In vivo platelet activation with in vitro hyperaggregability to arachidonic acid in renal allograft recipients.
Frampton G, Parbtani A, Marchesi D, Duffus P, Livio M, Remuzzi G, Cameron JS
Kidney Int 1983 Mar;23(3):506-13. doi: 10.1038/ki.1983.48. PMID: 6405075

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