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Decreased circulating vitamin K concentration

MedGen UID:
1684852
Concept ID:
C5139061
Finding
Synonym: Vitamin K deficiency
 
HPO: HP:0011892

Definition

The concentration of vitamin K in the blood circulation is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating vitamin K concentration

Conditions with this feature

Autosomal dominant chondrodysplasia punctata
MedGen UID:
303176
Concept ID:
C1442935
Disease or Syndrome
Autosomal dominant form of chondrodysplasia punctata.
Celiac disease, susceptibility to, 1
MedGen UID:
395227
Concept ID:
C1859310
Finding
Celiac disease is a systemic autoimmune disease that can be associated with gastrointestinal findings (diarrhea, malabsorption, abdominal pain and distension, bloating, vomiting, and weight loss) and/or highly variable non-gastrointestinal findings (dermatitis herpetiformis, chronic fatigue, joint pain/inflammation, iron deficiency anemia, migraines, depression, attention-deficit disorder, epilepsy, osteoporosis/osteopenia, infertility and/or recurrent fetal loss, vitamin deficiencies, short stature, failure to thrive, delayed puberty, dental enamel defects, and autoimmune disorders). Classic celiac disease, characterized by mild to severe gastrointestinal symptoms, is less common than non-classic celiac disease, characterized by absence of gastrointestinal symptoms.
Hypercholanemia, familial 1
MedGen UID:
1781366
Concept ID:
C5542604
Disease or Syndrome
Familial hypercholanemia-1 (FHCA1) is an autosomal recessive disorder characterized by elevated concentrations of bile acids (usually conjugated), itching, and fat malabsorption, leading to poor overall growth and deficiencies of fat-soluble vitamins. Vitamin D deficiency results in rickets, and vitamin K deficiency results in a coagulopathy (Morton et al., 2000; Shneider et al., 1997; summary by Carlton et al., 2003). See also bile acid conjugation defect-1 (BACD1; 619232), which can also show increased bile acid levels, although the bile acids in BACD1 are unconjugated. Genetic Heterogeneity of FHCA See FHCA2 (619256), caused by mutation in the SLC10A1 gene (182396) on chromosome 14q24.

Professional guidelines

PubMed

Masotti L, Di Napoli M, Godoy DA, Rafanelli D, Liumbruno G, Koumpouros N, Landini G, Pampana A, Cappelli R, Poli D, Prisco D
Int J Stroke 2011 Jun;6(3):228-40. Epub 2011 Apr 18 doi: 10.1111/j.1747-4949.2011.00595.x. PMID: 21557810
Kobayashi T
Curr Drug Targets 2005 Aug;6(5):559-66. doi: 10.2174/1389450054546042. PMID: 16026276
S Afr Med J 1998 Oct;88(10):1344-7. PMID: 9807194

Recent clinical studies

Etiology

Li Z, Li Y, Hou Y, Fan Y, Jiang H, Li B, Zhu H, Liu Y, Zhang L, Zhang J, Wu M, Ma T, Zhao T, Ma L
Nutrients 2023 Jun 30;15(13) doi: 10.3390/nu15132985. PMID: 37447314Free PMC Article
Elzehery R, Effat N, El Farahaty R, Elsayed Farag R, Abo-Hashem EM, Elhelaly R
Am J Clin Pathol 2022 Aug 4;158(2):254-262. doi: 10.1093/ajcp/aqac037. PMID: 35403666
Kremer D, Groothof D, Keyzer CA, Eelderink C, Knobbe TJ, Post A, van Londen M, Eisenga MF, TransplantLines Investigators, Schurgers LJ, Berger SP, de Borst MH, Bakker SJL
Nutrients 2021 Aug 31;13(9) doi: 10.3390/nu13093069. PMID: 34578950Free PMC Article
Zwakenberg SR, Burgess S, Sluijs I, Weiderpass E; EPIC-CVD consortium, Beulens JWJ, van der Schouw YT
Clin Nutr 2020 Apr;39(4):1131-1136. Epub 2019 May 7 doi: 10.1016/j.clnu.2019.04.024. PMID: 31103344Free PMC Article
Shea MK, Dallal GE, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Gundberg CM, Peterson JW, Booth SL
Am J Clin Nutr 2008 Aug;88(2):356-63. doi: 10.1093/ajcn/88.2.356. PMID: 18689371Free PMC Article

Diagnosis

Elzehery R, Effat N, El Farahaty R, Elsayed Farag R, Abo-Hashem EM, Elhelaly R
Am J Clin Pathol 2022 Aug 4;158(2):254-262. doi: 10.1093/ajcp/aqac037. PMID: 35403666
Rehder DS, Gundberg CM, Booth SL, Borges CR
Mol Cell Proteomics 2015 Jun;14(6):1546-55. Epub 2015 Apr 8 doi: 10.1074/mcp.M114.047621. PMID: 25855755Free PMC Article
Azharuddin MK, O'Reilly DS, Gray A, Talwar D
Clin Chem 2007 Sep;53(9):1706-13. doi: 10.1373/clinchem.2007.086280. PMID: 17712007
Tokunaga F, Takeuchi S, Omura S, Arvan P, Koide T
Thromb Res 2000 Sep 1;99(5):511-21. doi: 10.1016/s0049-3848(00)00258-9. PMID: 10973682
Ekenstam E, Stålenheim G, Hällgren R
Metabolism 1988 Feb;37(2):141-4. doi: 10.1016/s0026-0495(98)90008-7. PMID: 3257542

Therapy

Zwakenberg SR, Burgess S, Sluijs I, Weiderpass E; EPIC-CVD consortium, Beulens JWJ, van der Schouw YT
Clin Nutr 2020 Apr;39(4):1131-1136. Epub 2019 May 7 doi: 10.1016/j.clnu.2019.04.024. PMID: 31103344Free PMC Article
Janssen R, Vermeer C
Med Hypotheses 2017 Oct;108:38-41. Epub 2017 Jul 21 doi: 10.1016/j.mehy.2017.07.029. PMID: 29055397
Masotti L, Di Napoli M, Godoy DA, Rafanelli D, Liumbruno G, Koumpouros N, Landini G, Pampana A, Cappelli R, Poli D, Prisco D
Int J Stroke 2011 Jun;6(3):228-40. Epub 2011 Apr 18 doi: 10.1111/j.1747-4949.2011.00595.x. PMID: 21557810
Shea MK, Dallal GE, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Gundberg CM, Peterson JW, Booth SL
Am J Clin Nutr 2008 Aug;88(2):356-63. doi: 10.1093/ajcn/88.2.356. PMID: 18689371Free PMC Article
Bügel S
Vitam Horm 2008;78:393-416. doi: 10.1016/S0083-6729(07)00016-7. PMID: 18374202

Prognosis

Zwakenberg SR, Burgess S, Sluijs I, Weiderpass E; EPIC-CVD consortium, Beulens JWJ, van der Schouw YT
Clin Nutr 2020 Apr;39(4):1131-1136. Epub 2019 May 7 doi: 10.1016/j.clnu.2019.04.024. PMID: 31103344Free PMC Article
van den Heuvel EG, van Schoor NM, Lips P, Magdeleyns EJ, Deeg DJ, Vermeer C, den Heijer M
Maturitas 2014 Feb;77(2):137-41. Epub 2013 Oct 24 doi: 10.1016/j.maturitas.2013.10.008. PMID: 24210635
Shea MK, Dallal GE, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Gundberg CM, Peterson JW, Booth SL
Am J Clin Nutr 2008 Aug;88(2):356-63. doi: 10.1093/ajcn/88.2.356. PMID: 18689371Free PMC Article
Hemmer CJ, Kern P, Holst FG, Radtke KP, Egbring R, Bierhaus A, Nawroth PP, Dietrich M
Am J Med 1991 Jul;91(1):37-44. doi: 10.1016/0002-9343(91)90071-5. PMID: 1858827

Clinical prediction guides

Zwakenberg SR, Burgess S, Sluijs I, Weiderpass E; EPIC-CVD consortium, Beulens JWJ, van der Schouw YT
Clin Nutr 2020 Apr;39(4):1131-1136. Epub 2019 May 7 doi: 10.1016/j.clnu.2019.04.024. PMID: 31103344Free PMC Article
Rehder DS, Gundberg CM, Booth SL, Borges CR
Mol Cell Proteomics 2015 Jun;14(6):1546-55. Epub 2015 Apr 8 doi: 10.1074/mcp.M114.047621. PMID: 25855755Free PMC Article
Dalmeijer GW, van der Schouw YT, Vermeer C, Magdeleyns EJ, Schurgers LJ, Beulens JW
J Nutr Biochem 2013 Apr;24(4):624-8. Epub 2012 Jul 20 doi: 10.1016/j.jnutbio.2012.02.012. PMID: 22819559
Shea MK, Dallal GE, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Gundberg CM, Peterson JW, Booth SL
Am J Clin Nutr 2008 Aug;88(2):356-63. doi: 10.1093/ajcn/88.2.356. PMID: 18689371Free PMC Article
Tsugawa N, Shiraki M, Suhara Y, Kamao M, Tanaka K, Okano T
Am J Clin Nutr 2006 Feb;83(2):380-6. doi: 10.1093/ajcn/83.2.380. PMID: 16469998

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