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Benign Parapharyngeal Neoplasm

MedGen UID:
1686401
•Concept ID:
C5206834
•
Neoplastic Process

Definition

A neoplasm that arises from the parapharyngeal space and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Parapharyngeal Neoplasm

Professional guidelines

PubMed

Management of Parapharyngeal Space Tumors: Clinical Experience with a Large Sample and Review of the Literature.
Jiang C, Wang W, Chen S, Liu Y
Curr Oncol 2023 Jan 11;30(1):1020-1031. doi: 10.3390/curroncol30010078. PMID: 36661727Free PMC Article
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Contemporary management of primary parapharyngeal space tumors.
López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P, Hanna EY, Rodrigo JP, de Bree R, Quer M, Takes RP, Bradford CR, Shaha AR, Sanabria A, Rinaldo A, Ferlito A
Head Neck 2019 Feb;41(2):522-535. Epub 2018 Dec 14 doi: 10.1002/hed.25439. PMID: 30549361

Recent clinical studies

Etiology

Transoral Approach to Parotid Tumors: A Review of the Literature.
Riva G, Lorenzi A, Borello A, Albera A, Canale A, Pecorari G
Curr Oncol 2022 Dec 1;29(12):9416-9427. doi: 10.3390/curroncol29120740. PMID: 36547154Free PMC Article
Primary neoplasms of the parapharyngeal space: diagnostic and therapeutic pearls and pitfalls.
Bulut OC, Giger R, Alwagdani A, Aldabal N, Stenzinger A, Heimgartner S, Nisa L, Borner U
Eur Arch Otorhinolaryngol 2021 Dec;278(12):4933-4941. Epub 2021 Mar 19 doi: 10.1007/s00405-021-06718-4. PMID: 33740083Free PMC Article
Parapharyngeal space primary tumours.
Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):138-144. doi: 10.1016/j.otorri.2016.06.003. PMID: 27663220
Contemporary evaluation and management of parapharyngeal space neoplasms.
Eisele DW, Richmon JD
J Laryngol Otol 2013 Jun;127(6):550-5. Epub 2013 Apr 10 doi: 10.1017/S0022215113000686. PMID: 23575439
Parapharyngeal space neoplasms.
Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809

Diagnosis

Parapharyngeal Space Ganglioneuroma: Clinical Experience and Review of the Literature.
Li F, Feng H, Liao J, Bao Y, Xu S, Qin G
Ear Nose Throat J 2023 Dec;102(12):765-771. Epub 2022 Nov 30 doi: 10.1177/01455613221142658. PMID: 36450599
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Contemporary management of primary parapharyngeal space tumors.
López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P, Hanna EY, Rodrigo JP, de Bree R, Quer M, Takes RP, Bradford CR, Shaha AR, Sanabria A, Rinaldo A, Ferlito A
Head Neck 2019 Feb;41(2):522-535. Epub 2018 Dec 14 doi: 10.1002/hed.25439. PMID: 30549361
Parapharyngeal space primary tumours.
Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):138-144. doi: 10.1016/j.otorri.2016.06.003. PMID: 27663220
Parapharyngeal space neoplasms.
Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809

Therapy

Endoscopy-Assisted Transoral Approach to Resect Parapharyngeal Space Tumors: A Systematic Review and Meta-Analysis.
Chen H, He Z, Li G, Liu C, Zhang D, Huang D, Xie C, Jiang W, Qiu Y, Zhang X, Liu Y
Laryngoscope 2021 Oct;131(10):2246-2253. Epub 2021 Feb 22 doi: 10.1002/lary.29458. PMID: 33616215
Management of a prestyloid parapharyngeal first branchial cleft cyst from puncture to surgical excision and how a routine procedure can turn into an emergency.
Fiedler LS
BMJ Case Rep 2021 Jan 12;14(1) doi: 10.1136/bcr-2020-238727. PMID: 33436361Free PMC Article
Inflammatory pseudotumor in head and neck.
Segawa Y, Yasumatsu R, Shiratsuchi H, Tamae A, Noda T, Yamamoto H, Komune S
Auris Nasus Larynx 2014 Jun;41(3):321-4. Epub 2013 Dec 17 doi: 10.1016/j.anl.2013.11.002. PMID: 24359703
Transcervical approach to benign parapharyngeal space tumors.
Chang SS, Goldenberg D, Koch WM
Ann Otol Rhinol Laryngol 2012 Sep;121(9):620-4. doi: 10.1177/000348941212100910. PMID: 23012902
Robotic skull base surgery: preclinical investigations to human clinical application.
O'Malley BW Jr, Weinstein GS
Arch Otolaryngol Head Neck Surg 2007 Dec;133(12):1215-9. doi: 10.1001/archotol.133.12.1215. PMID: 18086962

Prognosis

Extracranial Facial Nerve Schwannoma-Histological Surprise or Therapeutic Planning?
Vrinceanu D, Dumitru M, Popa-Cherecheanu M, Marinescu AN, Patrascu OM, Bobirca F
Medicina (Kaunas) 2023 Jun 17;59(6) doi: 10.3390/medicina59061167. PMID: 37374372Free PMC Article
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Comprehensive Analyses of Intraoral Benign and Malignant Nerve Sheath Tumors: The Rare Disease Entities Revisited.
Song Y, Hu J, Wu Y, Wang D, Wang Y, Zhang P, Jiang H, Yang J, Cheng J
J Craniofac Surg 2019 Jun;30(4):e317-e327. doi: 10.1097/SCS.0000000000005231. PMID: 30845091
Parapharyngeal space neoplasms.
Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809
Tumors and surgery of the parapharyngeal space.
Olsen KD
Laryngoscope 1994 May;104(5 Pt 2 Suppl 63):1-28. doi: 10.1288/00005537-199405000-00001. PMID: 8189998

Clinical prediction guides

Management of Parapharyngeal Space Tumors: Clinical Experience with a Large Sample and Review of the Literature.
Jiang C, Wang W, Chen S, Liu Y
Curr Oncol 2023 Jan 11;30(1):1020-1031. doi: 10.3390/curroncol30010078. PMID: 36661727Free PMC Article
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Parapharyngeal space tumors: a serial case study.
Lien KH, Young CK, Chin SC, Liao CT, Huang SF
J Int Med Res 2019 Aug;47(8):4004-4013. Epub 2019 Jul 29 doi: 10.1177/0300060519862659. PMID: 31353995Free PMC Article
Contemporary evaluation and management of parapharyngeal space neoplasms.
Eisele DW, Richmon JD
J Laryngol Otol 2013 Jun;127(6):550-5. Epub 2013 Apr 10 doi: 10.1017/S0022215113000686. PMID: 23575439
Update on the management of parapharyngeal tumours.
Bradley PJ, Bradley PT, Olsen KD
Curr Opin Otolaryngol Head Neck Surg 2011 Apr;19(2):92-8. doi: 10.1097/MOO.0b013e328342b9b4. PMID: 21178619

Recent systematic reviews

Head and neck lipoblastoma in children: A case report and systematic review.
Tyra J, Mierzwińska-Dolny P, Fishman AJ, Mierzwiński J
Int J Pediatr Otorhinolaryngol 2023 Oct;173:111699. Epub 2023 Aug 16 doi: 10.1016/j.ijporl.2023.111699. PMID: 37597314
Endoscopy-Assisted Transoral Approach to Resect Parapharyngeal Space Tumors: A Systematic Review and Meta-Analysis.
Chen H, He Z, Li G, Liu C, Zhang D, Huang D, Xie C, Jiang W, Qiu Y, Zhang X, Liu Y
Laryngoscope 2021 Oct;131(10):2246-2253. Epub 2021 Feb 22 doi: 10.1002/lary.29458. PMID: 33616215
Histopathologic classification of parapharyngeal space tumors: a case series and review of the literature.
Locketz GD, Horowitz G, Abu-Ghanem S, Wasserzug O, Abergel A, Yehuda M, Fliss DM
Eur Arch Otorhinolaryngol 2016 Mar;273(3):727-34. Epub 2015 Feb 24 doi: 10.1007/s00405-015-3545-5. PMID: 25708410
Management of tumors arising from the parapharyngeal space: A systematic review of 1,293 cases reported over 25 years.
Kuet ML, Kasbekar AV, Masterson L, Jani P
Laryngoscope 2015 Jun;125(6):1372-81. Epub 2014 Dec 2 doi: 10.1002/lary.25077. PMID: 25448637
A systematic review of 1143 parapharyngeal space tumors reported over 20 years.
Riffat F, Dwivedi RC, Palme C, Fish B, Jani P
Oral Oncol 2014 May;50(5):421-30. Epub 2014 Feb 28 doi: 10.1016/j.oraloncology.2014.02.007. PMID: 24589290

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