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Abnormal proportion of memory T cells

MedGen UID:
1686899
•Concept ID:
C5139179
•
Finding
Synonym: Abnormal proportion of CD4+CD29+ cells
 
HPO: HP:0032182

Definition

An abnormal proportion of memory T cells compared to the total number of T cells in the blood. Memory T cells have previously encountered and responded to their cognate antigen and upon a repeated encounter with the antigen can mount a faster and stronger response. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal proportion of memory T cells

Recent clinical studies

Etiology

The profile and prognostic significance of bone marrow T-cell differentiation subsets in adult AML at diagnosis.
Sun K, Shi ZY, Wang YZ, Xie DH, Liu YR, Jiang Q, Jiang H, Huang XJ, Qin YZ
Front Immunol 2024;15:1418792. Epub 2024 Jul 19 doi: 10.3389/fimmu.2024.1418792. PMID: 39100667Free PMC Article
Pregnancy-associated systemic gene expression compared to a pre-pregnancy baseline, among healthy women with term pregnancies.
Wright ML, Goin DE, Smed MK, Jewell NP, Nelson JL, Olsen J, Hetland ML, Zoffmann V, Jawaheer D
Front Immunol 2023;14:1161084. Epub 2023 Jun 5 doi: 10.3389/fimmu.2023.1161084. PMID: 37342349Free PMC Article
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Accelerated Maturation, Exhaustion, and Senescence of T cells in 22q11.2 Deletion Syndrome.
Smetanova J, Milota T, Rataj M, Bloomfield M, Sediva A, Klocperk A
J Clin Immunol 2022 Feb;42(2):274-285. Epub 2021 Oct 29 doi: 10.1007/s10875-021-01154-9. PMID: 34716533
Thymus variants on imaging in patients with rheumatoid arthritis-clinical and immunological significance.
Murata O, Suzuki K, Sugiura H, Kondo Y, Takeshita M, Koga K, Takiguchi M, Kurisu R, Kassai Y, Yasuoka H, Yamaoka K, Morita R, Yoshimura A, Takeuchi T
Rheumatology (Oxford) 2021 Dec 1;60(12):5595-5600. doi: 10.1093/rheumatology/keab164. PMID: 33590850

Diagnosis

The profile and prognostic significance of bone marrow T-cell differentiation subsets in adult AML at diagnosis.
Sun K, Shi ZY, Wang YZ, Xie DH, Liu YR, Jiang Q, Jiang H, Huang XJ, Qin YZ
Front Immunol 2024;15:1418792. Epub 2024 Jul 19 doi: 10.3389/fimmu.2024.1418792. PMID: 39100667Free PMC Article
Identification of immune-related signatures and pathogenesis differences between thoracic aortic aneurysm patients with bicuspid versus tricuspid valves via weighted gene co-expression network analysis.
Huang M, Guan R, Qiu J, Gnamey AJE, Wang Y, Tian H, Sun H, Shi H, Sun W, Jia X, Wu J
PLoS One 2023;18(10):e0292673. Epub 2023 Oct 26 doi: 10.1371/journal.pone.0292673. PMID: 37883426Free PMC Article
Thymus variants on imaging in patients with rheumatoid arthritis-clinical and immunological significance.
Murata O, Suzuki K, Sugiura H, Kondo Y, Takeshita M, Koga K, Takiguchi M, Kurisu R, Kassai Y, Yasuoka H, Yamaoka K, Morita R, Yoshimura A, Takeuchi T
Rheumatology (Oxford) 2021 Dec 1;60(12):5595-5600. doi: 10.1093/rheumatology/keab164. PMID: 33590850
Immune memory limits human longevity: the role of memory СD4+ T cells in age-related immune abnormalities.
Seledtsov VI, von Delwig AA
Expert Rev Vaccines 2020 Mar;19(3):209-215. Epub 2020 Apr 6 doi: 10.1080/14760584.2020.1745638. PMID: 32191535
Expanded CD4(+) Effector/Memory T Cell Subset in APECED Produces Predominantly Interferon Gamma.
Heikkilä N, Laakso SM, Mannerström H, Kekäläinen E, Saavalainen P, Jarva H, Arstila TP
J Clin Immunol 2016 Aug;36(6):555-63. Epub 2016 Jun 4 doi: 10.1007/s10875-016-0302-5. PMID: 27262317

Therapy

Thymus variants on imaging in patients with rheumatoid arthritis-clinical and immunological significance.
Murata O, Suzuki K, Sugiura H, Kondo Y, Takeshita M, Koga K, Takiguchi M, Kurisu R, Kassai Y, Yasuoka H, Yamaoka K, Morita R, Yoshimura A, Takeuchi T
Rheumatology (Oxford) 2021 Dec 1;60(12):5595-5600. doi: 10.1093/rheumatology/keab164. PMID: 33590850
Immune dysregulation after cardiothoracic surgery and incidental thymectomy: maintenance of regulatory T cells despite impaired thymopoiesis.
Halnon NJ, Cooper P, Chen DY, Boechat MI, Uittenbogaart CH
Clin Dev Immunol 2011;2011:915864. Epub 2011 Jul 6 doi: 10.1155/2011/915864. PMID: 21776289Free PMC Article
Aberrant expression of the insulin-like growth factor-1 receptor by T cells from patients with Graves' disease may carry functional consequences for disease pathogenesis.
Douglas RS, Gianoukakis AG, Kamat S, Smith TJ
J Immunol 2007 Mar 1;178(5):3281-7. doi: 10.4049/jimmunol.178.5.3281. PMID: 17312178

Prognosis

The profile and prognostic significance of bone marrow T-cell differentiation subsets in adult AML at diagnosis.
Sun K, Shi ZY, Wang YZ, Xie DH, Liu YR, Jiang Q, Jiang H, Huang XJ, Qin YZ
Front Immunol 2024;15:1418792. Epub 2024 Jul 19 doi: 10.3389/fimmu.2024.1418792. PMID: 39100667Free PMC Article
Identification of immune-related signatures and pathogenesis differences between thoracic aortic aneurysm patients with bicuspid versus tricuspid valves via weighted gene co-expression network analysis.
Huang M, Guan R, Qiu J, Gnamey AJE, Wang Y, Tian H, Sun H, Shi H, Sun W, Jia X, Wu J
PLoS One 2023;18(10):e0292673. Epub 2023 Oct 26 doi: 10.1371/journal.pone.0292673. PMID: 37883426Free PMC Article
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Thymus variants on imaging in patients with rheumatoid arthritis-clinical and immunological significance.
Murata O, Suzuki K, Sugiura H, Kondo Y, Takeshita M, Koga K, Takiguchi M, Kurisu R, Kassai Y, Yasuoka H, Yamaoka K, Morita R, Yoshimura A, Takeuchi T
Rheumatology (Oxford) 2021 Dec 1;60(12):5595-5600. doi: 10.1093/rheumatology/keab164. PMID: 33590850

Clinical prediction guides

The profile and prognostic significance of bone marrow T-cell differentiation subsets in adult AML at diagnosis.
Sun K, Shi ZY, Wang YZ, Xie DH, Liu YR, Jiang Q, Jiang H, Huang XJ, Qin YZ
Front Immunol 2024;15:1418792. Epub 2024 Jul 19 doi: 10.3389/fimmu.2024.1418792. PMID: 39100667Free PMC Article
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Thymus variants on imaging in patients with rheumatoid arthritis-clinical and immunological significance.
Murata O, Suzuki K, Sugiura H, Kondo Y, Takeshita M, Koga K, Takiguchi M, Kurisu R, Kassai Y, Yasuoka H, Yamaoka K, Morita R, Yoshimura A, Takeuchi T
Rheumatology (Oxford) 2021 Dec 1;60(12):5595-5600. doi: 10.1093/rheumatology/keab164. PMID: 33590850
Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis.
Zhu W, Zhang X, Jiang Y, Liu X, Huang L, Wei Q, Huang Y, Wu W, Gu J
Clin Rheumatol 2020 Feb;39(2):523-532. Epub 2019 Oct 17 doi: 10.1007/s10067-019-04768-y. PMID: 31624962
Expanded CD4(+) Effector/Memory T Cell Subset in APECED Produces Predominantly Interferon Gamma.
Heikkilä N, Laakso SM, Mannerström H, Kekäläinen E, Saavalainen P, Jarva H, Arstila TP
J Clin Immunol 2016 Aug;36(6):555-63. Epub 2016 Jun 4 doi: 10.1007/s10875-016-0302-5. PMID: 27262317

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