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Abnormal HDL3b concentration

MedGen UID:
1688193
•Concept ID:
C5139338
•
Finding
HPO: HP:0032426

Definition

Any deviation from the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm. [from HPO]

Recent clinical studies

Etiology

Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
Characteristics of high-density lipoprotein subclasses distribution for subjects with desirable total cholesterol levels.
Tian L, Long S, Fu M, Liu Y, Xu Y, Jia L
Lipids Health Dis 2011 Apr 22;10:64. doi: 10.1186/1476-511X-10-64. PMID: 21513524Free PMC Article
High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyceride concentrations, and its association with insulin and C-reactive protein.
Medina-Urrutia A, Juarez-Rojas JG, Martínez-Alvarado R, Jorge-Galarza E, Posadas-Sánchez R, Cardoso-Saldaña G, Caracas-Portilla N, Mendoza-Perez E, Posadas-Romero C
Atherosclerosis 2008 Dec;201(2):392-7. Epub 2008 Mar 18 doi: 10.1016/j.atherosclerosis.2008.02.029. PMID: 18420210
Relationship between plasma lipid concentrations and HDL subclasses.
Yang Y, Yan B, Fu M, Xu Y, Tian Y
Clin Chim Acta 2005 Apr;354(1-2):49-58. Epub 2004 Dec 24 doi: 10.1016/j.cccn.2004.11.015. PMID: 15748599
Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients. Botnia Study Group.
Tilly-Kiesi M, Knudsen P, Groop L, Taskinen MR
J Lipid Res 1996 Jul;37(7):1569-78. PMID: 8827527

Diagnosis

Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients. Botnia Study Group.
Tilly-Kiesi M, Knudsen P, Groop L, Taskinen MR
J Lipid Res 1996 Jul;37(7):1569-78. PMID: 8827527

Prognosis

High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetes.
Tian L, Long S, Li C, Liu Y, Chen Y, Zeng Z, Fu M
Lipids Health Dis 2012 May 15;11:54. doi: 10.1186/1476-511X-11-54. PMID: 22584085Free PMC Article

Clinical prediction guides

Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetes.
Tian L, Long S, Li C, Liu Y, Chen Y, Zeng Z, Fu M
Lipids Health Dis 2012 May 15;11:54. doi: 10.1186/1476-511X-11-54. PMID: 22584085Free PMC Article
High-density lipoproteins are abnormal in young women with uncomplicated systemic lupus erythematosus.
Juárez-Rojas J, Medina-Urrutia A, Posadas-Sánchez R, Jorge-Galarza E, Mendoza-Pérez E, Caracas-Portilla N, Cardoso-Saldaña G, Muñoz-Gallegos G, Posadas-Romero C
Lupus 2008 Nov;17(11):981-7. doi: 10.1177/0961203308093072. PMID: 18852221
High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyceride concentrations, and its association with insulin and C-reactive protein.
Medina-Urrutia A, Juarez-Rojas JG, Martínez-Alvarado R, Jorge-Galarza E, Posadas-Sánchez R, Cardoso-Saldaña G, Caracas-Portilla N, Mendoza-Perez E, Posadas-Romero C
Atherosclerosis 2008 Dec;201(2):392-7. Epub 2008 Mar 18 doi: 10.1016/j.atherosclerosis.2008.02.029. PMID: 18420210
Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients. Botnia Study Group.
Tilly-Kiesi M, Knudsen P, Groop L, Taskinen MR
J Lipid Res 1996 Jul;37(7):1569-78. PMID: 8827527

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