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Stage IB3 Cervical Cancer FIGO 2018

MedGen UID:
1688980
•Concept ID:
C5206442
•
Neoplastic Process
Synonym: Stage IB3 Cervical Carcinoma FIGO 2018

Definition

Invasive cervical carcinoma equal or more than 4 cm in greatest dimension. (FIGO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage IB3 Cervical Cancer FIGO 2018

Professional guidelines

PubMed

Trends in guideline-adherent chemoradiation therapy for locally advanced cervical cancer before and after the affordable care act.
Thomas RJ, Provenzano D, Goyal S, Loew M, Lopez-Acevedo M, Long B, Chappell NP, Rao YJ
Gynecol Oncol 2022 Jul;166(1):165-172. Epub 2022 Apr 29 doi: 10.1016/j.ygyno.2022.04.015. PMID: 35491268

Recent clinical studies

Etiology

Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer.
Chakrabarti M, Nordin A, Khodabocus J
Cochrane Database Syst Rev 2022 Sep 16;9(9):CD012246. doi: 10.1002/14651858.CD012246.pub2. PMID: 36111784Free PMC Article
Clinical outcome of FIGO 2018 stage IB3/IIA2 cervical cancer treated by neoadjuvant chemotherapy followed by radical surgery due to lack of radiotherapy equipment: A retrospective comparison with concurrent chemoradiotherapy.
Zeng J, Sun P, Ping Q, Jiang S, Hu Y
PLoS One 2022;17(3):e0266001. Epub 2022 Mar 24 doi: 10.1371/journal.pone.0266001. PMID: 35324998Free PMC Article
Impact of hypoxia on cervical cancer outcomes.
Datta A, West C, O'Connor JPB, Choudhury A, Hoskin P
Int J Gynecol Cancer 2021 Nov;31(11):1459-1470. Epub 2021 Sep 30 doi: 10.1136/ijgc-2021-002806. PMID: 34593564
Optimal treatment in locally advanced cervical cancer.
Gennigens C, De Cuypere M, Hermesse J, Kridelka F, Jerusalem G
Expert Rev Anticancer Ther 2021 Jun;21(6):657-671. Epub 2021 Mar 11 doi: 10.1080/14737140.2021.1879646. PMID: 33472018
Validation of the 2018 FIGO cervical cancer staging system.
Matsuo K, Machida H, Mandelbaum RS, Konishi I, Mikami M
Gynecol Oncol 2019 Jan;152(1):87-93. Epub 2018 Oct 30 doi: 10.1016/j.ygyno.2018.10.026. PMID: 30389105Free PMC Article

Diagnosis

Fertility sparing therapy in women with lymph node negative cervical cancer >2cm - oncologic and fertility outcomes of neoadjuvant chemotherapy followed by radical vaginal trachelectomy.
Plaikner A, Siegler K, Hertel H, Jacob A, Petzel A, Schubert M, Blohmer JU, Böhmer G, Marnitz S, Ragosch V, Domröse C, Oppelt P, Jülicher A, Schneider A, Willems A, Favero G, Köhler C
Int J Gynecol Cancer 2023 Oct 2;33(10):1542-1547. doi: 10.1136/ijgc-2023-004669. PMID: 37696645
Diagnosis of advanced cervical cancer, missed opportunities?
Mattern J, Letendre I, Sibiude J, Pénager C, Jnifen A, Souare F, Ayel S, Nguyen T, Mandelbrot L
BMC Womens Health 2022 Mar 30;22(1):97. doi: 10.1186/s12905-022-01668-3. PMID: 35354463Free PMC Article
Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system.
Osaku D, Komatsu H, Okawa M, Iida Y, Sato S, Oishi T, Harada T
Taiwan J Obstet Gynecol 2021 Nov;60(6):1054-1058. doi: 10.1016/j.tjog.2021.09.016. PMID: 34794737
Five-fraction HDR brachytherapy in locally advanced cervical cancer: A monocentric experience.
Ogorodniitchouk O, Aunier J, Bousarsar A, Lahmamssi C, Sotton S, Ouaz H, Moreno-Acosta P, Moslemi D, Molekzadehmoghani M, Langrand-Escure J, Magne N, Vallard A
Cancer Radiother 2021 Jul;25(5):463-468. Epub 2021 May 19 doi: 10.1016/j.canrad.2021.03.006. PMID: 34023215
Prognostic Performance of the 2018 International Federation of Gynecology and Obstetrics Cervical Cancer Staging Guidelines.
Wright JD, Matsuo K, Huang Y, Tergas AI, Hou JY, Khoury-Collado F, St Clair CM, Ananth CV, Neugut AI, Hershman DL
Obstet Gynecol 2019 Jul;134(1):49-57. doi: 10.1097/AOG.0000000000003311. PMID: 31188324Free PMC Article

Therapy

Dose-dense neoadjuvant chemotherapy before radical surgery in cervical cancer: a retrospective cohort study and systematic literature review.
Caruso G, Bruni S, Lapresa M, De Vitis LA, Parma G, Minicucci V, Betella I, Schivardi G, Peccatori F, Lazzari R, Cliby W, Aletti GD, Zanagnolo V, Maggioni A, Colombo N, Multinu F
Int J Gynecol Cancer 2024 Jan 5;34(1):47-57. doi: 10.1136/ijgc-2023-004928. PMID: 37949488
Fertility sparing therapy in women with lymph node negative cervical cancer >2cm - oncologic and fertility outcomes of neoadjuvant chemotherapy followed by radical vaginal trachelectomy.
Plaikner A, Siegler K, Hertel H, Jacob A, Petzel A, Schubert M, Blohmer JU, Böhmer G, Marnitz S, Ragosch V, Domröse C, Oppelt P, Jülicher A, Schneider A, Willems A, Favero G, Köhler C
Int J Gynecol Cancer 2023 Oct 2;33(10):1542-1547. doi: 10.1136/ijgc-2023-004669. PMID: 37696645
Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer.
Chakrabarti M, Nordin A, Khodabocus J
Cochrane Database Syst Rev 2022 Sep 16;9(9):CD012246. doi: 10.1002/14651858.CD012246.pub2. PMID: 36111784Free PMC Article
Clinical outcome of FIGO 2018 stage IB3/IIA2 cervical cancer treated by neoadjuvant chemotherapy followed by radical surgery due to lack of radiotherapy equipment: A retrospective comparison with concurrent chemoradiotherapy.
Zeng J, Sun P, Ping Q, Jiang S, Hu Y
PLoS One 2022;17(3):e0266001. Epub 2022 Mar 24 doi: 10.1371/journal.pone.0266001. PMID: 35324998Free PMC Article
Combination of weekly paclitaxel-carboplatin plus standard bevacizumab as neoadjuvant treatment in stage IB-IIB cervical cancer.
Maene C, Salihi RR, Van Nieuwenhuysen E, Han SN, Concin N, Vergote I
Int J Gynecol Cancer 2021 Jun;31(6):824-828. Epub 2021 Apr 15 doi: 10.1136/ijgc-2021-002432. PMID: 33858952

Prognosis

Prognosis and treatment regimens for patients with different lymph node statuses in locally advanced cervical cancer.
Guo W, Ren R, Li N, Hu Y
Eur J Surg Oncol 2024 Nov;50(11):108522. Epub 2024 Jun 29 doi: 10.1016/j.ejso.2024.108522. PMID: 39255585
Comparing survival outcomes for cervical cancer based on the 2014 and 2018 International Federation of Gynecology and Obstetrics staging systems.
Shin W, Ham TY, Park YR, Lim MC, Won YJ
Sci Rep 2021 Mar 26;11(1):6988. doi: 10.1038/s41598-021-86283-2. PMID: 33772044Free PMC Article
Optimal treatment in locally advanced cervical cancer.
Gennigens C, De Cuypere M, Hermesse J, Kridelka F, Jerusalem G
Expert Rev Anticancer Ther 2021 Jun;21(6):657-671. Epub 2021 Mar 11 doi: 10.1080/14737140.2021.1879646. PMID: 33472018
FIGO 2018 stage IB endocervical adenocarcinomas: an international study of outcomes informed by prognostic biomarkers.
Stolnicu S, Boros M, Hoang L, Almadani N, de Brot L, Baiocchi G, Bonvolim G, Parra-Herran C, Lerias S, Felix A, Roma A, Pesci A, Oliva E, Park K, Soslow RA, Abu-Rustum NR
Int J Gynecol Cancer 2021 Feb;31(2):177-184. Epub 2020 Nov 11 doi: 10.1136/ijgc-2020-001893. PMID: 33177150Free PMC Article
Prognostic Performance of the 2018 International Federation of Gynecology and Obstetrics Cervical Cancer Staging Guidelines.
Wright JD, Matsuo K, Huang Y, Tergas AI, Hou JY, Khoury-Collado F, St Clair CM, Ananth CV, Neugut AI, Hershman DL
Obstet Gynecol 2019 Jul;134(1):49-57. doi: 10.1097/AOG.0000000000003311. PMID: 31188324Free PMC Article

Clinical prediction guides

Trends in guideline-adherent chemoradiation therapy for locally advanced cervical cancer before and after the affordable care act.
Thomas RJ, Provenzano D, Goyal S, Loew M, Lopez-Acevedo M, Long B, Chappell NP, Rao YJ
Gynecol Oncol 2022 Jul;166(1):165-172. Epub 2022 Apr 29 doi: 10.1016/j.ygyno.2022.04.015. PMID: 35491268
Diagnosis of advanced cervical cancer, missed opportunities?
Mattern J, Letendre I, Sibiude J, Pénager C, Jnifen A, Souare F, Ayel S, Nguyen T, Mandelbrot L
BMC Womens Health 2022 Mar 30;22(1):97. doi: 10.1186/s12905-022-01668-3. PMID: 35354463Free PMC Article
Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system.
Osaku D, Komatsu H, Okawa M, Iida Y, Sato S, Oishi T, Harada T
Taiwan J Obstet Gynecol 2021 Nov;60(6):1054-1058. doi: 10.1016/j.tjog.2021.09.016. PMID: 34794737
Combination of weekly paclitaxel-carboplatin plus standard bevacizumab as neoadjuvant treatment in stage IB-IIB cervical cancer.
Maene C, Salihi RR, Van Nieuwenhuysen E, Han SN, Concin N, Vergote I
Int J Gynecol Cancer 2021 Jun;31(6):824-828. Epub 2021 Apr 15 doi: 10.1136/ijgc-2021-002432. PMID: 33858952
Comparing survival outcomes for cervical cancer based on the 2014 and 2018 International Federation of Gynecology and Obstetrics staging systems.
Shin W, Ham TY, Park YR, Lim MC, Won YJ
Sci Rep 2021 Mar 26;11(1):6988. doi: 10.1038/s41598-021-86283-2. PMID: 33772044Free PMC Article

Recent systematic reviews

Dose-dense neoadjuvant chemotherapy before radical surgery in cervical cancer: a retrospective cohort study and systematic literature review.
Caruso G, Bruni S, Lapresa M, De Vitis LA, Parma G, Minicucci V, Betella I, Schivardi G, Peccatori F, Lazzari R, Cliby W, Aletti GD, Zanagnolo V, Maggioni A, Colombo N, Multinu F
Int J Gynecol Cancer 2024 Jan 5;34(1):47-57. doi: 10.1136/ijgc-2023-004928. PMID: 37949488
Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer.
Chakrabarti M, Nordin A, Khodabocus J
Cochrane Database Syst Rev 2022 Sep 16;9(9):CD012246. doi: 10.1002/14651858.CD012246.pub2. PMID: 36111784Free PMC Article
Fertility-sparing surgery after neo-adjuvant chemotherapy in women with cervical cancer larger than 4 cm: a systematic review.
Viveros-Carreño D, Rodriguez J, Rendon Pereira GJ, Slama J, Halaska MJ, Robova H, Pareja R
Int J Gynecol Cancer 2022 Apr 4;32(4):486-493. doi: 10.1136/ijgc-2021-003297. PMID: 35210296

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