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Cervical Cancer by FIGO Stage 2018

MedGen UID:
1706227
•Concept ID:
C5207005
•
Neoplastic Process
Synonym: Cervical Carcinoma by FIGO Stage 2018

Definition

A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2018. [from NCI]

Professional guidelines

PubMed

MR Imaging in Cervical Cancer: Initial Staging and Treatment.
Pak T, Sadowski EA, Patel-Lippmann K
Radiol Clin North Am 2023 Jul;61(4):639-649. Epub 2023 Mar 28 doi: 10.1016/j.rcl.2023.02.009. PMID: 37169429
Optimal treatment in locally advanced cervical cancer.
Gennigens C, De Cuypere M, Hermesse J, Kridelka F, Jerusalem G
Expert Rev Anticancer Ther 2021 Jun;21(6):657-671. Epub 2021 Mar 11 doi: 10.1080/14737140.2021.1879646. PMID: 33472018
What Is the Role of Imaging at Primary Diagnostic Work-Up in Uterine Cervical Cancer?
Haldorsen IS, Lura N, Blaakær J, Fischerova D, Werner HMJ
Curr Oncol Rep 2019 Jul 29;21(9):77. doi: 10.1007/s11912-019-0824-0. PMID: 31359169Free PMC Article

Recent clinical studies

Etiology

Cancer of the cervix uteri: 2021 update.
Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):28-44. doi: 10.1002/ijgo.13865. PMID: 34669203Free PMC Article
Optimal treatment in locally advanced cervical cancer.
Gennigens C, De Cuypere M, Hermesse J, Kridelka F, Jerusalem G
Expert Rev Anticancer Ther 2021 Jun;21(6):657-671. Epub 2021 Mar 11 doi: 10.1080/14737140.2021.1879646. PMID: 33472018
SEOM clinical guidelines for cervical cancer (2019).
de Juan A, Redondo A, Rubio MJ, García Y, Cueva J, Gaba L, Yubero A, Alarcón J, Maximiano C, Oaknin A
Clin Transl Oncol 2020 Feb;22(2):270-278. Epub 2020 Jan 24 doi: 10.1007/s12094-019-02271-z. PMID: 31981078
What Is the Role of Imaging at Primary Diagnostic Work-Up in Uterine Cervical Cancer?
Haldorsen IS, Lura N, Blaakær J, Fischerova D, Werner HMJ
Curr Oncol Rep 2019 Jul 29;21(9):77. doi: 10.1007/s11912-019-0824-0. PMID: 31359169Free PMC Article
Validation of the 2018 FIGO cervical cancer staging system.
Matsuo K, Machida H, Mandelbaum RS, Konishi I, Mikami M
Gynecol Oncol 2019 Jan;152(1):87-93. Epub 2018 Oct 30 doi: 10.1016/j.ygyno.2018.10.026. PMID: 30389105Free PMC Article

Diagnosis

Cancer of the cervix uteri: 2021 update.
Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):28-44. doi: 10.1002/ijgo.13865. PMID: 34669203Free PMC Article
Revised FIGO Staging for Cervical Cancer - A New Role for MRI.
Merz J, Bossart M, Bamberg F, Eisenblaetter M
Rofo 2020 Oct;192(10):937-944. Epub 2020 Jul 30 doi: 10.1055/a-1198-5729. PMID: 32731266
What Is the Role of Imaging at Primary Diagnostic Work-Up in Uterine Cervical Cancer?
Haldorsen IS, Lura N, Blaakær J, Fischerova D, Werner HMJ
Curr Oncol Rep 2019 Jul 29;21(9):77. doi: 10.1007/s11912-019-0824-0. PMID: 31359169Free PMC Article
Cancer of the cervix uteri.
Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:22-36. doi: 10.1002/ijgo.12611. PMID: 30306584
The Role of Computed Tomography and Magnetic Resonance Imaging in Gynecologic Oncology.
Laifer-Narin SL, Genestine WF, Okechukwu NC, Hecht EM, Newhouse JH
PET Clin 2018 Apr;13(2):127-141. Epub 2018 Jan 10 doi: 10.1016/j.cpet.2017.11.002. PMID: 29482746

Therapy

Infiltration by Intratumor and Stromal CD8 and CD68 in Cervical Cancer.
Dimitrova P, Vasileva-Slaveva M, Shivarov V, Hasan I, Yordanov A
Medicina (Kaunas) 2023 Apr 7;59(4) doi: 10.3390/medicina59040728. PMID: 37109686Free PMC Article
Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer.
Chakrabarti M, Nordin A, Khodabocus J
Cochrane Database Syst Rev 2022 Sep 16;9(9):CD012246. doi: 10.1002/14651858.CD012246.pub2. PMID: 36111784Free PMC Article
Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer: The STARS Phase 3 Randomized Clinical Trial.
Huang H, Feng YL, Wan T, Zhang YN, Cao XP, Huang YW, Xiong Y, Huang X, Zheng M, Li YF, Li JD, Chen GD, Li H, Chen YL, Ma LG, Yang HY, Li L, Yao SZ, Ye WJ, Tu H, Huang QD, Liang LZ, Liu FY, Liu Q, Liu JH
JAMA Oncol 2021 Mar 1;7(3):361-369. doi: 10.1001/jamaoncol.2020.7168. PMID: 33443541Free PMC Article
The management of locally advanced cervical cancer.
Naga Ch P, Gurram L, Chopra S, Mahantshetty U
Curr Opin Oncol 2018 Sep;30(5):323-329. doi: 10.1097/CCO.0000000000000471. PMID: 29994902
Chemotherapy and targeted therapy in the management of cervical cancer.
Kumar L, Harish P, Malik PS, Khurana S
Curr Probl Cancer 2018 Mar-Apr;42(2):120-128. Epub 2018 Feb 3 doi: 10.1016/j.currproblcancer.2018.01.016. PMID: 29530393

Prognosis

Optimal treatment in locally advanced cervical cancer.
Gennigens C, De Cuypere M, Hermesse J, Kridelka F, Jerusalem G
Expert Rev Anticancer Ther 2021 Jun;21(6):657-671. Epub 2021 Mar 11 doi: 10.1080/14737140.2021.1879646. PMID: 33472018
2018 FIGO Staging Classification for Cervical Cancer: Added Benefits of Imaging.
Salib MY, Russell JHB, Stewart VR, Sudderuddin SA, Barwick TD, Rockall AG, Bharwani N
Radiographics 2020 Oct;40(6):1807-1822. Epub 2020 Sep 18 doi: 10.1148/rg.2020200013. PMID: 32946322
Revised FIGO Staging for Cervical Cancer - A New Role for MRI.
Merz J, Bossart M, Bamberg F, Eisenblaetter M
Rofo 2020 Oct;192(10):937-944. Epub 2020 Jul 30 doi: 10.1055/a-1198-5729. PMID: 32731266
Cervical Cancer: 2018 Revised International Federation of Gynecology and Obstetrics Staging System and the Role of Imaging.
Saleh M, Virarkar M, Javadi S, Elsherif SB, de Castro Faria S, Bhosale P
AJR Am J Roentgenol 2020 May;214(5):1182-1195. Epub 2020 Mar 17 doi: 10.2214/AJR.19.21819. PMID: 32182097
SEOM clinical guidelines for cervical cancer (2019).
de Juan A, Redondo A, Rubio MJ, García Y, Cueva J, Gaba L, Yubero A, Alarcón J, Maximiano C, Oaknin A
Clin Transl Oncol 2020 Feb;22(2):270-278. Epub 2020 Jan 24 doi: 10.1007/s12094-019-02271-z. PMID: 31981078

Clinical prediction guides

Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer.
Halle MK, Bozickovic O, Forsse D, Wagner-Larsen KS, Gold RM, Lura NG, Woie K, Bertelsen BI, Haldorsen IS, Krakstad C
Gynecol Oncol 2024 Feb;181:110-117. Epub 2023 Dec 27 doi: 10.1016/j.ygyno.2023.12.014. PMID: 38150835
MRI-based radiomic signatures for pretreatment prognostication in cervical cancer.
Wagner-Larsen KS, Hodneland E, Fasmer KE, Lura N, Woie K, Bertelsen BI, Salvesen Ø, Halle MK, Smit N, Krakstad C, Haldorsen IS
Cancer Med 2023 Oct;12(20):20251-20265. Epub 2023 Oct 16 doi: 10.1002/cam4.6526. PMID: 37840437Free PMC Article
Overall survival in patients with FIGO stage IVA cervical cancer.
Schiff JP, Mintz R, Cohen AC, Huang Y, Thaker P, Massad LS, Powell M, Mutch D, Schwarz JK, Markovina ST, Grigsby PW
Gynecol Oncol 2022 Aug;166(2):292-299. Epub 2022 Jun 10 doi: 10.1016/j.ygyno.2022.05.022. PMID: 35691754
Prognostic value of the 2018 FIGO staging system for cervical cancer.
Mohamud A, Høgdall C, Schnack T
Gynecol Oncol 2022 Jun;165(3):506-513. Epub 2022 Mar 26 doi: 10.1016/j.ygyno.2022.02.017. PMID: 35346512
Implications of the new FIGO staging and the role of imaging in cervical cancer.
Kido A, Nakamoto Y
Br J Radiol 2021 Sep 1;94(1125):20201342. Epub 2021 May 14 doi: 10.1259/bjr.20201342. PMID: 33989030Free PMC Article

Recent systematic reviews

Survival outcomes of 2018 FIGO stage IIIC versus stages IIIA and IIIB in cervical cancer: A systematic review with meta-analysis.
Zhang Y, Wang C, Zhao Z, Cheng L, Xu S, Xie P, Xie L, Zhang S
Int J Gynaecol Obstet 2024 Jun;165(3):959-968. Epub 2023 Nov 11 doi: 10.1002/ijgo.15218. PMID: 37950594
Definitive pelvic radiotherapy for patients with newly diagnosed stage IVB cervical cancer: a systematic review.
Viveros-Carreño D, Vieira-Serna S, Grillo-Ardila CF, Rodriguez J, Mora-Soto N, Jhingran A, Ramirez PT, Pareja R
Int J Gynecol Cancer 2023 Jul 3;33(7):1057-1062. doi: 10.1136/ijgc-2023-004465. PMID: 37192760
Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer.
Chakrabarti M, Nordin A, Khodabocus J
Cochrane Database Syst Rev 2022 Sep 16;9(9):CD012246. doi: 10.1002/14651858.CD012246.pub2. PMID: 36111784Free PMC Article
Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer. A systematic review on fertility and recurrence rates.
van Kol KGG, Vergeldt TFM, Bekkers RLM
Gynecol Oncol 2019 Dec;155(3):515-521. Epub 2019 Oct 9 doi: 10.1016/j.ygyno.2019.09.025. PMID: 31606284
Influence of clinicopathological characteristics and comprehensive treatment models on the prognosis of small cell carcinoma of the cervix: A systematic review and meta-analysis.
Zhang Q, Xiong Y, Ye J, Zhang L, Li L
PLoS One 2018;13(4):e0192784. Epub 2018 Apr 11 doi: 10.1371/journal.pone.0192784. PMID: 29641578Free PMC Article

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