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Stage IB Cervical Cancer FIGO 2018

MedGen UID:
1708066
•Concept ID:
C5206439
•
Neoplastic Process
Synonym: Stage IB Cervical Carcinoma FIGO 2018

Definition

Invasive cervical carcinoma with measured deepest invasion equal or more than 5 mm (greater than Stage IA), lesion limited to the cervix uteri. (FIGO 2018) [from NCI]

Professional guidelines

PubMed

Combination of weekly paclitaxel-carboplatin plus standard bevacizumab as neoadjuvant treatment in stage IB-IIB cervical cancer.
Maene C, Salihi RR, Van Nieuwenhuysen E, Han SN, Concin N, Vergote I
Int J Gynecol Cancer 2021 Jun;31(6):824-828. Epub 2021 Apr 15 doi: 10.1136/ijgc-2021-002432. PMID: 33858952
Prognostic Performance of the 2018 International Federation of Gynecology and Obstetrics Cervical Cancer Staging Guidelines.
Wright JD, Matsuo K, Huang Y, Tergas AI, Hou JY, Khoury-Collado F, St Clair CM, Ananth CV, Neugut AI, Hershman DL
Obstet Gynecol 2019 Jul;134(1):49-57. doi: 10.1097/AOG.0000000000003311. PMID: 31188324Free PMC Article
MRI-guided adaptive brachytherapy for locally advanced cervix cancer: Treatment outcomes from a single institution in Hong Kong.
Wu PY, Wong TPW, Yip YYC, Chang TYA, Chan LKL, Lee MCH, Law LYA, Yeung MWR, Soong SI
Brachytherapy 2019 Mar-Apr;18(2):171-179. Epub 2018 Dec 21 doi: 10.1016/j.brachy.2018.11.007. PMID: 30581053

Recent clinical studies

Etiology

Prognostic factors of 2018 FIGO stage IB-IIA cervical cancer with absence of high/ intermediate surgical-pathological risk factors.
Shibuya Y, Shimada M, Tsuji K, Shigeta S, Tanase Y, Matsuo K, Yamaguchi S, Kanao H, Saito T, Mikami M
Jpn J Clin Oncol 2022 Nov 3;52(11):1289-1296. doi: 10.1093/jjco/hyac125. PMID: 35913375
Total mesometrial resection (TMMR) for cervical cancer FIGO IB-IIA: first results from the multicentric TMMR register study.
Buderath P, Stukan M, Ruhwedel W, Strutas D, Feisel-Schwickardi G, Wimberger P, Kimmig R
J Gynecol Oncol 2022 Jan;33(1):e9. Epub 2021 Dec 6 doi: 10.3802/jgo.2022.33.e9. PMID: 34910390Free PMC Article
Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer: The STARS Phase 3 Randomized Clinical Trial.
Huang H, Feng YL, Wan T, Zhang YN, Cao XP, Huang YW, Xiong Y, Huang X, Zheng M, Li YF, Li JD, Chen GD, Li H, Chen YL, Ma LG, Yang HY, Li L, Yao SZ, Ye WJ, Tu H, Huang QD, Liang LZ, Liu FY, Liu Q, Liu JH
JAMA Oncol 2021 Mar 1;7(3):361-369. doi: 10.1001/jamaoncol.2020.7168. PMID: 33443541Free PMC Article
FIGO 2018 stage IB endocervical adenocarcinomas: an international study of outcomes informed by prognostic biomarkers.
Stolnicu S, Boros M, Hoang L, Almadani N, de Brot L, Baiocchi G, Bonvolim G, Parra-Herran C, Lerias S, Felix A, Roma A, Pesci A, Oliva E, Park K, Soslow RA, Abu-Rustum NR
Int J Gynecol Cancer 2021 Feb;31(2):177-184. Epub 2020 Nov 11 doi: 10.1136/ijgc-2020-001893. PMID: 33177150Free PMC Article
Validation of the 2018 FIGO cervical cancer staging system.
Matsuo K, Machida H, Mandelbaum RS, Konishi I, Mikami M
Gynecol Oncol 2019 Jan;152(1):87-93. Epub 2018 Oct 30 doi: 10.1016/j.ygyno.2018.10.026. PMID: 30389105Free PMC Article

Diagnosis

Assessment of pelvic lymph node metastasis in FIGO IB and IIA cervical cancer using quantitative dynamic contrast-enhanced MRI parameters.
Kim SH, Cho SH
Diagn Interv Radiol 2020 Sep;26(5):382-389. doi: 10.5152/dir.2020.19365. PMID: 32673204Free PMC Article
Clinicopathological risk factors in the light of the revised 2018 International Federation of Gynecology and Obstetrics staging system for early cervical cancer with staging IB: A single center retrospective study.
Zeng J, Qu P, Hu Y, Sun P, Qi J, Zhao G, Gao Y
Medicine (Baltimore) 2020 Apr;99(16):e19714. doi: 10.1097/MD.0000000000019714. PMID: 32311956Free PMC Article
Prognostic Performance of the 2018 International Federation of Gynecology and Obstetrics Cervical Cancer Staging Guidelines.
Wright JD, Matsuo K, Huang Y, Tergas AI, Hou JY, Khoury-Collado F, St Clair CM, Ananth CV, Neugut AI, Hershman DL
Obstet Gynecol 2019 Jul;134(1):49-57. doi: 10.1097/AOG.0000000000003311. PMID: 31188324Free PMC Article
Lymph nodes metastasis in cervical cancer: Incidences, risk factors, consequences and imaging evaluations.
Du R, Li L, Ma S, Tan X, Zhong S, Wu M
Asia Pac J Clin Oncol 2018 Oct;14(5):e380-e385. Epub 2018 May 31 doi: 10.1111/ajco.12997. PMID: 29855154
Postoperative clinicopathological factors affecting cervical adenocarcinoma: Stages I-IIB.
Zhou J, Chen Y, Xu X, Yan D, Lou H
Medicine (Baltimore) 2018 Jan;97(2):e9323. doi: 10.1097/MD.0000000000009323. PMID: 29480826Free PMC Article

Therapy

Total mesometrial resection (TMMR) for cervical cancer FIGO IB-IIA: first results from the multicentric TMMR register study.
Buderath P, Stukan M, Ruhwedel W, Strutas D, Feisel-Schwickardi G, Wimberger P, Kimmig R
J Gynecol Oncol 2022 Jan;33(1):e9. Epub 2021 Dec 6 doi: 10.3802/jgo.2022.33.e9. PMID: 34910390Free PMC Article
Combination of weekly paclitaxel-carboplatin plus standard bevacizumab as neoadjuvant treatment in stage IB-IIB cervical cancer.
Maene C, Salihi RR, Van Nieuwenhuysen E, Han SN, Concin N, Vergote I
Int J Gynecol Cancer 2021 Jun;31(6):824-828. Epub 2021 Apr 15 doi: 10.1136/ijgc-2021-002432. PMID: 33858952
Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer: The STARS Phase 3 Randomized Clinical Trial.
Huang H, Feng YL, Wan T, Zhang YN, Cao XP, Huang YW, Xiong Y, Huang X, Zheng M, Li YF, Li JD, Chen GD, Li H, Chen YL, Ma LG, Yang HY, Li L, Yao SZ, Ye WJ, Tu H, Huang QD, Liang LZ, Liu FY, Liu Q, Liu JH
JAMA Oncol 2021 Mar 1;7(3):361-369. doi: 10.1001/jamaoncol.2020.7168. PMID: 33443541Free PMC Article
Prognostic model based on magnetic resonance imaging, whole-tumour apparent diffusion coefficient values and HPV genotyping for stage IB-IV cervical cancer patients following chemoradiotherapy.
Lin G, Yang LY, Lin YC, Huang YT, Liu FY, Wang CC, Lu HY, Chiang HJ, Chen YR, Wu RC, Ng KK, Hong JH, Yen TC, Lai CH
Eur Radiol 2019 Feb;29(2):556-565. Epub 2018 Jul 26 doi: 10.1007/s00330-018-5651-4. PMID: 30051142
Lymph nodes metastasis in cervical cancer: Incidences, risk factors, consequences and imaging evaluations.
Du R, Li L, Ma S, Tan X, Zhong S, Wu M
Asia Pac J Clin Oncol 2018 Oct;14(5):e380-e385. Epub 2018 May 31 doi: 10.1111/ajco.12997. PMID: 29855154

Prognosis

Prognostic factors of 2018 FIGO stage IB-IIA cervical cancer with absence of high/ intermediate surgical-pathological risk factors.
Shibuya Y, Shimada M, Tsuji K, Shigeta S, Tanase Y, Matsuo K, Yamaguchi S, Kanao H, Saito T, Mikami M
Jpn J Clin Oncol 2022 Nov 3;52(11):1289-1296. doi: 10.1093/jjco/hyac125. PMID: 35913375
FIGO 2018 stage IB endocervical adenocarcinomas: an international study of outcomes informed by prognostic biomarkers.
Stolnicu S, Boros M, Hoang L, Almadani N, de Brot L, Baiocchi G, Bonvolim G, Parra-Herran C, Lerias S, Felix A, Roma A, Pesci A, Oliva E, Park K, Soslow RA, Abu-Rustum NR
Int J Gynecol Cancer 2021 Feb;31(2):177-184. Epub 2020 Nov 11 doi: 10.1136/ijgc-2020-001893. PMID: 33177150Free PMC Article
FIGO Classification 2018: Validation Study in Patients With Locally Advanced Cervix Cancer Treated With Chemoradiation.
Raut A, Chopra S, Mittal P, Patil G, Mahantshetty U, Gurram L, Swamidas J, Ghosh J, Gulia S, Popat P, Deodhar K, Maheshwari A, Gupta S
Int J Radiat Oncol Biol Phys 2020 Dec 1;108(5):1248-1256. Epub 2020 Jul 15 doi: 10.1016/j.ijrobp.2020.07.020. PMID: 32681859
High-risk human papillomavirus status and prognosis in invasive cervical cancer: A nationwide cohort study.
Lei J, Ploner A, Lagheden C, Eklund C, Nordqvist Kleppe S, Andrae B, Elfström KM, Dillner J, Sparén P, Sundström K
PLoS Med 2018 Oct;15(10):e1002666. Epub 2018 Oct 1 doi: 10.1371/journal.pmed.1002666. PMID: 30273338Free PMC Article
Lymph nodes metastasis in cervical cancer: Incidences, risk factors, consequences and imaging evaluations.
Du R, Li L, Ma S, Tan X, Zhong S, Wu M
Asia Pac J Clin Oncol 2018 Oct;14(5):e380-e385. Epub 2018 May 31 doi: 10.1111/ajco.12997. PMID: 29855154

Clinical prediction guides

Total mesometrial resection (TMMR) for cervical cancer FIGO IB-IIA: first results from the multicentric TMMR register study.
Buderath P, Stukan M, Ruhwedel W, Strutas D, Feisel-Schwickardi G, Wimberger P, Kimmig R
J Gynecol Oncol 2022 Jan;33(1):e9. Epub 2021 Dec 6 doi: 10.3802/jgo.2022.33.e9. PMID: 34910390Free PMC Article
Carcinomatosis in Early-Stage Cervical Cancer Treated with Robotic Radical Hysterectomy: Recurrence Patterns, Risk Factors, and Survival.
Fitzsimmons CK, Stephens AJ, Kennard JA, Manyam M, Pepe JW, Ahmad S, McKenzie ND, Kendrick JE, Holloway RW
Ann Surg Oncol 2022 Mar;29(3):2006-2013. Epub 2021 Nov 10 doi: 10.1245/s10434-021-11052-4. PMID: 34757549
Combination of weekly paclitaxel-carboplatin plus standard bevacizumab as neoadjuvant treatment in stage IB-IIB cervical cancer.
Maene C, Salihi RR, Van Nieuwenhuysen E, Han SN, Concin N, Vergote I
Int J Gynecol Cancer 2021 Jun;31(6):824-828. Epub 2021 Apr 15 doi: 10.1136/ijgc-2021-002432. PMID: 33858952
Retrospective analysis for predictors of parametrial involvement in IB cervical cancer.
Kubota S, Kobayashi E, Kakuda M, Matsuzaki S, Ueda Y, Yoshino K, Kimura T
J Obstet Gynaecol Res 2019 Mar;45(3):679-685. Epub 2018 Nov 22 doi: 10.1111/jog.13855. PMID: 30565810
Lymph nodes metastasis in cervical cancer: Incidences, risk factors, consequences and imaging evaluations.
Du R, Li L, Ma S, Tan X, Zhong S, Wu M
Asia Pac J Clin Oncol 2018 Oct;14(5):e380-e385. Epub 2018 May 31 doi: 10.1111/ajco.12997. PMID: 29855154

Recent systematic reviews

Neoadjuvant chemotherapy followed by fertility sparing surgery in cervical cancers size 2-4 cm; emerging data and future perspectives.
Gwacham NI, McKenzie ND, Fitzgerald ER, Ahmad S, Holloway RW
Gynecol Oncol 2021 Sep;162(3):809-815. Epub 2021 Jun 12 doi: 10.1016/j.ygyno.2021.06.006. PMID: 34130862

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