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Stage IB Cervical Cancer FIGO 2018

MedGen UID:
1708066
•Concept ID:
C5206439
•
Neoplastic Process
Synonym: Stage IB Cervical Carcinoma FIGO 2018

Definition

Invasive cervical carcinoma with measured deepest invasion equal or more than 5 mm (greater than Stage IA), lesion limited to the cervix uteri. (FIGO 2018) [from NCI]

Professional guidelines

PubMed

Combination of weekly paclitaxel-carboplatin plus standard bevacizumab as neoadjuvant treatment in stage IB-IIB cervical cancer.
Maene C, Salihi RR, Van Nieuwenhuysen E, Han SN, Concin N, Vergote I
Int J Gynecol Cancer 2021 Jun;31(6):824-828. Epub 2021 Apr 15 doi: 10.1136/ijgc-2021-002432. PMID: 33858952
Prognostic Performance of the 2018 International Federation of Gynecology and Obstetrics Cervical Cancer Staging Guidelines.
Wright JD, Matsuo K, Huang Y, Tergas AI, Hou JY, Khoury-Collado F, St Clair CM, Ananth CV, Neugut AI, Hershman DL
Obstet Gynecol 2019 Jul;134(1):49-57. doi: 10.1097/AOG.0000000000003311. PMID: 31188324Free PMC Article
MRI-guided adaptive brachytherapy for locally advanced cervix cancer: Treatment outcomes from a single institution in Hong Kong.
Wu PY, Wong TPW, Yip YYC, Chang TYA, Chan LKL, Lee MCH, Law LYA, Yeung MWR, Soong SI
Brachytherapy 2019 Mar-Apr;18(2):171-179. Epub 2018 Dec 21 doi: 10.1016/j.brachy.2018.11.007. PMID: 30581053

Recent clinical studies

Etiology

Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer.
Halle MK, Bozickovic O, Forsse D, Wagner-Larsen KS, Gold RM, Lura NG, Woie K, Bertelsen BI, Haldorsen IS, Krakstad C
Gynecol Oncol 2024 Feb;181:110-117. Epub 2023 Dec 27 doi: 10.1016/j.ygyno.2023.12.014. PMID: 38150835
Prognostic factors of 2018 FIGO stage IB-IIA cervical cancer with absence of high/ intermediate surgical-pathological risk factors.
Shibuya Y, Shimada M, Tsuji K, Shigeta S, Tanase Y, Matsuo K, Yamaguchi S, Kanao H, Saito T, Mikami M
Jpn J Clin Oncol 2022 Nov 3;52(11):1289-1296. doi: 10.1093/jjco/hyac125. PMID: 35913375
Pretreatment C-Reactive Protein/Albumin Ratio is Associated With Poor Survival in Patients With 2018 FIGO Stage IB-IIA HPV-Positive Cervical Cancer.
Jiang Y, Gu H, Zheng X, Pan B, Liu P, Zheng M
Pathol Oncol Res 2021;27:1609946. Epub 2021 Dec 21 doi: 10.3389/pore.2021.1609946. PMID: 34992504Free PMC Article
Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer: The STARS Phase 3 Randomized Clinical Trial.
Huang H, Feng YL, Wan T, Zhang YN, Cao XP, Huang YW, Xiong Y, Huang X, Zheng M, Li YF, Li JD, Chen GD, Li H, Chen YL, Ma LG, Yang HY, Li L, Yao SZ, Ye WJ, Tu H, Huang QD, Liang LZ, Liu FY, Liu Q, Liu JH
JAMA Oncol 2021 Mar 1;7(3):361-369. doi: 10.1001/jamaoncol.2020.7168. PMID: 33443541Free PMC Article
Validation of the 2018 FIGO cervical cancer staging system.
Matsuo K, Machida H, Mandelbaum RS, Konishi I, Mikami M
Gynecol Oncol 2019 Jan;152(1):87-93. Epub 2018 Oct 30 doi: 10.1016/j.ygyno.2018.10.026. PMID: 30389105Free PMC Article

Diagnosis

Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer.
Halle MK, Bozickovic O, Forsse D, Wagner-Larsen KS, Gold RM, Lura NG, Woie K, Bertelsen BI, Haldorsen IS, Krakstad C
Gynecol Oncol 2024 Feb;181:110-117. Epub 2023 Dec 27 doi: 10.1016/j.ygyno.2023.12.014. PMID: 38150835
The risk of lymph node metastasis in the new FIGO 2018 stage IA cervical cancer with >7 mm diameter.
Nicolai L, Yigit R, Bleeker MCG, Bart J, van der Velden J, Mom CH
J Gynecol Oncol 2023 Nov;34(6):e75. Epub 2023 Jul 7 doi: 10.3802/jgo.2023.34.e75. PMID: 37477098Free PMC Article
The prognostic value of the presence of pelvic and/or para-aortic lymph node metastases in cervical cancer patients; the influence of the new FIGO classification (stage IIIC).
van Kol KGG, Ebisch RMF, van der Aa M, Wenzel HB, Piek JMJ, Bekkers RLM
Gynecol Oncol 2023 Apr;171:9-14. Epub 2023 Feb 16 doi: 10.1016/j.ygyno.2023.01.023. PMID: 36804623
Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system.
Osaku D, Komatsu H, Okawa M, Iida Y, Sato S, Oishi T, Harada T
Taiwan J Obstet Gynecol 2021 Nov;60(6):1054-1058. doi: 10.1016/j.tjog.2021.09.016. PMID: 34794737
Lymph nodes metastasis in cervical cancer: Incidences, risk factors, consequences and imaging evaluations.
Du R, Li L, Ma S, Tan X, Zhong S, Wu M
Asia Pac J Clin Oncol 2018 Oct;14(5):e380-e385. Epub 2018 May 31 doi: 10.1111/ajco.12997. PMID: 29855154

Therapy

Quality of Life in Cervical Cancer Survivors Treated with Concurrent Chemoradiotherapy.
Stuopelytė R, Žukienė G, Breivienė R, Rudaitis V, Bartkevičienė D
Medicina (Kaunas) 2023 Apr 17;59(4) doi: 10.3390/medicina59040777. PMID: 37109735Free PMC Article
Total mesometrial resection (TMMR) for cervical cancer FIGO IB-IIA: first results from the multicentric TMMR register study.
Buderath P, Stukan M, Ruhwedel W, Strutas D, Feisel-Schwickardi G, Wimberger P, Kimmig R
J Gynecol Oncol 2022 Jan;33(1):e9. Epub 2021 Dec 6 doi: 10.3802/jgo.2022.33.e9. PMID: 34910390Free PMC Article
Combination of weekly paclitaxel-carboplatin plus standard bevacizumab as neoadjuvant treatment in stage IB-IIB cervical cancer.
Maene C, Salihi RR, Van Nieuwenhuysen E, Han SN, Concin N, Vergote I
Int J Gynecol Cancer 2021 Jun;31(6):824-828. Epub 2021 Apr 15 doi: 10.1136/ijgc-2021-002432. PMID: 33858952
Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer: The STARS Phase 3 Randomized Clinical Trial.
Huang H, Feng YL, Wan T, Zhang YN, Cao XP, Huang YW, Xiong Y, Huang X, Zheng M, Li YF, Li JD, Chen GD, Li H, Chen YL, Ma LG, Yang HY, Li L, Yao SZ, Ye WJ, Tu H, Huang QD, Liang LZ, Liu FY, Liu Q, Liu JH
JAMA Oncol 2021 Mar 1;7(3):361-369. doi: 10.1001/jamaoncol.2020.7168. PMID: 33443541Free PMC Article
Lymph nodes metastasis in cervical cancer: Incidences, risk factors, consequences and imaging evaluations.
Du R, Li L, Ma S, Tan X, Zhong S, Wu M
Asia Pac J Clin Oncol 2018 Oct;14(5):e380-e385. Epub 2018 May 31 doi: 10.1111/ajco.12997. PMID: 29855154

Prognosis

Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer.
Halle MK, Bozickovic O, Forsse D, Wagner-Larsen KS, Gold RM, Lura NG, Woie K, Bertelsen BI, Haldorsen IS, Krakstad C
Gynecol Oncol 2024 Feb;181:110-117. Epub 2023 Dec 27 doi: 10.1016/j.ygyno.2023.12.014. PMID: 38150835
Oncologic outcome in patients with 2018 FIGO stage IB cervical cancer: Is tumor size important?
Tokalioglu AA, Kilic C, Oktar O, Kilic F, Cakir C, Yuksel D, Comert GK, Korkmaz V, Turan T
J Obstet Gynaecol Res 2023 Feb;49(2):709-716. Epub 2022 Nov 22 doi: 10.1111/jog.15505. PMID: 36415110
Prognostic factors of 2018 FIGO stage IB-IIA cervical cancer with absence of high/ intermediate surgical-pathological risk factors.
Shibuya Y, Shimada M, Tsuji K, Shigeta S, Tanase Y, Matsuo K, Yamaguchi S, Kanao H, Saito T, Mikami M
Jpn J Clin Oncol 2022 Nov 3;52(11):1289-1296. doi: 10.1093/jjco/hyac125. PMID: 35913375
Pretreatment C-Reactive Protein/Albumin Ratio is Associated With Poor Survival in Patients With 2018 FIGO Stage IB-IIA HPV-Positive Cervical Cancer.
Jiang Y, Gu H, Zheng X, Pan B, Liu P, Zheng M
Pathol Oncol Res 2021;27:1609946. Epub 2021 Dec 21 doi: 10.3389/pore.2021.1609946. PMID: 34992504Free PMC Article
FIGO 2018 stage IB endocervical adenocarcinomas: an international study of outcomes informed by prognostic biomarkers.
Stolnicu S, Boros M, Hoang L, Almadani N, de Brot L, Baiocchi G, Bonvolim G, Parra-Herran C, Lerias S, Felix A, Roma A, Pesci A, Oliva E, Park K, Soslow RA, Abu-Rustum NR
Int J Gynecol Cancer 2021 Feb;31(2):177-184. Epub 2020 Nov 11 doi: 10.1136/ijgc-2020-001893. PMID: 33177150Free PMC Article

Clinical prediction guides

Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer.
Halle MK, Bozickovic O, Forsse D, Wagner-Larsen KS, Gold RM, Lura NG, Woie K, Bertelsen BI, Haldorsen IS, Krakstad C
Gynecol Oncol 2024 Feb;181:110-117. Epub 2023 Dec 27 doi: 10.1016/j.ygyno.2023.12.014. PMID: 38150835
Quality of Life in Cervical Cancer Survivors Treated with Concurrent Chemoradiotherapy.
Stuopelytė R, Žukienė G, Breivienė R, Rudaitis V, Bartkevičienė D
Medicina (Kaunas) 2023 Apr 17;59(4) doi: 10.3390/medicina59040777. PMID: 37109735Free PMC Article
Oncologic outcome in patients with 2018 FIGO stage IB cervical cancer: Is tumor size important?
Tokalioglu AA, Kilic C, Oktar O, Kilic F, Cakir C, Yuksel D, Comert GK, Korkmaz V, Turan T
J Obstet Gynaecol Res 2023 Feb;49(2):709-716. Epub 2022 Nov 22 doi: 10.1111/jog.15505. PMID: 36415110
Total mesometrial resection (TMMR) for cervical cancer FIGO IB-IIA: first results from the multicentric TMMR register study.
Buderath P, Stukan M, Ruhwedel W, Strutas D, Feisel-Schwickardi G, Wimberger P, Kimmig R
J Gynecol Oncol 2022 Jan;33(1):e9. Epub 2021 Dec 6 doi: 10.3802/jgo.2022.33.e9. PMID: 34910390Free PMC Article
Pretreatment C-Reactive Protein/Albumin Ratio is Associated With Poor Survival in Patients With 2018 FIGO Stage IB-IIA HPV-Positive Cervical Cancer.
Jiang Y, Gu H, Zheng X, Pan B, Liu P, Zheng M
Pathol Oncol Res 2021;27:1609946. Epub 2021 Dec 21 doi: 10.3389/pore.2021.1609946. PMID: 34992504Free PMC Article

Recent systematic reviews

Dose-dense neoadjuvant chemotherapy before radical surgery in cervical cancer: a retrospective cohort study and systematic literature review.
Caruso G, Bruni S, Lapresa M, De Vitis LA, Parma G, Minicucci V, Betella I, Schivardi G, Peccatori F, Lazzari R, Cliby W, Aletti GD, Zanagnolo V, Maggioni A, Colombo N, Multinu F
Int J Gynecol Cancer 2024 Jan 5;34(1):47-57. doi: 10.1136/ijgc-2023-004928. PMID: 37949488
Neoadjuvant chemotherapy followed by fertility sparing surgery in cervical cancers size 2-4 cm; emerging data and future perspectives.
Gwacham NI, McKenzie ND, Fitzgerald ER, Ahmad S, Holloway RW
Gynecol Oncol 2021 Sep;162(3):809-815. Epub 2021 Jun 12 doi: 10.1016/j.ygyno.2021.06.006. PMID: 34130862

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