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Localized Childhood Rhabdomyosarcoma

MedGen UID:
1693981
•Concept ID:
C5206897
•
Neoplastic Process
Synonym: Non-Metastatic Childhood Rhabdomyosarcoma

Definition

Rhabdomyosarcoma that occurs during childhood and is confined to a specific site without evidence of spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Childhood Rhabdomyosarcoma

Professional guidelines

PubMed

Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines.
Dávila Fajardo R, Scarzello G, Gaze MN, Boterberg T, Cameron A, Fuchs J, Guérin F, Hoskin P, Krasin MJ, Kroon P, Magelssen H, Mercke C, Merks JHM, Paulsen F, Pommier P, Ramos M, Rees H, Rogers T, Schmid M, Seitz G, Slater O, Smeulders N, Stenman J, Terwisscha S, Chargari C, Mandeville HC
Radiother Oncol 2024 Jun;195:110273. Epub 2024 Apr 7 doi: 10.1016/j.radonc.2024.110273. PMID: 38588921
Radiotherapy in the Management of Childhood Rhabdomyosarcoma.
Mandeville HC
Clin Oncol (R Coll Radiol) 2019 Jul;31(7):462-470. Epub 2019 Apr 13 doi: 10.1016/j.clon.2019.03.047. PMID: 30992168
Diagnosis and Management of Rhabdomyosarcoma in Children and Adolescents: ICMR Consensus Document.
Panda SP, Chinnaswamy G, Vora T, Prasad M, Bansal D, Kapoor G, Radhakrishnan V, Agarwala S, Laskar S, Arora B, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 May;84(5):393-402. Epub 2017 Apr 5 doi: 10.1007/s12098-017-2315-3. PMID: 28378141

Recent clinical studies

Etiology

A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Recent progress in pediatric soft tissue sarcoma therapy.
Lautz TB, Hayes-Jordan A
Semin Pediatr Surg 2019 Dec;28(6):150862. Epub 2019 Nov 20 doi: 10.1016/j.sempedsurg.2019.150862. PMID: 31931970
Rhabdomyosarcoma.
Dasgupta R, Fuchs J, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):276-283. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.011. PMID: 27955730
Update on rhabdomyosarcoma.
Dasgupta R, Rodeberg DA
Semin Pediatr Surg 2012 Feb;21(1):68-78. doi: 10.1053/j.sempedsurg.2011.10.007. PMID: 22248972
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383

Diagnosis

Anaplasia in childhood rhabdomyosarcoma: An under reported entity.
Ahuja M, Tomar R, Thakur S, Mallya V, Mandal S, Khurana N, Sarin YK
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):864-868. doi: 10.4103/ijpm.ijpm_178_21. PMID: 36308195
Paediatric non-rhabdomyosarcoma soft tissue sarcomas: the prospective NRSTS 2005 study by the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG).
Ferrari A, van Noesel MM, Brennan B, Zanetti I, Corradini N, Casanova M, Berlanga P, Merks JHM, Alaggio R, Schifflers S, Ramirez-Villar GL, Giraudo C, Burrieza GG, Safwat A, Bisogno G, De Salvo GL, Orbach D
Lancet Child Adolesc Health 2021 Aug;5(8):546-558. Epub 2021 Jun 30 doi: 10.1016/S2352-4642(21)00159-0. PMID: 34214481
Rhabdomyosarcoma.
Dasgupta R, Fuchs J, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):276-283. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.011. PMID: 27955730
Acute Raoultella planticola cystitis in a child with rhabdomyosarcoma of the bladder neck.
Yoon JH, Ahn YH, Chun JI, Park HJ, Park BK
Pediatr Int 2015 Oct;57(5):985-7. doi: 10.1111/ped.12677. PMID: 26508180
Common musculoskeletal tumors of childhood and adolescence.
Arndt CA, Crist WM
N Engl J Med 1999 Jul 29;341(5):342-52. doi: 10.1056/NEJM199907293410507. PMID: 10423470

Therapy

Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-of-concept on cell death inducers.
Savary C, Luciana L, Huchedé P, Tourbez A, Coquet C, Broustal M, Lopez Gonzalez A, Deligne C, Diot T, Naret O, Costa M, Meynard N, Barbet V, Müller K, Tonon L, Gadot N, Degletagne C, Attignon V, Léon S, Vanbelle C, Bomane A, Rochet I, Mournetas V, Oliveira L, Rinaudo P, Bergeron C, Dutour A, Cordier-Bussat M, Roch A, Brandenberg N, El Zein S, Watson S, Orbach D, Delattre O, Dijoud F, Corradini N, Picard C, Maucort-Boulch D, Le Grand M, Pasquier E, Blay JY, Castets M, Broutier L
Cell Rep Med 2023 Dec 19;4(12):101339. doi: 10.1016/j.xcrm.2023.101339. PMID: 38118405Free PMC Article
A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Common musculoskeletal tumors of childhood and adolescence.
Arndt CA, Crist WM
N Engl J Med 1999 Jul 29;341(5):342-52. doi: 10.1056/NEJM199907293410507. PMID: 10423470
Paratesticular rhabdomyosarcoma in childhood.
Raney RB Jr, Hays DM, Lawrence W Jr, Soule EH, Tefft M, Donaldson MH
Cancer 1978 Aug;42(2):729-36. doi: 10.1002/1097-0142(197808)42:2<729::aid-cncr2820420246>3.0.co;2-r. PMID: 354776

Prognosis

Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-of-concept on cell death inducers.
Savary C, Luciana L, Huchedé P, Tourbez A, Coquet C, Broustal M, Lopez Gonzalez A, Deligne C, Diot T, Naret O, Costa M, Meynard N, Barbet V, Müller K, Tonon L, Gadot N, Degletagne C, Attignon V, Léon S, Vanbelle C, Bomane A, Rochet I, Mournetas V, Oliveira L, Rinaudo P, Bergeron C, Dutour A, Cordier-Bussat M, Roch A, Brandenberg N, El Zein S, Watson S, Orbach D, Delattre O, Dijoud F, Corradini N, Picard C, Maucort-Boulch D, Le Grand M, Pasquier E, Blay JY, Castets M, Broutier L
Cell Rep Med 2023 Dec 19;4(12):101339. doi: 10.1016/j.xcrm.2023.101339. PMID: 38118405Free PMC Article
Rhabdomyosarcoma.
Dasgupta R, Fuchs J, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):276-283. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.011. PMID: 27955730
Update on rhabdomyosarcoma.
Dasgupta R, Rodeberg DA
Semin Pediatr Surg 2012 Feb;21(1):68-78. doi: 10.1053/j.sempedsurg.2011.10.007. PMID: 22248972
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383
Paratesticular rhabdomyosarcoma in childhood.
Raney RB Jr, Hays DM, Lawrence W Jr, Soule EH, Tefft M, Donaldson MH
Cancer 1978 Aug;42(2):729-36. doi: 10.1002/1097-0142(197808)42:2<729::aid-cncr2820420246>3.0.co;2-r. PMID: 354776

Clinical prediction guides

Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-of-concept on cell death inducers.
Savary C, Luciana L, Huchedé P, Tourbez A, Coquet C, Broustal M, Lopez Gonzalez A, Deligne C, Diot T, Naret O, Costa M, Meynard N, Barbet V, Müller K, Tonon L, Gadot N, Degletagne C, Attignon V, Léon S, Vanbelle C, Bomane A, Rochet I, Mournetas V, Oliveira L, Rinaudo P, Bergeron C, Dutour A, Cordier-Bussat M, Roch A, Brandenberg N, El Zein S, Watson S, Orbach D, Delattre O, Dijoud F, Corradini N, Picard C, Maucort-Boulch D, Le Grand M, Pasquier E, Blay JY, Castets M, Broutier L
Cell Rep Med 2023 Dec 19;4(12):101339. doi: 10.1016/j.xcrm.2023.101339. PMID: 38118405Free PMC Article
Anaplasia in childhood rhabdomyosarcoma: An under reported entity.
Ahuja M, Tomar R, Thakur S, Mallya V, Mandal S, Khurana N, Sarin YK
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):864-868. doi: 10.4103/ijpm.ijpm_178_21. PMID: 36308195
A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Update on rhabdomyosarcoma.
Dasgupta R, Rodeberg DA
Semin Pediatr Surg 2012 Feb;21(1):68-78. doi: 10.1053/j.sempedsurg.2011.10.007. PMID: 22248972

Recent systematic reviews

A systematic review of combined surgery and brachytherapy approaches for children and young people with relapsed and refractory rhabdomyosarcoma (Local-REFoRMS).
Ballantyne E, Evans C, Shepherd L, Fulbright H, Wakeling S, Phillips B, Morgan JE
Pediatr Blood Cancer 2024 Jun;71(6):e30952. Epub 2024 Apr 2 doi: 10.1002/pbc.30952. PMID: 38566349
A systematic review of early phase studies for children and young people with relapsed and refractory rhabdomyosarcoma: The REFoRMS-SR project.
Evans C, Shepherd L, Bryan G, Fulbright H, Crowther S, Wakeling S, Stewart A, Stewart C, Chisholm J, Gibson F, Phillips B, Morgan JE
Int J Cancer 2024 Apr 1;154(7):1235-1260. Epub 2023 Dec 10 doi: 10.1002/ijc.34808. PMID: 38071594
Identifying barriers to treatment of childhood rhabdomyosarcoma in resource-limited settings: A literature review.
Papyan R, Tamamyan G, Danielyan S, Tananyan A, Muradyan A, Saab R
Pediatr Blood Cancer 2019 Jul;66(7):e27708. Epub 2019 Mar 25 doi: 10.1002/pbc.27708. PMID: 30907501
Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma soft tissue sarcomas.
Peinemann F, Enk H, Smith LA
Cochrane Database Syst Rev 2017 Apr 13;4(4):CD008216. doi: 10.1002/14651858.CD008216.pub5. PMID: 28407197Free PMC Article

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