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Localized Childhood Rhabdomyosarcoma

MedGen UID:
1693981
•Concept ID:
C5206897
•
Neoplastic Process
Synonym: Non-Metastatic Childhood Rhabdomyosarcoma

Definition

Rhabdomyosarcoma that occurs during childhood and is confined to a specific site without evidence of spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Childhood Rhabdomyosarcoma

Professional guidelines

PubMed

Radiotherapy in the Management of Childhood Rhabdomyosarcoma.
Mandeville HC
Clin Oncol (R Coll Radiol) 2019 Jul;31(7):462-470. Epub 2019 Apr 13 doi: 10.1016/j.clon.2019.03.047. PMID: 30992168
Diagnosis and Management of Rhabdomyosarcoma in Children and Adolescents: ICMR Consensus Document.
Panda SP, Chinnaswamy G, Vora T, Prasad M, Bansal D, Kapoor G, Radhakrishnan V, Agarwala S, Laskar S, Arora B, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 May;84(5):393-402. Epub 2017 Apr 5 doi: 10.1007/s12098-017-2315-3. PMID: 28378141
Orbital cysts of childhood--classification, clinical features, and management.
Shields JA, Shields CL
Surv Ophthalmol 2004 May-Jun;49(3):281-99. doi: 10.1016/j.survophthal.2004.02.001. PMID: 15110666

Recent clinical studies

Etiology

A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Rhabdomyosarcoma.
Dasgupta R, Fuchs J, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):276-283. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.011. PMID: 27955730
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383
Childhood rhabdomyosarcoma.
Rodeberg D, Paidas C
Semin Pediatr Surg 2006 Feb;15(1):57-62. doi: 10.1053/j.sempedsurg.2005.11.009. PMID: 16458847

Diagnosis

Machine learning for rhabdomyosarcoma histopathology.
Frankel AO, Lathara M, Shaw CY, Wogmon O, Jackson JM, Clark MM, Eshraghi N, Keenen SE, Woods AD, Purohit R, Ishi Y, Moran N, Eguchi M, Ahmed FUA, Khan S, Ioannou M, Perivoliotis K, Li P, Zhou H, Alkhaledi A, Davis EJ, Galipeau D, Randall RL, Wozniak A, Schoffski P, Lee CJ, Huang PH, Jones RL, Rubin BP, Darrow M, Srinivasa G, Rudzinski ER, Chen S, Berlow NE, Keller C
Mod Pathol 2022 Sep;35(9):1193-1203. Epub 2022 Apr 21 doi: 10.1038/s41379-022-01075-x. PMID: 35449398
Diagnosis and Management of Rhabdomyosarcoma in Children and Adolescents: ICMR Consensus Document.
Panda SP, Chinnaswamy G, Vora T, Prasad M, Bansal D, Kapoor G, Radhakrishnan V, Agarwala S, Laskar S, Arora B, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 May;84(5):393-402. Epub 2017 Apr 5 doi: 10.1007/s12098-017-2315-3. PMID: 28378141
Rhabdomyosarcoma.
Dasgupta R, Fuchs J, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):276-283. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.011. PMID: 27955730
Childhood rhabdomyosarcoma.
Rodeberg D, Paidas C
Semin Pediatr Surg 2006 Feb;15(1):57-62. doi: 10.1053/j.sempedsurg.2005.11.009. PMID: 16458847
Rhabdomyosarcoma: an overview.
Dagher R, Helman L
Oncologist 1999;4(1):34-44. PMID: 10337369

Therapy

A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Outcome and Patterns of Relapse in Childhood Parameningeal Rhabdomyosarcoma Treated With Proton Beam Therapy.
Doyen J, Jazmati D, Geismar D, Frisch S, Schleithoff SS, Vermeren X, Scheer M, Blase C, Tippelt S, Timmermann B
Int J Radiat Oncol Biol Phys 2019 Dec 1;105(5):1043-1054. Epub 2019 Aug 13 doi: 10.1016/j.ijrobp.2019.08.005. PMID: 31419513
Rhabdomyosarcoma: current challenges and their implications for developing therapies.
Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C
Cold Spring Harb Perspect Med 2014 Nov 3;4(11):a025650. doi: 10.1101/cshperspect.a025650. PMID: 25368019Free PMC Article
Selecting multimodal therapy for rhabdomyosarcoma.
Sultan I, Ferrari A
Expert Rev Anticancer Ther 2010 Aug;10(8):1285-301. doi: 10.1586/era.10.96. PMID: 20735314

Prognosis

Rhabdomyosarcoma.
Dasgupta R, Fuchs J, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):276-283. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.011. PMID: 27955730
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383
Childhood rhabdomyosarcoma.
Rodeberg D, Paidas C
Semin Pediatr Surg 2006 Feb;15(1):57-62. doi: 10.1053/j.sempedsurg.2005.11.009. PMID: 16458847
Liver tumours.
Perilongo G, Shafford EA
Eur J Cancer 1999 Jun;35(6):953-8; discussion 958-9. doi: 10.1016/s0959-8049(99)00049-0. PMID: 10533478
Rhabdomyosarcoma: an overview.
Dagher R, Helman L
Oncologist 1999;4(1):34-44. PMID: 10337369

Clinical prediction guides

A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Synovial sarcoma in children and adolescents.
Kerouanton A, Jimenez I, Cellier C, Laurence V, Helfre S, Pannier S, Mary P, Freneaux P, Orbach D
J Pediatr Hematol Oncol 2014 May;36(4):257-62. doi: 10.1097/MPH.0000000000000154. PMID: 24633301
Update on rhabdomyosarcoma.
Dasgupta R, Rodeberg DA
Semin Pediatr Surg 2012 Feb;21(1):68-78. doi: 10.1053/j.sempedsurg.2011.10.007. PMID: 22248972
Orbital cysts of childhood--classification, clinical features, and management.
Shields JA, Shields CL
Surv Ophthalmol 2004 May-Jun;49(3):281-99. doi: 10.1016/j.survophthal.2004.02.001. PMID: 15110666

Recent systematic reviews

Identifying barriers to treatment of childhood rhabdomyosarcoma in resource-limited settings: A literature review.
Papyan R, Tamamyan G, Danielyan S, Tananyan A, Muradyan A, Saab R
Pediatr Blood Cancer 2019 Jul;66(7):e27708. Epub 2019 Mar 25 doi: 10.1002/pbc.27708. PMID: 30907501
Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma soft tissue sarcomas.
Peinemann F, Enk H, Smith LA
Cochrane Database Syst Rev 2017 Apr 13;4(4):CD008216. doi: 10.1002/14651858.CD008216.pub5. PMID: 28407197Free PMC Article

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