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Childhood Soft Tissue Sarcoma

MedGen UID:
66311
•Concept ID:
C0220645
•
Neoplastic Process
Synonyms: Childhood Sarcoma of Soft Tissue; Childhood Sarcoma of the Soft Tissue; Pediatric Sarcoma of Soft Tissue; Pediatric Sarcoma of the Soft Tissue; Pediatric Soft Tissue Sarcoma

Definition

Soft tissue sarcoma occurring in childhood. [from NCI]

Professional guidelines

PubMed

Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma.
Slemmons KK, Yeung C, Baumgart JT, Juarez JOM, McCalla A, Helman LJ
Cancer Res 2020 Jul 15;80(14):3046-3056. Epub 2020 Apr 30 doi: 10.1158/0008-5472.CAN-19-3853. PMID: 32354737
Second malignant neoplasms in children after treatment of soft tissue sarcoma.
Rich DC, Corpron CA, Smith MB, Black CT, Lally KP, Andrassy RJ
J Pediatr Surg 1997 Feb;32(2):369-72. doi: 10.1016/s0022-3468(97)90213-x. PMID: 9044156

Recent clinical studies

Etiology

The prognostic significance of anaplasia in childhood rhabdomyosarcoma: A report from the Children's Oncology Group.
Shenoy A, Alvarez E, Chi YY, Li M, Shern JF, Khan J, Hiniker SM, Granberg CF, Hawkins DS, Parham DM, Teot LA, Rudzinski ER
Eur J Cancer 2021 Jan;143:127-133. Epub 2020 Dec 7 doi: 10.1016/j.ejca.2020.10.018. PMID: 33302115Free PMC Article
Neurocognitive and psychosocial outcomes in adult survivors of childhood soft-tissue sarcoma: A report from the St. Jude Lifetime Cohort.
Tonning Olsson I, Brinkman TM, Wang M, Ehrhardt MJ, Banerjee P, Mulrooney DA, Huang IC, Ness KK, Bishop MW, Srivastava D, Robison LL, Hudson MM, Krull KR
Cancer 2020 Apr 1;126(7):1576-1584. Epub 2020 Jan 8 doi: 10.1002/cncr.32694. PMID: 31913509Free PMC Article
Interstitial brachytherapy for childhood soft tissue sarcoma.
Laskar S, Bahl G, Ann Muckaden M, Puri A, Agarwal MG, Patil N, Shrivastava SK, Dinshaw KA
Pediatr Blood Cancer 2007 Oct 15;49(5):649-55. doi: 10.1002/pbc.21118. PMID: 17226842
The Li-Fraumeni syndrome: from clinical epidemiology to molecular genetics.
Strong LC, Williams WR, Tainsky MA
Am J Epidemiol 1992 Jan 15;135(2):190-9. doi: 10.1093/oxfordjournals.aje.a116271. PMID: 1536134
Cancer in survivors of childhood soft tissue sarcoma and their relatives.
Strong LC, Stine M, Norsted TL
J Natl Cancer Inst 1987 Dec;79(6):1213-20. PMID: 3480372

Diagnosis

Entinostat as a combinatorial therapeutic for rhabdomyosarcoma.
Chauhan S, Lian E, Habib I, Liu Q, Anders NM, Bugg MM, Federman NC, Reid JM, Stewart CF, Cates T, Michalek JE, Keller C
Sci Rep 2024 Aug 15;14(1):18936. doi: 10.1038/s41598-024-66545-5. PMID: 39147820Free PMC Article
Clinical presentation of childhood soft tissue sarcomas: a systematic review and meta-analysis.
Ni Cheallaigh L, Liu JF, Fern L, Winyard P, Walker D, Ball-Gamble A, Shanmugavadivel D
Arch Dis Child 2024 Jan 22;109(2):113-120. doi: 10.1136/archdischild-2023-325875. PMID: 37857451
Defining an embryonal rhabdomyosarcoma endotype.
Ricker CA, Crawford K, Matlock K, Lathara M, Seguin B, Rudzinski ER, Berlow NE, Keller C
Cold Spring Harb Mol Case Stud 2020 Apr;6(2) Epub 2020 Apr 1 doi: 10.1101/mcs.a005066. PMID: 32238403Free PMC Article
Neurocognitive and psychosocial outcomes in adult survivors of childhood soft-tissue sarcoma: A report from the St. Jude Lifetime Cohort.
Tonning Olsson I, Brinkman TM, Wang M, Ehrhardt MJ, Banerjee P, Mulrooney DA, Huang IC, Ness KK, Bishop MW, Srivastava D, Robison LL, Hudson MM, Krull KR
Cancer 2020 Apr 1;126(7):1576-1584. Epub 2020 Jan 8 doi: 10.1002/cncr.32694. PMID: 31913509Free PMC Article
Cancer in survivors of childhood soft tissue sarcoma and their relatives.
Strong LC, Stine M, Norsted TL
J Natl Cancer Inst 1987 Dec;79(6):1213-20. PMID: 3480372

Therapy

Entinostat as a combinatorial therapeutic for rhabdomyosarcoma.
Chauhan S, Lian E, Habib I, Liu Q, Anders NM, Bugg MM, Federman NC, Reid JM, Stewart CF, Cates T, Michalek JE, Keller C
Sci Rep 2024 Aug 15;14(1):18936. doi: 10.1038/s41598-024-66545-5. PMID: 39147820Free PMC Article
Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma.
Singh S, Abu-Zaid A, Jin H, Fang J, Wu Q, Wang T, Feng H, Quarni W, Shao Y, Maxham L, Abdolvahabi A, Yun MK, Vaithiyalingam S, Tan H, Bowling J, Honnell V, Young B, Guo Y, Bajpai R, Pruett-Miller SM, Grosveld GC, Hatley M, Xu B, Fan Y, Wu G, Chen EY, Chen T, Lewis PW, Rankovic Z, Li Y, Murphy AJ, Easton J, Peng J, Chen X, Wang R, White SW, Davidoff AM, Yang J
Sci Transl Med 2022 Jul 13;14(653):eabq2096. doi: 10.1126/scitranslmed.abq2096. PMID: 35857643Free PMC Article
Defining an embryonal rhabdomyosarcoma endotype.
Ricker CA, Crawford K, Matlock K, Lathara M, Seguin B, Rudzinski ER, Berlow NE, Keller C
Cold Spring Harb Mol Case Stud 2020 Apr;6(2) Epub 2020 Apr 1 doi: 10.1101/mcs.a005066. PMID: 32238403Free PMC Article
Neurocognitive and psychosocial outcomes in adult survivors of childhood soft-tissue sarcoma: A report from the St. Jude Lifetime Cohort.
Tonning Olsson I, Brinkman TM, Wang M, Ehrhardt MJ, Banerjee P, Mulrooney DA, Huang IC, Ness KK, Bishop MW, Srivastava D, Robison LL, Hudson MM, Krull KR
Cancer 2020 Apr 1;126(7):1576-1584. Epub 2020 Jan 8 doi: 10.1002/cncr.32694. PMID: 31913509Free PMC Article
Interstitial brachytherapy for childhood soft tissue sarcoma.
Laskar S, Bahl G, Ann Muckaden M, Puri A, Agarwal MG, Patil N, Shrivastava SK, Dinshaw KA
Pediatr Blood Cancer 2007 Oct 15;49(5):649-55. doi: 10.1002/pbc.21118. PMID: 17226842

Prognosis

Entinostat as a combinatorial therapeutic for rhabdomyosarcoma.
Chauhan S, Lian E, Habib I, Liu Q, Anders NM, Bugg MM, Federman NC, Reid JM, Stewart CF, Cates T, Michalek JE, Keller C
Sci Rep 2024 Aug 15;14(1):18936. doi: 10.1038/s41598-024-66545-5. PMID: 39147820Free PMC Article
The prognostic significance of anaplasia in childhood rhabdomyosarcoma: A report from the Children's Oncology Group.
Shenoy A, Alvarez E, Chi YY, Li M, Shern JF, Khan J, Hiniker SM, Granberg CF, Hawkins DS, Parham DM, Teot LA, Rudzinski ER
Eur J Cancer 2021 Jan;143:127-133. Epub 2020 Dec 7 doi: 10.1016/j.ejca.2020.10.018. PMID: 33302115Free PMC Article
Defining an embryonal rhabdomyosarcoma endotype.
Ricker CA, Crawford K, Matlock K, Lathara M, Seguin B, Rudzinski ER, Berlow NE, Keller C
Cold Spring Harb Mol Case Stud 2020 Apr;6(2) Epub 2020 Apr 1 doi: 10.1101/mcs.a005066. PMID: 32238403Free PMC Article
Interstitial brachytherapy for childhood soft tissue sarcoma.
Laskar S, Bahl G, Ann Muckaden M, Puri A, Agarwal MG, Patil N, Shrivastava SK, Dinshaw KA
Pediatr Blood Cancer 2007 Oct 15;49(5):649-55. doi: 10.1002/pbc.21118. PMID: 17226842
The Li-Fraumeni syndrome: from clinical epidemiology to molecular genetics.
Strong LC, Williams WR, Tainsky MA
Am J Epidemiol 1992 Jan 15;135(2):190-9. doi: 10.1093/oxfordjournals.aje.a116271. PMID: 1536134

Clinical prediction guides

Entinostat as a combinatorial therapeutic for rhabdomyosarcoma.
Chauhan S, Lian E, Habib I, Liu Q, Anders NM, Bugg MM, Federman NC, Reid JM, Stewart CF, Cates T, Michalek JE, Keller C
Sci Rep 2024 Aug 15;14(1):18936. doi: 10.1038/s41598-024-66545-5. PMID: 39147820Free PMC Article
Neurocognitive and psychosocial outcomes in adult survivors of childhood soft-tissue sarcoma: A report from the St. Jude Lifetime Cohort.
Tonning Olsson I, Brinkman TM, Wang M, Ehrhardt MJ, Banerjee P, Mulrooney DA, Huang IC, Ness KK, Bishop MW, Srivastava D, Robison LL, Hudson MM, Krull KR
Cancer 2020 Apr 1;126(7):1576-1584. Epub 2020 Jan 8 doi: 10.1002/cncr.32694. PMID: 31913509Free PMC Article
The risk of developing second cancers among survivors of childhood soft tissue sarcoma.
Cohen RJ, Curtis RE, Inskip PD, Fraumeni JF Jr
Cancer 2005 Jun 1;103(11):2391-6. doi: 10.1002/cncr.21040. PMID: 15852362
Childhood soft tissue sarcoma: a 20-year experience.
Marcus KC, Grier HE, Shamberger RC, Gebhardt MC, Perez-Atayde A, Silver B, Tarbell NJ
J Pediatr 1997 Oct;131(4):603-7. doi: 10.1016/s0022-3476(97)70070-2. PMID: 9386667
Cancer in survivors of childhood soft tissue sarcoma and their relatives.
Strong LC, Stine M, Norsted TL
J Natl Cancer Inst 1987 Dec;79(6):1213-20. PMID: 3480372

Recent systematic reviews

Clinical presentation of childhood soft tissue sarcomas: a systematic review and meta-analysis.
Ni Cheallaigh L, Liu JF, Fern L, Winyard P, Walker D, Ball-Gamble A, Shanmugavadivel D
Arch Dis Child 2024 Jan 22;109(2):113-120. doi: 10.1136/archdischild-2023-325875. PMID: 37857451
Adult parameningial alveolar rhabdomyosarcoma: Case report and literature review.
Barthère X, Guillerm S, Quero L, Le Maignan C, Torossian N, Verillaud B, Itti R, Hennequin C
Cancer Radiother 2020 Dec;24(8):870-875. Epub 2020 Nov 7 doi: 10.1016/j.canrad.2020.03.015. PMID: 33172776

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