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Abnormal HDL3a concentration

MedGen UID:
1695107
•Concept ID:
C5139337
•
Finding
HPO: HP:0032425

Definition

Any deviation from the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm. [from HPO]

Recent clinical studies

Etiology

Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
Characteristics of high-density lipoprotein subclasses distribution for subjects with desirable total cholesterol levels.
Tian L, Long S, Fu M, Liu Y, Xu Y, Jia L
Lipids Health Dis 2011 Apr 22;10:64. doi: 10.1186/1476-511X-10-64. PMID: 21513524Free PMC Article
The impact of plasma triglyceride and apolipoproteins concentrations on high-density lipoprotein subclasses distribution.
Tian L, Xu Y, Fu M, Peng T, Liu Y, Long S
Lipids Health Dis 2011 Jan 21;10:17. doi: 10.1186/1476-511X-10-17. PMID: 21251287Free PMC Article
Relationship between plasma lipid concentrations and HDL subclasses.
Yang Y, Yan B, Fu M, Xu Y, Tian Y
Clin Chim Acta 2005 Apr;354(1-2):49-58. Epub 2004 Dec 24 doi: 10.1016/j.cccn.2004.11.015. PMID: 15748599
Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients. Botnia Study Group.
Tilly-Kiesi M, Knudsen P, Groop L, Taskinen MR
J Lipid Res 1996 Jul;37(7):1569-78. PMID: 8827527

Diagnosis

Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients. Botnia Study Group.
Tilly-Kiesi M, Knudsen P, Groop L, Taskinen MR
J Lipid Res 1996 Jul;37(7):1569-78. PMID: 8827527

Clinical prediction guides

Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients. Botnia Study Group.
Tilly-Kiesi M, Knudsen P, Groop L, Taskinen MR
J Lipid Res 1996 Jul;37(7):1569-78. PMID: 8827527

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