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Abnormal HDL2b concentration

MedGen UID:
1696329
•Concept ID:
C5139334
•
Finding
HPO: HP:0032422

Definition

Any deviation from the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm. [from HPO]

Recent clinical studies

Etiology

Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
The impact of plasma triglyceride and apolipoproteins concentrations on high-density lipoprotein subclasses distribution.
Tian L, Xu Y, Fu M, Peng T, Liu Y, Long S
Lipids Health Dis 2011 Jan 21;10:17. doi: 10.1186/1476-511X-10-17. PMID: 21251287Free PMC Article
The relationship between high density lipoprotein subclass profile and plasma lipids concentrations.
Tian L, Fu M
Lipids Health Dis 2010 Oct 17;9:118. doi: 10.1186/1476-511X-9-118. PMID: 20950490Free PMC Article
High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyceride concentrations, and its association with insulin and C-reactive protein.
Medina-Urrutia A, Juarez-Rojas JG, Martínez-Alvarado R, Jorge-Galarza E, Posadas-Sánchez R, Cardoso-Saldaña G, Caracas-Portilla N, Mendoza-Perez E, Posadas-Romero C
Atherosclerosis 2008 Dec;201(2):392-7. Epub 2008 Mar 18 doi: 10.1016/j.atherosclerosis.2008.02.029. PMID: 18420210
Alterations of high density lipoprotein subclasses in obese subjects.
Tian L, Jia L, Mingde F, Tian Y, Xu Y, Tian H, Yang Y
Lipids 2006 Aug;41(8):789-96. doi: 10.1007/s11745-006-5032-7. PMID: 17120933

Diagnosis

Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores.
García-Sánchez C, Posadas-Romero C, Posadas-Sánchez R, Carreón-Torres E, Rodríguez-Pérez JM, Juárez-Rojas JG, Martínez-Sánchez C, Fragoso JM, González-Pacheco H, Vargas-Alarcón G, Pérez-Méndez Ó
Atherosclerosis 2015 Feb;238(2):250-5. Epub 2014 Dec 9 doi: 10.1016/j.atherosclerosis.2014.12.004. PMID: 25528434
The relationship between high density lipoprotein subclass profile and plasma lipids concentrations.
Tian L, Fu M
Lipids Health Dis 2010 Oct 17;9:118. doi: 10.1186/1476-511X-9-118. PMID: 20950490Free PMC Article
Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients. Botnia Study Group.
Tilly-Kiesi M, Knudsen P, Groop L, Taskinen MR
J Lipid Res 1996 Jul;37(7):1569-78. PMID: 8827527

Therapy

Glycemic control and high-density lipoprotein characteristics in adolescents with type 1 diabetes.
Medina-Bravo P, Medina-Urrutia A, Juárez-Rojas JG, Cardoso-Saldaña G, Jorge-Galarza E, Posadas-Sánchez R, Coyote-Estrada N, Nishimura-Meguro E, Posadas-Romero C
Pediatr Diabetes 2013 Sep;14(6):399-406. Epub 2012 Oct 11 doi: 10.1111/j.1399-5448.2012.00924.x. PMID: 23057424
Low cholesteryl ester transfer protein (CETP) concentration but normal CETP activity in serum from patients with short-term hypothyroidism Lack of relationship to lipoprotein abnormalities.
Dedecjus M, Masson D, Gautier T, de Barros JP, Gambert P, Lewinski A, Adamczewski Z, Moulin P, Lagrost L
Clin Endocrinol (Oxf) 2003 May;58(5):581-8. doi: 10.1046/j.1365-2265.2003.01755.x. PMID: 12699439

Prognosis

Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores.
García-Sánchez C, Posadas-Romero C, Posadas-Sánchez R, Carreón-Torres E, Rodríguez-Pérez JM, Juárez-Rojas JG, Martínez-Sánchez C, Fragoso JM, González-Pacheco H, Vargas-Alarcón G, Pérez-Méndez Ó
Atherosclerosis 2015 Feb;238(2):250-5. Epub 2014 Dec 9 doi: 10.1016/j.atherosclerosis.2014.12.004. PMID: 25528434
Glycemic control and high-density lipoprotein characteristics in adolescents with type 1 diabetes.
Medina-Bravo P, Medina-Urrutia A, Juárez-Rojas JG, Cardoso-Saldaña G, Jorge-Galarza E, Posadas-Sánchez R, Coyote-Estrada N, Nishimura-Meguro E, Posadas-Romero C
Pediatr Diabetes 2013 Sep;14(6):399-406. Epub 2012 Oct 11 doi: 10.1111/j.1399-5448.2012.00924.x. PMID: 23057424
High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetes.
Tian L, Long S, Li C, Liu Y, Chen Y, Zeng Z, Fu M
Lipids Health Dis 2012 May 15;11:54. doi: 10.1186/1476-511X-11-54. PMID: 22584085Free PMC Article

Clinical prediction guides

Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores.
García-Sánchez C, Posadas-Romero C, Posadas-Sánchez R, Carreón-Torres E, Rodríguez-Pérez JM, Juárez-Rojas JG, Martínez-Sánchez C, Fragoso JM, González-Pacheco H, Vargas-Alarcón G, Pérez-Méndez Ó
Atherosclerosis 2015 Feb;238(2):250-5. Epub 2014 Dec 9 doi: 10.1016/j.atherosclerosis.2014.12.004. PMID: 25528434
Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyceride concentrations, and its association with insulin and C-reactive protein.
Medina-Urrutia A, Juarez-Rojas JG, Martínez-Alvarado R, Jorge-Galarza E, Posadas-Sánchez R, Cardoso-Saldaña G, Caracas-Portilla N, Mendoza-Perez E, Posadas-Romero C
Atherosclerosis 2008 Dec;201(2):392-7. Epub 2008 Mar 18 doi: 10.1016/j.atherosclerosis.2008.02.029. PMID: 18420210
Alterations of high density lipoprotein subclasses in obese subjects.
Tian L, Jia L, Mingde F, Tian Y, Xu Y, Tian H, Yang Y
Lipids 2006 Aug;41(8):789-96. doi: 10.1007/s11745-006-5032-7. PMID: 17120933
Low cholesteryl ester transfer protein (CETP) concentration but normal CETP activity in serum from patients with short-term hypothyroidism Lack of relationship to lipoprotein abnormalities.
Dedecjus M, Masson D, Gautier T, de Barros JP, Gambert P, Lewinski A, Adamczewski Z, Moulin P, Lagrost L
Clin Endocrinol (Oxf) 2003 May;58(5):581-8. doi: 10.1046/j.1365-2265.2003.01755.x. PMID: 12699439

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