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Stage II Cervical Cancer FIGO 2018

MedGen UID:
1697584
•Concept ID:
C5206443
•
Neoplastic Process
Synonym: Stage II Cervical Carcinoma FIGO 2018

Definition

The cervical carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall. (FIGO 2018) [from NCI]

Professional guidelines

PubMed

Management of stage I and II cervical cancer: a review.
Chou B, Prasad Venkatesulu B, Coleman RL, Harkenrider M, Small W Jr
Int J Gynecol Cancer 2022 Mar;32(3):216-224. doi: 10.1136/ijgc-2021-002527. PMID: 35256406
FIGO 2018 staging criteria for cervical cancer: Impact on stage migration and survival.
Grigsby PW, Massad LS, Mutch DG, Powell MA, Thaker PH, McCourt C, Hagemann A, Fuh K, Kuroki L, Schwarz JK, Markovina S, Lin AJ, Dehdashti F, Siegel BA
Gynecol Oncol 2020 Jun;157(3):639-643. Epub 2020 Apr 2 doi: 10.1016/j.ygyno.2020.03.027. PMID: 32248993
Individualization of surgical management of cervical cancer stages IA1, IA2.
Pichlík T, Rob L, Robová H, Halaška MJ, Drozenová J, Hruda M, Drochýtek V
Ceska Gynekol 2019 Spring;84(3):172-176. PMID: 31324105

Recent clinical studies

Etiology

Improved stratification of stage-specific survival for cervical uterine cancer by integrating FDG-PET/CT and MRI for lymph node staging in 2018 FIGO classification.
Holm J, Gerke O, Vilstrup MH, Spasojevic D, Sponholtz SE, Jochumsen KM, Thomassen A, Hildebrandt MG, Jensen PT
Gynecol Oncol 2022 Nov;167(2):152-158. Epub 2022 Sep 28 doi: 10.1016/j.ygyno.2022.09.021. PMID: 36182533
Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer.
Chakrabarti M, Nordin A, Khodabocus J
Cochrane Database Syst Rev 2022 Sep 16;9(9):CD012246. doi: 10.1002/14651858.CD012246.pub2. PMID: 36111784Free PMC Article
Management of stage I and II cervical cancer: a review.
Chou B, Prasad Venkatesulu B, Coleman RL, Harkenrider M, Small W Jr
Int J Gynecol Cancer 2022 Mar;32(3):216-224. doi: 10.1136/ijgc-2021-002527. PMID: 35256406
Comparison of laparoscopic and open radical hysterectomy in cervical cancer patients with tumor size ≤2 cm.
Chen X, Zhao N, Ye P, Chen J, Nan X, Zhao H, Zhou K, Zhang Y, Xue J, Zhou H, Shang H, Zhu H, Leanne VM, Yan X
Int J Gynecol Cancer 2020 May;30(5):564-571. Epub 2020 Apr 9 doi: 10.1136/ijgc-2019-000994. PMID: 32276941
Proton MRS of cervical cancer at 7 T.
Arteaga de Castro CS, Hoogendam JP, van Kalleveen IML, Raaijmakers AJE, Zweemer RP, Verheijen RHM, Luijten PR, Veldhuis WB, Klomp DWJ
NMR Biomed 2019 Jan;32(1):e4015. Epub 2018 Oct 30 doi: 10.1002/nbm.4015. PMID: 30376201Free PMC Article

Diagnosis

FIGO 2018 staging criteria for cervical cancer: Impact on stage migration and survival.
Grigsby PW, Massad LS, Mutch DG, Powell MA, Thaker PH, McCourt C, Hagemann A, Fuh K, Kuroki L, Schwarz JK, Markovina S, Lin AJ, Dehdashti F, Siegel BA
Gynecol Oncol 2020 Jun;157(3):639-643. Epub 2020 Apr 2 doi: 10.1016/j.ygyno.2020.03.027. PMID: 32248993
Individualization of surgical management of cervical cancer stages IA1, IA2.
Pichlík T, Rob L, Robová H, Halaška MJ, Drozenová J, Hruda M, Drochýtek V
Ceska Gynekol 2019 Spring;84(3):172-176. PMID: 31324105
FIGO 2018 stage IB2 (2-4 cm) Cervical cancer treated with Neo-adjuvant chemotherapy followed by fertility Sparing Surgery (CONTESSA); Neo-Adjuvant Chemotherapy and Conservative Surgery in Cervical Cancer to Preserve Fertility (NEOCON-F). A PMHC, DGOG, GCIG/CCRN and multicenter study.
Plante M, van Trommel N, Lheureux S, Oza AM, Wang L, Sikorska K, Ferguson SE, Han K, Amant F
Int J Gynecol Cancer 2019 Jun;29(5):969-975. Epub 2019 May 17 doi: 10.1136/ijgc-2019-000398. PMID: 31101688
Proton MRS of cervical cancer at 7 T.
Arteaga de Castro CS, Hoogendam JP, van Kalleveen IML, Raaijmakers AJE, Zweemer RP, Verheijen RHM, Luijten PR, Veldhuis WB, Klomp DWJ
NMR Biomed 2019 Jan;32(1):e4015. Epub 2018 Oct 30 doi: 10.1002/nbm.4015. PMID: 30376201Free PMC Article
Level of human development is associated with cervical cancer stage at diagnosis.
Vale DB, Sauvaget C, Muwonge R, Thuler LCS, Basu P, Zeferino LC, Sankaranarayanan R
J Obstet Gynaecol 2019 Jan;39(1):86-90. Epub 2018 Sep 19 doi: 10.1080/01443615.2018.1463976. PMID: 30229689

Therapy

Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer.
Chakrabarti M, Nordin A, Khodabocus J
Cochrane Database Syst Rev 2022 Sep 16;9(9):CD012246. doi: 10.1002/14651858.CD012246.pub2. PMID: 36111784Free PMC Article
Definitive chemoradiotherapy for cervical cancer: A 11-year population-based study.
Kalampokas E, Macdonald G, Young H, Bednarek A, Kennedy AM, Cairns M, Parkin DE
Eur J Cancer Care (Engl) 2020 May;29(3):e13223. Epub 2020 Jan 15 doi: 10.1111/ecc.13223. PMID: 31944444
Risk factors for failure of bilateral sentinel lymph node mapping in early-stage cervical cancer.
Balaya V, Bresset A, Guani B, Magaud L, Montero Macias R, Delomenie M, Bonsang-Kitzis H, Ngô C, Bats AS, Mathevet P, Lécuru F
Gynecol Oncol 2020 Jan;156(1):93-99. Epub 2019 Dec 12 doi: 10.1016/j.ygyno.2019.10.027. PMID: 31839343
FIGO 2018 stage IB2 (2-4 cm) Cervical cancer treated with Neo-adjuvant chemotherapy followed by fertility Sparing Surgery (CONTESSA); Neo-Adjuvant Chemotherapy and Conservative Surgery in Cervical Cancer to Preserve Fertility (NEOCON-F). A PMHC, DGOG, GCIG/CCRN and multicenter study.
Plante M, van Trommel N, Lheureux S, Oza AM, Wang L, Sikorska K, Ferguson SE, Han K, Amant F
Int J Gynecol Cancer 2019 Jun;29(5):969-975. Epub 2019 May 17 doi: 10.1136/ijgc-2019-000398. PMID: 31101688
Locally advanced cervical cancer: A study of 5-year outcomes.
Chopra S, Gupta M, Mathew A, Mahantshetty U, Engineer R, Lavanya G, Gupta S, Ghosh J, Thakur M, Deodhar K, Menon S, Rekhi B, Bajpai J, Gulia S, Maheshwari A, Kerkar R, Shylasree TS, Shrivastava SK
Indian J Cancer 2018 Jan-Mar;55(1):45-49. doi: 10.4103/ijc.IJC_428_17. PMID: 30147092

Prognosis

Improved stratification of stage-specific survival for cervical uterine cancer by integrating FDG-PET/CT and MRI for lymph node staging in 2018 FIGO classification.
Holm J, Gerke O, Vilstrup MH, Spasojevic D, Sponholtz SE, Jochumsen KM, Thomassen A, Hildebrandt MG, Jensen PT
Gynecol Oncol 2022 Nov;167(2):152-158. Epub 2022 Sep 28 doi: 10.1016/j.ygyno.2022.09.021. PMID: 36182533
Comparison of laparoscopic and open radical hysterectomy in cervical cancer patients with tumor size ≤2 cm.
Chen X, Zhao N, Ye P, Chen J, Nan X, Zhao H, Zhou K, Zhang Y, Xue J, Zhou H, Shang H, Zhu H, Leanne VM, Yan X
Int J Gynecol Cancer 2020 May;30(5):564-571. Epub 2020 Apr 9 doi: 10.1136/ijgc-2019-000994. PMID: 32276941
FIGO 2018 staging criteria for cervical cancer: Impact on stage migration and survival.
Grigsby PW, Massad LS, Mutch DG, Powell MA, Thaker PH, McCourt C, Hagemann A, Fuh K, Kuroki L, Schwarz JK, Markovina S, Lin AJ, Dehdashti F, Siegel BA
Gynecol Oncol 2020 Jun;157(3):639-643. Epub 2020 Apr 2 doi: 10.1016/j.ygyno.2020.03.027. PMID: 32248993
Human papillomavirus genotype and prognosis of cervical cancer: Favorable survival of patients with HPV16-positive tumors.
Onuki M, Matsumoto K, Tenjimbayashi Y, Tasaka N, Akiyama A, Sakurai M, Minaguchi T, Oki A, Satoh T, Yoshikawa H
Papillomavirus Res 2018 Dec;6:41-45. Epub 2018 Oct 19 doi: 10.1016/j.pvr.2018.10.005. PMID: 30347290Free PMC Article
Locally advanced cervical cancer: A study of 5-year outcomes.
Chopra S, Gupta M, Mathew A, Mahantshetty U, Engineer R, Lavanya G, Gupta S, Ghosh J, Thakur M, Deodhar K, Menon S, Rekhi B, Bajpai J, Gulia S, Maheshwari A, Kerkar R, Shylasree TS, Shrivastava SK
Indian J Cancer 2018 Jan-Mar;55(1):45-49. doi: 10.4103/ijc.IJC_428_17. PMID: 30147092

Clinical prediction guides

Oncologic outcome in patients with 2018 FIGO stage IB cervical cancer: Is tumor size important?
Tokalioglu AA, Kilic C, Oktar O, Kilic F, Cakir C, Yuksel D, Comert GK, Korkmaz V, Turan T
J Obstet Gynaecol Res 2023 Feb;49(2):709-716. Epub 2022 Nov 22 doi: 10.1111/jog.15505. PMID: 36415110
Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system.
Osaku D, Komatsu H, Okawa M, Iida Y, Sato S, Oishi T, Harada T
Taiwan J Obstet Gynecol 2021 Nov;60(6):1054-1058. doi: 10.1016/j.tjog.2021.09.016. PMID: 34794737
Locally advanced cervical cancer: A study of 5-year outcomes.
Chopra S, Gupta M, Mathew A, Mahantshetty U, Engineer R, Lavanya G, Gupta S, Ghosh J, Thakur M, Deodhar K, Menon S, Rekhi B, Bajpai J, Gulia S, Maheshwari A, Kerkar R, Shylasree TS, Shrivastava SK
Indian J Cancer 2018 Jan-Mar;55(1):45-49. doi: 10.4103/ijc.IJC_428_17. PMID: 30147092
Underutilization of brachytherapy and disparities in survival for patients with cervical cancer in California.
Mayadev J, Klapheke A, Yashar C, Hsu IC, Kamrava M, Mundt AJ, Mell LK, Einck J, Benedict S, Valicenti R, Cress R
Gynecol Oncol 2018 Jul;150(1):73-78. Epub 2018 Apr 27 doi: 10.1016/j.ygyno.2018.04.563. PMID: 29709291
Stage I and II Endometrial Adenocarcinoma: Analysis of 2009 FIGO Staging Revision and Impact on Survival by Adjuvant Therapy.
Cahan B, Kim JH, Schultheiss TE, Wong JYC, Chen YJ
Am J Clin Oncol 2018 Mar;41(3):302-306. doi: 10.1097/COC.0000000000000273. PMID: 26886945

Recent systematic reviews

Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer.
Chakrabarti M, Nordin A, Khodabocus J
Cochrane Database Syst Rev 2022 Sep 16;9(9):CD012246. doi: 10.1002/14651858.CD012246.pub2. PMID: 36111784Free PMC Article
Neoadjuvant chemotherapy followed by fertility sparing surgery in cervical cancers size 2-4 cm; emerging data and future perspectives.
Gwacham NI, McKenzie ND, Fitzgerald ER, Ahmad S, Holloway RW
Gynecol Oncol 2021 Sep;162(3):809-815. Epub 2021 Jun 12 doi: 10.1016/j.ygyno.2021.06.006. PMID: 34130862
Palliative interventions for controlling vaginal bleeding in advanced cervical cancer.
Eleje GU, Eke AC, Igberase GO, Igwegbe AO, Eleje LI
Cochrane Database Syst Rev 2019 Mar 19;3(3):CD011000. doi: 10.1002/14651858.CD011000.pub3. PMID: 30888060Free PMC Article

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