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Stage II Cervical Cancer FIGO 2018

MedGen UID:
1697584
•Concept ID:
C5206443
•
Neoplastic Process
Synonym: Stage II Cervical Carcinoma FIGO 2018

Definition

The cervical carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall. (FIGO 2018) [from NCI]

Professional guidelines

PubMed

Management of stage I and II cervical cancer: a review.
Chou B, Prasad Venkatesulu B, Coleman RL, Harkenrider M, Small W Jr
Int J Gynecol Cancer 2022 Mar;32(3):216-224. doi: 10.1136/ijgc-2021-002527. PMID: 35256406
FIGO 2018 staging criteria for cervical cancer: Impact on stage migration and survival.
Grigsby PW, Massad LS, Mutch DG, Powell MA, Thaker PH, McCourt C, Hagemann A, Fuh K, Kuroki L, Schwarz JK, Markovina S, Lin AJ, Dehdashti F, Siegel BA
Gynecol Oncol 2020 Jun;157(3):639-643. Epub 2020 Apr 2 doi: 10.1016/j.ygyno.2020.03.027. PMID: 32248993
Individualization of surgical management of cervical cancer stages IA1, IA2.
Pichlík T, Rob L, Robová H, Halaška MJ, Drozenová J, Hruda M, Drochýtek V
Ceska Gynekol 2019 Spring;84(3):172-176. PMID: 31324105

Recent clinical studies

Etiology

Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer.
Halle MK, Bozickovic O, Forsse D, Wagner-Larsen KS, Gold RM, Lura NG, Woie K, Bertelsen BI, Haldorsen IS, Krakstad C
Gynecol Oncol 2024 Feb;181:110-117. Epub 2023 Dec 27 doi: 10.1016/j.ygyno.2023.12.014. PMID: 38150835
MRI-based radiomic signatures for pretreatment prognostication in cervical cancer.
Wagner-Larsen KS, Hodneland E, Fasmer KE, Lura N, Woie K, Bertelsen BI, Salvesen Ø, Halle MK, Smit N, Krakstad C, Haldorsen IS
Cancer Med 2023 Oct;12(20):20251-20265. Epub 2023 Oct 16 doi: 10.1002/cam4.6526. PMID: 37840437Free PMC Article
Oncologic outcome in patients with 2018 FIGO stage IB cervical cancer: Is tumor size important?
Tokalioglu AA, Kilic C, Oktar O, Kilic F, Cakir C, Yuksel D, Comert GK, Korkmaz V, Turan T
J Obstet Gynaecol Res 2023 Feb;49(2):709-716. Epub 2022 Nov 22 doi: 10.1111/jog.15505. PMID: 36415110
Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer.
Chakrabarti M, Nordin A, Khodabocus J
Cochrane Database Syst Rev 2022 Sep 16;9(9):CD012246. doi: 10.1002/14651858.CD012246.pub2. PMID: 36111784Free PMC Article
Management of stage I and II cervical cancer: a review.
Chou B, Prasad Venkatesulu B, Coleman RL, Harkenrider M, Small W Jr
Int J Gynecol Cancer 2022 Mar;32(3):216-224. doi: 10.1136/ijgc-2021-002527. PMID: 35256406

Diagnosis

Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer.
Halle MK, Bozickovic O, Forsse D, Wagner-Larsen KS, Gold RM, Lura NG, Woie K, Bertelsen BI, Haldorsen IS, Krakstad C
Gynecol Oncol 2024 Feb;181:110-117. Epub 2023 Dec 27 doi: 10.1016/j.ygyno.2023.12.014. PMID: 38150835
Systematic assessment of tumor necrosis at baseline in cervical cancer - An independent factor associated with poor outcome.
Chouchane-Mlik O, Oniga A, Latouche A, Halladjian M, Kleine-Borgmann FB, Gérardy JJ, Mittelbronn M, Kamal M, Scholl SM
Hum Pathol 2024 Jan;143:62-70. Epub 2023 Dec 20 doi: 10.1016/j.humpath.2023.12.003. PMID: 38135059
FIGO 2018 staging criteria for cervical cancer: Impact on stage migration and survival.
Grigsby PW, Massad LS, Mutch DG, Powell MA, Thaker PH, McCourt C, Hagemann A, Fuh K, Kuroki L, Schwarz JK, Markovina S, Lin AJ, Dehdashti F, Siegel BA
Gynecol Oncol 2020 Jun;157(3):639-643. Epub 2020 Apr 2 doi: 10.1016/j.ygyno.2020.03.027. PMID: 32248993
Primary squamous cell carcinoma of endometrium: case report and literature review.
Farhane FZ, Alami Z, Bouhafa T, Elmazghi A, Hassouni K
Pan Afr Med J 2018;30:208. Epub 2018 Jul 16 doi: 10.11604/pamj.2018.30.208.9654. PMID: 30574227Free PMC Article
Primary squamous cell carcinoma of endometrium: case report and literature review.
Farhane FZ, Alami Z, Bouhafa T, Elmazghi A, Hassouni K
Pan Afr Med J 2018;30:8. Epub 2018 May 4 doi: 10.11604/pamj.2018.30.8.8983. PMID: 30123411Free PMC Article

Therapy

Impact of HIV infection on access to cancer care and survival among women with invasive cervical cancer in Côte d'Ivoire: A prospective cohort study.
Boni SP, Horo A, Didi-Kouko-Coulibaly J, Tanon A, Tchounga BK, Coffie PA, Comoe JC, Moh RD, Dabis F, Adoubi I, Jaquet A; IeDEA West Africa Collaboration
Int J Gynaecol Obstet 2023 Nov;163(2):392-401. Epub 2023 Jun 22 doi: 10.1002/ijgo.14925. PMID: 37350012Free PMC Article
Impact of preoperative brachytherapy followed by radical hysterectomy in stage IB2 (FIGO 2018) cervical cancer: An analysis of SENTICOL I-II trials.
Kissel M, Balaya V, Guani B, Magaud L, Mathevet P, Lécuru F; SENTICOL group
Gynecol Oncol 2023 Mar;170:309-316. Epub 2023 Feb 7 doi: 10.1016/j.ygyno.2023.01.027. PMID: 36758421
Proof-of-concept randomized phase II non-inferiority trial of simple versus type B2 hysterectomy in early-stage cervical cancer ≤2 cm (LESSER).
Carneiro VCG, Batista TP, Andrade MR, Barros AV, Câmara LHLD, Ramalho NM, Lucena MA, Fontão DFS, Tancredi R, Silva Júnior TC, Bezerra ALR, Baiocchi G
Int J Gynecol Cancer 2023 Apr 3;33(4):498-503. doi: 10.1136/ijgc-2022-004092. PMID: 36696980
Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer.
Chakrabarti M, Nordin A, Khodabocus J
Cochrane Database Syst Rev 2022 Sep 16;9(9):CD012246. doi: 10.1002/14651858.CD012246.pub2. PMID: 36111784Free PMC Article
Definitive chemoradiotherapy for cervical cancer: A 11-year population-based study.
Kalampokas E, Macdonald G, Young H, Bednarek A, Kennedy AM, Cairns M, Parkin DE
Eur J Cancer Care (Engl) 2020 May;29(3):e13223. Epub 2020 Jan 15 doi: 10.1111/ecc.13223. PMID: 31944444

Prognosis

Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer.
Halle MK, Bozickovic O, Forsse D, Wagner-Larsen KS, Gold RM, Lura NG, Woie K, Bertelsen BI, Haldorsen IS, Krakstad C
Gynecol Oncol 2024 Feb;181:110-117. Epub 2023 Dec 27 doi: 10.1016/j.ygyno.2023.12.014. PMID: 38150835
Systematic assessment of tumor necrosis at baseline in cervical cancer - An independent factor associated with poor outcome.
Chouchane-Mlik O, Oniga A, Latouche A, Halladjian M, Kleine-Borgmann FB, Gérardy JJ, Mittelbronn M, Kamal M, Scholl SM
Hum Pathol 2024 Jan;143:62-70. Epub 2023 Dec 20 doi: 10.1016/j.humpath.2023.12.003. PMID: 38135059
MRI-based radiomic signatures for pretreatment prognostication in cervical cancer.
Wagner-Larsen KS, Hodneland E, Fasmer KE, Lura N, Woie K, Bertelsen BI, Salvesen Ø, Halle MK, Smit N, Krakstad C, Haldorsen IS
Cancer Med 2023 Oct;12(20):20251-20265. Epub 2023 Oct 16 doi: 10.1002/cam4.6526. PMID: 37840437Free PMC Article
Primary squamous cell carcinoma of endometrium: case report and literature review.
Farhane FZ, Alami Z, Bouhafa T, Elmazghi A, Hassouni K
Pan Afr Med J 2018;30:208. Epub 2018 Jul 16 doi: 10.11604/pamj.2018.30.208.9654. PMID: 30574227Free PMC Article
Primary squamous cell carcinoma of endometrium: case report and literature review.
Farhane FZ, Alami Z, Bouhafa T, Elmazghi A, Hassouni K
Pan Afr Med J 2018;30:8. Epub 2018 May 4 doi: 10.11604/pamj.2018.30.8.8983. PMID: 30123411Free PMC Article

Clinical prediction guides

Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer.
Halle MK, Bozickovic O, Forsse D, Wagner-Larsen KS, Gold RM, Lura NG, Woie K, Bertelsen BI, Haldorsen IS, Krakstad C
Gynecol Oncol 2024 Feb;181:110-117. Epub 2023 Dec 27 doi: 10.1016/j.ygyno.2023.12.014. PMID: 38150835
MRI-based radiomic signatures for pretreatment prognostication in cervical cancer.
Wagner-Larsen KS, Hodneland E, Fasmer KE, Lura N, Woie K, Bertelsen BI, Salvesen Ø, Halle MK, Smit N, Krakstad C, Haldorsen IS
Cancer Med 2023 Oct;12(20):20251-20265. Epub 2023 Oct 16 doi: 10.1002/cam4.6526. PMID: 37840437Free PMC Article
Oncologic outcome in patients with 2018 FIGO stage IB cervical cancer: Is tumor size important?
Tokalioglu AA, Kilic C, Oktar O, Kilic F, Cakir C, Yuksel D, Comert GK, Korkmaz V, Turan T
J Obstet Gynaecol Res 2023 Feb;49(2):709-716. Epub 2022 Nov 22 doi: 10.1111/jog.15505. PMID: 36415110
Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system.
Osaku D, Komatsu H, Okawa M, Iida Y, Sato S, Oishi T, Harada T
Taiwan J Obstet Gynecol 2021 Nov;60(6):1054-1058. doi: 10.1016/j.tjog.2021.09.016. PMID: 34794737
Underutilization of brachytherapy and disparities in survival for patients with cervical cancer in California.
Mayadev J, Klapheke A, Yashar C, Hsu IC, Kamrava M, Mundt AJ, Mell LK, Einck J, Benedict S, Valicenti R, Cress R
Gynecol Oncol 2018 Jul;150(1):73-78. Epub 2018 Apr 27 doi: 10.1016/j.ygyno.2018.04.563. PMID: 29709291

Recent systematic reviews

Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer.
Chakrabarti M, Nordin A, Khodabocus J
Cochrane Database Syst Rev 2022 Sep 16;9(9):CD012246. doi: 10.1002/14651858.CD012246.pub2. PMID: 36111784Free PMC Article
Neoadjuvant chemotherapy followed by fertility sparing surgery in cervical cancers size 2-4 cm; emerging data and future perspectives.
Gwacham NI, McKenzie ND, Fitzgerald ER, Ahmad S, Holloway RW
Gynecol Oncol 2021 Sep;162(3):809-815. Epub 2021 Jun 12 doi: 10.1016/j.ygyno.2021.06.006. PMID: 34130862
Palliative interventions for controlling vaginal bleeding in advanced cervical cancer.
Eleje GU, Eke AC, Igberase GO, Igwegbe AO, Eleje LI
Cochrane Database Syst Rev 2019 Mar 19;3(3):CD011000. doi: 10.1002/14651858.CD011000.pub3. PMID: 30888060Free PMC Article

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