U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Esophageal Intramucosal Adenocarcinoma

MedGen UID:
1698382
•Concept ID:
C5206186
•
Neoplastic Process

Definition

Adenocarcinoma that arises from the esophagus and is confined entirely to the mucosa. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Intramucosal Adenocarcinoma

Professional guidelines

PubMed

Impact of bariatric surgery on surveillance and treatment outcomes of Barrett's esophagus: A stage-matched cohort study.
Jaruvongvanich V, Osman K, Matar R, Baroud S, Hanada Y, Chesta FNU, Maselli DB, Mahmoud T, Wang KK, Abu Dayyeh BK
Surg Obes Relat Dis 2021 Aug;17(8):1457-1464. Epub 2021 Apr 28 doi: 10.1016/j.soard.2021.04.018. PMID: 34083137
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Endoscopic Treatment of High-Grade Dysplasia and Intramucosal Esophageal Adenocarcinoma.
Reed CC, Shaheen NJ
J Laparoendosc Adv Surg Tech A 2016 Oct;26(10):768-772. Epub 2016 Aug 19 doi: 10.1089/lap.2016.29012.ccr. PMID: 27541732Free PMC Article

Recent clinical studies

Etiology

Barrett's Esophagus: Diagnosis, Management, and Key Updates.
Chang K, Jackson CS, Vega KJ
Gastroenterol Clin North Am 2021 Dec;50(4):751-768. Epub 2021 Oct 6 doi: 10.1016/j.gtc.2021.08.009. PMID: 34717869
Mucosal Ablation Techniques for Barrett's Esophagus and Early Esophageal Cancer.
Rajaram R, Hofstetter WL
Thorac Surg Clin 2018 Nov;28(4):473-480. doi: 10.1016/j.thorsurg.2018.07.004. PMID: 30268293
Current Concepts in Treatment of Barrett's Esophagus With and Without Dysplasia.
Schlottmann F, Patti MG
J Gastrointest Surg 2017 Aug;21(8):1354-1360. Epub 2017 Mar 28 doi: 10.1007/s11605-017-3371-8. PMID: 28353175
Advances in the Endoscopic Diagnosis of Barrett Esophagus.
Davis-Yadley AH, Neill KG, Malafa MP, Pena LR
Cancer Control 2016 Jan;23(1):67-77. doi: 10.1177/107327481602300112. PMID: 27009460
Long-term durability of radiofrequency ablation for Barrett's-related neoplasia.
Haidry R, Lovat L
Curr Opin Gastroenterol 2015 Jul;31(4):316-20. doi: 10.1097/MOG.0000000000000190. PMID: 26039723

Diagnosis

Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
Barrett's esophagus, towards improved clinical practice.
Martínez-Domínguez SJ, Lanas Á, Domper-Arnal MJ
Med Clin (Barc) 2022 Jul 22;159(2):92-100. Epub 2022 May 21 doi: 10.1016/j.medcli.2022.02.012. PMID: 35606193
Barrett's Esophagus: Diagnosis, Management, and Key Updates.
Chang K, Jackson CS, Vega KJ
Gastroenterol Clin North Am 2021 Dec;50(4):751-768. Epub 2021 Oct 6 doi: 10.1016/j.gtc.2021.08.009. PMID: 34717869
Current Concepts in Treatment of Barrett's Esophagus With and Without Dysplasia.
Schlottmann F, Patti MG
J Gastrointest Surg 2017 Aug;21(8):1354-1360. Epub 2017 Mar 28 doi: 10.1007/s11605-017-3371-8. PMID: 28353175
Advances in the Endoscopic Diagnosis of Barrett Esophagus.
Davis-Yadley AH, Neill KG, Malafa MP, Pena LR
Cancer Control 2016 Jan;23(1):67-77. doi: 10.1177/107327481602300112. PMID: 27009460

Therapy

Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
Barrett's esophagus, towards improved clinical practice.
Martínez-Domínguez SJ, Lanas Á, Domper-Arnal MJ
Med Clin (Barc) 2022 Jul 22;159(2):92-100. Epub 2022 May 21 doi: 10.1016/j.medcli.2022.02.012. PMID: 35606193
Management of Early-Stage Adenocarcinoma of the Esophagus: Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection.
Seewald S, Ang TL, Pouw RE, Bannwart F, Bergman JJ
Dig Dis Sci 2018 Aug;63(8):2146-2154. doi: 10.1007/s10620-018-5158-5. PMID: 29934725
Post-ablation surveillance in Barrett's esophagus: A review of the literature.
Stier MW, Konda VJ, Hart J, Waxman I
World J Gastroenterol 2016 May 7;22(17):4297-306. doi: 10.3748/wjg.v22.i17.4297. PMID: 27158198Free PMC Article
Surgical Management of Barrett's Esophagus.
Peyre CG, Watson TJ
Gastroenterol Clin North Am 2015 Jun;44(2):459-71. Epub 2015 Mar 24 doi: 10.1016/j.gtc.2015.02.013. PMID: 26021205

Prognosis

Refined Criteria for Separating Low-grade Dysplasia and Nondysplastic Barrett Esophagus Reduce Equivocal Diagnoses and Improve Prediction of Patient Outcome: A 10-Year Review.
Waters KM, Salimian KJ, Voltaggio L, Montgomery EA
Am J Surg Pathol 2018 Dec;42(12):1723-1729. doi: 10.1097/PAS.0000000000001162. PMID: 30234520
Endoscopic resection with or without mucosal ablation of high grade dysplasia and early oesophageal adenocarcinoma--long term follow up from a regional UK centre.
Oliphant Z, Snow A, Knight H, Barr H, Almond LM
Int J Surg 2014 Nov;12(11):1148-50. Epub 2014 Sep 16 doi: 10.1016/j.ijsu.2014.09.002. PMID: 25234253
Barrett's oesophagus: an ideal model to study cancer genetics.
di Pietro M, Fitzgerald RC
Hum Genet 2009 Aug;126(2):233-46. Epub 2009 Apr 14 doi: 10.1007/s00439-009-0665-2. PMID: 19365640
Endotherapy for Barrett's esophagus with high-grade dysplasia and intramucosal carcinoma.
Schembre DB
J Gastrointest Surg 2009 Jul;13(7):1172-8. Epub 2009 Mar 26 doi: 10.1007/s11605-009-0862-2. PMID: 19322616
Total endoscopic resection of Barrett esophagus.
Seewald S, Ang TL, Gotoda T, Soehendra N
Endoscopy 2008 Dec;40(12):1016-20. Epub 2008 Dec 8 doi: 10.1055/s-0028-1103401. PMID: 19065485

Clinical prediction guides

Efficacy of liquid nitrogen cryotherapy for Barrett's esophagus after endoscopic resection of intramucosal cancer: A multicenter study.
Trindade AJ, Pleskow DK, Sengupta N, Kothari S, Inamdar S, Berkowitz J, Kaul V
J Gastroenterol Hepatol 2018 Feb;33(2):461-465. doi: 10.1111/jgh.13909. PMID: 28770555
Perfusion of the gastric conduit during esophagectomy.
Linder G, Hedberg J, Björck M, Sundbom M
Dis Esophagus 2017 Jan 1;30(1):143-149. doi: 10.1111/dote.12537. PMID: 27766735
Screening for Barrett's Esophagus.
di Pietro M, Chan D, Fitzgerald RC, Wang KK
Gastroenterology 2015 May;148(5):912-23. Epub 2015 Feb 17 doi: 10.1053/j.gastro.2015.02.012. PMID: 25701083Free PMC Article
Controversies in the diagnosis of Barrett esophagus and Barrett-related dysplasia: one pathologist's perspective.
Goldblum JR
Arch Pathol Lab Med 2010 Oct;134(10):1479-84. doi: 10.5858/2010-0249-RA.1. PMID: 20923304
Intramucosal adenocarcinoma arising under squamous re-epithelialisation of Barrett's oesophagus.
Van Laethem JL, Peny MO, Salmon I, Cremer M, Devière J
Gut 2000 Apr;46(4):574-7. doi: 10.1136/gut.46.4.574. PMID: 10716690Free PMC Article

Recent systematic reviews

Efficacy of Cryotherapy as a Primary Endoscopic Ablation Modality for Dysplastic Barrett's Esophagus and Early Esophageal Neoplasia: A Systematic Review and Meta-Analysis.
Tariq R, Enslin S, Hayat M, Kaul V
Cancer Control 2020 Jan-Dec;27(1):1073274820976668. doi: 10.1177/1073274820976668. PMID: 33297725Free PMC Article
Efficacy and safety outcomes of multimodal endoscopic eradication therapy in Barrett's esophagus-related neoplasia: a systematic review and pooled analysis.
Desai M, Saligram S, Gupta N, Vennalaganti P, Bansal A, Choudhary A, Vennelaganti S, He J, Titi M, Maselli R, Qumseya B, Olyaee M, Waxman I, Repici A, Hassan C, Sharma P
Gastrointest Endosc 2017 Mar;85(3):482-495.e4. Epub 2016 Sep 23 doi: 10.1016/j.gie.2016.09.022. PMID: 27670227
Endoscopic eradication therapy for mucosal neoplasia in Barrett's esophagus.
Dunbar KB
Curr Opin Gastroenterol 2013 Jul;29(4):446-53. doi: 10.1097/MOG.0b013e3283622848. PMID: 23703368
Efficacy and durability of radiofrequency ablation for Barrett's Esophagus: systematic review and meta-analysis.
Orman ES, Li N, Shaheen NJ
Clin Gastroenterol Hepatol 2013 Oct;11(10):1245-55. Epub 2013 May 2 doi: 10.1016/j.cgh.2013.03.039. PMID: 23644385Free PMC Article
Is endoscopic surveillance for non-dysplastic Barrett's esophagus cost-effective? Review of economic evaluations.
Hirst NG, Gordon LG, Whiteman DC, Watson DI, Barendregt JJ
J Gastroenterol Hepatol 2011 Feb;26(2):247-54. doi: 10.1111/j.1440-1746.2010.06506.x. PMID: 21261712

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...