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Increased circulating arachidonic acid concentration

MedGen UID:
1704816
•Concept ID:
C5209279
•
Finding
Synonyms: Increased circulating arachidonate level; Increased circulating arachidonic acid level
 
HPO: HP:0020197

Definition

An increased circulation of arachidonic acid in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating arachidonic acid concentration

Recent clinical studies

Etiology

Non-esterified erythrocyte linoleic acid, arachidonic acid, and subjective sleep outcomes.
Sanders AE, Wallace ED, Ehrmann BM, Soma PS, Shaikh SR, Preisser JS, Ohrbach R, Fillingim RB, Slade GD
Prostaglandins Leukot Essent Fatty Acids 2023 Aug;195:102580. Epub 2023 Jul 7 doi: 10.1016/j.plefa.2023.102580. PMID: 37451068Free PMC Article
Regulation of blood flow by aspirin following muscle ischemia.
Cameron SJ, Goulopoulou S, Weil BR, Kanaley JA
Eur Rev Med Pharmacol Sci 2012 Feb;16(2):143-50. PMID: 22428464
The utility of (11)C-arachidonate PET to study in vivo dopaminergic neurotransmission in humans.
Thambisetty M, Gallardo KA, Liow JS, Beason-Held LL, Umhau JC, Bhattacharjee AK, Der M, Herscovitch P, Rapoport JL, Rapoport SI
J Cereb Blood Flow Metab 2012 Apr;32(4):676-84. Epub 2011 Dec 14 doi: 10.1038/jcbfm.2011.171. PMID: 22167235Free PMC Article
Apolipoprotein D.
Rassart E, Bedirian A, Do Carmo S, Guinard O, Sirois J, Terrisse L, Milne R
Biochim Biophys Acta 2000 Oct 18;1482(1-2):185-98. doi: 10.1016/s0167-4838(00)00162-x. PMID: 11058760
Chest trauma and its impact on the release of vasoactive mediators.
Gebhard F, Kelbel MW, Strecker W, Kinzl L, Brückner UB
Shock 1997 May;7(5):313-7. doi: 10.1097/00024382-199705000-00001. PMID: 9165664

Diagnosis

Diagnostic Performance of Circulating miRNAs and Extracellular Vesicles in Acute Ischemic Stroke.
Eyileten C, Jakubik D, Shahzadi A, Gasecka A, van der Pol E, De Rosa S, Siwik D, Gajewska M, Mirowska-Guzel D, Kurkowska-Jastrzebska I, Czlonkowska A, Postula M
Int J Mol Sci 2022 Apr 20;23(9) doi: 10.3390/ijms23094530. PMID: 35562921Free PMC Article
Metabolomics Signature of Patients With Narcolepsy.
Dauvilliers Y, Barateau L, Middleton B, van der Veen DR, Skene DJ
Neurology 2022 Feb 1;98(5):e493-e505. Epub 2021 Nov 29 doi: 10.1212/WNL.0000000000013128. PMID: 34845055
Dose- and time-dependent increase in circulating anti-inflammatory and pro-resolving lipid mediators following eicosapentaenoic acid supplementation in patients with major depressive disorder and chronic inflammation.
Lamon-Fava S, So J, Mischoulon D, Ziegler TR, Dunlop BW, Kinkead B, Schettler PJ, Nierenberg AA, Felger JC, Maddipati KR, Fava M, Rapaport MH
Prostaglandins Leukot Essent Fatty Acids 2021 Jan;164:102219. Epub 2020 Dec 5 doi: 10.1016/j.plefa.2020.102219. PMID: 33316626Free PMC Article
Epoxyeicosatrienoic acids and glucose homeostasis in mice and men.
Luther JM, Brown NJ
Prostaglandins Other Lipid Mediat 2016 Sep;125:2-7. Epub 2016 Jul 19 doi: 10.1016/j.prostaglandins.2016.07.010. PMID: 27448715Free PMC Article
Modification of platelet function by isosorbide dinitrate in patients with coronary artery disease.
Sinzinger H, Virgolini I, O'Grady J, Rauscha F, Fitscha P
Thromb Res 1992 Feb 1;65(3):323-35. doi: 10.1016/0049-3848(92)90163-5. PMID: 1385908

Therapy

Regulation of blood flow by aspirin following muscle ischemia.
Cameron SJ, Goulopoulou S, Weil BR, Kanaley JA
Eur Rev Med Pharmacol Sci 2012 Feb;16(2):143-50. PMID: 22428464
The utility of (11)C-arachidonate PET to study in vivo dopaminergic neurotransmission in humans.
Thambisetty M, Gallardo KA, Liow JS, Beason-Held LL, Umhau JC, Bhattacharjee AK, Der M, Herscovitch P, Rapoport JL, Rapoport SI
J Cereb Blood Flow Metab 2012 Apr;32(4):676-84. Epub 2011 Dec 14 doi: 10.1038/jcbfm.2011.171. PMID: 22167235Free PMC Article
Chest trauma and its impact on the release of vasoactive mediators.
Gebhard F, Kelbel MW, Strecker W, Kinzl L, Brückner UB
Shock 1997 May;7(5):313-7. doi: 10.1097/00024382-199705000-00001. PMID: 9165664
Modification of platelet function by isosorbide dinitrate in patients with coronary artery disease.
Sinzinger H, Virgolini I, O'Grady J, Rauscha F, Fitscha P
Thromb Res 1992 Feb 1;65(3):323-35. doi: 10.1016/0049-3848(92)90163-5. PMID: 1385908
Measurement of prostaglandin D2 and identification of metabolites in human plasma during intravenous infusion.
Barrow SE, Heavey DJ, Ennis M, Chappell CG, Blair IA, Dollery CT
Prostaglandins 1984 Dec;28(6):743-54. doi: 10.1016/0090-6980(84)90032-7. PMID: 6441188

Prognosis

Serum Levels of Arachidonic Acid, Interleukin-6, and C-Reactive Protein as Potential Indicators of Pulmonary Viral Infections: Comparative Analysis of Influenza A, Respiratory Syncytial Virus Infection, and COVID-19.
Iftimie S, Gabaldó-Barrios X, Penadés-Nadal J, Canela-Capdevila M, Piñana R, Jiménez-Franco A, López-Azcona AF, Castañé H, Cárcel M, Camps J, Castro A, Joven J
Viruses 2024 Jul 1;16(7) doi: 10.3390/v16071065. PMID: 39066228Free PMC Article
Diagnostic Performance of Circulating miRNAs and Extracellular Vesicles in Acute Ischemic Stroke.
Eyileten C, Jakubik D, Shahzadi A, Gasecka A, van der Pol E, De Rosa S, Siwik D, Gajewska M, Mirowska-Guzel D, Kurkowska-Jastrzebska I, Czlonkowska A, Postula M
Int J Mol Sci 2022 Apr 20;23(9) doi: 10.3390/ijms23094530. PMID: 35562921Free PMC Article
Apolipoprotein D.
Rassart E, Bedirian A, Do Carmo S, Guinard O, Sirois J, Terrisse L, Milne R
Biochim Biophys Acta 2000 Oct 18;1482(1-2):185-98. doi: 10.1016/s0167-4838(00)00162-x. PMID: 11058760
Inflammatory mediators and modulation of blood-brain barrier permeability.
Abbott NJ
Cell Mol Neurobiol 2000 Apr;20(2):131-47. doi: 10.1023/a:1007074420772. PMID: 10696506
Inflammatory lipid mediator generation elicited by viable hemolysin-forming Escherichia coli in lung vasculature.
Grimminger F, Thomas M, Obernitz R, Walmrath D, Bhakdi S, Seeger W
J Exp Med 1990 Oct 1;172(4):1115-25. doi: 10.1084/jem.172.4.1115. PMID: 2120384Free PMC Article

Clinical prediction guides

Non-esterified erythrocyte linoleic acid, arachidonic acid, and subjective sleep outcomes.
Sanders AE, Wallace ED, Ehrmann BM, Soma PS, Shaikh SR, Preisser JS, Ohrbach R, Fillingim RB, Slade GD
Prostaglandins Leukot Essent Fatty Acids 2023 Aug;195:102580. Epub 2023 Jul 7 doi: 10.1016/j.plefa.2023.102580. PMID: 37451068Free PMC Article
The utility of (11)C-arachidonate PET to study in vivo dopaminergic neurotransmission in humans.
Thambisetty M, Gallardo KA, Liow JS, Beason-Held LL, Umhau JC, Bhattacharjee AK, Der M, Herscovitch P, Rapoport JL, Rapoport SI
J Cereb Blood Flow Metab 2012 Apr;32(4):676-84. Epub 2011 Dec 14 doi: 10.1038/jcbfm.2011.171. PMID: 22167235Free PMC Article
Apolipoprotein D.
Rassart E, Bedirian A, Do Carmo S, Guinard O, Sirois J, Terrisse L, Milne R
Biochim Biophys Acta 2000 Oct 18;1482(1-2):185-98. doi: 10.1016/s0167-4838(00)00162-x. PMID: 11058760
Chest trauma and its impact on the release of vasoactive mediators.
Gebhard F, Kelbel MW, Strecker W, Kinzl L, Brückner UB
Shock 1997 May;7(5):313-7. doi: 10.1097/00024382-199705000-00001. PMID: 9165664
Gender-related variations and interaction of human neutrophil cyclooxygenase and oxidative burst metabolites.
Mallery SR, Zeligs BJ, Ramwell PW, Bellanti JA
J Leukoc Biol 1986 Aug;40(2):133-46. doi: 10.1002/jlb.40.2.133. PMID: 3090179

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