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Metastatic Merkel Cell Carcinoma

MedGen UID:
1705388
Concept ID:
C5206655
Neoplastic Process

Definition

A Merkel cell carcinoma that has spread from the original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Merkel Cell Carcinoma

Professional guidelines

PubMed

Averbuch I, Stoff R, Miodovnik M, Fennig S, Bar-Sela G, Yakobson A, Daliot J, Asher N, Fenig E
Cancer Med 2023 Jun;12(11):12065-12070. Epub 2023 Apr 3 doi: 10.1002/cam4.5890. PMID: 37012213Free PMC Article
Gonzalez MR, Bryce-Alberti M, Portmann-Baracco A, Castillo-Flores S, Pretell-Mazzini J
Cancer Treat Res Commun 2022;33:100665. Epub 2022 Nov 24 doi: 10.1016/j.ctarc.2022.100665. PMID: 36446191
Cordes LM, Gulley JL
Drugs Today (Barc) 2017 Jul;53(7):377-383. doi: 10.1358/dot.2017.53.7.2654888. PMID: 28837181Free PMC Article

Recent clinical studies

Etiology

Askari E, Moghadam SZ, Wild D, Delpassand E, Baldari S, Nilica B, Hartrampf PE, Kong G, Grana CM, Alexander Walter M, Capoccetti F, Kasi PM, Strosberg J
J Nucl Med Technol 2023 Mar;51(1):22-25. Epub 2022 Oct 4 doi: 10.2967/jnmt.122.264904. PMID: 36195446
Gonzalez MR, Bryce-Alberti M, Portmann-Baracco A, Castillo-Flores S, Pretell-Mazzini J
Cancer Treat Res Commun 2022;33:100665. Epub 2022 Nov 24 doi: 10.1016/j.ctarc.2022.100665. PMID: 36446191
Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
D'Angelo SP, Lebbé C, Mortier L, Brohl AS, Fazio N, Grob JJ, Prinzi N, Hanna GJ, Hassel JC, Kiecker F, Georges S, Ellers-Lenz B, Shah P, Güzel G, Nghiem P
J Immunother Cancer 2021 Jul;9(7) doi: 10.1136/jitc-2021-002646. PMID: 34301810Free PMC Article
Shirley M
Target Oncol 2018 Jun;13(3):409-416. doi: 10.1007/s11523-018-0571-4. PMID: 29799096

Diagnosis

Wagner WD, Lahm DW, Dave A, Chundury RV
Orbit 2024 Apr;43(2):244-247. Epub 2022 Aug 3 doi: 10.1080/01676830.2022.2104324. PMID: 35920584
Gonzalez MR, Bryce-Alberti M, Portmann-Baracco A, Castillo-Flores S, Pretell-Mazzini J
Cancer Treat Res Commun 2022;33:100665. Epub 2022 Nov 24 doi: 10.1016/j.ctarc.2022.100665. PMID: 36446191
Lawrence LEB, Saleem A, Sahoo MK, Tan SK, Pinsky BA, Natkunam Y, Kunder CA, Stehr H, Zehnder JL
Am J Clin Pathol 2020 Aug 5;154(3):369-380. doi: 10.1093/ajcp/aqaa051. PMID: 32445471
Dasgeb B, Mehregan D, Ring C, Nartker N, Brownell I
J Cutan Pathol 2019 Oct;46(10):748-752. Epub 2019 Jul 11 doi: 10.1111/cup.13528. PMID: 31218705Free PMC Article
Sangoi AR, Cassarino DS
Am J Dermatopathol 2013 Jun;35(4):448-51. doi: 10.1097/DAD.0b013e318271ce53. PMID: 23612030

Therapy

Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
D'Angelo SP, Lebbé C, Mortier L, Brohl AS, Fazio N, Grob JJ, Prinzi N, Hanna GJ, Hassel JC, Kiecker F, Georges S, Ellers-Lenz B, Shah P, Güzel G, Nghiem P
J Immunother Cancer 2021 Jul;9(7) doi: 10.1136/jitc-2021-002646. PMID: 34301810Free PMC Article
Collins JM, Gulley JL
Hum Vaccin Immunother 2019;15(4):891-908. Epub 2018 Dec 20 doi: 10.1080/21645515.2018.1551671. PMID: 30481100Free PMC Article
Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG
Nat Commun 2018 Sep 24;9(1):3868. doi: 10.1038/s41467-018-06300-3. PMID: 30250229Free PMC Article
Shirley M
Target Oncol 2018 Jun;13(3):409-416. doi: 10.1007/s11523-018-0571-4. PMID: 29799096

Prognosis

D'Angelo SP, Bhatia S, Brohl AS, Hamid O, Mehnert JM, Terheyden P, Shih KC, Brownell I, Lebbé C, Lewis KD, Linette GP, Milella M, Xiong H, Guezel G, Nghiem PT
ESMO Open 2021 Dec;6(6):100290. Epub 2021 Oct 26 doi: 10.1016/j.esmoop.2021.100290. PMID: 34715570Free PMC Article
D'Angelo SP, Lebbé C, Mortier L, Brohl AS, Fazio N, Grob JJ, Prinzi N, Hanna GJ, Hassel JC, Kiecker F, Georges S, Ellers-Lenz B, Shah P, Güzel G, Nghiem P
J Immunother Cancer 2021 Jul;9(7) doi: 10.1136/jitc-2021-002646. PMID: 34301810Free PMC Article
Chang WC, Lin AY, Hsu JC, Wu CE, Goh C, Chou P, Kuo K, Chang A, Palencia R
Cancer Rep (Hoboken) 2021 Dec;4(6):e1399. Epub 2021 May 2 doi: 10.1002/cnr2.1399. PMID: 33934577Free PMC Article
Shirley M
Target Oncol 2018 Jun;13(3):409-416. doi: 10.1007/s11523-018-0571-4. PMID: 29799096
Baker M, Cordes L, Brownell I
Expert Rev Anticancer Ther 2018 Apr;18(4):319-326. Epub 2018 Feb 28 doi: 10.1080/14737140.2018.1445528. PMID: 29482384

Clinical prediction guides

Hu P, Dai HI, Bourdage J, Zhou D, Trang K, Kowalski K, Bello C, Hibma J, Khandelwal A, Cowan K, Dong J, Venkatakrishnan K, Gao W
Clin Transl Sci 2024 Mar;17(3):e13730. doi: 10.1111/cts.13730. PMID: 38411318Free PMC Article
Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
D'Angelo SP, Bhatia S, Brohl AS, Hamid O, Mehnert JM, Terheyden P, Shih KC, Brownell I, Lebbé C, Lewis KD, Linette GP, Milella M, Xiong H, Guezel G, Nghiem PT
ESMO Open 2021 Dec;6(6):100290. Epub 2021 Oct 26 doi: 10.1016/j.esmoop.2021.100290. PMID: 34715570Free PMC Article
D'Angelo SP, Lebbé C, Mortier L, Brohl AS, Fazio N, Grob JJ, Prinzi N, Hanna GJ, Hassel JC, Kiecker F, Georges S, Ellers-Lenz B, Shah P, Güzel G, Nghiem P
J Immunother Cancer 2021 Jul;9(7) doi: 10.1136/jitc-2021-002646. PMID: 34301810Free PMC Article
Shirley M
Target Oncol 2018 Jun;13(3):409-416. doi: 10.1007/s11523-018-0571-4. PMID: 29799096

Recent systematic reviews

Nghiem P, Kaufman HL, Bharmal M, Mahnke L, Phatak H, Becker JC
Future Oncol 2017 Jun;13(14):1263-1279. Epub 2017 Mar 28 doi: 10.2217/fon-2017-0072. PMID: 28350180Free PMC Article

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