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Advanced Merkel Cell Carcinoma

MedGen UID:
1717071
Concept ID:
C5237070
Neoplastic Process

Definition

A Merkel cell carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Merkel Cell Carcinoma

Professional guidelines

PubMed

Sharma AN, Shah KS, Sharma AA, Yu SS
Dermatol Surg 2024 May 1;50(5):407-411. Epub 2024 Feb 13 doi: 10.1097/DSS.0000000000004107. PMID: 38349855
Br J Dermatol 2021 Feb;184(2):e32-e52. doi: 10.1111/bjd.19723. PMID: 33544438
Femia D, Prinzi N, Anichini A, Mortarini R, Nichetti F, Corti F, Torchio M, Peverelli G, Pagani F, Maurichi A, Mattavelli I, Milione M, Bedini N, Corti A, Di Bartolomeo M, de Braud F, Pusceddu S
Target Oncol 2018 Oct;13(5):567-582. doi: 10.1007/s11523-018-0585-y. PMID: 30073632

Recent clinical studies

Etiology

Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Hasmat S, Howle JR, Karikios DJ, Carlino MS, Veness MJ
J Med Imaging Radiat Oncol 2021 Oct;65(6):760-767. Epub 2021 May 30 doi: 10.1111/1754-9485.13243. PMID: 34053196
Nghiem P, Bhatia S, Lipson EJ, Sharfman WH, Kudchadkar RR, Brohl AS, Friedlander PA, Daud A, Kluger HM, Reddy SA, Boulmay BC, Riker A, Burgess MA, Hanks BA, Olencki T, Kendra K, Church C, Akaike T, Ramchurren N, Shinohara MM, Salim B, Taube JM, Jensen E, Kalabis M, Fling SP, Homet Moreno B, Sharon E, Cheever MA, Topalian SL
J Immunother Cancer 2021 Apr;9(4) doi: 10.1136/jitc-2021-002478. PMID: 33879601Free PMC Article
Levy S, Aarts MJB, Eskens FALM, Keymeulen KBMI, Been LB, Grünhagen D, van Akkooi A, Jalving M, Tesselaar MET
J Immunother Cancer 2020 Sep;8(2) doi: 10.1136/jitc-2020-001076. PMID: 32948651Free PMC Article
Kwiatkowska D, Reich A
Dermatol Ther 2020 May;33(3):e13281. Epub 2020 Feb 28 doi: 10.1111/dth.13281. PMID: 32083780

Diagnosis

da Costa CM, de Souza ZS, Real Salgues AC, Harada G, Marino Rodrigues Ayres PP, Vieira Nunes DB, Katz A, Munhoz RR
Immunotherapy 2020 Oct;12(15):1133-1138. Epub 2020 Sep 9 doi: 10.2217/imt-2020-0193. PMID: 32900245Free PMC Article
Steuten L, Garmo V, Phatak H, Sullivan SD, Nghiem P, Ramsey SD
Appl Health Econ Health Policy 2019 Oct;17(5):733-740. doi: 10.1007/s40258-019-00492-5. PMID: 31250217Free PMC Article
Zaremba A, Chorti E, Jockenhöfer F, Bolz S, Sirin S, Glas M, Becker JC, Ugurel S, Roesch A, Schadendorf D, Livingstone E, Hagenacker T, Zimmer L
J Immunother Cancer 2019 May 29;7(1):141. doi: 10.1186/s40425-019-0626-9. PMID: 31142383Free PMC Article
Jouary T, Lalanne N, Siberchicot F, Ricard AS, Versapuech J, Lepreux S, Delaunay M, Taieb A
Nat Rev Clin Oncol 2009 Sep;6(9):544-8. doi: 10.1038/nrclinonc.2009.109. PMID: 19707243

Therapy

Kang C
Drugs 2023 Jun;83(8):731-737. doi: 10.1007/s40265-023-01884-7. PMID: 37184754
Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Hasmat S, Howle JR, Karikios DJ, Carlino MS, Veness MJ
J Med Imaging Radiat Oncol 2021 Oct;65(6):760-767. Epub 2021 May 30 doi: 10.1111/1754-9485.13243. PMID: 34053196
Nghiem P, Bhatia S, Lipson EJ, Sharfman WH, Kudchadkar RR, Brohl AS, Friedlander PA, Daud A, Kluger HM, Reddy SA, Boulmay BC, Riker A, Burgess MA, Hanks BA, Olencki T, Kendra K, Church C, Akaike T, Ramchurren N, Shinohara MM, Salim B, Taube JM, Jensen E, Kalabis M, Fling SP, Homet Moreno B, Sharon E, Cheever MA, Topalian SL
J Immunother Cancer 2021 Apr;9(4) doi: 10.1136/jitc-2021-002478. PMID: 33879601Free PMC Article
Lee AY, Berman RS
Ann Surg Oncol 2020 Jan;27(1):22-27. Epub 2019 Sep 23 doi: 10.1245/s10434-019-07831-9. PMID: 31549317

Prognosis

Sharma AN, Shah KS, Sharma AA, Yu SS
Dermatol Surg 2024 May 1;50(5):407-411. Epub 2024 Feb 13 doi: 10.1097/DSS.0000000000004107. PMID: 38349855
Spassova I, Ugurel S, Kubat L, Zimmer L, Terheyden P, Mohr A, Björn Andtback H, Villabona L, Leiter U, Eigentler T, Loquai C, Hassel JC, Gambichler T, Haferkamp S, Mohr P, Pfoehler C, Heinzerling L, Gutzmer R, Utikal JS, Horny K, Schildhaus HU, Habermann D, Hoffmann D, Schadendorf D, Becker JC
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-003198. PMID: 35074902Free PMC Article
Andruska N, Mahapatra L, Brenneman RJ, Huang Y, Paniello RC, Puram SV, Mansour M, Rich JT, Baumann BC, Thorstad WL, Daly MD
Radiother Oncol 2021 Feb;155:246-253. Epub 2020 Nov 16 doi: 10.1016/j.radonc.2020.11.003. PMID: 33212121
Femia D, Prinzi N, Anichini A, Mortarini R, Nichetti F, Corti F, Torchio M, Peverelli G, Pagani F, Maurichi A, Mattavelli I, Milione M, Bedini N, Corti A, Di Bartolomeo M, de Braud F, Pusceddu S
Target Oncol 2018 Oct;13(5):567-582. doi: 10.1007/s11523-018-0585-y. PMID: 30073632
Lowry PA, Freeman ML, Russell JS
Oncol Nurs Forum 2016 Nov 1;43(6):680-683. doi: 10.1188/16.ONF.680-683. PMID: 27768129

Clinical prediction guides

Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Spassova I, Ugurel S, Kubat L, Zimmer L, Terheyden P, Mohr A, Björn Andtback H, Villabona L, Leiter U, Eigentler T, Loquai C, Hassel JC, Gambichler T, Haferkamp S, Mohr P, Pfoehler C, Heinzerling L, Gutzmer R, Utikal JS, Horny K, Schildhaus HU, Habermann D, Hoffmann D, Schadendorf D, Becker JC
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-003198. PMID: 35074902Free PMC Article
Kwiatkowska D, Reich A
Dermatol Ther 2020 May;33(3):e13281. Epub 2020 Feb 28 doi: 10.1111/dth.13281. PMID: 32083780
Femia D, Prinzi N, Anichini A, Mortarini R, Nichetti F, Corti F, Torchio M, Peverelli G, Pagani F, Maurichi A, Mattavelli I, Milione M, Bedini N, Corti A, Di Bartolomeo M, de Braud F, Pusceddu S
Target Oncol 2018 Oct;13(5):567-582. doi: 10.1007/s11523-018-0585-y. PMID: 30073632
Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, Annamalai L, Berry S, Chartash EK, Daud A, Fling SP, Friedlander PA, Kluger HM, Kohrt HE, Lundgren L, Margolin K, Mitchell A, Olencki T, Pardoll DM, Reddy SA, Shantha EM, Sharfman WH, Sharon E, Shemanski LR, Shinohara MM, Sunshine JC, Taube JM, Thompson JA, Townson SM, Yearley JH, Topalian SL, Cheever MA
N Engl J Med 2016 Jun 30;374(26):2542-52. Epub 2016 Apr 19 doi: 10.1056/NEJMoa1603702. PMID: 27093365Free PMC Article

Recent systematic reviews

Sharma AN, Shah KS, Sharma AA, Yu SS
Dermatol Surg 2024 May 1;50(5):407-411. Epub 2024 Feb 13 doi: 10.1097/DSS.0000000000004107. PMID: 38349855

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