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Kidney Large Cell Neuroendocrine Carcinoma

MedGen UID:
1706568
•Concept ID:
C2111725
•
Neoplastic Process

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the kidney. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKidney Large Cell Neuroendocrine Carcinoma

Recent clinical studies

Etiology

The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Radiological features and metastatic patterns of thymic neuroendocrine tumours.
Araki T, Sholl LM, Hatabu H, Nishino M
Clin Radiol 2018 May;73(5):479-484. Epub 2018 Jan 6 doi: 10.1016/j.crad.2017.11.025. PMID: 29310810
Renal cell carcinoma, unclassified with medullary phenotype: poorly differentiated adenocarcinomas overlapping with renal medullary carcinoma.
Sirohi D, Smith SC, Ohe C, Colombo P, Divatia M, Dragoescu E, Rao P, Hirsch MS, Chen YB, Mehra R, Amin MB
Hum Pathol 2017 Sep;67:134-145. Epub 2017 Jul 15 doi: 10.1016/j.humpath.2017.07.006. PMID: 28716439
Complications associated with sickle cell trait: a brief narrative review.
Tsaras G, Owusu-Ansah A, Boateng FO, Amoateng-Adjepong Y
Am J Med 2009 Jun;122(6):507-12. Epub 2009 Apr 24 doi: 10.1016/j.amjmed.2008.12.020. PMID: 19393983
Renal medullary carcinoma: the Bronx experience.
Hakimi AA, Koi PT, Milhoua PM, Blitman NM, Li M, Hugec V, Dutcher JP, Ghavamian R
Urology 2007 Nov;70(5):878-82. doi: 10.1016/j.urology.2007.06.1124. PMID: 18068443

Diagnosis

Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling.
El Zarif T, Meador CB, Qiu X, Seo JH, Davidsohn MP, Savignano H, Lakshminarayanan G, McClure HM, Canniff J, Fortunato B, Li R, Banwait MK, Semaan K, Eid M, Long H, Hung YP, Mahadevan NR, Barbie DA, Oser MG, Piotrowska Z, Choueiri TK, Baca SC, Hata AN, Freedman ML, Berchuck JE
Clin Cancer Res 2024 Sep 3;30(17):3798-3811. doi: 10.1158/1078-0432.CCR-24-0466. PMID: 38912901Free PMC Article
Urinary Tract Large Cell Neuroendocrine Carcinoma: Diagnostic, Prognostic and Therapeutic Issues.
Sanguedolce F, Calò B, Chirico M, Tortorella S, Carrieri G, Cormio L
Anticancer Res 2020 May;40(5):2439-2447. doi: 10.21873/anticanres.14213. PMID: 32366387
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
von Hippel-Lindau syndrome.
Chou A, Toon C, Pickett J, Gill AJ
Front Horm Res 2013;41:30-49. Epub 2013 Mar 19 doi: 10.1159/000345668. PMID: 23652669
Renal medullary carcinoma.
Baig MA, Lin YS, Rasheed J, Mittman N
J Natl Med Assoc 2006 Jul;98(7):1171-4. PMID: 16895289Free PMC Article

Therapy

Alpelisib in combination with everolimus ± exemestane in solid tumours: Phase Ib randomised, open-label, multicentre study.
Curigliano G, Martin M, Jhaveri K, Beck JT, Tortora G, Fazio N, Maur M, Hubner RA, Lahner H, Donnet V, Ajipa O, Li Z, Blumenstein L, Andre F
Eur J Cancer 2021 Jul;151:49-62. Epub 2021 May 5 doi: 10.1016/j.ejca.2021.03.042. PMID: 33964572
Systematic review and two new cases of primary upper urinary tract neuroendocrine carcinomas.
Nakasato T, Hiramatsu A, Matsui Y, Unoki T, Shimoyama H, Oshinomi K, Morita J, Maeda Y, Naoe M, Fuji K, Ogura H, Homma M, Yamochi T, Takimoto M, Ogawa Y
Cancer Treat Res Commun 2018;17:23-30. Epub 2018 Oct 9 doi: 10.1016/j.ctarc.2018.10.003. PMID: 30326420
Comparison of the diagnostic performance of 2 core biopsy needles for EUS-guided tissue acquisition from solid pancreatic lesions.
Nayar MK, Paranandi B, Dawwas MF, Leeds JS, Darne A, Haugk B, Majumdar D, Ahmed MM, Oppong KW
Gastrointest Endosc 2017 May;85(5):1017-1024. Epub 2016 Sep 12 doi: 10.1016/j.gie.2016.08.048. PMID: 27633157
mTOR inhibitor-associated stomatitis (mIAS) in three patients with cancer treated with everolimus.
Kalogirou EM, Tosios KI, Piperi EP, Sklavounou A
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jan;119(1):e13-9. Epub 2014 Sep 16 doi: 10.1016/j.oooo.2014.08.023. PMID: 25442249
Renal medullary carcinoma: case report and review of the literature.
Noguera-Irizarry WG, Hibshoosh H, Papadopoulos KP
Am J Clin Oncol 2003 Oct;26(5):489-92. doi: 10.1097/01.coc.0000037663.61643.5A. PMID: 14528077

Prognosis

Urinary Tract Large Cell Neuroendocrine Carcinoma: Diagnostic, Prognostic and Therapeutic Issues.
Sanguedolce F, Calò B, Chirico M, Tortorella S, Carrieri G, Cormio L
Anticancer Res 2020 May;40(5):2439-2447. doi: 10.21873/anticanres.14213. PMID: 32366387
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Large cell neuroendocrine carcinoma of the kidney with cardiac metastasis: a case report.
Shimbori M, Osaka K, Kawahara T, Kasahara R, Kawabata S, Makiyama K, Kondo K, Nakaigawa N, Yamanaka S, Yao M
J Med Case Rep 2017 Oct 20;11(1):297. doi: 10.1186/s13256-017-1460-7. PMID: 29052535Free PMC Article
Neuroendocrine tumours of the urinary system and male genital organs: clinical significance.
Mazzucchelli R, Morichetti D, Lopez-Beltran A, Cheng L, Scarpelli M, Kirkali Z, Montironi R
BJU Int 2009 Jun;103(11):1464-70. Epub 2009 Feb 27 doi: 10.1111/j.1464-410X.2009.08451.x. PMID: 19254281
Renal medullary carcinoma.
Baig MA, Lin YS, Rasheed J, Mittman N
J Natl Med Assoc 2006 Jul;98(7):1171-4. PMID: 16895289Free PMC Article

Clinical prediction guides

Rare Case of Small Cell Metastatic Prostatic Adenocarcinoma, Properly Staged by 68Ga-PSMA PET/CT Scan.
Golestani ZB, Soltani S, Kalantari MR, Ghorbani HR, Aghaee A
Clin Nucl Med 2022 Mar 1;47(3):e259-e261. doi: 10.1097/RLU.0000000000004033. PMID: 35025791
Added value of [(68)Ga]Ga-DOTA-TOC PET/CT for characterizing pancreatic neuroendocrine neoplasms: a comparison with contrast-enhanced CT and/or MRI in a large study cohort.
Yoo J, Kim SH, Jeon SK, Bae JS, Han JK
Eur Radiol 2021 Oct;31(10):7734-7745. Epub 2021 Mar 31 doi: 10.1007/s00330-021-07859-0. PMID: 33787974
Pure large cell neuroendocrine carcinoma of the bladder without urological symptoms.
Akdeniz E, Bakirtas M, Bolat MS, Akdeniz S, Özer I
Pan Afr Med J 2018;30:134. Epub 2018 Jun 14 doi: 10.11604/pamj.2018.30.134.13437. PMID: 30374380Free PMC Article
Renal cell carcinoma, unclassified with medullary phenotype: poorly differentiated adenocarcinomas overlapping with renal medullary carcinoma.
Sirohi D, Smith SC, Ohe C, Colombo P, Divatia M, Dragoescu E, Rao P, Hirsch MS, Chen YB, Mehra R, Amin MB
Hum Pathol 2017 Sep;67:134-145. Epub 2017 Jul 15 doi: 10.1016/j.humpath.2017.07.006. PMID: 28716439
Morphological, immunohistochemical, and chromosomal analysis of multicystic chromophobe renal cell carcinoma, an architecturally unusual challenging variant.
Foix MP, Dunatov A, Martinek P, Mundó EC, Suster S, Sperga M, Lopez JI, Ulamec M, Bulimbasic S, Montiel DP, Alaghehbandan R, Peckova K, Pivovarcikova K, Ondrej D, Rotterova P, Skenderi F, Prochazkova K, Dusek M, Hora M, Michal M, Hes O
Virchows Arch 2016 Dec;469(6):669-678. Epub 2016 Sep 15 doi: 10.1007/s00428-016-2022-x. PMID: 27631338

Recent systematic reviews

Systematic review and two new cases of primary upper urinary tract neuroendocrine carcinomas.
Nakasato T, Hiramatsu A, Matsui Y, Unoki T, Shimoyama H, Oshinomi K, Morita J, Maeda Y, Naoe M, Fuji K, Ogura H, Homma M, Yamochi T, Takimoto M, Ogawa Y
Cancer Treat Res Commun 2018;17:23-30. Epub 2018 Oct 9 doi: 10.1016/j.ctarc.2018.10.003. PMID: 30326420

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