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Advanced Pancreatic Neuroendocrine Neoplasm

MedGen UID:
1712751
•Concept ID:
C5237189
•
Neoplastic Process

Definition

A pancreatic neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Pancreatic Neuroendocrine Neoplasm

Professional guidelines

PubMed

Advances in Management of Nonfunctional Pancreas Neuroendocrine Tumors.
Acher AW, Hallet J
Surg Clin North Am 2024 Oct;104(5):1095-1111. Epub 2024 Apr 23 doi: 10.1016/j.suc.2024.03.010. PMID: 39237166
Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management.
Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH
World J Gastroenterol 2020 May 21;26(19):2305-2322. doi: 10.3748/wjg.v26.i19.2305. PMID: 32476795Free PMC Article
Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Pavel M, Öberg K, Falconi M, Krenning EP, Sundin A, Perren A, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2020 Jul;31(7):844-860. Epub 2020 Apr 6 doi: 10.1016/j.annonc.2020.03.304. PMID: 32272208

Recent clinical studies

Etiology

The Evolving Landscape of Neuroendocrine Tumors.
Russo A, Gangi A
Surg Oncol Clin N Am 2023 Jan;32(1):185-198. Epub 2022 Nov 3 doi: 10.1016/j.soc.2022.08.003. PMID: 36410917
Radiopharmaceuticals for Neuroendocrine Tumors.
Chin RI, Wu FS, Menda Y, Kim H
Semin Radiat Oncol 2021 Jan;31(1):60-70. doi: 10.1016/j.semradonc.2020.07.007. PMID: 33246637
Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management.
Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH
World J Gastroenterol 2020 May 21;26(19):2305-2322. doi: 10.3748/wjg.v26.i19.2305. PMID: 32476795Free PMC Article
Pancreatic neuroendocrine tumors: a review.
Young K, Iyer R, Morganstein D, Chau I, Cunningham D, Starling N
Future Oncol 2015;11(5):853-64. doi: 10.2217/fon.14.285. PMID: 25757686
Pancreatic neuroendocrine tumors.
Shrikhande SV, Sirohi B, Goel M, Barreto SG
Indian J Gastroenterol 2013 Jan;32(1):3-17. Epub 2012 Oct 3 doi: 10.1007/s12664-012-0257-2. PMID: 23054950

Diagnosis

European Neuroendocrine Tumor Society 2023 guidance paper for functioning pancreatic neuroendocrine tumour syndromes.
Hofland J, Falconi M, Christ E, Castaño JP, Faggiano A, Lamarca A, Perren A, Petrucci S, Prasad V, Ruszniewski P, Thirlwell C, Vullierme MP, Welin S, Bartsch DK
J Neuroendocrinol 2023 Aug;35(8):e13318. Epub 2023 Aug 14 doi: 10.1111/jne.13318. PMID: 37578384
Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management.
Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH
World J Gastroenterol 2020 May 21;26(19):2305-2322. doi: 10.3748/wjg.v26.i19.2305. PMID: 32476795Free PMC Article
Treatment of symptomatic neuroendocrine tumor syndromes: recent advances and controversies.
Ito T, Lee L, Jensen RT
Expert Opin Pharmacother 2016 Nov;17(16):2191-2205. Epub 2016 Sep 23 doi: 10.1080/14656566.2016.1236916. PMID: 27635672Free PMC Article
Pancreatic neuroendocrine tumors: a review.
Young K, Iyer R, Morganstein D, Chau I, Cunningham D, Starling N
Future Oncol 2015;11(5):853-64. doi: 10.2217/fon.14.285. PMID: 25757686
Gastroenteropancreatic endocrine tumors.
Meeker A, Heaphy C
Mol Cell Endocrinol 2014 Apr 5;386(1-2):101-20. Epub 2013 Jul 30 doi: 10.1016/j.mce.2013.07.015. PMID: 23906538

Therapy

The Evolving Landscape of Neuroendocrine Tumors.
Russo A, Gangi A
Surg Oncol Clin N Am 2023 Jan;32(1):185-198. Epub 2022 Nov 3 doi: 10.1016/j.soc.2022.08.003. PMID: 36410917
The Landmark Series: Management of Small Bowel Neuroendocrine Tumors.
Tran CG, Sherman SK, Howe JR
Ann Surg Oncol 2021 May;28(5):2741-2751. Epub 2021 Jan 15 doi: 10.1245/s10434-020-09566-4. PMID: 33452604Free PMC Article
Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management.
Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH
World J Gastroenterol 2020 May 21;26(19):2305-2322. doi: 10.3748/wjg.v26.i19.2305. PMID: 32476795Free PMC Article
Treatment of Gastroenteropancreatic Neuroendocrine Tumors.
Perez K, Chan J
Surg Pathol Clin 2019 Dec;12(4):1045-1053. doi: 10.1016/j.path.2019.08.011. PMID: 31672293
Radionuclide Therapy for Neuroendocrine Tumors.
Cives M, Strosberg J
Curr Oncol Rep 2017 Feb;19(2):9. doi: 10.1007/s11912-017-0567-8. PMID: 28220446

Prognosis

Radiopharmaceuticals for Neuroendocrine Tumors.
Chin RI, Wu FS, Menda Y, Kim H
Semin Radiat Oncol 2021 Jan;31(1):60-70. doi: 10.1016/j.semradonc.2020.07.007. PMID: 33246637
Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management.
Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH
World J Gastroenterol 2020 May 21;26(19):2305-2322. doi: 10.3748/wjg.v26.i19.2305. PMID: 32476795Free PMC Article
Chemotherapy in NETs: When and how.
Angelousi A, Kaltsas G, Koumarianou A, Weickert MO, Grossman A
Rev Endocr Metab Disord 2017 Dec;18(4):485-497. doi: 10.1007/s11154-017-9432-1. PMID: 28890993
Pancreatic neuroendocrine tumors: a review.
Young K, Iyer R, Morganstein D, Chau I, Cunningham D, Starling N
Future Oncol 2015;11(5):853-64. doi: 10.2217/fon.14.285. PMID: 25757686
Gastroenteropancreatic endocrine tumors.
Meeker A, Heaphy C
Mol Cell Endocrinol 2014 Apr 5;386(1-2):101-20. Epub 2013 Jul 30 doi: 10.1016/j.mce.2013.07.015. PMID: 23906538

Clinical prediction guides

Multiple Endocrine Neoplasia Type 1 Syndrome Pancreatic Neuroendocrine Tumor Genotype/Phenotype: Is There Any Advance on Predicting or Preventing?
Ramamoorthy B, Nilubol N
Surg Oncol Clin N Am 2023 Apr;32(2):315-325. doi: 10.1016/j.soc.2022.10.008. PMID: 36925188Free PMC Article
Systemic Therapies for Metastatic Pancreatic Neuroendocrine Tumors.
Hauser H, Gerson DS, Reidy-Lagunes D, Raj N
Curr Treat Options Oncol 2019 Nov 27;20(12):87. doi: 10.1007/s11864-019-0690-x. PMID: 31776785
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy.
Łuksza M, Riaz N, Makarov V, Balachandran VP, Hellmann MD, Solovyov A, Rizvi NA, Merghoub T, Levine AJ, Chan TA, Wolchok JD, Greenbaum BD
Nature 2017 Nov 23;551(7681):517-520. Epub 2017 Nov 8 doi: 10.1038/nature24473. PMID: 29132144Free PMC Article
Surgical management of neuroendocrine tumors.
Tamburrino D, Spoletini G, Partelli S, Muffatti F, Adamenko O, Crippa S, Falconi M
Best Pract Res Clin Endocrinol Metab 2016 Jan;30(1):93-102. Epub 2015 Oct 8 doi: 10.1016/j.beem.2015.10.003. PMID: 26971846

Recent systematic reviews

Metformin and pancreatic neuroendocrine tumors: A systematic review and meta-analysis.
Cigrovski Berkovic M, Coppola A, Sesa V, Mrzljak A, Lai Q
World J Gastroenterol 2024 Feb 21;30(7):759-769. doi: 10.3748/wjg.v30.i7.759. PMID: 38515954Free PMC Article
Changing biological behaviour of NETs during the evolution of the disease: progress on progression.
Alexandraki KI, Spyroglou A, Kykalos S, Daskalakis K, Kyriakopoulos G, Sotiropoulos GC, Kaltsas GA, Grossman AB
Endocr Relat Cancer 2021 Apr 29;28(5):R121-R140. doi: 10.1530/ERC-20-0473. PMID: 33827047
Cystic pancreatic neuroendocrine tumors (cPNETs): a systematic review and meta-analysis of case series.
Hurtado-Pardo L, Cienfuegos JA, Ruiz-Canela M, Panadero P, Benito A, Hernández Lizoain JL
Rev Esp Enferm Dig 2017 Nov;109(11):778-787. doi: 10.17235/reed.2017.5044/2017. PMID: 29072081
Evolution in the treatment of gastroenteropancreatic-neuroendocrine neoplasms, focus on systemic therapeutic options: a systematic review.
Pusceddu S, De Braud F, Festinese F, Bregant C, Lorenzoni A, Maccauro M, Milione M, Concas L, Formisano B, Leuzzi L, Mazzaferro V, Buzzoni R
Future Oncol 2015;11(13):1947-59. doi: 10.2217/fon.15.86. PMID: 26161929
A systematic review of non-surgical treatments for pancreatic neuroendocrine tumours.
Valle JW, Eatock M, Clueit B, Gabriel Z, Ferdinand R, Mitchell S
Cancer Treat Rev 2014 Apr;40(3):376-89. Epub 2013 Sep 8 doi: 10.1016/j.ctrv.2013.08.007. PMID: 24296109

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