Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Advanced Malignant Digestive System Neoplasm

MedGen UID:: 1780145
•Concept ID:: C5446611
•: Neoplastic Process

Definition

A malignant digestive system neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAdvanced Malignant Digestive System Neoplasm

Disease
- Neoplasm
  - Neoplasm by Special Category
    - Metastatic neoplasm
      - Metastatic malignant neoplasm
        Advanced Malignant Neoplasm
        Advanced Malignant Digestive System Neoplasm
        Advanced Digestive System Carcinoma
        Advanced Anal Carcinoma
        Advanced Anal Canal Squamous Cell Carcinoma
        Advanced Colorectal Carcinoma
        Advanced Colon Carcinoma
        Advanced Colorectal Adenocarcinoma
        Advanced Microsatellite Stable Colorectal Carcinoma
        Advanced Rectal Carcinoma
        Advanced Esophageal Carcinoma
        Advanced Esophageal Adenocarcinoma
        Advanced Esophageal Squamous Cell Carcinoma
        Advanced Gastric Carcinoma
        Advanced Gastric Adenocarcinoma
        Advanced Gastric Neuroendocrine Carcinoma
        Advanced Gastroesophageal Junction Adenocarcinoma
        Advanced Hepatocellular Carcinoma
        Advanced Adult Hepatocellular Carcinoma
        Advanced Pancreatobiliary Carcinoma
        Advanced Ampulla of Vater Carcinoma
        Advanced Biliary Tract Carcinoma
        Advanced Pancreatic Carcinoma
        Advanced Small Intestinal Neuroendocrine Carcinoma
        Advanced Small Intestinal Large Cell Neuroendocrine Carcinoma
        Advanced Small Intestinal Small Cell Neuroendocrine Carcinoma
        Advanced Digestive System Neuroendocrine Neoplasm
        Advanced Digestive System Neuroendocrine Tumor G1
        Advanced Pancreatic Neuroendocrine Neoplasm
        Advanced Pancreatic Neuroendocrine Tumor
        Advanced Malignant Small Intestinal Neoplasm

Professional guidelines

PubMed

Advances in screening and detection of gastric cancer.

Xia JY, Aadam AA
J Surg Oncol 2022 Jun;125(7):1104-1109. doi: 10.1002/jso.26844. PMID: 35481909 Free PMC Article

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review.

Biller LH, Schrag D
JAMA 2021 Feb 16;325(7):669-685. doi: 10.1001/jama.2021.0106. PMID: 33591350

Pathophysiology, clinical presentation, and management of colon cancer.

Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

See all (4932)

Recent clinical studies

Etiology

Interventional gastroenterology in oncology.

Wadhwa V, Patel N, Grover D, Ali FS, Thosani N
CA Cancer J Clin 2023 May-Jun;73(3):286-319. Epub 2022 Dec 10 doi: 10.3322/caac.21766. PMID: 36495087

Cyclooxygenases and Prostaglandins in Tumor Immunology and Microenvironment of Gastrointestinal Cancer.

Wang D, Cabalag CS, Clemons NJ, DuBois RN
Gastroenterology 2021 Dec;161(6):1813-1829. Epub 2021 Oct 2 doi: 10.1053/j.gastro.2021.09.059. PMID: 34606846

ESTRO ACROP guidelines for the delineation of lymph nodal areas in upper gastrointestinal malignancies.

Valentini V, Cellini F, Riddell A, Brunner TB, Roeder F, Giuliante F, Alfieri S, Manfredi R, Ardito F, Fiorillo C, Porziella V, Morganti AG, Haustermans K, Margaritora S, De Bari B, Matzinger O, Gkika E, Belka C, Allum W, Verheij M
Radiother Oncol 2021 Nov;164:92-97. Epub 2021 Sep 20 doi: 10.1016/j.radonc.2021.08.026. PMID: 34547352

Management of Gastrointestinal Stromal Tumors.

Keung EZ, Raut CP
Surg Clin North Am 2017 Apr;97(2):437-452. doi: 10.1016/j.suc.2016.12.001. PMID: 28325196

Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.

Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916 Free PMC Article

See all (26386)

Diagnosis

Recent Advancements in the Diagnosis and Treatment of Gastrointestinal Cancers.

Davila RE, Davila ML
Gastroenterol Clin North Am 2022 Sep;51(3):xiii-xiv. Epub 2022 Aug 29 doi: 10.1016/j.gtc.2022.07.009. PMID: 36153117

Gastroenteropancreatic endocrine tumors.

Meeker A, Heaphy C
Mol Cell Endocrinol 2014 Apr 5;386(1-2):101-20. Epub 2013 Jul 30 doi: 10.1016/j.mce.2013.07.015. PMID: 23906538

Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.

Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916 Free PMC Article

Gastrointestinal stromal tumor.

Stamatakos M, Douzinas E, Stefanaki C, Safioleas P, Polyzou E, Levidou G, Safioleas M
World J Surg Oncol 2009 Aug 1;7:61. doi: 10.1186/1477-7819-7-61. PMID: 19646278 Free PMC Article

Endoscopic oncology.

Haluszka O, Tokar JL, Greenwald BD
Curr Probl Cancer 2005 Mar-Apr;29(2):37-112. doi: 10.1016/j.currproblcancer.2005.03.001. PMID: 16100845

See all (18134)

Therapy

Gastrointestinal stromal tumours.

Blay JY, Kang YK, Nishida T, von Mehren M
Nat Rev Dis Primers 2021 Mar 18;7(1):22. doi: 10.1038/s41572-021-00254-5. PMID: 33737510

Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies.

Nakamura Y, Taniguchi H, Ikeda M, Bando H, Kato K, Morizane C, Esaki T, Komatsu Y, Kawamoto Y, Takahashi N, Ueno M, Kagawa Y, Nishina T, Kato T, Yamamoto Y, Furuse J, Denda T, Kawakami H, Oki E, Nakajima T, Nishida N, Yamaguchi K, Yasui H, Goto M, Matsuhashi N, Ohtsubo K, Yamazaki K, Tsuji A, Okamoto W, Tsuchihara K, Yamanaka T, Miki I, Sakamoto Y, Ichiki H, Hata M, Yamashita R, Ohtsu A, Odegaard JI, Yoshino T
Nat Med 2020 Dec;26(12):1859-1864. Epub 2020 Oct 5 doi: 10.1038/s41591-020-1063-5. PMID: 33020649

A review of antibody-based therapeutics targeting G protein-coupled receptors: an update.

Hutchings CJ
Expert Opin Biol Ther 2020 Aug;20(8):925-935. Epub 2020 Apr 8 doi: 10.1080/14712598.2020.1745770. PMID: 32264722

Gastrointestinal stromal tumor.

Stamatakos M, Douzinas E, Stefanaki C, Safioleas P, Polyzou E, Levidou G, Safioleas M
World J Surg Oncol 2009 Aug 1;7:61. doi: 10.1186/1477-7819-7-61. PMID: 19646278 Free PMC Article

Gastrointestinal lymphoma.

Thomas CR Jr, Share R
Med Pediatr Oncol 1991;19(1):48-60. doi: 10.1002/mpo.2950190109. PMID: 1990257

See all (22409)

Prognosis

Advances in screening and detection of gastric cancer.

Xia JY, Aadam AA
J Surg Oncol 2022 Jun;125(7):1104-1109. doi: 10.1002/jso.26844. PMID: 35481909 Free PMC Article

Conceptual Development of Immunotherapeutic Approaches to Gastrointestinal Cancer.

Abolarinwa BA, Ibrahim RB, Huang YH
Int J Mol Sci 2019 Sep 18;20(18) doi: 10.3390/ijms20184624. PMID: 31540435 Free PMC Article

Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States.

Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, Shih T, Yao JC
JAMA Oncol 2017 Oct 1;3(10):1335-1342. doi: 10.1001/jamaoncol.2017.0589. PMID: 28448665 Free PMC Article

Gastrointestinal Stromal Tumors: A Review.

Asija AP, Mejia AV, Prestipino A, Pillai MV
Am J Ther 2016 Mar-Apr;23(2):e550-7. doi: 10.1097/MJT.0b013e3182a1be76. PMID: 23942136

Gastroenteropancreatic endocrine tumors.

Meeker A, Heaphy C
Mol Cell Endocrinol 2014 Apr 5;386(1-2):101-20. Epub 2013 Jul 30 doi: 10.1016/j.mce.2013.07.015. PMID: 23906538

See all (24984)

Clinical prediction guides

Multi-omics of the gut microbial ecosystem in patients with microsatellite-instability-high gastrointestinal cancer resistant to immunotherapy.

Cheng S, Han Z, Dai D, Li F, Zhang X, Lu M, Lu Z, Wang X, Zhou J, Li J, Guo X, Song P, Qiu C, Shen W, Zhang Q, Zhu N, Wang X, Tan Y, Kou Y, Yin X, Shen L, Peng Z
Cell Rep Med 2024 Jan 16;5(1):101355. Epub 2024 Jan 8 doi: 10.1016/j.xcrm.2023.101355. PMID: 38194971 Free PMC Article

CircRNA in cancer: Fundamental mechanism and clinical potential.

Chen L, Shan G
Cancer Lett 2021 May 1;505:49-57. Epub 2021 Feb 18 doi: 10.1016/j.canlet.2021.02.004. PMID: 33609610

Targeting the immune milieu in gastrointestinal cancers.

Turkes F, Mencel J, Starling N
J Gastroenterol 2020 Oct;55(10):909-926. Epub 2020 Aug 3 doi: 10.1007/s00535-020-01710-x. PMID: 32748171 Free PMC Article

Progress in determining response to treatment in gastrointestinal stromal tumor.

Arshad J, Ahmed J, Subhawong T, Trent JC
Expert Rev Anticancer Ther 2020 Apr;20(4):279-288. Epub 2020 Apr 12 doi: 10.1080/14737140.2020.1745068. PMID: 32191549 Free PMC Article

Interval colorectal carcinoma: An unsolved debate.

Benedict M, Galvao Neto A, Zhang X
World J Gastroenterol 2015 Dec 7;21(45):12735-41. doi: 10.3748/wjg.v21.i45.12735. PMID: 26668498 Free PMC Article

See all (19021)

Recent systematic reviews

Efficacy and safety of Zolbetuximab plus chemotherapy for advanced CLDN18.2-positive gastric or gastro-oesophageal adenocarcinoma: a meta-analysis of randomized clinical trials.

de Moraes FCA, Pasqualotto E, Chavez MP, Ferreira ROM, De Castria TB, Burbano RMR
BMC Cancer 2024 Feb 21;24(1):240. doi: 10.1186/s12885-024-11980-w. PMID: 38383390 Free PMC Article

Predictive biomarkers in radioresistant rectal cancer: A systematic review.

Slipsager A, Henrichsen SN, Falkmer UG, Dybkær K, Belting M, Poulsen LØ
Crit Rev Oncol Hematol 2023 Jun;186:103991. Epub 2023 Apr 13 doi: 10.1016/j.critrevonc.2023.103991. PMID: 37059272

Risk Factors for Early-Onset Colorectal Cancer: A Systematic Review and Meta-analysis.

O'Sullivan DE, Sutherland RL, Town S, Chow K, Fan J, Forbes N, Heitman SJ, Hilsden RJ, Brenner DR
Clin Gastroenterol Hepatol 2022 Jun;20(6):1229-1240.e5. Epub 2021 Jan 29 doi: 10.1016/j.cgh.2021.01.037. PMID: 33524598

Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline.

Shah MA, Kennedy EB, Catenacci DV, Deighton DC, Goodman KA, Malhotra NK, Willett C, Stiles B, Sharma P, Tang L, Wijnhoven BPL, Hofstetter WL
J Clin Oncol 2020 Aug 10;38(23):2677-2694. Epub 2020 Jun 22 doi: 10.1200/JCO.20.00866. PMID: 32568633

Meta-analysis of colorectal cancer follow-up after potentially curative resection.

Mokhles S, Macbeth F, Farewell V, Fiorentino F, Williams NR, Younes RN, Takkenberg JJ, Treasure T
Br J Surg 2016 Sep;103(10):1259-68. Epub 2016 Aug 4 doi: 10.1002/bjs.10233. PMID: 27488593 Free PMC Article

See all (1079)

MedGen

National Center for Biotechnology Information