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Advanced Colon Carcinoma

MedGen UID:
1712846
•Concept ID:
C5238389
•
Neoplastic Process

Definition

Colon carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Colon Carcinoma

Professional guidelines

PubMed

A phase III evaluation of a somatostatin analogue (octreotide) in the treatment of patients with asymptomatic advanced colon carcinoma.
Morris DL
Cancer 1996 May 1;77(9):1956-7. doi: 10.1002/(SICI)1097-0142(19960501)77:9<1956::AID-CNCR29>3.0.CO;2-Y. PMID: 8646698
Phase II studies of mitoxantrone (dihydroxyanthracenedione) in the treatment of advanced colorectal carcinoma.
DeSimone PA, Gams R, Bartolucci A
Am J Clin Oncol 1984 Oct;7(5):517-22. doi: 10.1097/00000421-198410000-00024. PMID: 6507372

Recent clinical studies

Etiology

Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer.
Huang KC, Ke TW, Chen JY, Hong WZ, Chiang SF, Lai CY, Chen TW, Yang PC, Chen LC, Liang JA, Chen WT, Chao KSC
Sci Rep 2023 Nov 9;13(1):19440. doi: 10.1038/s41598-023-46254-1. PMID: 37945630Free PMC Article
Colo-pancreaticoduodenectomy for locally advanced colon carcinoma-feasibility in patients presenting with acute abdomen.
Chen JB, Luo SC, Chen CC, Wu CC, Yen Y, Chang CH, Chen YA, P'eng FK
World J Emerg Surg 2021 Feb 27;16(1):7. doi: 10.1186/s13017-021-00351-6. PMID: 33639983Free PMC Article
Peritoneal implants without ascites: preoperative CT diagnosis in colon carcinoma patients.
Saida Y, Tsunoda HS, Itai Y, Matsueda K
Radiat Med 1994 Sep-Oct;12(5):221-4. PMID: 7863026
5-fluorouracil modulation in the chemotherapy of colorectal cancer.
Codacci-Pisanelli G, Franchi F
Ital J Gastroenterol 1994 Sep;26(7):369-76. PMID: 7529067
Phase II studies of mitoxantrone (dihydroxyanthracenedione) in the treatment of advanced colorectal carcinoma.
DeSimone PA, Gams R, Bartolucci A
Am J Clin Oncol 1984 Oct;7(5):517-22. doi: 10.1097/00000421-198410000-00024. PMID: 6507372

Diagnosis

Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy (HIPEC) by Minimally Invasive Approach, an Initial Experience.
Arjona-Sanchez A, Rufian-Peña S, Sanchez-Hidalgo JM, Casado-Adam A, Cosano-Alvarez A, Briceño-Delgado J
World J Surg 2018 Oct;42(10):3120-3124. doi: 10.1007/s00268-018-4634-6. PMID: 29691625
Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors.
Elola MT, Ferragut F, Cárdenas Delgado VM, Nugnes LG, Gentilini L, Laderach D, Troncoso MF, Compagno D, Wolfenstein-Todel C, Rabinovich GA
Histol Histopathol 2014 Sep;29(9):1093-105. Epub 2014 Mar 31 doi: 10.14670/HH-29.1093. PMID: 24696431
Expression of MUC1 recognized by monoclonal antibody MY.1E12 is a useful biomarker for tumor aggressiveness of advanced colon carcinoma.
Suzuki H, Shoda J, Kawamoto T, Shinozaki E, Miyahara N, Hotta S, Iizuka Y, Nakahara A, Tanaka N, Yanaka A, Irimura T
Clin Exp Metastasis 2004;21(4):321-9. doi: 10.1023/b:clin.0000046133.35133.cc. PMID: 15554388
A phase III evaluation of a somatostatin analogue (octreotide) in the treatment of patients with asymptomatic advanced colon carcinoma. North Central Cancer Treatment Group and the Mayo Clinic.
Goldberg RM, Moertel CG, Wieand HS, Krook JE, Schutt AJ, Veeder MH, Mailliard JA, Dalton RJ
Cancer 1995 Sep 15;76(6):961-6. doi: 10.1002/1097-0142(19950915)76:6<961::aid-cncr2820760608>3.0.co;2-a. PMID: 8625221
Peritoneal implants without ascites: preoperative CT diagnosis in colon carcinoma patients.
Saida Y, Tsunoda HS, Itai Y, Matsueda K
Radiat Med 1994 Sep-Oct;12(5):221-4. PMID: 7863026

Therapy

Evaluating the oncological safety of neoadjuvant chemotherapy in locally advanced colon carcinoma: a systematic review and meta-analysis of randomised clinical trials and propensity-matched studies.
Davey MG, Amir AH, Ryan OK, Donnelly M, Donlon NE, Regan M, Meshkat B, Nugent E, Joyce M, Hogan AM
Int J Colorectal Dis 2023 Jul 11;38(1):193. doi: 10.1007/s00384-023-04482-x. PMID: 37432559Free PMC Article
5-fluorouracil modulation in the chemotherapy of colorectal cancer.
Codacci-Pisanelli G, Franchi F
Ital J Gastroenterol 1994 Sep;26(7):369-76. PMID: 7529067
Hypertriglyceridemia during long-term interferon-alpha therapy: efficacy of diet and gemfibrosil treatment. A case report.
Berruti A, Gorzegno G, Vitetta G, Tampellini M, Dogliotti L
Tumori 1992 Oct 31;78(5):353-5. doi: 10.1177/030089169207800515. PMID: 1494811
Severe hypotension in disseminated colon cancer due to a possible decreased dopamine brain content: a case report.
Lissoni P, Barni S, Meregalli S, Gattaneo G, Archili C, Tancini G
Tumori 1990 Aug 31;76(4):398-9. doi: 10.1177/030089169007600419. PMID: 2399570
Phase I study and pharmacokinetics of caracemide (NSC-253272) administered as a short infusion.
Pazdur R, Chabot GG, Baker LH
Invest New Drugs 1987 Dec;5(4):365-71. doi: 10.1007/BF00169976. PMID: 3436742

Prognosis

Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer.
Huang KC, Ke TW, Chen JY, Hong WZ, Chiang SF, Lai CY, Chen TW, Yang PC, Chen LC, Liang JA, Chen WT, Chao KSC
Sci Rep 2023 Nov 9;13(1):19440. doi: 10.1038/s41598-023-46254-1. PMID: 37945630Free PMC Article
Adoptive transfer of natural killer cells in combination with chemotherapy improves outcomes of patients with locally advanced colon carcinoma.
Li L, Li W, Wang C, Yan X, Wang Y, Niu C, Zhang X, Li M, Tian H, Yao C, Jin H, Han F, Xu D, Han W, Li D, Cui J
Cytotherapy 2018 Jan;20(1):134-148. Epub 2017 Oct 19 doi: 10.1016/j.jcyt.2017.09.009. PMID: 29056549
Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors.
Elola MT, Ferragut F, Cárdenas Delgado VM, Nugnes LG, Gentilini L, Laderach D, Troncoso MF, Compagno D, Wolfenstein-Todel C, Rabinovich GA
Histol Histopathol 2014 Sep;29(9):1093-105. Epub 2014 Mar 31 doi: 10.14670/HH-29.1093. PMID: 24696431
Irinotecan (CPT-11) in patients with advanced colon carcinoma relapsing after 5-fluorouracil-leucovorin combination.
Tsavaris NB, Polyzos A, Gennatas K, Kosmas Ch, Vadiaka M, Dimitrakopoulos A, Macheras A, Papastratis G, Tsipras H, Margaris H, Papalambros E, Giannopoulos A, Koufos Ch
Chemotherapy 2002 May;48(2):94-9. doi: 10.1159/000057669. PMID: 12011542
Peritoneal implants without ascites: preoperative CT diagnosis in colon carcinoma patients.
Saida Y, Tsunoda HS, Itai Y, Matsueda K
Radiat Med 1994 Sep-Oct;12(5):221-4. PMID: 7863026

Clinical prediction guides

Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer.
Huang KC, Ke TW, Chen JY, Hong WZ, Chiang SF, Lai CY, Chen TW, Yang PC, Chen LC, Liang JA, Chen WT, Chao KSC
Sci Rep 2023 Nov 9;13(1):19440. doi: 10.1038/s41598-023-46254-1. PMID: 37945630Free PMC Article
Evaluating the oncological safety of neoadjuvant chemotherapy in locally advanced colon carcinoma: a systematic review and meta-analysis of randomised clinical trials and propensity-matched studies.
Davey MG, Amir AH, Ryan OK, Donnelly M, Donlon NE, Regan M, Meshkat B, Nugent E, Joyce M, Hogan AM
Int J Colorectal Dis 2023 Jul 11;38(1):193. doi: 10.1007/s00384-023-04482-x. PMID: 37432559Free PMC Article
Peritoneal implants without ascites: preoperative CT diagnosis in colon carcinoma patients.
Saida Y, Tsunoda HS, Itai Y, Matsueda K
Radiat Med 1994 Sep-Oct;12(5):221-4. PMID: 7863026
5-fluorouracil modulation in the chemotherapy of colorectal cancer.
Codacci-Pisanelli G, Franchi F
Ital J Gastroenterol 1994 Sep;26(7):369-76. PMID: 7529067
Phase II trial of high-dose melphalan and autologous bone marrow transplantation for metastatic colon carcinoma.
Leff RS, Thompson JM, Johnson DB, Mosley KR, Daly MB, Knight WA 3rd, Ruxer RL Jr, Messerschmidt GL
J Clin Oncol 1986 Nov;4(11):1586-91. doi: 10.1200/JCO.1986.4.11.1586. PMID: 3534154

Recent systematic reviews

Evaluating the oncological safety of neoadjuvant chemotherapy in locally advanced colon carcinoma: a systematic review and meta-analysis of randomised clinical trials and propensity-matched studies.
Davey MG, Amir AH, Ryan OK, Donnelly M, Donlon NE, Regan M, Meshkat B, Nugent E, Joyce M, Hogan AM
Int J Colorectal Dis 2023 Jul 11;38(1):193. doi: 10.1007/s00384-023-04482-x. PMID: 37432559Free PMC Article

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