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Locally Advanced Myxofibrosarcoma

MedGen UID:
1713985
•Concept ID:
C5239032
•
Neoplastic Process

Definition

Myxofibrosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Myxofibrosarcoma

Recent clinical studies

Etiology

Imaging of soft tissue sarcomas of the extremities with radiologic-pathologic correlation.
Ramakrishnan K, Levy N, Goldbach A, Nagarathinam R, Ali S, Ling S, Jonnalagadda P
Curr Probl Diagn Radiol 2022 Nov-Dec;51(6):868-877. Epub 2022 May 2 doi: 10.1067/j.cpradiol.2022.04.005. PMID: 35654634
The role of Ifosfamide-doxorubicin chemotherapy in histology-specific, high grade, locally advanced soft tissue sarcoma, a 14-year experience.
Goy BW, Syed S, Padmanabhan A, Burchette RJ, Helmstedter CS
Radiother Oncol 2021 Dec;165:174-178. Epub 2021 Nov 7 doi: 10.1016/j.radonc.2021.10.019. PMID: 34758339
Predictors of lung recurrence and disease-specific mortality after pulmonary metastasectomy for soft tissue sarcoma.
Tetta C, Rocca M, Salone M, Longhi A, Ferrari C, Londero F, Parise G, Parise O, Giugliano A, Maessen JG, La Meir M, Gelsomino S
Surg Oncol 2021 Jun;37:101532. Epub 2021 Feb 20 doi: 10.1016/j.suronc.2021.101532. PMID: 33639455
Establishment and Characterization of Histologically and Molecularly Stable Soft-tissue Sarcoma Xenograft Models for Biological Studies and Preclinical Drug Testing.
Cornillie J, Wozniak A, Li H, Wang Y, Boeckx B, Gebreyohannes YK, Wellens J, Vanleeuw U, Hompes D, Stas M, Sinnaeve F, Wafa H, Lambrechts D, Debiec-Rychter M, Sciot R, Schöffski P
Mol Cancer Ther 2019 Jun;18(6):1168-1178. Epub 2019 Apr 8 doi: 10.1158/1535-7163.MCT-18-1045. PMID: 30962320
Prognostic implication of ezrin overexpression in myxofibrosarcomas.
Huang HY, Li CF, Fang FM, Tsai JW, Li SH, Lee YT, Wei HM
Ann Surg Oncol 2010 Dec;17(12):3212-9. Epub 2010 Jun 29 doi: 10.1245/s10434-010-1185-y. PMID: 20585869

Diagnosis

The landscape of genetic aberrations in myxofibrosarcoma.
Takeuchi Y, Yoshida K, Halik A, Kunitz A, Suzuki H, Kakiuchi N, Shiozawa Y, Yokoyama A, Inoue Y, Hirano T, Yoshizato T, Aoki K, Fujii Y, Nannya Y, Makishima H, Pfitzner BM, Bullinger L, Hirata M, Jinnouchi K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Okamoto T, Haga H, Ogawa S, Damm F
Int J Cancer 2022 Aug 15;151(4):565-577. Epub 2022 May 13 doi: 10.1002/ijc.34051. PMID: 35484982
DDIT3 Immunohistochemistry Is a Useful Tool for the Diagnosis of Myxoid Liposarcoma.
Scapa JV, Cloutier JM, Raghavan SS, Peters-Schulze G, Varma S, Charville GW
Am J Surg Pathol 2021 Feb 1;45(2):230-239. doi: 10.1097/PAS.0000000000001564. PMID: 32815829Free PMC Article
5-Aminolevulinic acid tumor paint and photodynamic therapy for myxofibrosarcoma: an in vitro study.
Kenan S, Liang H, Goodman HJ, Jacobs AJ, Chan A, Grande DA, Levin AS
J Orthop Surg Res 2020 Mar 5;15(1):94. doi: 10.1186/s13018-020-01606-9. PMID: 32138774Free PMC Article
Intramuscular low-grade myxoid neoplasm with recurrent potential (cellular myxoma) of the lower extremity: case report with cytohistologic correlation and review of the literature.
Catroppo JF, Olesnicky L, Ringer P, Goldenkranz R, Casas V, Wright T
Diagn Cytopathol 2002 May;26(5):301-5. doi: 10.1002/dc.10087. PMID: 11992372

Therapy

The role of Ifosfamide-doxorubicin chemotherapy in histology-specific, high grade, locally advanced soft tissue sarcoma, a 14-year experience.
Goy BW, Syed S, Padmanabhan A, Burchette RJ, Helmstedter CS
Radiother Oncol 2021 Dec;165:174-178. Epub 2021 Nov 7 doi: 10.1016/j.radonc.2021.10.019. PMID: 34758339
Predictors of lung recurrence and disease-specific mortality after pulmonary metastasectomy for soft tissue sarcoma.
Tetta C, Rocca M, Salone M, Longhi A, Ferrari C, Londero F, Parise G, Parise O, Giugliano A, Maessen JG, La Meir M, Gelsomino S
Surg Oncol 2021 Jun;37:101532. Epub 2021 Feb 20 doi: 10.1016/j.suronc.2021.101532. PMID: 33639455
5-Aminolevulinic acid tumor paint and photodynamic therapy for myxofibrosarcoma: an in vitro study.
Kenan S, Liang H, Goodman HJ, Jacobs AJ, Chan A, Grande DA, Levin AS
J Orthop Surg Res 2020 Mar 5;15(1):94. doi: 10.1186/s13018-020-01606-9. PMID: 32138774Free PMC Article
Prognostic implication of MET overexpression in myxofibrosarcomas: an integrative array comparative genomic hybridization, real-time quantitative PCR, immunoblotting, and immunohistochemical analysis.
Lee JC, Li CF, Fang FM, Wang JW, Jeng YM, Yu SC, Lin YT, Wu JM, Tsai JW, Li SH, Huang HY
Mod Pathol 2010 Oct;23(10):1379-92. Epub 2010 Jul 16 doi: 10.1038/modpathol.2010.128. PMID: 20639860

Prognosis

The role of Ifosfamide-doxorubicin chemotherapy in histology-specific, high grade, locally advanced soft tissue sarcoma, a 14-year experience.
Goy BW, Syed S, Padmanabhan A, Burchette RJ, Helmstedter CS
Radiother Oncol 2021 Dec;165:174-178. Epub 2021 Nov 7 doi: 10.1016/j.radonc.2021.10.019. PMID: 34758339
Predictors of lung recurrence and disease-specific mortality after pulmonary metastasectomy for soft tissue sarcoma.
Tetta C, Rocca M, Salone M, Longhi A, Ferrari C, Londero F, Parise G, Parise O, Giugliano A, Maessen JG, La Meir M, Gelsomino S
Surg Oncol 2021 Jun;37:101532. Epub 2021 Feb 20 doi: 10.1016/j.suronc.2021.101532. PMID: 33639455
Detection of circulating sarcoma tumor cells using a microfluidic chip-type cell sorter.
Hasegawa N, Takeda Nakamura I, Ueno T, Kojima S, Kawazu M, Akaike K, Okubo T, Takagi T, Suehara Y, Hayashi T, Saito T, Kaneko K, Mano H, Kohsaka S
Sci Rep 2019 Dec 27;9(1):20047. doi: 10.1038/s41598-019-56377-z. PMID: 31882696Free PMC Article
Prognostic implication of MET overexpression in myxofibrosarcomas: an integrative array comparative genomic hybridization, real-time quantitative PCR, immunoblotting, and immunohistochemical analysis.
Lee JC, Li CF, Fang FM, Wang JW, Jeng YM, Yu SC, Lin YT, Wu JM, Tsai JW, Li SH, Huang HY
Mod Pathol 2010 Oct;23(10):1379-92. Epub 2010 Jul 16 doi: 10.1038/modpathol.2010.128. PMID: 20639860
Prognostic implication of ezrin overexpression in myxofibrosarcomas.
Huang HY, Li CF, Fang FM, Tsai JW, Li SH, Lee YT, Wei HM
Ann Surg Oncol 2010 Dec;17(12):3212-9. Epub 2010 Jun 29 doi: 10.1245/s10434-010-1185-y. PMID: 20585869

Clinical prediction guides

The role of Ifosfamide-doxorubicin chemotherapy in histology-specific, high grade, locally advanced soft tissue sarcoma, a 14-year experience.
Goy BW, Syed S, Padmanabhan A, Burchette RJ, Helmstedter CS
Radiother Oncol 2021 Dec;165:174-178. Epub 2021 Nov 7 doi: 10.1016/j.radonc.2021.10.019. PMID: 34758339
Predictors of lung recurrence and disease-specific mortality after pulmonary metastasectomy for soft tissue sarcoma.
Tetta C, Rocca M, Salone M, Longhi A, Ferrari C, Londero F, Parise G, Parise O, Giugliano A, Maessen JG, La Meir M, Gelsomino S
Surg Oncol 2021 Jun;37:101532. Epub 2021 Feb 20 doi: 10.1016/j.suronc.2021.101532. PMID: 33639455
DDIT3 Immunohistochemistry Is a Useful Tool for the Diagnosis of Myxoid Liposarcoma.
Scapa JV, Cloutier JM, Raghavan SS, Peters-Schulze G, Varma S, Charville GW
Am J Surg Pathol 2021 Feb 1;45(2):230-239. doi: 10.1097/PAS.0000000000001564. PMID: 32815829Free PMC Article
Detection of circulating sarcoma tumor cells using a microfluidic chip-type cell sorter.
Hasegawa N, Takeda Nakamura I, Ueno T, Kojima S, Kawazu M, Akaike K, Okubo T, Takagi T, Suehara Y, Hayashi T, Saito T, Kaneko K, Mano H, Kohsaka S
Sci Rep 2019 Dec 27;9(1):20047. doi: 10.1038/s41598-019-56377-z. PMID: 31882696Free PMC Article
Establishment and Characterization of Histologically and Molecularly Stable Soft-tissue Sarcoma Xenograft Models for Biological Studies and Preclinical Drug Testing.
Cornillie J, Wozniak A, Li H, Wang Y, Boeckx B, Gebreyohannes YK, Wellens J, Vanleeuw U, Hompes D, Stas M, Sinnaeve F, Wafa H, Lambrechts D, Debiec-Rychter M, Sciot R, Schöffski P
Mol Cancer Ther 2019 Jun;18(6):1168-1178. Epub 2019 Apr 8 doi: 10.1158/1535-7163.MCT-18-1045. PMID: 30962320

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