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Locally Advanced Malignant Neoplasm

MedGen UID:
195665
Concept ID:
C0677984
Neoplastic Process
Synonyms: Locally advanced cancer; Locally Advanced Cancer; Locally advanced malignant neoplasm; Locally advanced malignant tumor; Locally Metastatic Malignant Neoplasm
SNOMED CT: Locally advanced cancer (1255249000); Locally advanced malignant tumor (1255249000); Locally advanced malignant neoplasm (1255249000)

Definition

A malignant neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Malignant Neoplasm

Professional guidelines

PubMed

Sekhoacha M, Riet K, Motloung P, Gumenku L, Adegoke A, Mashele S
Molecules 2022 Sep 5;27(17) doi: 10.3390/molecules27175730. PMID: 36080493Free PMC Article
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884
Brioude F, Kalish JM, Mussa A, Foster AC, Bliek J, Ferrero GB, Boonen SE, Cole T, Baker R, Bertoletti M, Cocchi G, Coze C, De Pellegrin M, Hussain K, Ibrahim A, Kilby MD, Krajewska-Walasek M, Kratz CP, Ladusans EJ, Lapunzina P, Le Bouc Y, Maas SM, Macdonald F, Õunap K, Peruzzi L, Rossignol S, Russo S, Shipster C, Skórka A, Tatton-Brown K, Tenorio J, Tortora C, Grønskov K, Netchine I, Hennekam RC, Prawitt D, Tümer Z, Eggermann T, Mackay DJG, Riccio A, Maher ER
Nat Rev Endocrinol 2018 Apr;14(4):229-249. Epub 2018 Jan 29 doi: 10.1038/nrendo.2017.166. PMID: 29377879Free PMC Article

Recent clinical studies

Etiology

Williams IS, McVey A, Perera S, O'Brien JS, Kostos L, Chen K, Siva S, Azad AA, Murphy DG, Kasivisvanathan V, Lawrentschuk N, Frydenberg M
Med J Aust 2022 Oct 17;217(8):424-433. Epub 2022 Oct 2 doi: 10.5694/mja2.51722. PMID: 36183329Free PMC Article
Schneider M, Hackert T, Strobel O, Büchler MW
Br J Surg 2021 Jul 23;108(7):777-785. doi: 10.1093/bjs/znab133. PMID: 34046668
Mizrahi JD, Surana R, Valle JW, Shroff RT
Lancet 2020 Jun 27;395(10242):2008-2020. doi: 10.1016/S0140-6736(20)30974-0. PMID: 32593337
Hartman RI, Lin JY
Hematol Oncol Clin North Am 2019 Feb;33(1):25-38. doi: 10.1016/j.hoc.2018.09.005. PMID: 30497675
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article

Diagnosis

Williams IS, McVey A, Perera S, O'Brien JS, Kostos L, Chen K, Siva S, Azad AA, Murphy DG, Kasivisvanathan V, Lawrentschuk N, Frydenberg M
Med J Aust 2022 Oct 17;217(8):424-433. Epub 2022 Oct 2 doi: 10.5694/mja2.51722. PMID: 36183329Free PMC Article
Mizrahi JD, Surana R, Valle JW, Shroff RT
Lancet 2020 Jun 27;395(10242):2008-2020. doi: 10.1016/S0140-6736(20)30974-0. PMID: 32593337
Hartman RI, Lin JY
Hematol Oncol Clin North Am 2019 Feb;33(1):25-38. doi: 10.1016/j.hoc.2018.09.005. PMID: 30497675
Rao R, Honavar SG
Indian J Pediatr 2017 Dec;84(12):937-944. Epub 2017 Jun 16 doi: 10.1007/s12098-017-2395-0. PMID: 28620731
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article

Therapy

Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Hopstaken JS, Bomers JGR, Sedelaar MJP, Valerio M, Fütterer JJ, Rovers MM
Eur Urol 2022 Jan;81(1):5-33. Epub 2021 Sep 4 doi: 10.1016/j.eururo.2021.08.005. PMID: 34489140
Vale CL, Fisher D, Kneebone A, Parker C, Pearse M, Richaud P, Sargos P, Sydes MR, Brawley C, Brihoum M, Brown C, Chabaud S, Cook A, Forcat S, Fraser-Browne C, Latorzeff I, Parmar MKB, Tierney JF; ARTISTIC Meta-analysis Group
Lancet 2020 Oct 31;396(10260):1422-1431. Epub 2020 Sep 28 doi: 10.1016/S0140-6736(20)31952-8. PMID: 33002431Free PMC Article
Mayadev J, Nunes AT, Li M, Marcovitz M, Lanasa MC, Monk BJ
Int J Gynecol Cancer 2020 Jul;30(7):1065-1070. Epub 2020 May 23 doi: 10.1136/ijgc-2019-001135. PMID: 32447296Free PMC Article
Chargari C, Deutsch E, Blanchard P, Gouy S, Martelli H, Guérin F, Dumas I, Bossi A, Morice P, Viswanathan AN, Haie-Meder C
CA Cancer J Clin 2019 Sep;69(5):386-401. Epub 2019 Jul 30 doi: 10.3322/caac.21578. PMID: 31361333

Prognosis

Vos EL, Carr RA, Hsu M, Nakauchi M, Nobel T, Russo A, Barbetta A, Tan KS, Tang L, Ilson D, Ku GY, Wu AJ, Janjigian YY, Yoon SS, Bains MS, Jones DR, Coit D, Molena D, Strong VE
Br J Surg 2021 Nov 11;108(11):1332-1340. doi: 10.1093/bjs/znab228. PMID: 34476473Free PMC Article
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261
Maloney DG
Curr Opin Hematol 1995 Jul;2(4):255-61. doi: 10.1097/00062752-199502040-00004. PMID: 9372005

Clinical prediction guides

Wang W, Peng Y, Feng X, Zhao Y, Seeruttun SR, Zhang J, Cheng Z, Li Y, Liu Z, Zhou Z
JAMA Netw Open 2021 Aug 2;4(8):e2121143. doi: 10.1001/jamanetworkopen.2021.21143. PMID: 34410397Free PMC Article
Jiang M, Li CL, Luo XM, Chuan ZR, Lv WZ, Li X, Cui XW, Dietrich CF
Eur J Cancer 2021 Apr;147:95-105. Epub 2021 Feb 24 doi: 10.1016/j.ejca.2021.01.028. PMID: 33639324
Gaiser MR, von Bubnoff N, Gebhardt C, Utikal JS
J Dtsch Dermatol Ges 2018 Apr;16(4):405-414. Epub 2018 Mar 7 doi: 10.1111/ddg.13461. PMID: 29512873
Fridman WH, Zitvogel L, Sautès-Fridman C, Kroemer G
Nat Rev Clin Oncol 2017 Dec;14(12):717-734. Epub 2017 Jul 25 doi: 10.1038/nrclinonc.2017.101. PMID: 28741618
Offersen BV, Boersma LJ, Kirkove C, Hol S, Aznar MC, Biete Sola A, Kirova YM, Pignol JP, Remouchamps V, Verhoeven K, Weltens C, Arenas M, Gabrys D, Kopek N, Krause M, Lundstedt D, Marinko T, Montero A, Yarnold J, Poortmans P
Radiother Oncol 2015 Jan;114(1):3-10. Epub 2015 Jan 24 doi: 10.1016/j.radonc.2014.11.030. PMID: 25630428

Recent systematic reviews

Madariaga A, Lau J, Ghoshal A, Dzierżanowski T, Larkin P, Sobocki J, Dickman A, Furness K, Fazelzad R, Crawford GB, Lheureux S
Support Care Cancer 2022 Jun;30(6):4711-4728. Epub 2022 Mar 10 doi: 10.1007/s00520-022-06889-8. PMID: 35274188Free PMC Article
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Gosavi R, Chia C, Michael M, Heriot AG, Warrier SK, Kong JC
Int J Colorectal Dis 2021 Oct;36(10):2063-2070. Epub 2021 May 4 doi: 10.1007/s00384-021-03945-3. PMID: 33945007
Kasi A, Abbasi S, Handa S, Al-Rajabi R, Saeed A, Baranda J, Sun W
JAMA Netw Open 2020 Dec 1;3(12):e2030097. doi: 10.1001/jamanetworkopen.2020.30097. PMID: 33326026Free PMC Article
Vale CL, Fisher D, Kneebone A, Parker C, Pearse M, Richaud P, Sargos P, Sydes MR, Brawley C, Brihoum M, Brown C, Chabaud S, Cook A, Forcat S, Fraser-Browne C, Latorzeff I, Parmar MKB, Tierney JF; ARTISTIC Meta-analysis Group
Lancet 2020 Oct 31;396(10260):1422-1431. Epub 2020 Sep 28 doi: 10.1016/S0140-6736(20)31952-8. PMID: 33002431Free PMC Article

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