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Locally Advanced Malignant Neoplasm

MedGen UID:
195665
Concept ID:
C0677984
Neoplastic Process
Synonyms: Locally advanced cancer; Locally Advanced Cancer; Locally advanced malignant neoplasm; Locally advanced malignant tumor; Locally Metastatic Malignant Neoplasm
SNOMED CT: Locally advanced cancer (1255249000); Locally advanced malignant tumor (1255249000); Locally advanced malignant neoplasm (1255249000)

Definition

A malignant neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Malignant Neoplasm

Professional guidelines

PubMed

Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, Bataille V, Brochez L, Del Marmol V, Dummer R, Forsea AM, Gaudy-Marqueste C, Harwood CA, Hauschild A, Höller C, Kandolf L, Kellerners-Smeets NWJ, Lallas A, Leiter U, Malvehy J, Marinović B, Mijuskovic Z, Moreno-Ramirez D, Nagore E, Nathan P, Stratigos AJ, Stockfleth E, Tagliaferri L, Trakatelli M, Vieira R, Zalaudek I, Garbe C; EADO”A, EDF”B, ESTRO”C, UEMS”D and EADV”E
Eur J Cancer 2023 Oct;192:113254. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113254. PMID: 37604067
Sekhoacha M, Riet K, Motloung P, Gumenku L, Adegoke A, Mashele S
Molecules 2022 Sep 5;27(17) doi: 10.3390/molecules27175730. PMID: 36080493Free PMC Article
Brioude F, Kalish JM, Mussa A, Foster AC, Bliek J, Ferrero GB, Boonen SE, Cole T, Baker R, Bertoletti M, Cocchi G, Coze C, De Pellegrin M, Hussain K, Ibrahim A, Kilby MD, Krajewska-Walasek M, Kratz CP, Ladusans EJ, Lapunzina P, Le Bouc Y, Maas SM, Macdonald F, Õunap K, Peruzzi L, Rossignol S, Russo S, Shipster C, Skórka A, Tatton-Brown K, Tenorio J, Tortora C, Grønskov K, Netchine I, Hennekam RC, Prawitt D, Tümer Z, Eggermann T, Mackay DJG, Riccio A, Maher ER
Nat Rev Endocrinol 2018 Apr;14(4):229-249. Epub 2018 Jan 29 doi: 10.1038/nrendo.2017.166. PMID: 29377879Free PMC Article

Recent clinical studies

Etiology

Manso L, Ramchandani-Vaswani A, Romero I, Sánchez-Lorenzo L, Bermejo-Pérez MJ, Estévez-García P, Fariña-Madrid L, García García Y, Gil-Martin M, Quindós M
Clin Transl Oncol 2024 Nov;26(11):2771-2782. Epub 2024 Aug 31 doi: 10.1007/s12094-024-03604-3. PMID: 39215938Free PMC Article
van Goor IWJM, Andel PCM, Buijs FS, Besselink MG, Bonsing BA, Bosscha K, Busch OR, Cirkel GA, van Dam RM, Festen S, Koerkamp BG, van der Harst E, de Hingh IHJT, Kazemier G, Liem MSL, Meijer G, de Meijer VE, Nieuwenhuijs VB, Roos D, Schreinemakers JMJ, Stommel MWJ, Wit F, Verdonk RC, van Santvoort HC, Molenaar IQ, Intven MPW, Daamen LA; Dutch Pancreatic Cancer Group
Ann Surg Oncol 2024 Nov;31(12):8264-8275. Epub 2024 Jun 27 doi: 10.1245/s10434-024-15664-4. PMID: 38937412Free PMC Article
Tseng I, Ai D, Chen Y, Zhu H, Li F, Xu Y, Yu L, Liu Q, Deng J, Hao S, Zhu Z, Zhao W, Fan M, Li L, Su F, Zhao K
Radiat Oncol 2023 Oct 19;18(1):172. doi: 10.1186/s13014-023-02354-w. PMID: 37858121Free PMC Article
Mrosk F, Doll C, Scheer J, Neumann F, Hofmann E, Kreutzer K, Voss J, Rubarth K, Beck M, Heiland M, Koerdt S
JAMA Otolaryngol Head Neck Surg 2023 Nov 1;149(11):1027-1033. doi: 10.1001/jamaoto.2023.3111. PMID: 37824130Free PMC Article
Yin C, Hu B, Yang X, Kou L, Tian B, Wang C, Li S, Liu B, Ge J
World J Surg Oncol 2023 Sep 26;21(1):304. doi: 10.1186/s12957-023-03194-4. PMID: 37749594Free PMC Article

Diagnosis

Manso L, Ramchandani-Vaswani A, Romero I, Sánchez-Lorenzo L, Bermejo-Pérez MJ, Estévez-García P, Fariña-Madrid L, García García Y, Gil-Martin M, Quindós M
Clin Transl Oncol 2024 Nov;26(11):2771-2782. Epub 2024 Aug 31 doi: 10.1007/s12094-024-03604-3. PMID: 39215938Free PMC Article
Rivera F, Longo F, Martín Richard M, Richart P, Alsina M, Carmona A, Custodio AB, Fernández Montes A, Gallego J, Fleitas Kanonnikoff T
Clin Transl Oncol 2024 Nov;26(11):2826-2840. Epub 2024 Jul 18 doi: 10.1007/s12094-024-03600-7. PMID: 39023829Free PMC Article
Arranz Arija JA, Del Muro XG, Caro RL, Méndez-Vidal MJ, Pérez-Valderrama B, Aparicio J, Climent Durán MÁ, Caballero Díaz C, Durán I, González-Billalabeitia E
Clin Transl Oncol 2024 Nov;26(11):2783-2799. Epub 2024 Jul 3 doi: 10.1007/s12094-024-03532-2. PMID: 38958901Free PMC Article
López CL, Calvo M, Cámara JC, García-Paredes B, Gómez-Martin C, López AM, Pazo-Cid R, Sastre J, Yaya R, Feliu J
Clin Transl Oncol 2024 Nov;26(11):2800-2811. Epub 2024 Jun 24 doi: 10.1007/s12094-024-03568-4. PMID: 38914756Free PMC Article
Yin C, Hu B, Yang X, Kou L, Tian B, Wang C, Li S, Liu B, Ge J
World J Surg Oncol 2023 Sep 26;21(1):304. doi: 10.1186/s12957-023-03194-4. PMID: 37749594Free PMC Article

Therapy

Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Hopstaken JS, Bomers JGR, Sedelaar MJP, Valerio M, Fütterer JJ, Rovers MM
Eur Urol 2022 Jan;81(1):5-33. Epub 2021 Sep 4 doi: 10.1016/j.eururo.2021.08.005. PMID: 34489140
Vale CL, Fisher D, Kneebone A, Parker C, Pearse M, Richaud P, Sargos P, Sydes MR, Brawley C, Brihoum M, Brown C, Chabaud S, Cook A, Forcat S, Fraser-Browne C, Latorzeff I, Parmar MKB, Tierney JF; ARTISTIC Meta-analysis Group
Lancet 2020 Oct 31;396(10260):1422-1431. Epub 2020 Sep 28 doi: 10.1016/S0140-6736(20)31952-8. PMID: 33002431Free PMC Article
Mayadev J, Nunes AT, Li M, Marcovitz M, Lanasa MC, Monk BJ
Int J Gynecol Cancer 2020 Jul;30(7):1065-1070. Epub 2020 May 23 doi: 10.1136/ijgc-2019-001135. PMID: 32447296Free PMC Article
Chargari C, Deutsch E, Blanchard P, Gouy S, Martelli H, Guérin F, Dumas I, Bossi A, Morice P, Viswanathan AN, Haie-Meder C
CA Cancer J Clin 2019 Sep;69(5):386-401. Epub 2019 Jul 30 doi: 10.3322/caac.21578. PMID: 31361333

Prognosis

Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
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Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261
Maloney DG
Curr Opin Hematol 1995 Jul;2(4):255-61. doi: 10.1097/00062752-199502040-00004. PMID: 9372005

Clinical prediction guides

Wang W, Peng Y, Feng X, Zhao Y, Seeruttun SR, Zhang J, Cheng Z, Li Y, Liu Z, Zhou Z
JAMA Netw Open 2021 Aug 2;4(8):e2121143. doi: 10.1001/jamanetworkopen.2021.21143. PMID: 34410397Free PMC Article
Jiang M, Li CL, Luo XM, Chuan ZR, Lv WZ, Li X, Cui XW, Dietrich CF
Eur J Cancer 2021 Apr;147:95-105. Epub 2021 Feb 24 doi: 10.1016/j.ejca.2021.01.028. PMID: 33639324
Gaiser MR, von Bubnoff N, Gebhardt C, Utikal JS
J Dtsch Dermatol Ges 2018 Apr;16(4):405-414. Epub 2018 Mar 7 doi: 10.1111/ddg.13461. PMID: 29512873
Fridman WH, Zitvogel L, Sautès-Fridman C, Kroemer G
Nat Rev Clin Oncol 2017 Dec;14(12):717-734. Epub 2017 Jul 25 doi: 10.1038/nrclinonc.2017.101. PMID: 28741618
Offersen BV, Boersma LJ, Kirkove C, Hol S, Aznar MC, Biete Sola A, Kirova YM, Pignol JP, Remouchamps V, Verhoeven K, Weltens C, Arenas M, Gabrys D, Kopek N, Krause M, Lundstedt D, Marinko T, Montero A, Yarnold J, Poortmans P
Radiother Oncol 2015 Jan;114(1):3-10. Epub 2015 Jan 24 doi: 10.1016/j.radonc.2014.11.030. PMID: 25630428

Recent systematic reviews

Madariaga A, Lau J, Ghoshal A, Dzierżanowski T, Larkin P, Sobocki J, Dickman A, Furness K, Fazelzad R, Crawford GB, Lheureux S
Support Care Cancer 2022 Jun;30(6):4711-4728. Epub 2022 Mar 10 doi: 10.1007/s00520-022-06889-8. PMID: 35274188Free PMC Article
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Gosavi R, Chia C, Michael M, Heriot AG, Warrier SK, Kong JC
Int J Colorectal Dis 2021 Oct;36(10):2063-2070. Epub 2021 May 4 doi: 10.1007/s00384-021-03945-3. PMID: 33945007
Kasi A, Abbasi S, Handa S, Al-Rajabi R, Saeed A, Baranda J, Sun W
JAMA Netw Open 2020 Dec 1;3(12):e2030097. doi: 10.1001/jamanetworkopen.2020.30097. PMID: 33326026Free PMC Article
Vale CL, Fisher D, Kneebone A, Parker C, Pearse M, Richaud P, Sargos P, Sydes MR, Brawley C, Brihoum M, Brown C, Chabaud S, Cook A, Forcat S, Fraser-Browne C, Latorzeff I, Parmar MKB, Tierney JF; ARTISTIC Meta-analysis Group
Lancet 2020 Oct 31;396(10260):1422-1431. Epub 2020 Sep 28 doi: 10.1016/S0140-6736(20)31952-8. PMID: 33002431Free PMC Article

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