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Smoker-inclusions in alveolar macrophages

MedGen UID:
1714914
Concept ID:
C5397978
Finding
HPO: HP:0032986

Definition

In otherwise healthy smokers, characteristic so called smoker-inclusion can be found within the macrophages in the bronchoalveolar fluid. These blue/ black/ round/ oval cytoplasmic inclusions consist of pigmented lipid deposits. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Park JA
Int J Mol Sci 2021 Jan 14;22(2) doi: 10.3390/ijms22020793. PMID: 33466873Free PMC Article
Gopalaswamy R, Shanmugam S, Mondal R, Subbian S
J Biomed Sci 2020 Jun 17;27(1):74. doi: 10.1186/s12929-020-00667-6. PMID: 32552732Free PMC Article
Heukels P, Moor CC, von der Thüsen JH, Wijsenbeek MS, Kool M
Respir Med 2019 Feb;147:79-91. Epub 2019 Jan 9 doi: 10.1016/j.rmed.2018.12.015. PMID: 30704705

Recent clinical studies

Etiology

Malainou C, Abdin SM, Lachmann N, Matt U, Herold S
J Clin Invest 2023 Oct 2;133(19) doi: 10.1172/JCI170501. PMID: 37781922Free PMC Article
Lugg ST, Scott A, Parekh D, Naidu B, Thickett DR
Thorax 2022 Jan;77(1):94-101. Epub 2021 May 13 doi: 10.1136/thoraxjnl-2020-216296. PMID: 33986144Free PMC Article
Grant RA, Morales-Nebreda L, Markov NS, Swaminathan S, Querrey M, Guzman ER, Abbott DA, Donnelly HK, Donayre A, Goldberg IA, Klug ZM, Borkowski N, Lu Z, Kihshen H, Politanska Y, Sichizya L, Kang M, Shilatifard A, Qi C, Lomasney JW, Argento AC, Kruser JM, Malsin ES, Pickens CO, Smith SB, Walter JM, Pawlowski AE, Schneider D, Nannapaneni P, Abdala-Valencia H, Bharat A, Gottardi CJ, Budinger GRS, Misharin AV, Singer BD, Wunderink RG; NU SCRIPT Study Investigators
Nature 2021 Feb;590(7847):635-641. Epub 2021 Jan 11 doi: 10.1038/s41586-020-03148-w. PMID: 33429418Free PMC Article
Williams CM, Lundblad LK
Pulm Pharmacol Ther 2012 Aug;25(4):255-6. Epub 2012 Mar 24 doi: 10.1016/j.pupt.2012.03.004. PMID: 22465563
Ziegenhagen MW, Müller-Quernheim J
J Intern Med 2003 Jan;253(1):18-30. doi: 10.1046/j.1365-2796.2003.01074.x. PMID: 12588535

Diagnosis

Prieto LI, Sturmlechner I, Graves SI, Zhang C, Goplen NP, Yi ES, Sun J, Li H, Baker DJ
Cancer Cell 2023 Jul 10;41(7):1261-1275.e6. Epub 2023 Jun 1 doi: 10.1016/j.ccell.2023.05.006. PMID: 37267954Free PMC Article
Bo H, Moure UAE, Yang Y, Pan J, Li L, Wang M, Ke X, Cui H
Front Cell Infect Microbiol 2023;13:1062963. Epub 2023 Mar 3 doi: 10.3389/fcimb.2023.1062963. PMID: 36936766Free PMC Article
Kho SS, Ganapaty S, Omar N, Tan SZ, Nasarudin MZ, Abdul Rahaman JA
Thorax 2022 Aug;77(8):842-843. Epub 2022 Mar 18 doi: 10.1136/thoraxjnl-2021-217940. PMID: 35304426
Sordillo J, Raby BA
Adv Exp Med Biol 2014;795:157-81. doi: 10.1007/978-1-4614-8603-9_10. PMID: 24162908
Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED
Drug Saf 2010 Jul 1;33(7):539-58. doi: 10.2165/11532320-000000000-00000. PMID: 20553056

Therapy

Wołoszczak J, Wrześniewska M, Hrapkowicz A, Janowska K, Szydziak J, Gomułka K
Int J Mol Sci 2024 Jun 28;25(13) doi: 10.3390/ijms25137092. PMID: 39000201Free PMC Article
Lugg ST, Scott A, Parekh D, Naidu B, Thickett DR
Thorax 2022 Jan;77(1):94-101. Epub 2021 May 13 doi: 10.1136/thoraxjnl-2020-216296. PMID: 33986144Free PMC Article
Ogger PP, Albers GJ, Hewitt RJ, O'Sullivan BJ, Powell JE, Calamita E, Ghai P, Walker SA, McErlean P, Saunders P, Kingston S, Molyneaux PL, Halket JM, Gray R, Chambers DC, Maher TM, Lloyd CM, Byrne AJ
Sci Immunol 2020 Oct 23;5(52) doi: 10.1126/sciimmunol.abc1884. PMID: 33097591Free PMC Article
Urdahl KB
Semin Immunol 2014 Dec;26(6):578-87. Epub 2014 Oct 28 doi: 10.1016/j.smim.2014.10.003. PMID: 25453230Free PMC Article
Sorenson WG
Environ Health Perspect 1999 Jun;107 Suppl 3(Suppl 3):469-72. doi: 10.1289/ehp.99107s3469. PMID: 10423389Free PMC Article

Prognosis

Malainou C, Abdin SM, Lachmann N, Matt U, Herold S
J Clin Invest 2023 Oct 2;133(19) doi: 10.1172/JCI170501. PMID: 37781922Free PMC Article
Perrot CY, Karampitsakos T, Herazo-Maya JD
Am J Physiol Cell Physiol 2023 Oct 1;325(4):C1046-C1057. Epub 2023 Sep 11 doi: 10.1152/ajpcell.00302.2023. PMID: 37694283Free PMC Article
Bikle DD
Curr Osteoporos Rep 2022 Jun;20(3):186-193. Epub 2022 May 4 doi: 10.1007/s11914-022-00732-z. PMID: 35507293Free PMC Article
McCarthy C, Carey BC, Trapnell BC
Am J Respir Crit Care Med 2022 May 1;205(9):1016-1035. doi: 10.1164/rccm.202112-2742SO. PMID: 35227171Free PMC Article
Gigliotti F, Wright TW
Expert Rev Mol Med 2005 Nov 14;7(26):1-16. doi: 10.1017/S1462399405010203. PMID: 16842636

Clinical prediction guides

Arias AA, Neehus AL, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J, Corcini Berndt M, Rojas J, Li H, Rinchai D, Erazo-Borrás L, Han JE, Pillay B, Ponsin K, Chaldebas M, Philippot Q, Bohlen J, Rosain J, Le Voyer T, Janotte T, Amarajeeva K, Soudée C, Brollo M, Wiegmann K, Marquant Q, Seeleuthner Y, Lee D, Lainé C, Kloos D, Bailey R, Bastard P, Keating N, Rapaport F, Khan T, Moncada-Vélez M, Carmona MC, Obando C, Alvarez J, Cataño JC, Martínez-Rosado LL, Sanchez JP, Tejada-Giraldo M, L'Honneur AS, Agudelo ML, Perez-Zapata LJ, Arboleda DM, Alzate JF, Cabarcas F, Zuluaga A, Pelham SJ, Ensser A, Schmidt M, Velásquez-Lopera MM, Jouanguy E, Puel A, Krönke M, Ghirardello S, Borghesi A, Pahari S, Boisson B, Pittaluga S, Ma CS, Emile JF, Notarangelo LD, Tangye SG, Marr N, Lachmann N, Salvator H, Schlesinger LS, Zhang P, Glickman MS, Nathan CF, Geissmann F, Abel L, Franco JL, Bustamante J, Casanova JL, Boisson-Dupuis S
Nature 2024 Sep;633(8029):417-425. Epub 2024 Aug 28 doi: 10.1038/s41586-024-07866-3. PMID: 39198650Free PMC Article
Li X, Kolling FW, Aridgides D, Mellinger D, Ashare A, Jakubzick CV
Life Sci Alliance 2022 Nov;5(11) Epub 2022 Jul 12 doi: 10.26508/lsa.202201458. PMID: 35820705Free PMC Article
Dong T, Chen X, Xu H, Song Y, Wang H, Gao Y, Wang J, Du R, Lou H, Dong T
Pharmacol Ther 2022 Nov;239:108208. Epub 2022 May 13 doi: 10.1016/j.pharmthera.2022.108208. PMID: 35569553
Liu X, Gao C, Wang Y, Niu L, Jiang S, Pan S
Oxid Med Cell Longev 2021;2021:9973457. Epub 2021 Jun 13 doi: 10.1155/2021/9973457. PMID: 34234888Free PMC Article
Todd EM, Ramani R, Szasz TP, Morley SC
Sci Adv 2019 Aug;5(8):eaax3387. Epub 2019 Aug 14 doi: 10.1126/sciadv.aax3387. PMID: 31453341Free PMC Article

Recent systematic reviews

Fukasawa T, Yoshizaki-Ogawa A, Enomoto A, Yamashita T, Miyagawa K, Sato S, Yoshizaki A
Immunol Med 2024 Sep;47(3):118-129. Epub 2024 May 31 doi: 10.1080/25785826.2024.2360690. PMID: 38818750
Torres AJL, Marchioro SB, Ribeiro MB, de Morais IRB, Freire SM, Nascimento RJM
Crit Rev Immunol 2021;41(3):15-25. doi: 10.1615/CritRevImmunol.2021039675. PMID: 35378008
Chen HJ, Li Yim AYF, Griffith GR, de Jonge WJ, Mannens MMAM, Ferrero E, Henneman P, de Winther MPJ
Front Immunol 2019;10:2887. Epub 2019 Dec 11 doi: 10.3389/fimmu.2019.02887. PMID: 31921150Free PMC Article
Thompson CM, Suh M, Mittal L, Wikoff DS, Welsh B, Proctor DM
Regul Toxicol Pharmacol 2016 Oct;80:60-70. Epub 2016 May 24 doi: 10.1016/j.yrtph.2016.05.031. PMID: 27233922
Lee A, Kinney P, Chillrud S, Jack D
Ann Glob Health 2015 May-Jun;81(3):368-74. doi: 10.1016/j.aogh.2015.08.006. PMID: 26615071Free PMC Article

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      Smoker-inclusions in alveolar macrophages
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    • Fatty Acids
      Fatty Acids
      Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsat...<br/>Year introduced: /metabolism was FATTY ACID METABOLISM 1965
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