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Abnormal alveolar macrophage morphology

MedGen UID:
1717121
•Concept ID:
C5397976
•
Cell or Molecular Dysfunction
HPO: HP:0032984

Definition

Alveolar macrophages usually make up the majority of cells in the bronchoalveolar space (over 80%). The may contain intracellular material depending on underlying diseases or due to exposition to inhaled particles. [from HPO]

Professional guidelines

PubMed

Cytokine modulation in patients with idiopathic pulmonary fibrosis undergoing treatment with steroids, immunosuppressants, and IFN-γ 1b.
Marinari S, De Iuliis V, Dadorante V, Colella S, Marino A, Nunziata A, Flati V, Caruso M, Pennelli A, De Benedetto F, Matera S, Capodifoglio S, Martinotti S, Caputi S, Toniato E
J Biol Regul Homeost Agents 2017 Jan-Mar;31(1):59-69. PMID: 28337871
Pulmonary alveolar proteinosis during a 30-year observation. Diagnosis and treatment.
Fijołek J, Wiatr E, Radzikowska E, Bestry I, Langfort R, Polubiec-Kownacka M, Prokopowicz J, Roszkowski-Śliż K
Pneumonol Alergol Pol 2014;82(3):206-17. doi: 10.5603/PiAP.2014.0028. PMID: 24793148
Alveolar hemorrhage. Diagnostic criteria and results in 194 immunocompromised hosts.
De Lassence A, Fleury-Feith J, Escudier E, Beaune J, Bernaudin JF, Cordonnier C
Am J Respir Crit Care Med 1995 Jan;151(1):157-63. doi: 10.1164/ajrccm.151.1.7812547. PMID: 7812547

Recent clinical studies

Etiology

Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis.
Sakaue S, Yamaguchi E, Inoue Y, Takahashi M, Hirata J, Suzuki K, Ito S, Arai T, Hirose M, Tanino Y, Nikaido T, Ichiwata T, Ohkouchi S, Hirano T, Takada T, Miyawaki S, Dofuku S, Maeda Y, Nii T, Kishikawa T, Ogawa K, Masuda T, Yamamoto K, Sonehara K, Tazawa R, Morimoto K, Takaki M, Konno S, Suzuki M, Tomii K, Nakagawa A, Handa T, Tanizawa K, Ishii H, Ishida M, Kato T, Takeda N, Yokomura K, Matsui T, Watanabe M, Inoue H, Imaizumi K, Goto Y, Kida H, Fujisawa T, Suda T, Yamada T, Satake Y, Ibata H, Hizawa N, Mochizuki H, Kumanogoh A, Matsuda F, Nakata K, Hirota T, Tamari M, Okada Y
Nat Commun 2021 Feb 15;12(1):1032. doi: 10.1038/s41467-021-21011-y. PMID: 33589587Free PMC Article
Inhaled GM-CSF for Pulmonary Alveolar Proteinosis.
Tazawa R, Ueda T, Abe M, Tatsumi K, Eda R, Kondoh S, Morimoto K, Tanaka T, Yamaguchi E, Takahashi A, Oda M, Ishii H, Izumi S, Sugiyama H, Nakagawa A, Tomii K, Suzuki M, Konno S, Ohkouchi S, Tode N, Handa T, Hirai T, Inoue Y, Arai T, Asakawa K, Sakagami T, Hashimoto A, Tanaka T, Takada T, Mikami A, Kitamura N, Nakata K
N Engl J Med 2019 Sep 5;381(10):923-932. doi: 10.1056/NEJMoa1816216. PMID: 31483963
Atypical image of pulmonary alveolar proteinosis - a case report.
Fijołek J, Wiatr E, Opoka L, Rudziński P, Nierebińska M, Szołkowska M, Roszkowski-Śliż K
Pneumonol Alergol Pol 2015;83(6):453-6. doi: 10.5603/PiAP.2015.0074. PMID: 26559798
Imaging of macrophage-related lung diseases.
Marten K, Hansell DM
Eur Radiol 2005 Apr;15(4):727-41. Epub 2005 Jan 5 doi: 10.1007/s00330-004-2554-3. PMID: 15633061
Aspiration complicating bronchopulmonary dysplasia.
Radford PJ, Stillwell PC, Blue B, Hertel G
Chest 1995 Jan;107(1):185-8. doi: 10.1378/chest.107.1.185. PMID: 7813274

Diagnosis

Clofazimine pulmonary crystal deposition syndrome: a case of pseudo haemoptysis.
Rechal R, Prasad VP, Shah M, Maturu VN
BMJ Case Rep 2024 Jul 16;17(7) doi: 10.1136/bcr-2024-261340. PMID: 39013623
Autoimmune Pulmonary Alveolar Proteinosis.
McCarthy C, Carey BC, Trapnell BC
Am J Respir Crit Care Med 2022 May 1;205(9):1016-1035. doi: 10.1164/rccm.202112-2742SO. PMID: 35227171Free PMC Article
A unique, histopathologic lesion in a subset of patients with spontaneous pneumothorax.
Belchis DA, Shekitka K, Gocke CD
Arch Pathol Lab Med 2012 Dec;136(12):1522-7. doi: 10.5858/arpa.2012-0330-OA. PMID: 23194045
Pulmonary pathology.
deMello DE
Semin Neonatol 2004 Aug;9(4):311-29. doi: 10.1016/j.siny.2003.12.001. PMID: 15251148
Aspiration complicating bronchopulmonary dysplasia.
Radford PJ, Stillwell PC, Blue B, Hertel G
Chest 1995 Jan;107(1):185-8. doi: 10.1378/chest.107.1.185. PMID: 7813274

Therapy

Autoimmune Pulmonary Alveolar Proteinosis.
McCarthy C, Carey BC, Trapnell BC
Am J Respir Crit Care Med 2022 May 1;205(9):1016-1035. doi: 10.1164/rccm.202112-2742SO. PMID: 35227171Free PMC Article
Inhaled GM-CSF for Pulmonary Alveolar Proteinosis.
Tazawa R, Ueda T, Abe M, Tatsumi K, Eda R, Kondoh S, Morimoto K, Tanaka T, Yamaguchi E, Takahashi A, Oda M, Ishii H, Izumi S, Sugiyama H, Nakagawa A, Tomii K, Suzuki M, Konno S, Ohkouchi S, Tode N, Handa T, Hirai T, Inoue Y, Arai T, Asakawa K, Sakagami T, Hashimoto A, Tanaka T, Takada T, Mikami A, Kitamura N, Nakata K
N Engl J Med 2019 Sep 5;381(10):923-932. doi: 10.1056/NEJMoa1816216. PMID: 31483963
Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis.
Craig VJ, Zhang L, Hagood JS, Owen CA
Am J Respir Cell Mol Biol 2015 Nov;53(5):585-600. doi: 10.1165/rcmb.2015-0020TR. PMID: 26121236Free PMC Article
Pathogenesis of chronic obstructive pulmonary disease.
MacNee W
Proc Am Thorac Soc 2005;2(4):258-66; discussion 290-1. doi: 10.1513/pats.200504-045SR. PMID: 16267346Free PMC Article
Leucoencephalopathy after inhaling "heroin" pyrolysate.
Wolters EC, van Wijngaarden GK, Stam FC, Rengelink H, Lousberg RJ, Schipper ME, Verbeeten B
Lancet 1982 Dec 4;2(8310):1233-7. doi: 10.1016/s0140-6736(82)90101-5. PMID: 6128545

Prognosis

Monocytes and macrophages: emerging mechanisms and novel therapeutic targets in pulmonary fibrosis.
Perrot CY, Karampitsakos T, Herazo-Maya JD
Am J Physiol Cell Physiol 2023 Oct 1;325(4):C1046-C1057. Epub 2023 Sep 11 doi: 10.1152/ajpcell.00302.2023. PMID: 37694283Free PMC Article
Autoimmune Pulmonary Alveolar Proteinosis.
McCarthy C, Carey BC, Trapnell BC
Am J Respir Crit Care Med 2022 May 1;205(9):1016-1035. doi: 10.1164/rccm.202112-2742SO. PMID: 35227171Free PMC Article
Subclinical pulmonary haemorrhage causing a restrictive lung defect in three siblings with a unique urticarial vasculitis syndrome.
Al Riyami BM, Al Kaabi JK, Elagib EM, El Khatim HS, Woodhouse NJ
Clin Rheumatol 2003 Oct;22(4-5):309-13. doi: 10.1007/s10067-003-0738-x. PMID: 14579162
Focal congenital alveolar proteinosis associated with abnormal surfactant protein B messenger RNA.
Mildenberger E, deMello DE, Lin Z, Kössel H, Hoehn T, Versmold HT
Chest 2001 Feb;119(2):645-7. doi: 10.1378/chest.119.2.645. PMID: 11171752
Subclinical alveolitis in immunologic systemic disorders.
Wallaert B
Lung 1990;168 Suppl:974-83. doi: 10.1007/BF02718235. PMID: 2117218

Clinical prediction guides

A detailed insight into macrophages' role in shaping lung carcinogenesis.
Aktar T, Modak S, Majumder D, Maiti D
Life Sci 2024 Sep 1;352:122896. Epub 2024 Jul 6 doi: 10.1016/j.lfs.2024.122896. PMID: 38972632
Idiopathic pulmonary hemosiderosis and stroke secondary to protein C deficiency in a child with Down syndrome: a case report.
Ajmi H, Bouafsoun C, Arifa N, Chemli J, Abroug S
J Med Case Rep 2023 Mar 11;17(1):105. doi: 10.1186/s13256-023-03807-2. PMID: 36899396Free PMC Article
Successful treatment with idarucizumab for diffuse alveolar hemorrhage induced by dabigatran etexilate: a case report.
Shiroshita A, Nakashima K, Tanaka Y, Tateishi A, Nemoto M, Aoshima M
J Thromb Thrombolysis 2018 Aug;46(2):271-273. doi: 10.1007/s11239-018-1676-4. PMID: 29740732
Alveolar lipoproteinosis in lung allograft recipients.
Yousem SA
Hum Pathol 1997 Dec;28(12):1383-6. doi: 10.1016/s0046-8177(97)90228-8. PMID: 9416695
Leucoencephalopathy after inhaling "heroin" pyrolysate.
Wolters EC, van Wijngaarden GK, Stam FC, Rengelink H, Lousberg RJ, Schipper ME, Verbeeten B
Lancet 1982 Dec 4;2(8310):1233-7. doi: 10.1016/s0140-6736(82)90101-5. PMID: 6128545

Recent systematic reviews

Single cell analysis in systemic sclerosis - A systematic review.
Fukasawa T, Yoshizaki-Ogawa A, Enomoto A, Yamashita T, Miyagawa K, Sato S, Yoshizaki A
Immunol Med 2024 Sep;47(3):118-129. Epub 2024 May 31 doi: 10.1080/25785826.2024.2360690. PMID: 38818750
The association between marijuana smoking and lung cancer: a systematic review.
Mehra R, Moore BA, Crothers K, Tetrault J, Fiellin DA
Arch Intern Med 2006 Jul 10;166(13):1359-67. doi: 10.1001/archinte.166.13.1359. PMID: 16832000

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