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Metastatic Endometrial Serous Adenocarcinoma

MedGen UID:
1732879
•Concept ID:
C5418808
•
Neoplastic Process

Definition

An endometrial serous adenocarcinoma that has spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Endometrial Serous Adenocarcinoma

Professional guidelines

PubMed

International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Uterine papillary serous carcinoma: epidemiology, pathogenesis and management.
Fader AN, Boruta D, Olawaiye AB, Gehrig PA
Curr Opin Obstet Gynecol 2010 Feb;22(1):21-9. doi: 10.1097/GCO.0b013e328334d8a3. PMID: 19952744
Clear-cell and papillary serous cancer: treatment options.
Tropé C, Kristensen GB, Abeler VM
Best Pract Res Clin Obstet Gynaecol 2001 Jun;15(3):433-46. doi: 10.1053/beog.2000.0187. PMID: 11476564

Recent clinical studies

Etiology

Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis.
Fader AN, Roque DM, Siegel E, Buza N, Hui P, Abdelghany O, Chambers S, Secord AA, Havrilesky L, O'Malley DM, Backes FJ, Nevadunsky N, Edraki B, Pikaart D, Lowery W, ElSahwi K, Celano P, Bellone S, Azodi M, Litkouhi B, Ratner E, Silasi DA, Schwartz PE, Santin AD
Clin Cancer Res 2020 Aug 1;26(15):3928-3935. Epub 2020 Jun 29 doi: 10.1158/1078-0432.CCR-20-0953. PMID: 32601075Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Bone metastases in endometrial cancer: report on 19 patients and review of the medical literature.
Uccella S, Morris JM, Bakkum-Gamez JN, Keeney GL, Podratz KC, Mariani A
Gynecol Oncol 2013 Sep;130(3):474-82. Epub 2013 May 15 doi: 10.1016/j.ygyno.2013.05.010. PMID: 23685013Free PMC Article

Diagnosis

Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis.
Fader AN, Roque DM, Siegel E, Buza N, Hui P, Abdelghany O, Chambers S, Secord AA, Havrilesky L, O'Malley DM, Backes FJ, Nevadunsky N, Edraki B, Pikaart D, Lowery W, ElSahwi K, Celano P, Bellone S, Azodi M, Litkouhi B, Ratner E, Silasi DA, Schwartz PE, Santin AD
Clin Cancer Res 2020 Aug 1;26(15):3928-3935. Epub 2020 Jun 29 doi: 10.1158/1078-0432.CCR-20-0953. PMID: 32601075Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Endometrial carcinomas: a review emphasizing overlapping and distinctive morphological and immunohistochemical features.
Bartosch C, Manuel Lopes J, Oliva E
Adv Anat Pathol 2011 Nov;18(6):415-37. doi: 10.1097/PAP.0b013e318234ab18. PMID: 21993268

Therapy

Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis.
Fader AN, Roque DM, Siegel E, Buza N, Hui P, Abdelghany O, Chambers S, Secord AA, Havrilesky L, O'Malley DM, Backes FJ, Nevadunsky N, Edraki B, Pikaart D, Lowery W, ElSahwi K, Celano P, Bellone S, Azodi M, Litkouhi B, Ratner E, Silasi DA, Schwartz PE, Santin AD
Clin Cancer Res 2020 Aug 1;26(15):3928-3935. Epub 2020 Jun 29 doi: 10.1158/1078-0432.CCR-20-0953. PMID: 32601075Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Development of targeted therapy in uterine serous carcinoma, a biologically aggressive variant of endometrial cancer.
El-Sahwi KS, Schwartz PE, Santin AD
Expert Rev Anticancer Ther 2012 Jan;12(1):41-9. doi: 10.1586/era.11.192. PMID: 22149431Free PMC Article
Systemic therapy in metastatic or recurrent endometrial cancer.
Pectasides D, Pectasides E, Economopoulos T
Cancer Treat Rev 2007 Apr;33(2):177-90. Epub 2006 Dec 29 doi: 10.1016/j.ctrv.2006.10.007. PMID: 17196749
Clear-cell and papillary serous cancer: treatment options.
Tropé C, Kristensen GB, Abeler VM
Best Pract Res Clin Obstet Gynaecol 2001 Jun;15(3):433-46. doi: 10.1053/beog.2000.0187. PMID: 11476564

Prognosis

Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis.
Fader AN, Roque DM, Siegel E, Buza N, Hui P, Abdelghany O, Chambers S, Secord AA, Havrilesky L, O'Malley DM, Backes FJ, Nevadunsky N, Edraki B, Pikaart D, Lowery W, ElSahwi K, Celano P, Bellone S, Azodi M, Litkouhi B, Ratner E, Silasi DA, Schwartz PE, Santin AD
Clin Cancer Res 2020 Aug 1;26(15):3928-3935. Epub 2020 Jun 29 doi: 10.1158/1078-0432.CCR-20-0953. PMID: 32601075Free PMC Article
p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Singh N, Piskorz AM, Bosse T, Jimenez-Linan M, Rous B, Brenton JD, Gilks CB, Köbel M
J Pathol 2020 Mar;250(3):336-345. Epub 2020 Jan 29 doi: 10.1002/path.5375. PMID: 31829441
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Endometrial metaplasias and reactive changes: a spectrum of altered differentiation.
Nicolae A, Preda O, Nogales FF
J Clin Pathol 2011 Feb;64(2):97-106. Epub 2010 Dec 1 doi: 10.1136/jcp.2010.085555. PMID: 21126963

Clinical prediction guides

p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Singh N, Piskorz AM, Bosse T, Jimenez-Linan M, Rous B, Brenton JD, Gilks CB, Köbel M
J Pathol 2020 Mar;250(3):336-345. Epub 2020 Jan 29 doi: 10.1002/path.5375. PMID: 31829441
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Endometrial giant cell carcinoma: a case series and review of the spectrum of endometrial neoplasms containing giant cells.
Mulligan AM, Plotkin A, Rouzbahman M, Soslow RA, Gilks CB, Clarke BA
Am J Surg Pathol 2010 Aug;34(8):1132-8. doi: 10.1097/PAS.0b013e3181e6579c. PMID: 20588176
Uterine papillary serous carcinoma: epidemiology, pathogenesis and management.
Fader AN, Boruta D, Olawaiye AB, Gehrig PA
Curr Opin Obstet Gynecol 2010 Feb;22(1):21-9. doi: 10.1097/GCO.0b013e328334d8a3. PMID: 19952744

Recent systematic reviews

Incidence of omental metastasis in uterine serous carcinoma: a systematic review and meta-analysis.
Xu H, Cui SS, Ran L, Liu Y, Hu C, Xu Y, Tian Y
J Gynecol Obstet Hum Reprod 2022 Jun;51(6):102395. Epub 2022 Apr 28 doi: 10.1016/j.jogoh.2022.102395. PMID: 35489712

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