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Advanced Biliary Tract Carcinoma

MedGen UID:
1737009
•Concept ID:
C5401308
•
Neoplastic Process

Definition

Carcinoma that arises from the intrahepatic, hilar, extrahepatic bile ducts, cystic duct, or gallbladder and has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Mutational spectrum for guiding the decision of adjuvant treatment in patients with resected biliary tract carcinoma.
Li Y, Tan C, Yin X, Zhu S, Cai R, Liao C, Wu Y, Zeng Q, Cai C, Xie W, He X, Wen HQ, Lin G, He Q, He T, Gu P, Liu CJ
Cancer Med 2023 Aug;12(15):16076-16086. Epub 2023 Jun 21 doi: 10.1002/cam4.6261. PMID: 37341068Free PMC Article
Treatment of biliary tract carcinoma over the last 30 years.
Midorikawa Y
Biosci Trends 2022 Jul 20;16(3):189-197. Epub 2022 Jun 23 doi: 10.5582/bst.2022.01267. PMID: 35732436
Systemic treatment options for advanced biliary tract carcinoma.
Xie C, McGrath NA, Monge Bonilla C, Fu J
J Gastroenterol 2020 Oct;55(10):944-957. Epub 2020 Aug 3 doi: 10.1007/s00535-020-01712-9. PMID: 32748173Free PMC Article

Recent clinical studies

Etiology

Clinical characteristics of liver injury induced by immune checkpoint inhibitors in patients with advanced biliary tract carcinoma.
Gao Z, Wu S, Yang Y, Sun M, Tian X, Jin X
Invest New Drugs 2023 Oct;41(5):719-726. Epub 2023 Aug 17 doi: 10.1007/s10637-023-01391-2. PMID: 37589864
Mutational spectrum for guiding the decision of adjuvant treatment in patients with resected biliary tract carcinoma.
Li Y, Tan C, Yin X, Zhu S, Cai R, Liao C, Wu Y, Zeng Q, Cai C, Xie W, He X, Wen HQ, Lin G, He Q, He T, Gu P, Liu CJ
Cancer Med 2023 Aug;12(15):16076-16086. Epub 2023 Jun 21 doi: 10.1002/cam4.6261. PMID: 37341068Free PMC Article
Effectiveness and safety of radiotherapy plus programmed death-1 inhibitors and lenvatinib in patients with advanced biliary tract carcinoma: a real-world study.
Wang Y, Yang X, Wang Y, Xue J, Zhang N, Yang X, Cong N, Zhang J, Zhu C, Zhang L, Hou X, Zhao H
Cancer Immunol Immunother 2023 Jul;72(7):2197-2204. Epub 2023 Mar 1 doi: 10.1007/s00262-023-03399-2. PMID: 36856834Free PMC Article
The Effect of Inflammatory Markers on Survival in Advanced Biliary Tract Carcinoma Treated with Gemcitabine/Oxaliplatin Regimen.
Buyuksimsek M, Kidi MM, Ogul A, Mirili C, Paydas S
J Gastrointest Cancer 2021 Mar;52(1):249-255. doi: 10.1007/s12029-020-00396-x. PMID: 32185743
Chemotherapy for advanced biliary tract carcinoma: A meta-analysis of randomized controlled trials.
Chen L, Chen C, Yen Y, Tam KW
Medicine (Baltimore) 2016 Aug;95(33):e4584. doi: 10.1097/MD.0000000000004584. PMID: 27537589Free PMC Article

Diagnosis

Clinical characteristics of liver injury induced by immune checkpoint inhibitors in patients with advanced biliary tract carcinoma.
Gao Z, Wu S, Yang Y, Sun M, Tian X, Jin X
Invest New Drugs 2023 Oct;41(5):719-726. Epub 2023 Aug 17 doi: 10.1007/s10637-023-01391-2. PMID: 37589864
The Effect of Inflammatory Markers on Survival in Advanced Biliary Tract Carcinoma Treated with Gemcitabine/Oxaliplatin Regimen.
Buyuksimsek M, Kidi MM, Ogul A, Mirili C, Paydas S
J Gastrointest Cancer 2021 Mar;52(1):249-255. doi: 10.1007/s12029-020-00396-x. PMID: 32185743
Phase II Trial of Trifluridine/Tipiracil in Patients with Advanced, Refractory Biliary Tract Carcinoma.
Chakrabarti S, Zemla TJ, Ahn DH, Ou FS, Fruth B, Borad MJ, Hartgers ML, Wessling J, Walkes RL, Alberts SR, McWilliams RR, Liu MC, Durgin LM, Bekaii-Saab TS, Mahipal A
Oncologist 2020 May;25(5):380-e763. Epub 2019 Dec 11 doi: 10.1634/theoncologist.2019-0874. PMID: 31826977Free PMC Article
Advanced biliary tract carcinomas: a retrospective multicenter analysis of first and second-line chemotherapy.
Fiteni F, Jary M, Monnien F, Nguyen T, Beohou E, Demarchi M, Dobi E, Fein F, Cleau D, Fratté S, Nerich V, Bonnetain F, Pivot X, Borg C, Kim S
BMC Gastroenterol 2014 Aug 13;14:143. doi: 10.1186/1471-230X-14-143. PMID: 25117717Free PMC Article
Gemcitabine and oxaliplatin in advanced biliary tract carcinoma: a phase II study.
André T, Reyes-Vidal JM, Fartoux L, Ross P, Leslie M, Rosmorduc O, Clemens MR, Louvet C, Perez N, Mehmud F, Scheithauer W
Br J Cancer 2008 Sep 16;99(6):862-7. doi: 10.1038/sj.bjc.6604628. PMID: 19238628Free PMC Article

Therapy

Treatment of biliary tract carcinoma over the last 30 years.
Midorikawa Y
Biosci Trends 2022 Jul 20;16(3):189-197. Epub 2022 Jun 23 doi: 10.5582/bst.2022.01267. PMID: 35732436
Systemic treatment options for advanced biliary tract carcinoma.
Xie C, McGrath NA, Monge Bonilla C, Fu J
J Gastroenterol 2020 Oct;55(10):944-957. Epub 2020 Aug 3 doi: 10.1007/s00535-020-01712-9. PMID: 32748173Free PMC Article
Chemotherapy for advanced biliary tract carcinoma: A meta-analysis of randomized controlled trials.
Chen L, Chen C, Yen Y, Tam KW
Medicine (Baltimore) 2016 Aug;95(33):e4584. doi: 10.1097/MD.0000000000004584. PMID: 27537589Free PMC Article
Chemotherapy and targeted therapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials.
Eckel F, Schmid RM
Chemotherapy 2014;60(1):13-23. Epub 2014 Oct 21 doi: 10.1159/000365781. PMID: 25341559
Chemotherapy with gemcitabine in advanced biliary tract carcinoma.
Serrano A, Gerson R
Rev Recent Clin Trials 2008 Jan;3(1):70-8. doi: 10.2174/157488708783330512. PMID: 18474016

Prognosis

The Effect of Inflammatory Markers on Survival in Advanced Biliary Tract Carcinoma Treated with Gemcitabine/Oxaliplatin Regimen.
Buyuksimsek M, Kidi MM, Ogul A, Mirili C, Paydas S
J Gastrointest Cancer 2021 Mar;52(1):249-255. doi: 10.1007/s12029-020-00396-x. PMID: 32185743
Systemic treatment options for advanced biliary tract carcinoma.
Xie C, McGrath NA, Monge Bonilla C, Fu J
J Gastroenterol 2020 Oct;55(10):944-957. Epub 2020 Aug 3 doi: 10.1007/s00535-020-01712-9. PMID: 32748173Free PMC Article
Chemotherapy for advanced biliary tract carcinoma: A meta-analysis of randomized controlled trials.
Chen L, Chen C, Yen Y, Tam KW
Medicine (Baltimore) 2016 Aug;95(33):e4584. doi: 10.1097/MD.0000000000004584. PMID: 27537589Free PMC Article
Chemotherapy and targeted therapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials.
Eckel F, Schmid RM
Chemotherapy 2014;60(1):13-23. Epub 2014 Oct 21 doi: 10.1159/000365781. PMID: 25341559
Chemotherapy with gemcitabine in advanced biliary tract carcinoma.
Serrano A, Gerson R
Rev Recent Clin Trials 2008 Jan;3(1):70-8. doi: 10.2174/157488708783330512. PMID: 18474016

Clinical prediction guides

Clinical characteristics of liver injury induced by immune checkpoint inhibitors in patients with advanced biliary tract carcinoma.
Gao Z, Wu S, Yang Y, Sun M, Tian X, Jin X
Invest New Drugs 2023 Oct;41(5):719-726. Epub 2023 Aug 17 doi: 10.1007/s10637-023-01391-2. PMID: 37589864
Effectiveness and safety of radiotherapy plus programmed death-1 inhibitors and lenvatinib in patients with advanced biliary tract carcinoma: a real-world study.
Wang Y, Yang X, Wang Y, Xue J, Zhang N, Yang X, Cong N, Zhang J, Zhu C, Zhang L, Hou X, Zhao H
Cancer Immunol Immunother 2023 Jul;72(7):2197-2204. Epub 2023 Mar 1 doi: 10.1007/s00262-023-03399-2. PMID: 36856834Free PMC Article
The Effect of Inflammatory Markers on Survival in Advanced Biliary Tract Carcinoma Treated with Gemcitabine/Oxaliplatin Regimen.
Buyuksimsek M, Kidi MM, Ogul A, Mirili C, Paydas S
J Gastrointest Cancer 2021 Mar;52(1):249-255. doi: 10.1007/s12029-020-00396-x. PMID: 32185743
Chemotherapy versus Best Supportive Care in Advanced Biliary Tract Carcinoma: A Multi-institutional Propensity Score Matching Analysis.
Ji JH, Kim YS, Park I, Lee SI, Kim RB, Park JO, Oh SY, Hwang IG, Jang JS, Song HN, Kang JH
Cancer Res Treat 2018 Jul;50(3):791-800. Epub 2017 Aug 23 doi: 10.4143/crt.2017.044. PMID: 28838033Free PMC Article
Progranulin as a predictive factor of response to chemotherapy in advanced biliary tract carcinoma.
Kim JH, Do IG, Kim K, Sohn JH, Kim HJ, Jeon WK, Lee SR, Son BH, Shin JH, Nam H, Kwon HJ, Kim MS, Hong HP, Serrero G, Koo DH; KBSMC Pancreatobiliary Cancer Team
Cancer Chemother Pharmacol 2016 Nov;78(5):1085-1092. Epub 2016 Oct 15 doi: 10.1007/s00280-016-3170-z. PMID: 27744566

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